Publications:

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p53 sensitizes chemoresistant non-small cell lung cancer via elevation of reactive oxygen species and suppression of EGFR/PI3K/AKT signaling.

Cancer Cell International

Zhang, Yize Y; Han, Chae Young CY; Duan, Fu Gang FG; Fan, Xing-Xing XX; Yao, Xiao-Jun XJ; Parks, Robin J RJ; Tang, Yi-Jun YJ; Wang, Mei-Fang MF; Liu, Liang L; Tsang, Benjamin K BK; Leung, Elaine Lai-Han EL

Publication Date: 2019

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PubMed Link: 31360122

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Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells.

Scientific Reports

Chen, Yu-Han YH; Su, Ching-Chieh CC; Deng, Wu W; Lock, Leslie F LF; Donovan, Peter J PJ; Kayala, Matthew A MA; Baldi, Pierre P; Lee, Hsiao-Chen HC; Chen, Yumay Y; Wang, Ping H PH

Publication Date: 2019-07-09

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PubMed Link: 31289326

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Cross-Talk Between Insulin Signaling and G Protein-Coupled Receptors.

Journal Of Cardiovascular Pharmacology

Fu, Qin Q; Shi, Qian Q; West, Toni M TM; Xiang, Yang K YK

Publication Date: 2017-08

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PubMed Link: 28328746

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Activating Akt1 mutations alter DNA double strand break repair and radiosensitivity.

Scientific Reports

Oeck, S S; Al-Refae, K K; Riffkin, H H; Wiel, G G; Handrick, R R; Klein, D D; Iliakis, G G; Jendrossek, V V

Publication Date: 2017-02-17

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PubMed Link: 28209968

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BMP-7 enhances cell migration and αvβ3 integrin expression via a c-Src-dependent pathway in human chondrosarcoma cells.

Plos One

Chen, Jui-Chieh JC; Yang, Shu-Ting ST; Lin, Chih-Yang CY; Hsu, Chin-Jung CJ; Tsai, Chun-Hao CH; Su, Jen-Liang JL; Tang, Chih-Hsin CH

Publication Date: 2014

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PubMed Link: 25390068

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The effects of amphiregulin induced MMP-13 production in human osteoarthritis synovial fibroblast.

Mediators Of Inflammation

Chen, Yi-Te YT; Hou, Chun-Han CH; Hou, Sheng-Mou SM; Liu, Ju-Fang JF

Publication Date: 2014

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PubMed Link: 25147440

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Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion.

Nature

Ralston, Katherine S KS; Solga, Michael D MD; Mackey-Lawrence, Nicole M NM; Somlata, ; Bhattacharya, Alok A; Petri, William A WA

Publication Date: 2014-04-24

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PubMed Link: 24717428

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Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons.

The Journal Of Biological Chemistry

Xifró, Xavier X; Miñano-Molina, Alfredo J AJ; Saura, Carlos A CA; Rodríguez-Álvarez, José J

Publication Date: 2014-03-21

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PubMed Link: 24523415

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Mechanisms of Adipocytokine-Mediated Trastuzumab Resistance in HER2-Positive Breast Cancer Cell Lines.

Current Pharmacogenomics And Personalized Medicine

Griner, Samantha E SE; Wang, Katherine J KJ; Joshi, Jayashree P JP; Nahta, Rita R

Publication Date: 2013-03-01

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PubMed Link: 24179558

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β5 integrin up-regulation in brain-derived neurotrophic factor promotes cell motility in human chondrosarcoma.

Plos One

Lin, Chih-Yang CY; Chen, Hui-Jye HJ; Li, Te-Mao TM; Fong, Yi-Chin YC; Liu, Shan-Chi SC; Chen, Po-Chun PC; Tang, Chih-Hsin CH

Publication Date: 2013

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PubMed Link: 23874483

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Involvement of intercellular adhesion molecule-1 up-regulation in bradykinin promotes cell motility in human prostate cancers.

International Journal Of Molecular Sciences

Yu, Hsin-Shan HS; Lin, Tien-Huang TH; Tang, Chih-Hsin CH

Publication Date: 2013-06-26

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PubMed Link: 23803661

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An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Guo, Huang H; Zhao, Zhen Z; Yang, Qi Q; Wang, Min M; Bell, Robert D RD; Wang, Su S; Chow, Nienwen N; Davis, Thomas P TP; Griffin, John H JH; Goldman, Steven A SA; Zlokovic, Berislav V BV

Publication Date: 2013-04-03

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PubMed Link: 23554499

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Impaired translocation and activation of mitochondrial Akt1 mitigated mitochondrial oxidative phosphorylation Complex V activity in diabetic myocardium.

Journal Of Molecular And Cellular Cardiology

Yang, Jia-Ying JY; Deng, Wu W; Chen, Yumay Y; Fan, Weiwei W; Baldwin, Kenneth M KM; Jope, Richard S RS; Wallace, Douglas C DC; Wang, Ping H PH

Publication Date: 2013-06

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PubMed Link: 23500391

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CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts.

