Publications:

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The Role of Biomarkers in Guiding Clinical Decision-Making in Oncology.

Journal Of The Advanced Practitioner In Oncology

Moore, Donald C DC; Guinigundo, Andrew S AS

Publication Date: 2023-04

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 37206905

Variant Present in the following documents:

• Main text
• jadpro-14-15.pdf

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PIK3CA mutations in breast cancer: A Tunisian series.

Plos One

Ben Rekaya, Mariem M; Sassi, Farah F; Saied, Essya E; Bel Haj Kacem, Linda L; Mansouri, Nada N; Zarrouk, Sinda S; Azouz, Saifeddine S; Rammeh, Soumaya S

Publication Date: 2023

Variant appearance in text: PI3K: 1636C>G; rs121913286

PubMed Link: 37195967

Variant Present in the following documents:

• Main text
• pone.0285413.pdf

View BVdb publication page

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Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2-, PIK3CA-mutated breast cancers.

Genome Medicine

Hutchinson, Katherine E KE; Chen, Jessica W JW; Savage, Heidi M HM; Stout, Thomas J TJ; Schimmoller, Frauke F; Cortés, Javier J; Dent, Susan S; Harbeck, Nadia N; Jacot, William W; Krop, Ian I; Trabucco, Sally E SE; Sivakumar, Smruthy S; Sokol, Ethan S ES; Wilson, Timothy R TR

Publication Date: 2023-04-26

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 37101291

Variant Present in the following documents:

• 13073_2023_1181_MOESM1_ESM.pdf

View BVdb publication page

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Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer Research Communications

White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C

Publication Date: 2022-09

Variant appearance in text: PIK3CA: 1636C>G; Gln546Glu; rs121913286

PubMed Link: 36922933

Variant Present in the following documents:

• crc-22-0136-s01.xlsx, sheet 3

View BVdb publication page

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Clinical Circulating Tumor DNA testing for Precision Oncology.

Cancer Research And Treatment

Kim, Hyunji H; Park, Kyoung Un KU

Publication Date: 2023-03-13

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36915242

Variant Present in the following documents:

• crt-2022-1026.pdf

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Genomics-Driven Precision Medicine in Pediatric Solid Tumors.

Cancers

Suthapot, Praewa P; Chiangjong, Wararat W; Chaiyawat, Parunya P; Choochuen, Pongsakorn P; Pruksakorn, Dumnoensun D; Sangkhathat, Surasak S; Hongeng, Suradej S; Anurathapan, Usanarat U; Chutipongtanate, Somchai S

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36900212

Variant Present in the following documents:

• Main text

View BVdb publication page

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Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics

Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P

Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 1636C>G; Gln546Glu

PubMed Link: 36823319

Variant Present in the following documents:

• 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6

View BVdb publication page

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APOBEC mutagenesis is a common process in normal human small intestine.

Nature Genetics

Wang, Yichen Y; Robinson, Philip S PS; Coorens, Tim H H THH; Moore, Luiza L; Lee-Six, Henry H; Noorani, Ayesha A; Sanders, Mathijs A MA; Jung, Hyunchul H; Katainen, Riku R; Heuschkel, Robert R; Brunton-Sim, Roxanne R; Weston, Robyn R; Read, Debbie D; Nobbs, Beverley B; Fitzgerald, Rebecca C RC; Saeb-Parsy, Kourosh K; Martincorena, Iñigo I; Campbell, Peter J PJ; Rushbrook, Simon S; Zilbauer, Matthias M; Buczacki, Simon James Alexander SJA; Stratton, Michael R MR

Publication Date: 2023-01-26

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36702998

Variant Present in the following documents:

• Main text
• 41588_2022_1296_MOESM4_ESM.xlsx, sheet 4
• 41588_2022_Article_1296.pdf

View BVdb publication page

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PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative.

