PIK3CA c.1645G>A ;(p.D549N)

Variant ID: 3-178936103-G-A

NM_006218.2(PIK3CA):c.1645G>A;(p.D549N)

This variant was identified in 60 publications

View GRCh38 version.




Publications:


Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 1645G>A; Asp549Asn
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Sivakumar, Smruthy S; Jin, Dexter X DX; Rathod, Ruchita R; Ross, Jeffrey J; Cantley, Lewis C LC; Scaltriti, Maurizio M; Chen, Jessica W JW; Hutchinson, Katherine E KE; Wilson, Timothy R TR; Sokol, Ethan S ES; Vasan, Neil N
Publication Date: 2023-01-03

Variant appearance in text: PIK3CA: D549N
PubMed Link: 36595567
Variant Present in the following documents:
  • ccr-22-2270_supplementary_tables_s1-14_suppts1-14.xlsx, sheet 12
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: D549N
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 5
View BVdb publication page



Hepcidin Upregulation in Colorectal Cancer Associates with Accumulation of Regulatory Macrophages and Epithelial-Mesenchymal Transition and Correlates with Progression of the Disease.

Cancers
Di Grazia, Antonio A; Di Fusco, Davide D; Franzè, Eleonora E; Colella, Marco M; Strimpakos, Georgios G; Salvatori, Silvia S; Formica, Vincenzo V; Laudisi, Federica F; Maresca, Claudia C; Colantoni, Alfredo A; Ortenzi, Angela A; Stolfi, Carmine C; Monteleone, Ivan I; Monteleone, Giovanni G
Publication Date: 2022-10-27

Variant appearance in text: PIK3CA: D549N
PubMed Link: 36358713
Variant Present in the following documents:
  • Main text
  • cancers-14-05294.pdf
View BVdb publication page



Heterogeneity of the cancer cell line metabolic landscape.

Molecular Systems Biology
Shorthouse, David D; Bradley, Jenna J; Critchlow, Susan E SE; Bendtsen, Claus C; Hall, Benjamin A BA
Publication Date: 2022-11

Variant appearance in text: PIK3CA: 1645G>A
PubMed Link: 36321551
Variant Present in the following documents:
  • MSB-18-e11006-s010.xlsx, sheet 1
View BVdb publication page



Mechanical Properties of Colorectal Cancer Cells Determined by Dynamic Atomic Force Microscopy: A Novel Biomarker.

Cancers
Brás, M Manuela MM; Cruz, Tânia B TB; Maia, André F AF; Oliveira, Maria José MJ; Sousa, Susana R SR; Granja, Pedro L PL; Radmacher, Manfred M
Publication Date: 2022-10-15

Variant appearance in text: PI3K: D549N
PubMed Link: 36291838
Variant Present in the following documents:
  • Main text
  • cancers-14-05053.pdf
View BVdb publication page



Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cells.

Bmc Cancer
Chauvin, Anaïs A; Bergeron, Danny D; Vencic, Jean J; Lévesque, Dominique D; Paquette, Benoit B; Scott, Michelle S MS; Boisvert, François-Michel FM
Publication Date: 2022-04-04

Variant appearance in text: PIK3CA: D549N
PubMed Link: 35379199
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_9417.pdf
View BVdb publication page



Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.

Nature Biotechnology
Sánchez-Rivera, Francisco J FJ; Diaz, Bianca J BJ; Kastenhuber, Edward R ER; Schmidt, Henri H; Katti, Alyna A; Kennedy, Margaret M; Tem, Vincent V; Ho, Yu-Jui YJ; Leibold, Josef J; Paffenholz, Stella V SV; Barriga, Francisco M FM; Chu, Kevan K; Goswami, Sukanya S; Wuest, Alexandra N AN; Simon, Janelle M JM; Tsanov, Kaloyan M KM; Chakravarty, Debyani D; Zhang, Hongxin H; Leslie, Christina S CS; Lowe, Scott W SW; Dow, Lukas E LE
Publication Date: 2022-06

Variant appearance in text: PIK3CA: D549N
PubMed Link: 35165384
Variant Present in the following documents:
  • NIHMS1760571-supplement-Supplementary_Table_S2.xlsx, sheet 4
  • NIHMS1760571-supplement-Supplementary_Table_S7.xlsx, sheet 5
  • NIHMS1760571-supplement-Supplementary_Table_S2.xlsx, sheet 6
View BVdb publication page



Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Bmc Genomics
Chen, Sixian S; Fu, Aizhen A; Lu, Yuan Y; Lu, Wei W; Chen, Yongfeng Y; Hong, Shuiqiang S; Zhou, Suli S; Xiang, Tianmin T; Zhang, Zhenzhen Z; Cai, Yongguang Y
Publication Date: 2022-01-15

Variant appearance in text: PIK3CA: 1645G>A; Asp549Asn
PubMed Link: 35031014
Variant Present in the following documents:
  • 12864_2021_8289_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Investigating the genomic alteration improved the clinical outcome of aged patients with lung carcinoma.

Bmc Genomics
Chen, Sixian S; Fu, Aizhen A; Lu, Yuan Y; Lu, Wei W; Chen, Yongfeng Y; Hong, Shuiqiang S; Zhou, Suli S; Xiang, Tianmin T; Zhang, Zhenzhen Z; Cai, Yongguang Y
Publication Date: 2022-01-15

Variant appearance in text: PIK3CA: 1645G>A; Asp549Asn
PubMed Link: 35031014
Variant Present in the following documents:
  • 12864_2021_8289_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: PIK3CA: D549N
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Evaluation of the MGISEQ-2000 Sequencing Platform for Illumina Target Capture Sequencing Libraries.

Frontiers In Genetics
Lang, Jidong J; Zhu, Rongrong R; Sun, Xue X; Zhu, Siyu S; Li, Tianbao T; Shi, Xiaoli X; Sun, Yanqi Y; Yang, Zhou Z; Wang, Weiwei W; Bing, Pingping P; He, Binsheng B; Tian, Geng G
Publication Date: 2021

Variant appearance in text: PIK3CA: D549N
PubMed Link: 34777467
Variant Present in the following documents:
  • DataSheet1.xlsx, sheet 4
View BVdb publication page



A Prospective Cohort Study of Biomarkers in Squamous Cell Carcinoma of the Anal Canal (SCCAC) and their Influence on Treatment Outcomes.

Journal Of Cancer
Moniz, Camila Motta Venchiarutti CMV; Riechelmann, Rachel Pimenta RP; Oliveira, Suilane Coelho Ribeiro SCR; Bariani, Giovanni Mendonça GM; Rivelli, Thomas Giollo TG; Ortega, Cintia C; Pereira, Allan Andresson Lima AAL; Meireles, Sibele Inácio SI; Franco, Rejane R; Chen, Andre A; Bonadio, Renata Colombo RC; Nahas, Caio C; Sabbaga, Jorge J; Coudry, Renata Almeida RA; Braghiroli, Maria Ignez MI; Hoff, Paulo Marcelo PM
Publication Date: 2021

Variant appearance in text: PIK3CA: 1645G>A
PubMed Link: 34729104
Variant Present in the following documents:
  • Main text
  • jcav12p7018.pdf
View BVdb publication page



RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.

Cancer Discovery
Song, Kyung W KW; Edgar, Kyle A KA; Hanan, Emily J EJ; Hafner, Marc M; Oeh, Jason J; Merchant, Mark M; Sampath, Deepak D; Nannini, Michelle A MA; Hong, Rebecca R; Phu, Lilian L; Forrest, William F WF; Stawiski, Eric E; Schmidt, Stephen S; Endres, Nicholas N; Guan, Jane J; Wallin, Jeffrey J JJ; Cheong, Jonathan J; Plise, Emile G EG; Lewis Phillips, Gail D GD; Salphati, Laurent L; Heffron, Timothy P TP; Olivero, Alan G AG; Malek, Shiva S; Staben, Steven T ST; Kirkpatrick, Donald S DS; Dey, Anwesha A; Friedman, Lori S LS
Publication Date: 2022-01

Variant appearance in text: PIK3CA: D549N
PubMed Link: 34544753
Variant Present in the following documents:
  • 204.pdf
View BVdb publication page



Establishment and characterization of a new human colon cancer cell line, PUMC-CRC1.

Scientific Reports
Bian, Xiaocui X; Cao, Fang F; Wang, Xiaowan X; Hou, Yuhong Y; Zhao, Haitao H; Liu, Yuqin Y
Publication Date: 2021-06-23

Variant appearance in text: PIK3CA: D549N
PubMed Link: 34162944
Variant Present in the following documents:
  • Main text
  • 41598_2021_Article_92491.pdf
View BVdb publication page



Circulating Tumor DNA Analyses Predict Disease Recurrence in Non-Muscle-Invasive Bladder Cancer.

