PIK3CA c.1358A>C ;(p.E453A)

Variant ID: 3-178928080-A-C

NM_006218.2(PIK3CA):c.1358A>C;(p.E453A)

This variant was identified in 12 publications

View GRCh38 version.




Publications:


Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: E453A
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: PIK3CA: E453A
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: PIK3CA: 1358A>C; E453A
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 1358A>C; E453A
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: PIK3CA: E453A
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: PIK3CA: E453A
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Cancer-Associated PIK3CA Mutations in Overgrowth Disorders.

Trends In Molecular Medicine
Madsen, Ralitsa R RR; Vanhaesebroeck, Bart B; Semple, Robert K RK
Publication Date: 2018-10

Variant appearance in text: PI3K: E453A
PubMed Link: 30197175
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: PIK3CA: 1358A>C; E453A
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



PI3 kinase mutations and mutational load as poor prognostic markers in diffuse glioma patients.

Acta Neuropathologica Communications
Draaisma, Kaspar K; Wijnenga, Maarten M J MM; Weenink, Bas B; Gao, Ya Y; Smid, Marcel M; Robe, P P; van den Bent, Martin J MJ; French, Pim J PJ
Publication Date: 2015-12-23

Variant appearance in text: PI3K: E453A
PubMed Link: 26699864
Variant Present in the following documents:
  • 40478_2015_265_MOESM1_ESM.xlsx, sheet 10
View BVdb publication page



PIK3R1 (p85α) is somatically mutated at high frequency in primary endometrial cancer.

Cancer Research
Urick, Mary E ME; Rudd, Meghan L ML; Godwin, Andrew K AK; Sgroi, Dennis D; Merino, Maria M; Bell, Daphne W DW
Publication Date: 2011-06-15

Variant appearance in text: PIK3CA: E453A
PubMed Link: 21478295
Variant Present in the following documents:
  • Main text
View BVdb publication page



A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Rudd, Meghan L ML; Price, Jessica C JC; Fogoros, Sarah S; Godwin, Andrew K AK; Sgroi, Dennis C DC; Merino, Maria J MJ; Bell, Daphne W DW
Publication Date: 2011-03-15

Variant appearance in text: PIK3CA: E453A
PubMed Link: 21266528
Variant Present in the following documents:
  • Main text
View BVdb publication page