PIK3CA c.1607C>T ;(p.T536I)

Variant ID: 3-178936065-C-T

NM_006218.2(PIK3CA):c.1607C>T;(p.T536I)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Concurrent Genetic Alterations and Other Biomarkers Predict Treatment Efficacy of EGFR-TKIs in EGFR-Mutant Non-Small Cell Lung Cancer: A Review.

Frontiers In Oncology
Guo, Yijia Y; Song, Jun J; Wang, Yanru Y; Huang, Letian L; Sun, Li L; Zhao, Jianzhu J; Zhang, Shuling S; Jing, Wei W; Ma, Jietao J; Han, Chengbo C
Publication Date: 2020

Variant appearance in text: PIK3CA: T536I
PubMed Link: 33363040
Variant Present in the following documents:
  • Main text
  • fonc-10-610923.pdf
View BVdb publication page



Immune Control by TRAF6-Mediated Pathways of Epithelial Cells in the EIME (Epithelial Immune Microenvironment).

Frontiers In Immunology
Dainichi, Teruki T; Matsumoto, Reiko R; Mostafa, Alshimaa A; Kabashima, Kenji K
Publication Date: 2019

Variant appearance in text: PI3K: T536I
PubMed Link: 31156649
Variant Present in the following documents:
  • Main text
  • fimmu-10-01107.pdf
View BVdb publication page



Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.

Nature
Miller, Alexandra M AM; Shah, Ronak H RH; Pentsova, Elena I EI; Pourmaleki, Maryam M; Briggs, Samuel S; Distefano, Natalie N; Zheng, Youyun Y; Skakodub, Anna A; Mehta, Smrutiben A SA; Campos, Carl C; Hsieh, Wan-Ying WY; Selcuklu, S Duygu SD; Ling, Lilan L; Meng, Fanli F; Jing, Xiaohong X; Samoila, Aliaksandra A; Bale, Tejus A TA; Tsui, Dana W Y DWY; Grommes, Christian C; Viale, Agnes A; Souweidane, Mark M MM; Tabar, Viviane V; Brennan, Cameron W CW; Reiner, Anne S AS; Rosenblum, Marc M; Panageas, Katherine S KS; DeAngelis, Lisa M LM; Young, Robert J RJ; Berger, Michael F MF; Mellinghoff, Ingo K IK
Publication Date: 2019-01

Variant appearance in text: PIK3CA: 1607C>T; T536I
PubMed Link: 30675060
Variant Present in the following documents:
  • NIHMS1516901-supplement-Sup_Table_5.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: PIK3CA: T536I
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



PIK3CA mutations frequently coexist with EGFR/KRAS mutations in non-small cell lung cancer and suggest poor prognosis in EGFR/KRAS wildtype subgroup.

Plos One
Wang, Lei L; Hu, Haichuan H; Pan, Yunjian Y; Wang, Rui R; Li, Yuan Y; Shen, Lei L; Yu, Yongfu Y; Li, Hang H; Cai, Deng D; Sun, Yihua Y; Chen, Haiquan H
Publication Date: 2014

Variant appearance in text: PIK3CA: T536I
PubMed Link: 24533074
Variant Present in the following documents:
  • Main text
  • pone.0088291.pdf
View BVdb publication page