Arthritis Research & Therapy

Hou, Chun-Han CH; Tang, Chih-Hsin CH; Hsu, Chin-Jung CJ; Hou, Sheng-Mon SM; Liu, Ju-Fang JF

Publication Date: 2013-01-23

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PubMed Link: 23343403

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HGF and c-Met interaction promotes migration in human chondrosarcoma cells.

Plos One

Tsou, Hsi-Kai HK; Chen, Hsien-Te HT; Hung, Ya-Huey YH; Chang, Chia-Hao CH; Li, Te-Mao TM; Fong, Yi-Chin YC; Tang, Chih-Hsin CH

Publication Date: 2013

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PubMed Link: 23320110

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Hepatocyte growth factor increases vascular endothelial growth factor-A production in human synovial fibroblasts through c-Met receptor pathway.

Plos One

Lin, Yu-Min YM; Huang, Yuan-Li YL; Fong, Yi-Chin YC; Tsai, Chun-Hao CH; Chou, Ming-Chih MC; Tang, Chih-Hsin CH

Publication Date: 2012

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PubMed Link: 23209838

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Hepatocyte growth factor increases osteopontin expression in human osteoblasts through PI3K, Akt, c-Src, and AP-1 signaling pathway.

Plos One

Chen, Hsien-Te HT; Tsou, Hsi-Kai HK; Chang, Chia-Hao CH; Tang, Chih-Hsin CH

Publication Date: 2012

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PubMed Link: 22675553

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The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration.

Molecular Biology Of The Cell

Broussard, Joshua A JA; Lin, Wan-hsin WH; Majumdar, Devi D; Anderson, Bridget B; Eason, Brady B; Brown, Claire M CM; Webb, Donna J DJ

Publication Date: 2012-04

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PubMed Link: 22379109

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Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice.

Journal Of Veterinary Science

Minai-Tehrani, Arash A; Park, Young-Chan YC; Hwang, Soon-Kyung SK; Kwon, Jung-Taek JT; Chang, Seung-Hee SH; Park, Sung-Jin SJ; Yu, Kyeong-Nam KN; Kim, Ji-Eun JE; Shin, Ji-Young JY; Kim, Ji-Hye JH; Kang, Bitna B; Hong, Seong-Ho SH; Cho, Myung-Haing MH

Publication Date: 2011-12

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PubMed Link: 22122896

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Pharmacologic inhibition of mTOR improves lapatinib sensitivity in HER2-overexpressing breast cancer cells with primary trastuzumab resistance.

Anti-Cancer Agents In Medicinal Chemistry

Gayle, Sylvia S SS; Arnold, Samuel L M SL; O'Regan, Ruth M RM; Nahta, Rita R

Publication Date: 2012-02

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PubMed Link: 22043997

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Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin.

Neoplasia (New York, N.Y.)

Laulajainen, Minja M; Muranen, Taru T; Nyman, Tuula A TA; Carpén, Olli O; Grönholm, Mikaela M

Publication Date: 2011-07

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PubMed Link: 21750658

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PPAR-γ ligands repress TGFβ-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

Plos One

Kulkarni, Ajit A AA; Thatcher, Thomas H TH; Olsen, Keith C KC; Maggirwar, Sanjay B SB; Phipps, Richard P RP; Sime, Patricia J PJ

Publication Date: 2011-01-06

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PubMed Link: 21253589

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Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Zhong, Zhihui Z; Wang, Yaoming Y; Guo, Huang H; Sagare, Abhay A; Fernández, José A JA; Bell, Robert D RD; Barrett, Theresa M TM; Griffin, John H JH; Freeman, Robert S RS; Zlokovic, Berislav V BV

Publication Date: 2010-11-17

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PubMed Link: 21084607

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TGF-{beta}1 protects against mesangial cell apoptosis via induction of autophagy.

The Journal Of Biological Chemistry

Ding, Yan Y; Kim, Jin Kuk JK; Kim, Sung Il SI; Na, Hee-Jun HJ; Jun, Soo Young SY; Lee, Seon Jin SJ; Choi, Mary E ME

Publication Date: 2010-11-26

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PubMed Link: 20876581

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The phosphatidylinositol 3-kinase/Akt pathway regulates transforming growth factor-{beta} signaling by destabilizing ski and inducing Smad7.

The Journal Of Biological Chemistry

Band, Arja M AM; Björklund, Mia M; Laiho, Marikki M

Publication Date: 2009-12-18

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PubMed Link: 19875456

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Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB.

Nature Cell Biology

Lin, Hui-Kuan HK; Wang, Guocan G; Chen, Zhenbang Z; Teruya-Feldstein, Julie J; Liu, Yan Y; Chan, Chia-Hsin CH; Yang, Wei-Lei WL; Erdjument-Bromage, Hediye H; Nakayama, Keiichi I KI; Nimer, Stephen S; Tempst, Paul P; Pandolfi, Pier Paolo PP

Publication Date: 2009-04

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PubMed Link: 19270694

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NF-kappaB activation by Helicobacter pylori requires Akt-mediated phosphorylation of p65.