Frontiers In Oncology
Zhang, Jinghua J; Dai, Daofeng D; Tian, Junqiang J; Li, Lifeng L; Bai, Jing J; Xu, Yaping Y; Wang, Zhiping Z; Tang, Aifa A
Publication Date: 2021

Variant appearance in text: PIK3CA: 1645G>A; D549N
PubMed Link: 33996580
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: PIK3CA: 1645G>A; D549N
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Beyond TNBC: Repositioning of Clofazimine Against a Broad Range of Wnt-Dependent Cancers.

Frontiers In Oncology
Xu, Jiabin J; Koval, Alexey A; Katanaev, Vladimir L VL
Publication Date: 2020

Variant appearance in text: PIK3CA: D549N
PubMed Link: 33363033
Variant Present in the following documents:
  • Main text
  • fonc-10-602817.pdf
View BVdb publication page



Modeling Adaptive Resistance of KRAS Mutant Colorectal Cancer to MAPK Pathway Inhibitors with a Three-Dimensional Tumor Model.

Acs Pharmacology & Translational Science
Shahi Thakuri, Pradip P; Lamichhane, Astha A; Singh, Sunil S; Gupta, Megha M; Luker, Gary D GD; Tavana, Hossein H
Publication Date: 2020-12-11

Variant appearance in text: PIK3CA: D549N
PubMed Link: 33344895
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of circulating free DNA in evaluating clinical tumor burden and predicting survival in Chinese metastatic colorectal cancer patients.

Bmc Cancer
Xu, Xiaojing X; Yu, Yiyi Y; Shen, Minna M; Liu, Mengling M; Wu, Shengchao S; Liang, Li L; Huang, Fei F; Zhang, Chenlu C; Guo, Wei W; Liu, Tianshu T
Publication Date: 2020-10-16

Variant appearance in text: PIK3CA: D549N
PubMed Link: 33066758
Variant Present in the following documents:
  • Main text
View BVdb publication page



BRAF status modulates Interelukin-8 expression through a CHOP-dependent mechanism in colorectal cancer.

Communications Biology
Conciatori, Fabiana F; Bazzichetto, Chiara C; Amoreo, Carla Azzurra CA; Sperduti, Isabella I; Donzelli, Sara S; Diodoro, Maria Grazia MG; Buglioni, Simonetta S; Falcone, Italia I; Shirasawa, Senji S; Blandino, Giovanni G; Ferretti, Gianluigi G; Cognetti, Francesco F; Milella, Michele M; Ciuffreda, Ludovica L
Publication Date: 2020-10-01

Variant appearance in text: PI3K: D549N
PubMed Link: 33004975
Variant Present in the following documents:
  • Main text
  • 42003_2020_Article_1263.pdf
  • 42003_2020_1263_MOESM1_ESM.pdf
View BVdb publication page



Construction of a reference material panel for detecting KRAS/NRAS/EGFR/BRAF/MET mutations in plasma ctDNA.

Journal Of Clinical Pathology
Xu, Jun J; Qu, Shoufang S; Sun, Nan N; Zhang, Wenxin W; Zhang, Juanli J; Song, Qingtao Q; Lin, Mufei M; Gao, Wei W; Zheng, Qiaosong Q; Han, Mipeng M; Na, Chenglong C; Xu, Ren R; Chang, Xiaoyan X; Yang, Xuexi X; Huang, Jie J
Publication Date: 2021-05

Variant appearance in text: PIK3CA: D549N
PubMed Link: 32817175
Variant Present in the following documents:
  • jclinpath-2020-206745supp001.pdf
View BVdb publication page



Drug-Drug Interactions of Irinotecan, 5-Fluorouracil, Folinic Acid and Oxaliplatin and Its Activity in Colorectal Carcinoma Treatment.

Molecules (Basel, Switzerland)
Zoetemelk, Marloes M; Ramzy, George M GM; Rausch, Magdalena M; Nowak-Sliwinska, Patrycja P
Publication Date: 2020-06-04

Variant appearance in text: PIK3CA: D549N
PubMed Link: 32512790
Variant Present in the following documents:
  • Main text
  • molecules-25-02614.pdf
View BVdb publication page



Phase and context shape the function of composite oncogenic mutations.

Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Publication Date: 2020-06

Variant appearance in text: PIK3CA: D549N
PubMed Link: 32461694
Variant Present in the following documents:
  • NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2
View BVdb publication page



OncoOmics approaches to reveal essential genes in breast cancer: a panoramic view from pathogenesis to precision medicine.

Scientific Reports
López-Cortés, Andrés A; Paz-Y-Miño, César C; Guerrero, Santiago S; Cabrera-Andrade, Alejandro A; Barigye, Stephen J SJ; Munteanu, Cristian R CR; González-Díaz, Humberto H; Pazos, Alejandro A; Pérez-Castillo, Yunierkis Y; Tejera, Eduardo E
Publication Date: 2020-03-24

Variant appearance in text: PIK3CA: D549N
PubMed Link: 32210335
Variant Present in the following documents:
  • 41598_2020_62279_MOESM2_ESM.xlsx, sheet 33
View BVdb publication page



Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth.

Science Advances
Shin, Seung-Min SM; Kim, Ji-Sun JS; Park, Seong-Wook SW; Jun, Sei-Yong SY; Kweon, Hye-Jin HJ; Choi, Dong-Ki DK; Lee, Dakeun D; Cho, Yong Beom YB; Kim, Yong-Sung YS
Publication Date: 2020-01

Variant appearance in text: PIK3CA: D549N
PubMed Link: 31998840
Variant Present in the following documents:
  • aay2174_SM.pdf
View BVdb publication page



Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
Publication Date: 2019-11

Variant appearance in text: PIK3CA: Asp549Asn
PubMed Link: 31645765
Variant Present in the following documents:
  • 41586_2019_1689_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases.

Plos One
Kim, Young-Ho YH; Song, Yura Y; Kim, Jong-Kwang JK; Kim, Tae-Min TM; Sim, Hye Won HW; Kim, Hyung-Lae HL; Jang, Hyonchol H; Kim, Young-Woo YW; Hong, Kyeong-Man KM
Publication Date: 2019

Variant appearance in text: PIK3CA: 1645G>A; D549N
PubMed Link: 31513681
Variant Present in the following documents:
  • pone.0222535.s006.xlsx, sheet 1
View BVdb publication page



Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells.

Oncology Letters
Heo, Gwangbeom G; Kang, Dongwan D; Park, Chaeun C; Kim, Su Jin SJ; Choo, Jieun J; Lee, Yunna Y; Yoo, Jin-Wook JW; Jung, Yunjin Y; Lee, Jaewon J; Kim, Nam Deuk ND; Chung, Hae Young HY; Moon, Hyung Ryong HR; Im, Eunok E
Publication Date: 2019-09

Variant appearance in text: PIK3CA: D549N
PubMed Link: 31452803
Variant Present in the following documents:
  • Main text
  • ol-18-03-3256.pdf
View BVdb publication page



Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Cancer Cell
Woolston, Andrew A; Khan, Khurum K; Spain, Georgia G; Barber, Louise J LJ; Griffiths, Beatrice B; Gonzalez-Exposito, Reyes R; Hornsteiner, Lisa L; Punta, Marco M; Patil, Yatish Y; Newey, Alice A; Mansukhani, Sonia S; Davies, Matthew N MN; Furness, Andrew A; Sclafani, Francesco F; Peckitt, Clare C; Jiménez, Mirta M; Kouvelakis, Kyriakos K; Ranftl, Romana R; Begum, Ruwaida R; Rana, Isma I; Thomas, Janet J; Bryant, Annette A; Quezada, Sergio S; Wotherspoon, Andrew A; Khan, Nasir N; Fotiadis, Nikolaos N; Marafioti, Teresa T; Powles, Thomas T; Lise, Stefano S; Calvo, Fernando F; Guettler, Sebastian S; von Loga, Katharina K; Rao, Sheela S; Watkins, David D; Starling, Naureen N; Chau, Ian I; Sadanandam, Anguraj A; Cunningham, David D; Gerlinger, Marco M
Publication Date: 2019-07-08

Variant appearance in text: PIK3CA: D549N
PubMed Link: 31287991
Variant Present in the following documents:
  • Main text
View BVdb publication page



Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine
Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A
Publication Date: 2019-06-28

Variant appearance in text: PIK3CA: D549N
PubMed Link: 31253177
Variant Present in the following documents:
  • 13073_2019_654_MOESM2_ESM.xlsx, sheet 20
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: PIK3CA: D549N
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.