Journal Of Personalized Medicine

Ascione, Liliana L; Zagami, Paola P; Nicolò, Eleonora E; Crimini, Edoardo E; Curigliano, Giuseppe G; Criscitiello, Carmen C

Publication Date: 2022-10-31

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36579519

Variant Present in the following documents:

• Main text
• jpm-12-01793.pdf

View BVdb publication page

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36561320

Variant Present in the following documents:

• Table2.xlsx, sheet 5
• Table3.xlsx, sheet 1

View BVdb publication page

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Molecular-Targeted Therapy for Tumor-Agnostic Mutations in Acute Myeloid Leukemia.

Biomedicines

Arai, Hironori H; Minami, Yosuke Y; Chi, SungGi S; Utsu, Yoshikazu Y; Masuda, Shinichi S; Aotsuka, Nobuyuki N

Publication Date: 2022-11-22

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36551764

Variant Present in the following documents:

• biomedicines-10-03008.pdf

View BVdb publication page

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The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.

Nature Genetics

Liu, Ilon I; Jiang, Li L; Samuelsson, Erik R ER; Marco Salas, Sergio S; Beck, Alexander A; Hack, Olivia A OA; Jeong, Daeun D; Shaw, McKenzie L ML; Englinger, Bernhard B; LaBelle, Jenna J; Mire, Hafsa M HM; Madlener, Sibylle S; Mayr, Lisa L; Quezada, Michael A MA; Trissal, Maria M; Panditharatna, Eshini E; Ernst, Kati J KJ; Vogelzang, Jayne J; Gatesman, Taylor A TA; Halbert, Matthew E ME; Palova, Hana H; Pokorna, Petra P; Sterba, Jaroslav J; Slaby, Ondrej O; Geyeregger, Rene R; Diaz, Aaron A; Findlay, Izac J IJ; Dun, Matthew D MD; Resnick, Adam A; Suvà, Mario L ML; Jones, David T W DTW; Agnihotri, Sameer S; Svedlund, Jessica J; Koschmann, Carl C; Haberler, Christine C; Czech, Thomas T; Slavc, Irene I; Cotter, Jennifer A JA; Ligon, Keith L KL; Alexandrescu, Sanda S; Yung, W K Alfred WKA; Arrillaga-Romany, Isabel I; Gojo, Johannes J; Monje, Michelle M; Nilsson, Mats M; Filbin, Mariella G MG

Publication Date: 2022-12

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36471067

Variant Present in the following documents:

• 41588_2022_1236_MOESM3_ESM.xlsx, sheet 18

View BVdb publication page

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Precision medicine in the real-world setting. Clinical activity of talazoparib in a woman with hormone receptor-positive HER2-negative metastatic breast cancer with pathogenic mutation in somatic BRCA2.

Ecancermedicalscience

Narváez, Dana D; Waisberg, Federico F; Soulé, Tomás T; Angel, Martín M; Bruno, Luisina L; Girotti, Maria Romina MR; Pupareli, Carmen C; Chacón, Matías M; Petracci, Fernando E FE

Publication Date: 2022

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36405946

Variant Present in the following documents:

• Main text
• can-16-1448.pdf

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics

Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q

Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 1636C>G; Q546E

PubMed Link: 36333792

Variant Present in the following documents:

• 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1

View BVdb publication page

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Biology and targetability of the extended spectrum of PIK3CA mutations (PIK3CAm) detected in breast carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Rugo, Hope S HS; Raskina, Kira K; Schrock, Alexa B AB; Madison, Russell W RW; Graf, Ryon P RP; Sokol, Ethan S ES; Sivakumar, Smruthy S SS; Lee, Jessica K JK; Fisher, Virginia V; Oxnard, Geoffrey R GR; Tukachinsky, Hanna H

Publication Date: 2022-11-02

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 36321996

Variant Present in the following documents:

• Main text
• 1056.pdf

View BVdb publication page

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Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network.

