Publications:

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The Role of Biomarkers in Guiding Clinical Decision-Making in Oncology.

Journal Of The Advanced Practitioner In Oncology

Moore, Donald C DC; Guinigundo, Andrew S AS

Publication Date: 2023-04

Variant appearance in text: PIK3CA: E545D

PubMed Link: 37206905

Variant Present in the following documents:

• Main text
• jadpro-14-15.pdf

View BVdb publication page

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Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer Research Communications

White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C

Publication Date: 2022-09

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp; rs121913275

PubMed Link: 36922933

Variant Present in the following documents:

• crc-22-0136-s01.xlsx, sheet 3

View BVdb publication page

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Cancers

Suthapot, Praewa P; Chiangjong, Wararat W; Chaiyawat, Parunya P; Choochuen, Pongsakorn P; Pruksakorn, Dumnoensun D; Sangkhathat, Surasak S; Hongeng, Suradej S; Anurathapan, Usanarat U; Chutipongtanate, Somchai S

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36900212

Variant Present in the following documents:

• Main text

View BVdb publication page

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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Pan-cancer clinical impact of latent drivers from double mutations.

Communications Biology

Yavuz, Bengi Ruken BR; Tsai, Chung-Jung CJ; Nussinov, Ruth R; Tuncbag, Nurcan N

Publication Date: 2023-02-20

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36808143

Variant Present in the following documents:

• 42003_2023_4519_MOESM3_ESM.xlsx, sheet 3

View BVdb publication page

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Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Sivakumar, Smruthy S; Jin, Dexter X DX; Rathod, Ruchita R; Ross, Jeffrey J; Cantley, Lewis C LC; Scaltriti, Maurizio M; Chen, Jessica W JW; Hutchinson, Katherine E KE; Wilson, Timothy R TR; Sokol, Ethan S ES; Vasan, Neil N

Publication Date: 2023-01-03

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36595567

Variant Present in the following documents:

• ccr-22-2270_supplementary_tables_s1-14_suppts1-14.xlsx, sheet 12

View BVdb publication page

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ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).

Plos Genetics

Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G

Publication Date: 2023-01-03

Variant appearance in text: rs121913275

PubMed Link: 36595552

Variant Present in the following documents:

• pgen.1010563.s004.xlsx, sheet 1

View BVdb publication page

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PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative.

Journal Of Personalized Medicine

Ascione, Liliana L; Zagami, Paola P; Nicolò, Eleonora E; Crimini, Edoardo E; Curigliano, Giuseppe G; Criscitiello, Carmen C

Publication Date: 2022-10-31

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36579519

Variant Present in the following documents:

• Main text
• jpm-12-01793.pdf

View BVdb publication page

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: rs121913275

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 5

View BVdb publication page

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Molecular-Targeted Therapy for Tumor-Agnostic Mutations in Acute Myeloid Leukemia.

Biomedicines

Arai, Hironori H; Minami, Yosuke Y; Chi, SungGi S; Utsu, Yoshikazu Y; Masuda, Shinichi S; Aotsuka, Nobuyuki N

Publication Date: 2022-11-22

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36551764

Variant Present in the following documents:

• biomedicines-10-03008.pdf

View BVdb publication page

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PAM-independent ultra-specific activation of CRISPR-Cas12a via sticky-end dsDNA.

Nucleic Acids Research

Zhang, Wei W; Mu, Yaoqin Y; Dong, Kejun K; Zhang, Lei L; Yan, Bei B; Hu, Hao H; Liao, Yangwei Y; Zhao, Rong R; Shu, Wan W; Ye, Zhengxin Z; Lu, Yaping Y; Wan, Chong C; Sun, Qiangqiang Q; Li, Longjie L; Wang, Hongbo H; Xiao, Xianjin X

Publication Date: 2022-12-09

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36484104

Variant Present in the following documents:

• gkac1144_supplemental_file.pdf

View BVdb publication page

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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