Bmc Microbiology

Takeshima, Eriko E; Tomimori, Koh K; Kawakami, Hirochika H; Ishikawa, Chie C; Sawada, Shigeki S; Tomita, Mariko M; Senba, Masachika M; Kinjo, Fukunori F; Mimuro, Hitomi H; Sasakawa, Chihiro C; Fujita, Jiro J; Mori, Naoki N

Publication Date: 2009-02-12

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PubMed Link: 19216748

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Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells.

Cancer Research

Castro-Rivera, Emely E; Ran, Sophia S; Brekken, Rolf A RA; Minna, John D JD

Publication Date: 2008-10-15

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PubMed Link: 18922901

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The human ERG1 channel polymorphism, K897T, creates a phosphorylation site that inhibits channel activity.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Gentile, Saverio S; Martin, Negin N; Scappini, Erica E; Williams, Jason J; Erxleben, Christian C; Armstrong, David L DL

Publication Date: 2008-09-23

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PubMed Link: 18791070

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Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling.

Molecular And Cellular Biology

Nakamura, Akito A; Naito, Mikihiko M; Tsuruo, Takashi T; Fujita, Naoya N

Publication Date: 2008-10

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PubMed Link: 18662999

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Regulation of neuron survival through an intersectin-phosphoinositide 3'-kinase C2beta-AKT pathway.

Molecular And Cellular Biology

Das, Margaret M; Scappini, Erica E; Martin, Negin P NP; Wong, Katy A KA; Dunn, Sara S; Chen, Yun-Ju YJ; Miller, Stephanie L H SL; Domin, Jan J; O'Bryan, John P JP

Publication Date: 2007-11

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PubMed Link: 17875942

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PIKE GTPase are phosphoinositide-3-kinase enhancers, suppressing programmed cell death.

Journal Of Cellular And Molecular Medicine

Chan, Chi Bun CB; Ye, Keqiang K

Publication Date: 2007

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PubMed Link: 17367500

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Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced apoptosis through attenuation of Akt protein synthesis in human choriocarcinoma cells.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Yung, Hong-wa HW; Korolchuk, Svitlana S; Tolkovsky, Aviva M AM; Charnock-Jones, D Stephen DS; Burton, Graham J GJ

Publication Date: 2007-03

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PubMed Link: 17167073

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Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation.

Molecular Biology Of The Cell

Yoshizaki, Hisayoshi H; Mochizuki, Naoki N; Gotoh, Yukiko Y; Matsuda, Michiyuki M

Publication Date: 2007-01

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PubMed Link: 17079732

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EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.

American Journal Of Respiratory Cell And Molecular Biology

Papaiahgari, Srinivas S; Yerrapureddy, Adinarayana A; Hassoun, Paul M PM; Garcia, Joe G N JG; Birukov, Konstantin G KG; Reddy, Sekhar P SP

Publication Date: 2007-03

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PubMed Link: 17008637

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Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation.

The Embo Journal

Song, Kyung K; Wang, Hui H; Krebs, Tracy L TL; Danielpour, David D

Publication Date: 2006-01-11

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PubMed Link: 16362038

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Akt/protein kinase B activation by adenovirus vectors contributes to NFkappaB-dependent CXCL10 expression.

Journal Of Virology

Liu, Qiang Q; White, Lindsay R LR; Clark, Sharon A SA; Heffner, Daniel J DJ; Winston, Brent W BW; Tibbles, Lee Anne LA; Muruve, Daniel A DA

Publication Date: 2005-12

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PubMed Link: 16282450

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Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition.

Molecular And Cellular Biology

Katayama, Kazuhiro K; Fujita, Naoya N; Tsuruo, Takashi T

Publication Date: 2005-07

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PubMed Link: 15964826

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Suppression of PTEN expression by NF-kappa B prevents apoptosis.

Molecular And Cellular Biology

Vasudevan, Krishna Murthi KM; Gurumurthy, Sushma S; Rangnekar, Vivek M VM

Publication Date: 2004-02

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PubMed Link: 14729949

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p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience

Zhang, Yan Y; Hong, Yanguo Y; Bounhar, Younes Y; Blacker, Megan M; Roucou, Xavier X; Tounekti, Omar O; Vereker, Emily E; Bowers, William J WJ; Federoff, Howard J HJ; Goodyer, Cynthia G CG; LeBlanc, Andrea A

Publication Date: 2003-08-13

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PubMed Link: 12917374

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Akt-dependent cytokine production in mast cells.

The Journal Of Experimental Medicine

Kitaura, J J; Asai, K K; Maeda-Yamamoto, M M; Kawakami, Y Y; Kikkawa, U U; Kawakami, T T

Publication Date: 2000-09-04

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PubMed Link: 10974038

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Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

Molecular And Cellular Biology

Madrid, L V LV; Wang, C Y CY; Guttridge, D C DC; Schottelius, A J AJ; Baldwin, A S AS; Mayo, M W MW

Publication Date: 2000-03

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PubMed Link: 10669740

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