The Oncologist

Dias-Santagata, Dora D; Heist, Rebecca S RS; Bard, Adam Z AZ; da Silva, Annacarolina F L AFL; Dagogo-Jack, Ibiayi I; Nardi, Valentina V; Ritterhouse, Lauren L LL; Spring, Laura M LM; Jessop, Nicholas N; Farahani, Alexander A AA; Mino-Kenudson, Mari M; Allen, Jill J; Goyal, Lipika L; Parikh, Aparna A; Misdraji, Joseph J; Shankar, Ganesh G; Jordan, Justin T JT; Martinez-Lage, Maria M; Frosch, Matthew M; Graubert, Timothy T; Fathi, Amir T AT; Hobbs, Gabriela S GS; Hasserjian, Robert P RP; Raje, Noopur N; Abramson, Jeremy J; Schwartz, Joel H JH; Sullivan, Ryan J RJ; Miller, David D; Hoang, Mai P MP; Isakoff, Steven S; Ly, Amy A; Bouberhan, Sara S; Watkins, Jaclyn J; Oliva, Esther E; Wirth, Lori L; Sadow, Peter M PM; Faquin, William W; Cote, Gregory M GM; Hung, Yin P YP; Gao, Xin X; Wu, Chin-Lee CL; Garg, Salil S; Rivera, Miguel M; Le, Long P LP; John Iafrate, A A; Juric, Dejan D; Hochberg, Ephraim P EP; Clark, Jeffrey J; Bardia, Aditya A; Lennerz, Jochen K JK

Publication Date: 2022-11-03

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35852437

Variant Present in the following documents:

• oyac134_suppl_supplementary_information_1.pdf

View BVdb publication page

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Circulating Tumor DNA-Based Genomic Profiling Assays in Adult Solid Tumors for Precision Oncology: Recent Advancements and Future Challenges.

Cancers

Chan, Hiu Ting HT; Chin, Yoon Ming YM; Low, Siew-Kee SK

Publication Date: 2022-07-04

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35805046

Variant Present in the following documents:

• cancers-14-03275.pdf

View BVdb publication page

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Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population.

Bmc Medical Genomics

Huang, Qingfeng Q; Zhou, Yang Y; Wang, Bowen B; Zhao, Yi Y; Zhang, Fengxia F; Ding, Bowen B

Publication Date: 2022-07-01

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35778737

Variant Present in the following documents:

• 12920_2022_Article_1297.pdf

View BVdb publication page

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Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status.

Cancers

Irelli, Azzurra A; Parisi, Alessandro A; D'Orazio, Carla C; Sidoni, Tina T; Rotondaro, Silvia S; Patruno, Leonardo L; Pavese, Francesco F; Bafile, Alberto A; Resta, Valter V; Pizzorno, Laura L; Ciuffetelli, Virginia V; Dal Mas, Antonella A; Calvisi, Giuseppe G; Di Sibio, Alessandra A; Marzullo, Anna A; Zelli, Veronica V; Compagnoni, Chiara C; Tessitore, Alessandra A; Alesse, Edoardo E; Ficorella, Corrado C; Cortellini, Alessio A; Cannita, Katia K

Publication Date: 2022-06-18

Variant appearance in text: PIK3CA: 1636C>G

PubMed Link: 35740668

Variant Present in the following documents:

• cancers-14-03003.pdf

View BVdb publication page

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A phase I/II study of ivaltinostat combined with gemcitabine and erlotinib in patients with untreated locally advanced or metastatic pancreatic adenocarcinoma.

International Journal Of Cancer

Jo, Jung Hyun JH; Jung, Dawoon E DE; Lee, Hee Seung HS; Park, Soo Been SB; Chung, Moon Jae MJ; Park, Jeong Youp JY; Bang, Seungmin S; Park, Seung Woo SW; Cho, Sangsook S; Song, Si Young SY

Publication Date: 2022-11-01

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35657348

Variant Present in the following documents:

• IJC-151-1565-s001.pdf

View BVdb publication page

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Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics

Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R

Publication Date: 2022-04-25

Variant appearance in text: PIK3CA: 1636C>G

PubMed Link: 35468810

Variant Present in the following documents:

• 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Analysis of PIK3CA Mutation Concordance and Frequency in Primary and Different Distant Metastatic Sites in Breast Cancer.

