PIK3CA c.1346C>G ;(p.P449R)

Variant ID: 3-178928068-C-G

NM_006218.2(PIK3CA):c.1346C>G;(p.P449R)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


Integrated Analysis of Genomic and Immunological Features in Lung Adenocarcinoma With Micropapillary Component.

Frontiers In Oncology
Zhang, Shirong S; Xu, Yang Y; Zhao, Pan P; Bao, Hua H; Wang, Xiyong X; Liu, Rui R; Xu, Rujun R; Xiang, Jingjing J; Jiang, Hong H; Yan, Junrong J; Wu, Xue X; Shao, Yang Y; Liang, Jiafeng J; Wu, Qiong Q; Zhang, Zhihao Z; Lu, Shun S; Ma, Shenglin S
Publication Date: 2021

Variant appearance in text: PIK3CA: 1346C>G; P449R
PubMed Link: 34221970
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



A phase 1b dose expansion study of the pan-class I PI3K inhibitor buparlisib (BKM120) plus carboplatin and paclitaxel in PTEN deficient tumors and with dose intensified carboplatin and paclitaxel.

Investigational New Drugs
Smyth, Lillian M LM; Monson, Kelsey R KR; Jhaveri, Komal K; Drilon, Alexander A; Li, Bob T BT; Abida, Wassim W; Iyer, Gopa G; Gerecitano, John F JF; Gounder, Mrinal M; Harding, James J JJ; Voss, Martin H MH; Makker, Vicky V; Ho, Alan L AL; Razavi, Pedram P; Iasonos, Alexia A; Bialer, Philip P; Lacouture, Mario E ME; Teitcher, Jerrold B JB; Erinjeri, Joseph P JP; Katabi, Nora N; Fury, Matthew G MG; Hyman, David M DM
Publication Date: 2017-12

Variant appearance in text: PIK3CA: P449R
PubMed Link: 28281183
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.

Oncotarget
Ashktorab, Hassan H; Mokarram, Pooneh P; Azimi, Hamed H; Olumi, Hasti H; Varma, Sudhir S; Nickerson, Michael L ML; Brim, Hassan H
Publication Date: 2017-01-31

Variant appearance in text: PIK3CA: P449R
PubMed Link: 28002797
Variant Present in the following documents:
  • oncotarget-08-7852-s002.xlsx, sheet 19
View BVdb publication page



In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

The Journal Of Pathology. Clinical Research
McConechy, Melissa K MK; Hoang, Lien N LN; Chui, Michael Herman MH; Senz, Janine J; Yang, Winnie W; Rozenberg, Nirit N; Mackenzie, Robertson R; McAlpine, Jessica N JN; Huntsman, David G DG; Clarke, Blaise A BA; Gilks, Cyril Blake CB; Lee, Cheng-Han CH
Publication Date: 2015-07

Variant appearance in text: PIK3CA: P449R
PubMed Link: 27499902
Variant Present in the following documents:
  • CJP2-1-173-s002.xlsx, sheet 1
View BVdb publication page