Nature Communications

Flanagan, Dustin J DJ; Amirkhah, Raheleh R; Vincent, David F DF; Gundaz, Nuray N; Gentaz, Pauline P; Cammareri, Patrizia P; McCooey, Aoife J AJ; McCorry, Amy M B AMB; Fisher, Natalie C NC; Davis, Hayley L HL; Ridgway, Rachel A RA; Lohuis, Jeroen J; Leach, Joshua D G JDG; Jackstadt, Rene R; Gilroy, Kathryn K; Mariella, Elisa E; Nixon, Colin C; Clark, William W; Hedley, Ann A; Markert, Elke K EK; Strathdee, Douglas D; Bartholin, Laurent L; Redmond, Keara L KL; Kerr, Emma M EM; Longley, Daniel B DB; Ginty, Fiona F; Cho, Sanghee S; Coleman, Helen G HG; Loughrey, Maurice B MB; Bardelli, Alberto A; Maughan, Timothy S TS; Campbell, Andrew D AD; Lawler, Mark M; Leedham, Simon J SJ; Barry, Simon T ST; Inman, Gareth J GJ; van Rheenen, Jacco J; Dunne, Philip D PD; Sansom, Owen J OJ

Publication Date: 2022-12-07

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36477656

Variant Present in the following documents:

• 41467_2022_35134_MOESM4_ESM.xlsx, sheet 3

View BVdb publication page

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Molecular diagnosis of pancreatobiliary tract cancer by detecting mutations and methylation changes in bile samples.

Eclinicalmedicine

He, Shun S; Zeng, Fanxin F; Yin, Huihui H; Wang, Pei P; Bai, Yinlei Y; Song, Qianqian Q; Chu, Jiangtao J; Huang, Zhen Z; Liu, Yumeng Y; Liu, Hong H; Chen, Qichen Q; Liu, Li L; Zhou, Jun J; Hu, Hanjie H; Li, Xingchen X; Li, Tengyan T; Wang, Guiqi G; Cai, Jianqiang J; Jiao, Yuchen Y; Zhao, Hong H

Publication Date: 2023-01

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp

PubMed Link: 36425869

Variant Present in the following documents:

• mmc1.xlsx, sheet 8
• mmc1.xlsx, sheet 4

View BVdb publication page

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Precision medicine in the real-world setting. Clinical activity of talazoparib in a woman with hormone receptor-positive HER2-negative metastatic breast cancer with pathogenic mutation in somatic BRCA2.

Ecancermedicalscience

Narváez, Dana D; Waisberg, Federico F; Soulé, Tomás T; Angel, Martín M; Bruno, Luisina L; Girotti, Maria Romina MR; Pupareli, Carmen C; Chacón, Matías M; Petracci, Fernando E FE

Publication Date: 2022

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36405946

Variant Present in the following documents:

• Main text
• can-16-1448.pdf

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 1635G>T; E545D

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Rugo, Hope S HS; Raskina, Kira K; Schrock, Alexa B AB; Madison, Russell W RW; Graf, Ryon P RP; Sokol, Ethan S ES; Sivakumar, Smruthy S SS; Lee, Jessica K JK; Fisher, Virginia V; Oxnard, Geoffrey R GR; Tukachinsky, Hanna H

Publication Date: 2022-11-02

Variant appearance in text: PIK3CA: E545D

PubMed Link: 36321996

Variant Present in the following documents:

• Main text
• 1056.pdf

View BVdb publication page

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An integrated somatic and germline approach to aid interpretation of germline variants of uncertain significance in cancer susceptibility genes.

Frontiers In Oncology

Schwartz, Alison A; Manning, Danielle K DK; Koeller, Diane R DR; Chittenden, Anu A; Isidro, Raymond A RA; Hayes, Connor P CP; Abraamyan, Feruza F; Manam, Monica Devi MD; Dwan, Meaghan M; Barletta, Justine A JA; Sholl, Lynette M LM; Yurgelun, Matthew B MB; Rana, Huma Q HQ; Garber, Judy E JE; Ghazani, Arezou A AA

Publication Date: 2022

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp

PubMed Link: 36091175

Variant Present in the following documents:

• fonc-12-942741.pdf

View BVdb publication page

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Landscape of somatic alterations in large-scale solid tumors from an Asian population.