Cancer Research And Treatment

Park, Jieun J; Cho, Soo Youn SY; Chang, Eun Sol ES; Sung, Minjung M; Song, Ji-Young JY; Jung, Kyungsoo K; Kim, Sung-Su SS; Shin, Young Kee YK; Choi, Yoon-La YL

Publication Date: 2022-04-20

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35468270

Variant Present in the following documents:

• Main text
• crt-2022-001.pdf

View BVdb publication page

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Genomic Analysis of Tumors from Patients with Glioblastoma with Long-Term Response to Afatinib.

Oncotargets And Therapy

Owen, Scott S; Alken, Scheryll S; Alshami, Jad J; Guiot, Marie-Christine MC; Kavan, Petr P; Reardon, David A DA; Muanza, Thierry T; Gibson, Neil N; Pemberton, Karine K; Solca, Flavio F; Cseh, Agnieszka A; Saran, Frank F

Publication Date: 2022

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35422631

Variant Present in the following documents:

• Main text
• ott-15-367.pdf

View BVdb publication page

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Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes.

Neuro-Oncology

Zhang, Yalan Y; Lucas, Calixto-Hope G CG; Young, Jacob S JS; Morshed, Ramin A RA; McCoy, Lucie L; Oberheim Bush, Nancy Ann NA; Taylor, Jennie W JW; Daras, Mariza M; Butowski, Nicholas A NA; Villanueva-Meyer, Javier E JE; Cha, Soonmee S; Wrensch, Margaret M; Wiencke, John K JK; Lee, Julieann C JC; Pekmezci, Melike M; Phillips, Joanna J JJ; Perry, Arie A; Bollen, Andrew W AW; Aghi, Manish K MK; Theodosopoulos, Philip P; Chang, Edward F EF; Hervey-Jumper, Shawn L SL; Berger, Mitchel S MS; Clarke, Jennifer L JL; Chang, Susan M SM; Molinaro, Annette M AM; Solomon, David A DA

Publication Date: 2022-10-03

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35395677

Variant Present in the following documents:

• noac089_suppl_supplementary_tables_s1-s11.xlsx, sheet 2

View BVdb publication page

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PIK3CA Mutations Drive Therapeutic Resistance in Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.

Jco Precision Oncology

Rasti, Aryana R AR; Guimaraes-Young, Amy A; Datko, Farrah F; Borges, Virginia F VF; Aisner, Dara L DL; Shagisultanova, Elena E

Publication Date: 2022-03

Variant appearance in text: PI3K: Q546E

PubMed Link: 35357905

Variant Present in the following documents:

• po-6-e2100370.pdf

View BVdb publication page

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Response prediction and risk stratification of patients with rectal cancer after neoadjuvant therapy through an analysis of circulating tumour DNA.

Ebiomedicine

Liu, Wenyang W; Li, Yifei Y; Tang, Yuan Y; Song, Qianqian Q; Wang, Jingjing J; Li, Ning N; Chen, Silin S; Shi, Jinming J; Wang, Shulian S; Li, Yexiong Y; Jiao, Yuchen Y; Zeng, Yixin Y; Jin, Jing J

Publication Date: 2022-04

Variant appearance in text: PIK3CA: Q546E; rs121913286

PubMed Link: 35306340

Variant Present in the following documents:

• mmc3.xlsx, sheet 2

View BVdb publication page

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Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors.

Plos One

Milbury, Coren A CA; Creeden, James J; Yip, Wai-Ki WK; Smith, David L DL; Pattani, Varun V; Maxwell, Kristi K; Sawchyn, Bethany B; Gjoerup, Ole O; Meng, Wei W; Skoletsky, Joel J; Concepcion, Alvin D AD; Tang, Yanhua Y; Bai, Xiaobo X; Dewal, Ninad N; Ma, Pei P; Bailey, Shannon T ST; Thornton, James J; Pavlick, Dean C DC; Frampton, Garrett M GM; Lieber, Daniel D; White, Jared J; Burns, Christine C; Vietz, Christine C

Publication Date: 2022

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35294956

Variant Present in the following documents:

• Main text
• pone.0264138.pdf

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: PIK3CA: Q546E; rs121913286

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 8

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913286

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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KLF3 and PAX6 are candidate driver genes in late-stage, MSI-hypermutated endometrioid endometrial carcinomas.

