PIK3CA c.749A>T ;(p.Y250F)

Variant ID: 3-178919264-A-T

NM_006218.2(PIK3CA):c.749A>T;(p.Y250F)

This variant was identified in 9 publications

View GRCh38 version.




Publications:


A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: PIK3CA: Y250F
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
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Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo.

Oncogene
Attalla, Sherif S; Taifour, Tarek T; Bui, Tung T; Muller, William W
Publication Date: 2021-01

Variant appearance in text: PI3K: Y250F
PubMed Link: 33235291
Variant Present in the following documents:
  • Main text
  • 41388_2020_Article_1560.pdf
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Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo.

Oncogene
Attalla, Sherif S; Taifour, Tarek T; Bui, Tung T; Muller, William W
Publication Date: 2021-01

Variant appearance in text: PI3K: Y250F
PubMed Link: 33235291
Variant Present in the following documents:
  • Main text
  • 41388_2020_Article_1560.pdf
View BVdb publication page



ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis.

Cancer Research
Cook, Rebecca S RS; Garrett, Joan T JT; Sánchez, Violeta V; Stanford, Jamie C JC; Young, Christian C; Chakrabarty, Anindita A; Rinehart, Cammie C; Zhang, Yixian Y; Wu, Yaming Y; Greenberger, Lee L; Horak, Ivan D ID; Arteaga, Carlos L CL
Publication Date: 2011-06-01

Variant appearance in text: PI3K: Y250F
PubMed Link: 21482676
Variant Present in the following documents:
  • Main text
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Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.

Microbiology And Molecular Biology Reviews : Mmbr
Fluck, Michele M MM; Schaffhausen, Brian S BS
Publication Date: 2009-09

Variant appearance in text: PI3K: Y250F
PubMed Link: 19721090
Variant Present in the following documents:
  • Main text
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Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.

Seminars In Cancer Biology
Cheng, Jingwei J; DeCaprio, James A JA; Fluck, Michele M MM; Schaffhausen, Brian S BS
Publication Date: 2009-08

Variant appearance in text: PI3K: Y250F
PubMed Link: 19505649
Variant Present in the following documents:
  • Main text
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Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.

Virology
Schaffhausen, Brian S BS; Roberts, Thomas M TM
Publication Date: 2009-02-20

Variant appearance in text: PI3K: Y250F
PubMed Link: 19022468
Variant Present in the following documents:
  • Main text
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The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation.

Journal Of Virology
Utermark, Tamara T; Schaffhausen, Brian S BS; Roberts, Thomas M TM; Zhao, Jean J JJ
Publication Date: 2007-07

Variant appearance in text: PI3K: Y250F
PubMed Link: 17442716
Variant Present in the following documents:
  • Main text
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Polyoma and SV40 proteins differentially regulate PP2A to activate distinct cellular signaling pathways involved in growth control.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Rodriguez-Viciana, Pablo P; Collins, Crista C; Fried, Mike M
Publication Date: 2006-12-19

Variant appearance in text: PI3K: Y250F
PubMed Link: 17158797
Variant Present in the following documents:
  • Main text
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ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation.

The Embo Journal
Ong, S H SH; Dilworth, S S; Hauck-Schmalenberger, I I; Pawson, T T; Kiefer, F F
Publication Date: 2001-11-15

Variant appearance in text: PI3K: Y250F
PubMed Link: 11707404
Variant Present in the following documents:
  • Main text
View BVdb publication page