The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs).
Frontiers In Oncology
Raphael, Ari A; Onn, Amir A; Holtzman, Liran L; Dudnik, Julia J; Urban, Damien D; Kian, Waleed W; Cohen, Aharon Y AY; Moskovitz, Mor M; Zer, Alona A; Bar, Jair J; Rabinovich, Natalie Maimon NM; Grynberg, Shirly S; Oedegaard, Cecilie C; Agbarya, Abed A; Peled, Nir N; Shochat, Tzippy T; Dudnik, Elizabeth E
PIK3CA Mutation as Potential Poor Prognostic Marker in Asian Female Breast Cancer Patients Who Received Adjuvant Chemotherapy.
Current Oncology (Toronto, Ont.)
Cho, Yoon Ah YA; Ko, Seung Yeon SY; Suh, Yong Joon YJ; Kim, Sanghwa S; Park, Jung Ho JH; Park, Hye-Rim HR; Seo, Jinwon J; Choi, Hyo Geun HG; Kang, Ho Suk HS; Lim, Hyun H; Park, Ha Young HY; Kwon, Mi Jung MJ
Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.
Acs Infectious Diseases
Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S
Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.
Nature Medicine
Chandran, Smita S SS; Ma, Jiaqi J; Klatt, Martin G MG; Dündar, Friederike F; Bandlamudi, Chaitanya C; Razavi, Pedram P; Wen, Hannah Y HY; Weigelt, Britta B; Zumbo, Paul P; Fu, Si Ning SN; Banks, Lauren B LB; Yi, Fei F; Vercher, Enric E; Etxeberria, Inaki I; Bestman, Watchain D WD; Da Cruz Paula, Arnaud A; Aricescu, Ilinca S IS; Drilon, Alexander A; Betel, Doron D; Scheinberg, David A DA; Baker, Brian M BM; Klebanoff, Christopher A CA
The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report.
Cold Spring Harbor Molecular Case Studies
Chen, Wei-Liang WL; Pao, Emily E; Owens, James J; Glass, Ian I; Pritchard, Colin C; Shirts, Brain H BH; Lockwood, Christina C; Mirzaa, Ghayda M GM
Preclinical Models for Acquired Resistance to Third-Generation EGFR Inhibitors in NSCLC: Functional Studies and Drug Combinations Used to Overcome Resistance.
Frontiers In Oncology
Mahfoudhi, Emna E; Ricordel, Charles C; Lecuyer, Gwendoline G; Mouric, Cécile C; Lena, Hervé H; Pedeux, Rémy R
Application of an Ultrasensitive NGS-Based Blood Test for the Diagnosis of Early-Stage Lung Cancer: Sensitivity, a Hurdle Still Difficult to Overcome.
Cancers
Van der Linden, Malaïka M; Van Gaever, Bram B; Raman, Lennart L; Vermaelen, Karim K; Demedts, Ingel I; Surmont, Veerle V; Himpe, Ulrike U; Lievens, Yolande Y; Ferdinande, Liesbeth L; Dedeurwaerdere, Franceska F; Van der Meulen, Joni J; Claes, Kathleen K; Menten, Björn B; Van Dorpe, Jo J
Publication Date: 2022-04-18
Variant appearance in text: PIK3CA: 1624G>A; Glu542Lys
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis.
Frontiers In Oncology
Kyrochristos, Ioannis D ID; Glantzounis, Georgios K GK; Goussia, Anna A; Eliades, Alexia A; Achilleos, Achilleas A; Tsangaras, Kyriakos K; Hadjidemetriou, Irene I; Elpidorou, Marilena M; Ioannides, Marios M; Koumbaris, George G; Mitsis, Michail M; Patsalis, Philippos C PC; Roukos, Dimitrios D
Plasma Genotyping at the Time of Diagnostic Tissue Biopsy Decreases Time-to-Treatment in Patients With Advanced NSCLC-Results From a Prospective Pilot Study.
Jto Clinical And Research Reports
Thompson, Jeffrey C JC; Aggarwal, Charu C; Wong, Janeline J; Nimgaonkar, Vivek V; Hwang, Wei-Ting WT; Andronov, Michelle M; Dibardino, David M DM; Hutchinson, Christoph T CT; Ma, Kevin C KC; Lanfranco, Anthony A; Moon, Edmund E; Haas, Andrew R AR; Singh, Aditi P AP; Ciunci, Christine A CA; Marmarelis, Melina M; D'Avella, Christopher C; Cohen, Justine V JV; Bauml, Joshua M JM; Cohen, Roger B RB; Langer, Corey J CJ; Vachani, Anil A; Carpenter, Erica L EL
Ensemble of nucleic acid absolute quantitation modules for copy number variation detection and RNA profiling.