Plos One

Rudd, Meghan L ML; Hansen, Nancy F NF; Zhang, Xiaolu X; Urick, Mary Ellen ME; Zhang, Suiyuan S; Merino, Maria J MJ; , ; Mullikin, James C JC; Brody, Lawrence C LC; Bell, Daphne W DW

Publication Date: 2022

Variant appearance in text: rs121913286

PubMed Link: 35081118

Variant Present in the following documents:

• pone.0251286.s005.xlsx, sheet 8

View BVdb publication page

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Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine

Duffy, Michael J MJ; Crown, John J

Publication Date: 2022-01-13

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35055414

Variant Present in the following documents:

• Main text
• jpm-12-00099.pdf

View BVdb publication page

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Use of Circulating Tumour DNA (ctDNA) for Measurement of Therapy Predictive Biomarkers in Patients with Cancer.

Journal Of Personalized Medicine

Duffy, Michael J MJ; Crown, John J

Publication Date: 2022-01-13

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 35055414

Variant Present in the following documents:

• Main text
• jpm-12-00099.pdf

View BVdb publication page

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Mutation analysis of a 10-gene panel for colorectal cancer in Huizhou, Guangdong Province of China.

The Journal Of International Medical Research

Li, Jun J; Sun, Aihua A; Zhong, Guofang G; He, Ying Y; Xiong, Hailin H; Yuan, Xia X

Publication Date: 2021-11

Variant appearance in text: PIK3CA: 1636C>G

PubMed Link: 34851763

Variant Present in the following documents:

• 10.1177_03000605211061040.pdf

View BVdb publication page

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Identification of copy number variation-driven molecular subtypes informative for prognosis and treatment in pancreatic adenocarcinoma of a Chinese cohort.

Ebiomedicine

Zhan, Qian Q; Wen, Chenlei C; Zhao, Yi Y; Fang, Lu L; Jin, Yangbing Y; Zhang, Zehui Z; Zou, Siyi S; Li, Fanlu F; Yang, Ying Y; Wu, Lijia L; Jin, Jiabin J; Lu, Xiongxiong X; Xie, Junjie J; Cheng, Dongfeng D; Xu, Zhiwei Z; Zhang, Jun J; Wang, Jiancheng J; Deng, XiaXing X; Chen, Hao H; Peng, Chenghong C; Li, Hongwei H; Zhang, Henghui H; Fang, Hai H; Wang, Chaofu C; Shen, Baiyong B

Publication Date: 2021-12

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34839264

Variant Present in the following documents:

• mmc5.xlsx, sheet 1

View BVdb publication page

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Identification of copy number variation-driven molecular subtypes informative for prognosis and treatment in pancreatic adenocarcinoma of a Chinese cohort.

Ebiomedicine

Zhan, Qian Q; Wen, Chenlei C; Zhao, Yi Y; Fang, Lu L; Jin, Yangbing Y; Zhang, Zehui Z; Zou, Siyi S; Li, Fanlu F; Yang, Ying Y; Wu, Lijia L; Jin, Jiabin J; Lu, Xiongxiong X; Xie, Junjie J; Cheng, Dongfeng D; Xu, Zhiwei Z; Zhang, Jun J; Wang, Jiancheng J; Deng, XiaXing X; Chen, Hao H; Peng, Chenghong C; Li, Hongwei H; Zhang, Henghui H; Fang, Hai H; Wang, Chaofu C; Shen, Baiyong B

Publication Date: 2021-11-25

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34839264

Variant Present in the following documents:

• mmc5.xlsx, sheet 1

View BVdb publication page

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Embryonal Rhabdomyosarcoma with Posttherapy Cytodifferentiation and Aggressive Clinical Course.

