Publications:

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Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α.

Scientific Reports

Ismail, Mohamed M; Martin, Stephen R SR; George, Roger R; Houghton, Francesca F; Kelly, Geoff G; Chaleil, Raphaël A G RAG; Anastasiou, Panayiotis P; Wang, Xinyue X; O'Reilly, Nicola N; Federico, Stefania S; Joshi, Dhira D; Nagaraj, Hemavathi H; Cooley, Rachel R; Hui, Ning Sze NS; Molina-Arcas, Miriam M; Hancock, David C DC; Tavassoli, Ali A; Downward, Julian J

Publication Date: 2023-02-02

Variant appearance in text: PI3K: K227A

PubMed Link: 36732563

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• Main text
• 41598_2023_Article_28756.pdf

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Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling.

International Journal Of Molecular Sciences

Zhang, Biqin B; Luk, Cheukyau C; Valadares, Joyce J; Aronis, Christos C; Foukas, Lazaros C LC

Publication Date: 2021-11-26

Variant appearance in text: PI3K: K227A

PubMed Link: 34884613

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• Main text
• ijms-22-12813.pdf

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Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling.

International Journal Of Molecular Sciences

Zhang, Biqin B; Luk, Cheukyau C; Valadares, Joyce J; Aronis, Christos C; Foukas, Lazaros C LC

Publication Date: 2021-11-26

Variant appearance in text: PI3K: K227A

PubMed Link: 34884613

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• Main text
• ijms-22-12813.pdf

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The Importance of Being PI3K in the RAS Signaling Network.

Genes

Cuesta, Cristina C; Arévalo-Alameda, Cristina C; Castellano, Esther E

Publication Date: 2021-07-19

Variant appearance in text: PI3K: K227A

PubMed Link: 34356110

Variant Present in the following documents:

• Main text
• genes-12-01094.pdf

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Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets.

Wellcome Open Research

Cooley, Rachel R; Kara, Neesha N; Hui, Ning Sze NS; Tart, Jonathan J; Roustan, Chloë C; George, Roger R; Hancock, David C DC; Binkowski, Brock F BF; Wood, Keith V KV; Ismail, Mohamed M; Downward, Julian J

Publication Date: 2020

Variant appearance in text: PI3K: K227A

PubMed Link: 32587898

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• Main text
• wellcomeopenres-5-17179.pdf

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Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.

Cell Reports

Murillo, Miguel M MM; Rana, Sareena S; Spencer-Dene, Bradley B; Nye, Emma E; Stamp, Gordon G; Downward, Julian J

Publication Date: 2018-12-26

Variant appearance in text: PI3K: K227A

PubMed Link: 30590030

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Quantitation of class IA PI3Ks in mice reveals p110-free-p85s and isoform-selective subunit associations and recruitment to receptors.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Tsolakos, N N; Durrant, T N TN; Chessa, T T; Suire, S M SM; Oxley, D D; Kulkarni, S S; Downward, J J; Perisic, O O; Williams, R L RL; Stephens, L L; Hawkins, P T PT

Publication Date: 2018-11-27

Variant appearance in text: PI3K: K227A

PubMed Link: 30442661

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• Main text
• pnas.201803446.pdf

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PI3K: A Crucial Piece in the RAS Signaling Puzzle.

Cold Spring Harbor Perspectives In Medicine

Krygowska, Agata Adelajda AA; Castellano, Esther E

Publication Date: 2018-06-01

Variant appearance in text: PI3K: K227A

PubMed Link: 28847905

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RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression.

Nature Communications

Castellano, Esther E; Molina-Arcas, Miriam M; Krygowska, Agata Adelajda AA; East, Philip P; Warne, Patricia P; Nicol, Alastair A; Downward, Julian J

Publication Date: 2016-04-13

Variant appearance in text: PI3K: K227A

PubMed Link: 27071537

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• Main text
• ncomms11245.pdf

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Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity.