Nature Communications
Wu, Lucia Ruojia LR; Dai, Peng P; Wang, Michael Xiangjiang MX; Chen, Sherry Xi SX; Cohen, Evan N EN; Jayachandran, Gitanjali G; Zhang, Jinny Xuemeng JX; Serrano, Angela V AV; Xie, Nina Guanyi NG; Ueno, Naoto T NT; Reuben, James M JM; Barcenas, Carlos H CH; Zhang, David Yu DY
Publication Date: 2022-04-04
Variant appearance in text: PIK3CA: 1624G>A; E542K
Somatic activating BRAF variants cause isolated lymphatic malformations.
Hgg Advances
Zenner, Kaitlyn K; Jensen, Dana M DM; Dmyterko, Victoria V; Shivaram, Giridhar M GM; Myers, Candace T CT; Paschal, Cate R CR; Rudzinski, Erin R ER; Pham, Minh-Hang M MM; Cheng, V Chi VC; Manning, Scott C SC; Bly, Randall A RA; Ganti, Sheila S; Perkins, Jonathan A JA; Bennett, James T JT
AKT1 and PIK3CA activating mutations in Moroccan bladder cancer patients´ biopsies and matched urine.
The Pan African Medical Journal
El Ahanidi, Hajar H; El Azzouzi, Meryem M; Arrouchi, Housna H; Alaoui, Chaimae Hafidi CH; Tetou, Mohammed M; Bensaid, Mounia M; Oukabli, Mohamed M; Ameur, Ahmed A; Al Bouzidi, Abderrahmane A; El Mzibri, Mohammed M; Attaleb, Mohammed M
p16INK4A-deficiency predicts response to combined HER2 and CDK4/6 inhibition in HER2+ breast cancer brain metastases.
Nature Communications
Ni, Jing J; Kabraji, Sheheryar S; Xie, Shaozhen S; Wang, Yanzhi Y; Pan, Peichen P; He, Xiaofang X; Liu, Zongming Z; Leone, Jose Palbo JP; Long, Henry W HW; Brown, Myles A MA; Winer, Eric P EP; Dillon, Deborah A R DAR; Lin, Nancy U NU; Zhao, Jean J JJ
Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors.
Plos One
Milbury, Coren A CA; Creeden, James J; Yip, Wai-Ki WK; Smith, David L DL; Pattani, Varun V; Maxwell, Kristi K; Sawchyn, Bethany B; Gjoerup, Ole O; Meng, Wei W; Skoletsky, Joel J; Concepcion, Alvin D AD; Tang, Yanhua Y; Bai, Xiaobo X; Dewal, Ninad N; Ma, Pei P; Bailey, Shannon T ST; Thornton, James J; Pavlick, Dean C DC; Frampton, Garrett M GM; Lieber, Daniel D; White, Jared J; Burns, Christine C; Vietz, Christine C
The Landscape of Actionable Genomic Alterations by Next-Generation Sequencing in Tumor Tissue Versus Circulating Tumor DNA in Chinese Patients With Non-Small Cell Lung Cancer.
PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival.
Cancers
Cochicho, Daniela D; Esteves, Susana S; Rito, Miguel M; Silva, Fernanda F; Martins, Luís L; Montalvão, Pedro P; Cunha, Mário M; Magalhães, Miguel M; Gil da Costa, Rui M RM; Felix, Ana A
Evaluation of the Clinical Utility of Genomic Profiling to Inform Selection of Clinical Trial Therapy in Salivary Gland Cancer.
Cancers
Rack, Samuel S; Feeney, Laura L; Hapuarachi, Brindley B; Adderley, Helen H; Woodhouse, Laura L; Betts, Guy G; Burghel, George J GJ; Harrington, Kevin J KJ; Metcalf, Robert R
The impact of whole genome and transcriptome analysis (WGTA) on predictive biomarker discovery and diagnostic accuracy of advanced malignancies.
The Journal Of Pathology. Clinical Research
Tessier-Cloutier, Basile B; Grewal, Jasleen K JK; Jones, Martin R MR; Pleasance, Erin E; Shen, Yaoqing Y; Cai, Ellen E; Dunham, Chris C; Hoang, Lynn L; Horst, Basil B; Huntsman, David G DG; Ionescu, Diana D; Karnezis, Anthony N AN; Lee, Anna F AF; Lee, Cheng Han CH; Lee, Tae Hoon TH; Twa, David Dw DD; Mungall, Andrew J AJ; Mungall, Karen K; Naso, Julia R JR; Ng, Tony T; Schaeffer, David F DF; Sheffield, Brandon S BS; Skinnider, Brian B; Smith, Tyler T; Williamson, Laura L; Zhong, Ellia E; Regier, Dean A DA; Laskin, Janessa J; Marra, Marco A MA; Gilks, C Blake CB; Jones, Steven Jm SJ; Yip, Stephen S
Publication Date: 2022-03-08
Variant appearance in text: PIK3CA: 1624G>A; Glu542Lys
An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer.