Nature Communications

Wu, Liqun L; Yao, Herui H; Chen, Hui H; Wang, Aodi A; Guo, Kun K; Gou, Wenli W; Yu, Yanfei Y; Li, Xiang X; Yao, Ming M; Yuan, Shaohua S; Pang, Fei F; Hu, Jinwei J; Chen, Lijuan L; Liu, Wenjin W; Yao, Jicheng J; Zhang, Shuirong S; Dong, Xiaowei X; Wang, Weifeng W; Hu, Jing J; Ling, Qi Q; Ding, Songming S; Wei, Yan Y; Li, Qiang Q; Cao, Weichun W; Wang, Shuang S; Di, Yang Y; Feng, Feiling F; Zhao, Gang G; Zhang, Jian J; Huang, Ling L; Xu, Jia J; Yan, Wangjun W; Tong, Zhongsheng Z; Jiang, Da D; Ji, Tao T; Li, Qiao Q; Xu, Ling L; He, Huiying H; Shang, Liang L; Liu, Jin J; Wang, Kefeng K; Wu, Duoguang D; Shen, Jingnan J; Liu, Ye Y; Zhang, Ting T; Liang, Chaojie C; Wang, Yusheng Y; Shang, Yanhong Y; Guo, Jianji J; Liang, Guanbiao G; Xu, Shifeng S; Liu, Junfeng J; Wang, Kai K; Wang, Minghui M

Publication Date: 2022-07-23

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35871175

Variant Present in the following documents:

• 41467_2022_Article_31780.pdf

View BVdb publication page

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Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.

The Oncologist

Dias-Santagata, Dora D; Heist, Rebecca S RS; Bard, Adam Z AZ; da Silva, Annacarolina F L AFL; Dagogo-Jack, Ibiayi I; Nardi, Valentina V; Ritterhouse, Lauren L LL; Spring, Laura M LM; Jessop, Nicholas N; Farahani, Alexander A AA; Mino-Kenudson, Mari M; Allen, Jill J; Goyal, Lipika L; Parikh, Aparna A; Misdraji, Joseph J; Shankar, Ganesh G; Jordan, Justin T JT; Martinez-Lage, Maria M; Frosch, Matthew M; Graubert, Timothy T; Fathi, Amir T AT; Hobbs, Gabriela S GS; Hasserjian, Robert P RP; Raje, Noopur N; Abramson, Jeremy J; Schwartz, Joel H JH; Sullivan, Ryan J RJ; Miller, David D; Hoang, Mai P MP; Isakoff, Steven S; Ly, Amy A; Bouberhan, Sara S; Watkins, Jaclyn J; Oliva, Esther E; Wirth, Lori L; Sadow, Peter M PM; Faquin, William W; Cote, Gregory M GM; Hung, Yin P YP; Gao, Xin X; Wu, Chin-Lee CL; Garg, Salil S; Rivera, Miguel M; Le, Long P LP; John Iafrate, A A; Juric, Dejan D; Hochberg, Ephraim P EP; Clark, Jeffrey J; Bardia, Aditya A; Lennerz, Jochen K JK

Publication Date: 2022-11-03

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35852437

Variant Present in the following documents:

• oyac134_suppl_supplementary_information_1.pdf

View BVdb publication page

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Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population.

Bmc Medical Genomics

Huang, Qingfeng Q; Zhou, Yang Y; Wang, Bowen B; Zhao, Yi Y; Zhang, Fengxia F; Ding, Bowen B

Publication Date: 2022-07-01

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35778737

Variant Present in the following documents:

• 12920_2022_Article_1297.pdf

View BVdb publication page

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Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status.

Cancers

Irelli, Azzurra A; Parisi, Alessandro A; D'Orazio, Carla C; Sidoni, Tina T; Rotondaro, Silvia S; Patruno, Leonardo L; Pavese, Francesco F; Bafile, Alberto A; Resta, Valter V; Pizzorno, Laura L; Ciuffetelli, Virginia V; Dal Mas, Antonella A; Calvisi, Giuseppe G; Di Sibio, Alessandra A; Marzullo, Anna A; Zelli, Veronica V; Compagnoni, Chiara C; Tessitore, Alessandra A; Alesse, Edoardo E; Ficorella, Corrado C; Cortellini, Alessio A; Cannita, Katia K

Publication Date: 2022-06-18

Variant appearance in text: PIK3CA: 1635G>T

PubMed Link: 35740668

Variant Present in the following documents:

• cancers-14-03003.pdf

View BVdb publication page

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Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer.