Case Reports In Pathology

Jeyaraju, Maniraj M; Macatangay, Regina Ann RA; Munchel, Ashley Taylor-King AT; York, Teresa Anne TA; Montgomery, Elizabeth A EA; Kallen, Michael E ME

Publication Date: 2021

Variant appearance in text: PIK3CA: 1636C>G

PubMed Link: 34790419

Variant Present in the following documents:

• Main text
• CRIPA2021-1800854.pdf

View BVdb publication page

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation

Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR

Publication Date: 2021-11-15

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34779417

Variant Present in the following documents:

• Main text

View BVdb publication page

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TP53 mutations are associated with primary endocrine resistance in luminal early breast cancer.

Cancer Medicine

Grote, Isabel I; Bartels, Stephan S; Kandt, Leonie L; Bollmann, Laura L; Christgen, Henriette H; Gronewold, Malte M; Raap, Mieke M; Lehmann, Ulrich U; Gluz, Oleg O; Nitz, Ulrike U; Kuemmel, Sherko S; Zu Eulenburg, Christine C; Braun, Michael M; Aktas, Bahriye B; Grischke, Eva-Maria EM; Schumacher, Claudia C; Luedtke-Heckenkamp, Kerstin K; Kates, Ronald R; Wuerstlein, Rachel R; Graeser, Monika M; Harbeck, Nadia N; Christgen, Matthias M; Kreipe, Hans H

Publication Date: 2021-12

Variant appearance in text: PIK3CA: 1636C>G; Q546E

PubMed Link: 34779146

Variant Present in the following documents:

• CAM4-10-8581-s002.xlsx, sheet 1

View BVdb publication page

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TP53 mutations are associated with primary endocrine resistance in luminal early breast cancer.

Cancer Medicine

Grote, Isabel I; Bartels, Stephan S; Kandt, Leonie L; Bollmann, Laura L; Christgen, Henriette H; Gronewold, Malte M; Raap, Mieke M; Lehmann, Ulrich U; Gluz, Oleg O; Nitz, Ulrike U; Kuemmel, Sherko S; Zu Eulenburg, Christine C; Braun, Michael M; Aktas, Bahriye B; Grischke, Eva-Maria EM; Schumacher, Claudia C; Luedtke-Heckenkamp, Kerstin K; Kates, Ronald R; Wuerstlein, Rachel R; Graeser, Monika M; Harbeck, Nadia N; Christgen, Matthias M; Kreipe, Hans H

Publication Date: 2021-12

Variant appearance in text: PIK3CA: 1636C>G; Q546E

PubMed Link: 34779146

Variant Present in the following documents:

• CAM4-10-8581-s002.xlsx, sheet 1

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Evaluation of the MGISEQ-2000 Sequencing Platform for Illumina Target Capture Sequencing Libraries.

Frontiers In Genetics

Lang, Jidong J; Zhu, Rongrong R; Sun, Xue X; Zhu, Siyu S; Li, Tianbao T; Shi, Xiaoli X; Sun, Yanqi Y; Yang, Zhou Z; Wang, Weiwei W; Bing, Pingping P; He, Binsheng B; Tian, Geng G

Publication Date: 2021

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34777467

Variant Present in the following documents:

• DataSheet1.xlsx, sheet 4

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Correlation of PIK3CA mutation with programmed death ligand-1 (PD-L1) expression and their clinicopathological significance in colorectal cancer.

Annals Of Translational Medicine

Ahn, Ae Ri AR; Kim, Kyoung Min KM; Jang, Kyu Yun KY; Moon, Woo Sung WS; Ha, Gi Won GW; Lee, Min Ro MR; Chung, Myoung Ja MJ

Publication Date: 2021-09

Variant appearance in text: PIK3CA: 1636C>G; Q546E

PubMed Link: 34733958

Variant Present in the following documents:

• atm-09-18-1406-supplementary.pdf

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Oncomine™ Comprehensive Assay v3 vs. Oncomine™ Comprehensive Assay Plus.

Cancers

Vestergaard, Lau K LK; Oliveira, Douglas N P DNP; Poulsen, Tim S TS; Høgdall, Claus K CK; Høgdall, Estrid V EV

Publication Date: 2021-10-18

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34680378

Variant Present in the following documents:

• Main text

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Breast Cancer Drug Approvals Issued by EMA: A Review of Clinical Trials.