Plos Genetics

Gobbini, Elisa E; Villa, Matteo M; Gnugnoli, Marco M; Menin, Luca L; Clerici, Michela M; Longhese, Maria Pia MP

Publication Date: 2015-11

Variant appearance in text: PI3K: K227A

PubMed Link: 26584331

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• Main text
• pgen.1005685.pdf

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The PTEN/PI3K/AKT Pathway in vivo, Cancer Mouse Models.

Frontiers In Oncology

Carnero, Amancio A; Paramio, Jesus M JM

Publication Date: 2014

Variant appearance in text: PIK3CA: K227A

PubMed Link: 25295225

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• Main text
• fonc-04-00252.pdf

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Requirement for interaction of PI3-kinase p110α with RAS in lung tumor maintenance.

Cancer Cell

Castellano, Esther E; Sheridan, Clare C; Thin, May Zaw MZ; Nye, Emma E; Spencer-Dene, Bradley B; Diefenbacher, Markus E ME; Moore, Christopher C; Kumar, Madhu S MS; Murillo, Miguel M MM; Grönroos, Eva E; Lassailly, Francois F; Stamp, Gordon G; Downward, Julian J

Publication Date: 2013-11-11

Variant appearance in text: PIK3CA: K227A

PubMed Link: 24229709

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Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.

Cancer Research

Wang, Grace M GM; Wong, Hong Yuen HY; Konishi, Hiroyuki H; Blair, Brian G BG; Abukhdeir, Abde M AM; Gustin, John P JP; Rosen, D Marc DM; Denmeade, Samuel Ray SR; Rasheed, Zeshaan Z; Matsui, William W; Garay, Joseph P JP; Mohseni, Morassa M; Higgins, Michaela J MJ; Cidado, Justin J; Jelovac, Danijela D; Croessmann, Sarah S; Cochran, Rory L RL; Karnan, Sivasundaram S; Konishi, Yuko Y; Ota, Akinobu A; Hosokawa, Yoshitaka Y; Argani, Pedram P; Lauring, Josh J; Park, Ben Ho BH

Publication Date: 2013-06-01

Variant appearance in text: PIK3CA: K227A

PubMed Link: 23580570

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Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector.

The Journal Of Cell Biology

Wynne, Joseph P JP; Wu, Jinhua J; Su, Wenjuan W; Mor, Adam A; Patsoukis, Nikolaos N; Boussiotis, Vassiliki A VA; Hubbard, Stevan R SR; Philips, Mark R MR

Publication Date: 2012-10-15

Variant appearance in text: PI3K: K227A

PubMed Link: 23045549

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• Main text
• JCB_201201157.pdf

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Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase.

Cell Cycle (Georgetown, Tex.)

Sun, Minghao M; Hart, Jonathan R JR; Hillmann, Petra P; Gymnopoulos, Marco M; Vogt, Peter K PK

Publication Date: 2011-11-01

Variant appearance in text: PI3K: K227A

PubMed Link: 22045127

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RAS Interaction with PI3K: More Than Just Another Effector Pathway.

Genes & Cancer

Castellano, Esther E; Downward, Julian J

Publication Date: 2011-03

Variant appearance in text: PI3K: K227A

PubMed Link: 21779497

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Hot-spot mutations in p110alpha of phosphatidylinositol 3-kinase (pI3K): differential interactions with the regulatory subunit p85 and with RAS.

Cell Cycle (Georgetown, Tex.)

Zhao, Li L; Vogt, Peter K PK

Publication Date: 2010-02-01

Variant appearance in text: PI3K: K227A

PubMed Link: 20009532

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Phosphoinositide 3-kinases p110alpha and p110beta regulate cell cycle entry, exhibiting distinct activation kinetics in G1 phase.

Molecular And Cellular Biology

Marqués, Miriam M; Kumar, Amit A; Cortés, Isabel I; Gonzalez-García, Ana A; Hernández, Carmen C; Moreno-Ortiz, M Carmen MC; Carrera, Ana C AC

Publication Date: 2008-04

Variant appearance in text: PI3K: K227A

PubMed Link: 18285463

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