Journal For Immunotherapy Of Cancer

Chakrabarti, Sakti S; Bucheit, Leslie L; Starr, Jason Scott JS; Innis-Shelton, Racquel R; Shergill, Ardaman A; Dada, Hiba H; Resta, Regina R; Wagner, Stephanie S; Fei, Naomi N; Kasi, Pashtoon Murtaza PM

Publication Date: 2022-06

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35710297

Variant Present in the following documents:

• jitc-2021-004485.pdf

View BVdb publication page

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Analysis of PIK3CA Mutation Concordance and Frequency in Primary and Different Distant Metastatic Sites in Breast Cancer.

Cancer Research And Treatment

Park, Jieun J; Cho, Soo Youn SY; Chang, Eun Sol ES; Sung, Minjung M; Song, Ji-Young JY; Jung, Kyungsoo K; Kim, Sung-Su SS; Shin, Young Kee YK; Choi, Yoon-La YL

Publication Date: 2022-04-20

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35468270

Variant Present in the following documents:

• Main text
• crt-2022-001-S2-Table.pdf
• crt-2022-001.pdf

View BVdb publication page

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Molecular landscape of TP53 mutations in breast cancer and their utility for predicting the response to HER-targeted therapy in HER2 amplification-positive and HER2 mutation-positive amplification-negative patients.

Cancer Medicine

Liu, Binliang B; Yi, Zongbi Z; Guan, Yanfang Y; Ouyang, Quchang Q; Li, Chunxiao C; Guan, Xiuwen X; Lv, Dan D; Li, Lixi L; Zhai, Jingtong J; Qian, Haili H; Xu, Binghe B; Ma, Fei F; Zeng, Yixin Y

Publication Date: 2022-07

Variant appearance in text: PIK3CA: 1635G>T; E545D

PubMed Link: 35393784

Variant Present in the following documents:

• CAM4-11-2767-s001.xlsx, sheet 1

View BVdb publication page

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A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets.

Frontiers In Oncology

Zhou, Si S; Liu, Songming S; Zhao, Lijian L; Sun, Hai-Xi HX

Publication Date: 2022

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35387130

Variant Present in the following documents:

• Table_2.xlsx, sheet 1

View BVdb publication page

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35357905

Variant Present in the following documents:

• po-6-e2100370.pdf

View BVdb publication page

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Diagnostic performance of automated, streamlined, daily updated exome analysis in patients with neurodevelopmental delay.

Molecular Medicine (Cambridge, Mass.)

Seo, Go Hun GH; Lee, Hane H; Lee, Jungsul J; Han, Heonjong H; Cho, You Kyung YK; Kim, Minji M; Choi, Yunha Y; Choi, Jeongmin J; Choi, In Hee IH; Rhie, Seonkyeong S; Chae, Kyu Young KY; Kim, Yoo-Mi YM; Cheon, Chong Kun CK; Kim, Su Jin SJ; Lee, Jieun J; Kang, Eungu E; Byeon, Jung Hye JH; Yu, Hee Joon HJ; Shin, Young-Lim YL; Oh, Arum A; Kim, Woo Jin WJ; Yum, Mi-Sun MS; Lee, Beom Hee BH; Eun, Baik-Lin BL

Publication Date: 2022-03-26

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp

PubMed Link: 35346031

Variant Present in the following documents:

• 10020_2022_464_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival.

Cancers

Cochicho, Daniela D; Esteves, Susana S; Rito, Miguel M; Silva, Fernanda F; Martins, Luís L; Montalvão, Pedro P; Cunha, Mário M; Magalhães, Miguel M; Gil da Costa, Rui M RM; Felix, Ana A

Publication Date: 2022-03-02

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35267596

Variant Present in the following documents:

• Main text
• cancers-14-01286.pdf

View BVdb publication page

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A Prediction Model for Tumor Recurrence in Stage II-III Colorectal Cancer Patients: From a Machine Learning Model to Genomic Profiling.