Cell Reports. Medicine
Johnson, Brett E BE; Creason, Allison L AL; Stommel, Jayne M JM; Keck, Jamie M JM; Parmar, Swapnil S; Betts, Courtney B CB; Blucher, Aurora A; Boniface, Christopher C; Bucher, Elmar E; Burlingame, Erik E; Camp, Todd T; Chin, Koei K; Eng, Jennifer J; Estabrook, Joseph J; Feiler, Heidi S HS; Heskett, Michael B MB; Hu, Zhi Z; Kolodzie, Annette A; Kong, Ben L BL; Labrie, Marilyne M; Lee, Jinho J; Leyshock, Patrick P; Mitri, Souraya S; Patterson, Janice J; Riesterer, Jessica L JL; Sivagnanam, Shamilene S; Somers, Julia J; Sudar, Damir D; Thibault, Guillaume G; Weeder, Benjamin R BR; Zheng, Christina C; Nan, Xiaolin X; Thompson, Reid F RF; Heiser, Laura M LM; Spellman, Paul T PT; Thomas, George G; Demir, Emek E; Chang, Young Hwan YH; Coussens, Lisa M LM; Guimaraes, Alexander R AR; Corless, Christopher C; Goecks, Jeremy J; Bergan, Raymond R; Mitri, Zahi Z; Mills, Gordon B GB; Gray, Joe W JW
Genome-wide aneuploidy detected by mFast-SeqS in circulating cell-free DNA is associated with poor response to pembrolizumab in patients with advanced urothelial cancer.
Molecular Oncology
Mendelaar, Pauline A J PAJ; Robbrecht, Debbie D; Rijnders, Maud M; de Wit, Ronald R; de Weerd, Vanja V; Deger, Teoman T; Westgeest, Hans M HM; Aarts, Maureen J B MJB; Voortman, Jens J; Martens, John W M JWM; van der Veldt, Astrid A M AAM; Nakauma-González, J Alberto JA; Wilting, Saskia M SM; Lolkema, Martijn M
Publication Date: 2022-02-18
Variant appearance in text: PIK3CA: 1624G>A; E542K
Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas.
Molecular Cancer
Eisenhardt, A E AE; Schmid, A A; Esser, J J; Brugger, Z Z; Lausch, U U; Kiefer, J J; Braig, M M; Runkel, A A; Wehrle, J J; Claus, R R; Bronsert, P P; Leithner, A A; Liegl-Atzwanger, B B; Zeller, J J; Papini, R R; von Laffert, M M; Pfitzner, B M BM; Koulaxouzidis, G G; Giunta, R E RE; Eisenhardt, S U SU; Braig, David D
Nanomedicine Strategies for Management of Drug Resistance in Lung Cancer.
International Journal Of Molecular Sciences
Haider, Mohamed M; Elsherbeny, Amr A; Pittalà, Valeria V; Consoli, Valeria V; Alghamdi, Maha Ali MA; Hussain, Zahid Z; Khoder, Ghalia G; Greish, Khaled K
Circulating tumor DNA predicts efficacy of a dual AKT/p70S6K inhibitor (LY2780301) plus paclitaxel in metastatic breast cancer: plasma analysis of the TAKTIC phase IB/II study.
Molecular Oncology
Sabatier, Renaud R; Vicier, Cécile C; Garnier, Séverine S; Guille, Arnaud A; Carbuccia, Nadine N; Isambert, Nicolas N; Dalenc, Florence F; Robert, Marie M; Levy, Christelle C; Pakradouni, Jihane J; Adelaïde, José J; Chaffanet, Max M; Sfumato, Patrick P; Mamessier, Emilie E; Bertucci, François F; Goncalves, Anthony A
KIT/PDGFRA/KDR amplification defines a novel molecular subtype of adenoid cystic carcinoma patients who may benefit from treatment with tyrosine kinase inhibitors.
Antitumor activity and safety of sirolimus for solid tumors with PIK3CA mutations: A multicenter, open-label, prospective single-arm study (KM 02-01, KCSG UN17-16).
Translational Cancer Research
Byeon, Seonggyu S; Kang, Myoung Joo MJ; Choi, Yoon Ji YJ; Kim, Yu Jung YJ; Kim, Miso M; Yun, Jina J; Yi, Seong Yoon SY; Kim, Jin Young JY; Kim, Seung Tae ST; Lee, Jeeyun J
Next-Generation Sequencing Reveals a Very Low Prevalence of Deleterious Mutations of Homologous Recombination Repair Genes and Homologous Recombination Deficiency in Ovarian Clear Cell Carcinoma.