Cancers

Duranti, Simona S; Fabi, Alessandra A; Filetti, Marco M; Falcone, Rosa R; Lombardi, Pasquale P; Daniele, Gennaro G; Franceschini, Gianluca G; Carbognin, Luisa L; Palazzo, Antonella A; Garganese, Giorgia G; Paris, Ida I; Scambia, Giovanni G; Pietragalla, Antonella A

Publication Date: 2021-10-16

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34680350

Variant Present in the following documents:

• Main text

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Companion Diagnostics: State of the Art and New Regulations.

Biomarker Insights

Valla, Vasiliki V; Alzabin, Saba S; Koukoura, Angeliki A; Lewis, Amy A; Nielsen, Anne Ahlmann AA; Vassiliadis, Efstathios E

Publication Date: 2021

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34658618

Variant Present in the following documents:

• Main text
• 10.1177_11772719211047763.pdf

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Multimodal liquid biopsy for early monitoring and outcome prediction of chemotherapy in metastatic breast cancer.

Npj Breast Cancer

Bortolini Silveira, Amanda A; Bidard, François-Clément FC; Tanguy, Marie-Laure ML; Girard, Elodie E; Trédan, Olivier O; Dubot, Coraline C; Jacot, William W; Goncalves, Anthony A; Debled, Marc M; Levy, Christelle C; Ferrero, Jean-Marc JM; Jouannaud, Christelle C; Rios, Maria M; Mouret-Reynier, Marie-Ange MA; Dalenc, Florence F; Hego, Caroline C; Rampanou, Aurore A; Albaud, Benoit B; Baulande, Sylvain S; Berger, Frédérique F; Lemonnier, Jérôme J; Renault, Shufang S; Desmoulins, Isabelle I; Proudhon, Charlotte C; Pierga, Jean-Yves JY

Publication Date: 2021-09-09

Variant appearance in text: PIK3CA: 1636C>G; Q546E

PubMed Link: 34504096

Variant Present in the following documents:

• 41523_2021_319_MOESM3_ESM.xlsx, sheet 1

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Real-World Performance of a Comprehensive Genomic Profiling Test Optimized for Small Tumor Samples.

Jco Precision Oncology

Tomlins, Scott A SA; Hovelson, Daniel H DH; Suga, Jennifer M JM; Anderson, Daniel M DM; Koh, Han A HA; Dees, Elizabeth C EC; McNulty, Brendan B; Burkard, Mark E ME; Guarino, Michael M; Khatri, Jamil J; Safa, Malek M MM; Matrana, Marc R MR; Yang, Eddy S ES; Menter, Alex R AR; Parsons, Benjamin M BM; Slim, Jennifer N JN; Thompson, Michael A MA; Hwang, Leon L; Edenfield, William J WJ; Nair, Suresh S; Onitilo, Adedayo A; Siegel, Robert R; Miller, Alan A; Wassenaar, Timothy T; Irvin, William J WJ; Schulz, William W; Padmanabhan, Arvinda A; Harish, Vallathucherry V; Gonzalez, Anneliese A; Mansoor, Abdul Hai AH; Kellum, Andrew A; Harms, Paul P; Drewery, Stephanie S; Falkner, Jayson J; Fischer, Andrew A; Hipp, Jennifer J; Kwiatkowski, Kat K; Lazo de la Vega, Lorena L; Mitchell, Khalis K; Reeder, Travis T; Siddiqui, Javed J; Vakil, Hana H; Johnson, D Bryan DB; Rhodes, Daniel R DR

Publication Date: 2021-08

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34476329

Variant Present in the following documents:

• po-5-po.20.00472.pdf

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PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer.