Biomedicines

Chen, Po-Chuan PC; Yeh, Yu-Min YM; Lin, Bo-Wen BW; Chan, Ren-Hao RH; Su, Pei-Fang PF; Liu, Yi-Chia YC; Lee, Chung-Ta CT; Chen, Shang-Hung SH; Lin, Peng-Chan PC

Publication Date: 2022-02-01

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35203549

Variant Present in the following documents:

• Main text
• biomedicines-10-00340.pdf

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913275

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913275

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine

Duffy, Michael J MJ; Crown, John J

Publication Date: 2022-01-13

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35055414

Variant Present in the following documents:

• Main text
• jpm-12-00099.pdf

View BVdb publication page

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Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine

Duffy, Michael J MJ; Crown, John J

Publication Date: 2022-01-13

Variant appearance in text: PIK3CA: E545D

PubMed Link: 35055414

Variant Present in the following documents:

• Main text
• jpm-12-00099.pdf

View BVdb publication page

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PIK3CA Mutations in Diffuse Gliomas: An Update on Molecular Stratification, Prognosis, Recurrence, and Aggressiveness.

Clinical Medicine Insights. Oncology

Brito, Cheila C; Tomás, Ana A; Azevedo, Ana A; Esteves, Susana S; Mafra, Manuela M; Roque, Lúcia L; Pojo, Marta M

Publication Date: 2022

Variant appearance in text: PIK3CA: 1635G>T

PubMed Link: 35023985

Variant Present in the following documents:

• Main text
• 10.1177_11795549211068804.pdf

View BVdb publication page

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NEBL and AKT1 maybe new targets to eliminate the colorectal cancer cells resistance to oncolytic effect of vesicular stomatitis virus M-protein.

Molecular Therapy Oncolytics

Mamizadeh, Zoleikha Z; Kalani, Mohamad Reza MR; Parsania, Masoud M; Soltan Dallal, Mohammad Mehdi MM; Moradi, Abdolvahab A

Publication Date: 2021-12-17

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34977336

Variant Present in the following documents:

• Main text
• main.pdf
• mmc2.pdf

View BVdb publication page

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Rearrangement-mediated cis-regulatory alterations in advanced patient tumors reveal interactions with therapy.

Cell Reports

Zhang, Yiqun Y; Chen, Fengju F; Pleasance, Erin E; Williamson, Laura L; Grisdale, Cameron J CJ; Titmuss, Emma E; Laskin, Janessa J; Jones, Steven J M SJM; Cortes-Ciriano, Isidro I; Marra, Marco A MA; Creighton, Chad J CJ

Publication Date: 2021-11-16

Variant appearance in text: PIK3CA: 1635G>T; Glu545Asp

PubMed Link: 34788622

Variant Present in the following documents:

• NIHMS1757901-supplement-2.xlsx, sheet 3

View BVdb publication page

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Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.

Frontiers In Pharmacology

Liao, Wei W; Yang, Wanren W; Xu, Jiecheng J; Yan, Zhengming Z; Pan, Mingxin M; Xu, Xiaoping X; Zhou, Shuqin S; Zhu, Yu Y; Lan, Jianqiang J; Zeng, Min M; Han, Xu X; Li, Shao S; Li, Yang Y; Liang, Kangyan K; Gao, Yi Y; Peng, Qing Q

Publication Date: 2021

Variant appearance in text: rs121913275

PubMed Link: 34776939

Variant Present in the following documents:

• Main text

View BVdb publication page

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Regulation of signal transduction pathways in colorectal cancer: implications for therapeutic resistance.

Peerj

Yeoh, Yeelon Y; Low, Teck Yew TY; Abu, Nadiah N; Lee, Pey Yee PY

Publication Date: 2021

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34733591

Variant Present in the following documents:

• Main text
• peerj-09-12338.pdf

View BVdb publication page

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Oncomine™ Comprehensive Assay v3 vs. Oncomine™ Comprehensive Assay Plus.

Cancers

Vestergaard, Lau K LK; Oliveira, Douglas N P DNP; Poulsen, Tim S TS; Høgdall, Claus K CK; Høgdall, Estrid V EV

Publication Date: 2021-10-18

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34680378

Variant Present in the following documents:

• Main text

View BVdb publication page

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Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials.

Cancers

Duranti, Simona S; Fabi, Alessandra A; Filetti, Marco M; Falcone, Rosa R; Lombardi, Pasquale P; Daniele, Gennaro G; Franceschini, Gianluca G; Carbognin, Luisa L; Palazzo, Antonella A; Garganese, Giorgia G; Paris, Ida I; Scambia, Giovanni G; Pietragalla, Antonella A

Publication Date: 2021-10-16

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34680350

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Companion Diagnostics: State of the Art and New Regulations.

Biomarker Insights

Valla, Vasiliki V; Alzabin, Saba S; Koukoura, Angeliki A; Lewis, Amy A; Nielsen, Anne Ahlmann AA; Vassiliadis, Efstathios E

Publication Date: 2021

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34658618

Variant Present in the following documents:

• Main text
• 10.1177_11772719211047763.pdf

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Signed in Blood: Circulating Tumor DNA in Cancer Diagnosis, Treatment and Screening.

Cancers

Adashek, Jacob J JJ; Janku, Filip F; Kurzrock, Razelle R

Publication Date: 2021-07-18

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34298813

Variant Present in the following documents:

• Main text
• cancers-13-03600.pdf

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The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine

Chang, Darwin D; Shain, A Hunter AH

Publication Date: 2021-07-16

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34272401

Variant Present in the following documents:

• 41525_2021_226_MOESM5_ESM.xlsx, sheet 1

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 31

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The molecular profiling of solid tumors by liquid biopsy: a position paper of the AIOM-SIAPEC-IAP-SIBioC-SIC-SIF Italian Scientific Societies.

Esmo Open

Russo, A A; Incorvaia, L L; Del Re, M M; Malapelle, U U; Capoluongo, E E; Gristina, V V; Castiglia, M M; Danesi, R R; Fassan, M M; Giuffrè, G G; Gori, S S; Marchetti, A A; Normanno, N N; Pinto, C C; Rossi, G G; Santini, D D; Sartore-Bianchi, A A; Silvestris, N N; Tagliaferri, P P; Troncone, G G; Cinieri, S S; Beretta, G D GD

Publication Date: 2021-06

Variant appearance in text: PIK3CA: E545D

PubMed Link: 34091263

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• Main text
• main.pdf

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Update Breast Cancer 2020 Part 5 - Moving Therapies From Advanced to Early Breast Cancer Patients.

Geburtshilfe Und Frauenheilkunde

Lux, Michael P MP; Schneeweiss, Andreas A; Hartkopf, Andreas D AD; Müller, Volkmar V; Janni, Wolfgang W; Belleville, Erik E; Stickeler, Elmar E; Thill, Marc M; Fasching, Peter A PA; Kolberg, Hans-Christian HC; Untch, Michael M; Harbeck, Nadia N; Wöckel, Achim A; Thomssen, Christoph C; Schulmeyer, Carla E CE; Welslau, Manfred M; Overkamp, Friedrich F; Schütz, Florian F; Lüftner, Diana D; Ditsch, Nina N

Publication Date: 2021-04

Variant appearance in text: PIK3CA: E545D

PubMed Link: 33867564

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Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications

Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A

Publication Date: 2021-04-14

Variant appearance in text: PIK3CA: E545D

PubMed Link: 33854067

Variant Present in the following documents:

• 41467_2021_22478_MOESM8_ESM.xlsx, sheet 9

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PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer.