Journal For Immunotherapy Of Cancer

Stein, Alexander A; Simnica, Donjete D; Schultheiß, Christoph C; Scholz, Rebekka R; Tintelnot, Joseph J; Gökkurt, Eray E; von Wenserski, Lisa L; Willscher, Edith E; Paschold, Lisa L; Sauer, Markus M; Lorenzen, Sylvie S; Riera-Knorrenschild, Jorge J; Depenbusch, Reinhard R; Ettrich, Thomas J TJ; Dörfel, Steffen S; Al-Batran, Salah-Eddin SE; Karthaus, Meinolf M; Pelzer, Uwe U; Waberer, Lisa L; Hinke, Axel A; Bauer, Marcus M; Massa, Chiara C; Seliger, Barbara B; Wickenhauser, Claudia C; Bokemeyer, Carsten C; Hegewisch-Becker, Susanna S; Binder, Mascha M

Publication Date: 2021-07

Variant appearance in text: PIK3CA: 1636C>G; Gln546Glu; rs121913286

PubMed Link: 34315821

Variant Present in the following documents:

• jitc-2021-002844supp002.xlsx, sheet 1

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Signed in Blood: Circulating Tumor DNA in Cancer Diagnosis, Treatment and Screening.

Cancers

Adashek, Jacob J JJ; Janku, Filip F; Kurzrock, Razelle R

Publication Date: 2021-07-18

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34298813

Variant Present in the following documents:

• Main text
• cancers-13-03600.pdf

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Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology

Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN

Publication Date: 2021

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34113354

Variant Present in the following documents:

• Table_1.xlsx, sheet 31
• Table_1.xlsx, sheet 15

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The molecular profiling of solid tumors by liquid biopsy: a position paper of the AIOM-SIAPEC-IAP-SIBioC-SIC-SIF Italian Scientific Societies.

Esmo Open

Russo, A A; Incorvaia, L L; Del Re, M M; Malapelle, U U; Capoluongo, E E; Gristina, V V; Castiglia, M M; Danesi, R R; Fassan, M M; Giuffrè, G G; Gori, S S; Marchetti, A A; Normanno, N N; Pinto, C C; Rossi, G G; Santini, D D; Sartore-Bianchi, A A; Silvestris, N N; Tagliaferri, P P; Troncone, G G; Cinieri, S S; Beretta, G D GD

Publication Date: 2021-06

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34091263

Variant Present in the following documents:

• Main text
• main.pdf

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Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer.

Journal Of Hematology & Oncology

Chen, Gong G; Peng, Junjie J; Xiao, Qian Q; Wu, Hao-Xiang HX; Wu, Xiaojun X; Wang, Fulong F; Li, Liren L; Ding, Peirong P; Zhao, Qi Q; Li, Yaqi Y; Wang, Da D; Shao, Yang Y; Bao, Hua H; Pan, Zhizhong Z; Ding, Ke-Feng KF; Cai, Sanjun S; Wang, Feng F; Xu, Rui-Hua RH

Publication Date: 2021-05-17

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 34001194

Variant Present in the following documents:

• 13045_2021_1089_MOESM6_ESM.xlsx, sheet 1

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Update Breast Cancer 2020 Part 5 - Moving Therapies From Advanced to Early Breast Cancer Patients.

Geburtshilfe Und Frauenheilkunde

Lux, Michael P MP; Schneeweiss, Andreas A; Hartkopf, Andreas D AD; Müller, Volkmar V; Janni, Wolfgang W; Belleville, Erik E; Stickeler, Elmar E; Thill, Marc M; Fasching, Peter A PA; Kolberg, Hans-Christian HC; Untch, Michael M; Harbeck, Nadia N; Wöckel, Achim A; Thomssen, Christoph C; Schulmeyer, Carla E CE; Welslau, Manfred M; Overkamp, Friedrich F; Schütz, Florian F; Lüftner, Diana D; Ditsch, Nina N

Publication Date: 2021-04

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 33867564

Variant Present in the following documents:

• Main text

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PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer.

Frontiers In Oncology

Fusco, Nicola N; Malapelle, Umberto U; Fassan, Matteo M; Marchiò, Caterina C; Buglioni, Simonetta S; Zupo, Simonetta S; Criscitiello, Carmen C; Vigneri, Paolo P; Dei Tos, Angelo Paolo AP; Maiorano, Eugenio E; Viale, Giuseppe G

Publication Date: 2021

Variant appearance in text: PIK3CA: Q546E

PubMed Link: 33842357

Variant Present in the following documents:

• fonc-11-644737.pdf

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