Frontiers In Oncology

Fusco, Nicola N; Malapelle, Umberto U; Fassan, Matteo M; Marchiò, Caterina C; Buglioni, Simonetta S; Zupo, Simonetta S; Criscitiello, Carmen C; Vigneri, Paolo P; Dei Tos, Angelo Paolo AP; Maiorano, Eugenio E; Viale, Giuseppe G

Publication Date: 2021

Variant appearance in text: PIK3CA: E545D

PubMed Link: 33842357

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• Main text
• fonc-11-644737.pdf

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The Spectrum, Tendency and Predictive Value of PIK3CA Mutation in Chinese Colorectal Cancer Patients.

Frontiers In Oncology

Fu, Xinhui X; Lin, Hanjie H; Fan, Xinjuan X; Zhu, Yaxi Y; Wang, Chao C; Chen, Zhiting Z; Tan, Xiaoli X; Huang, Jinglin J; Cai, Yacheng Y; Huang, Yan Y

Publication Date: 2021

Variant appearance in text: PIK3CA: 1635G>T; E545D

PubMed Link: 33842311

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The transcriptional landscape of Shh medulloblastoma.

Nature Communications

Skowron, Patryk P; Farooq, Hamza H; Cavalli, Florence M G FMG; Morrissy, A Sorana AS; Ly, Michelle M; Hendrikse, Liam D LD; Wang, Evan Y EY; Djambazian, Haig H; Zhu, Helen H; Mungall, Karen L KL; Trinh, Quang M QM; Zheng, Tina T; Dai, Shizhong S; Stucklin, Ana S Guerreiro ASG; Vladoiu, Maria C MC; Fong, Vernon V; Holgado, Borja L BL; Nor, Carolina C; Wu, Xiaochong X; Abd-Rabbo, Diala D; Bérubé, Pierre P; Wang, Yu Chang YC; Luu, Betty B; Suarez, Raul A RA; Rastan, Avesta A; Gillmor, Aaron H AH; Lee, John J Y JJY; Zhang, Xiao Yun XY; Daniels, Craig C; Dirks, Peter P; Malkin, David D; Bouffet, Eric E; Tabori, Uri U; Loukides, James J; Doz, François P FP; Bourdeaut, Franck F; Delattre, Olivier O OO; Masliah-Planchon, Julien J; Ayrault, Olivier O; Kim, Seung-Ki SK; Meyronet, David D; Grajkowska, Wieslawa A WA; Carlotti, Carlos G CG; de Torres, Carmen C; Mora, Jaume J; Eberhart, Charles G CG; Van Meir, Erwin G EG; Kumabe, Toshihiro T; French, Pim J PJ; Kros, Johan M JM; Jabado, Nada N; Lach, Boleslaw B; Pollack, Ian F IF; Hamilton, Ronald L RL; Rao, Amulya A Nageswara AAN; Giannini, Caterina C; Olson, James M JM; Bognár, László L; Klekner, Almos A; Zitterbart, Karel K; Phillips, Joanna J JJ; Thompson, Reid C RC; Cooper, Michael K MK; Rubin, Joshua B JB; Liau, Linda M LM; Garami, Miklós M; Hauser, Peter P; Li, Kay Ka Wai KKW; Ng, Ho-Keung HK; Poon, Wai Sang WS; Yancey Gillespie, G G; Chan, Jennifer A JA; Jung, Shin S; McLendon, Roger E RE; Thompson, Eric M EM; Zagzag, David D; Vibhakar, Rajeev R; Ra, Young Shin YS; Garre, Maria Luisa ML; Schüller, Ulrich U; Shofuda, Tomoko T; Faria, Claudia C CC; López-Aguilar, Enrique E; Zadeh, Gelareh G; Hui, Chi-Chung CC; Ramaswamy, Vijay V; Bailey, Swneke D SD; Jones, Steven J SJ; Mungall, Andrew J AJ; Moore, Richard A RA; Calarco, John A JA; Stein, Lincoln D LD; Bader, Gary D GD; Reimand, Jüri J; Ragoussis, Jiannis J; Weiss, William A WA; Marra, Marco A MA; Suzuki, Hiromichi H; Taylor, Michael D MD

Publication Date: 2021-03-19

Variant appearance in text: PIK3CA: E545D

PubMed Link: 33741928

Variant Present in the following documents:

• 41467_2021_21883_MOESM5_ESM.xlsx, sheet 2

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