Cell Death & Disease
De Bessa, Tiphany Coralie TC; Pagano, Alessandra A; Moretti, Ana Iochabel Soares AIS; Oliveira, Percillia Victoria Santos PVS; Mendonça, Samir Andrade SA; Kovacic, Herve H; Laurindo, Francisco Rafael Martins FRM
Publication Date: 2019-02-13

Variant appearance in text: PI3K: D549N
PubMed Link: 30760703
Variant Present in the following documents:
  • Main text
  • 41419_2019_Article_1402.pdf
View BVdb publication page



Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients.

Heliyon
Deng, Qinfang Q; Xie, Boxiong B; Wu, Leilei L; Ji, Xianxiu X; Li, Chao C; Feng, Li L; Fang, Qiyu Q; Bao, Yuchen Y; Li, Jialu J; Jin, Shengnan S; Ding, Chunming C; Li, Yixue Y; Zhou, Songwen S
Publication Date: 2018-12

Variant appearance in text: PIK3CA: D549N
PubMed Link: 30603682
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers.

Genome Medicine
Heim, Daniel D; Montavon, Grégoire G; Hufnagl, Peter P; Müller, Klaus-Robert KR; Klauschen, Frederick F
Publication Date: 2018-11-15

Variant appearance in text: PIK3CA: D549N
PubMed Link: 30442178
Variant Present in the following documents:
  • 13073_2018_591_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Enhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib.

Translational Oncology
Cuneo, Kyle C KC; Mehta, Ranjit K RK; Kurapati, Himabindu H; Thomas, Dafydd G DG; Lawrence, Theodore S TS; Nyati, Mukesh K MK
Publication Date: 2019-02

Variant appearance in text: PIK3CA: D549N
PubMed Link: 30412912
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines.

Oncotarget
Riffo-Campos, Ángela L ÁL; Gimeno-Valiente, Francisco F; Rodríguez, Fernanda M FM; Cervantes, Andrés A; López-Rodas, Gerardo G; Franco, Luis L; Castillo, Josefa J
Publication Date: 2018-04-17

Variant appearance in text: PIK3CA: D549N
PubMed Link: 29755673
Variant Present in the following documents:
  • Main text
  • oncotarget-09-20578.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: PIK3CA: D549N
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Toward an integrated map of genetic interactions in cancer cells.

Molecular Systems Biology
Rauscher, Benedikt B; Heigwer, Florian F; Henkel, Luisa L; Hielscher, Thomas T; Voloshanenko, Oksana O; Boutros, Michael M
Publication Date: 2018-02-21

Variant appearance in text: PIK3CA: D549N
PubMed Link: 29467179
Variant Present in the following documents:
  • MSB-14-e7656-s003.xlsx, sheet 1
View BVdb publication page



Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.

Bmc Cancer
Klauck, Peter J PJ; Bagby, Stacey M SM; Capasso, Anna A; Bradshaw-Pierce, Erica L EL; Selby, Heather M HM; Spreafico, Anna A; Tentler, John J JJ; Tan, Aik Choon AC; Kim, Jihye J; Arcaroli, John J JJ; Purkey, Alicia A; Messersmith, Wells A WA; Kuida, Keisuke K; Eckhardt, S Gail SG; Pitts, Todd M TM
Publication Date: 2018-02-05

Variant appearance in text: PIK3CA: D549N
PubMed Link: 29402316
Variant Present in the following documents:
  • Main text
View BVdb publication page



Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.

Oncotarget
Gu, Mancang M; Nishihara, Reiko R; Chen, Yang Y; Li, Wanwan W; Shi, Yan Y; Masugi, Yohei Y; Hamada, Tsuyoshi T; Kosumi, Keisuke K; Liu, Li L; da Silva, Annacarolina A; Nowak, Jonathan A JA; Twombly, Tyler T; Du, Chunxia C; Koh, Hideo H; Li, Wenbin W; Meyerhardt, Jeffrey A JA; Wolpin, Brian M BM; Giannakis, Marios M; Aguirre, Andrew J AJ; Bass, Adam J AJ; Drew, David A DA; Chan, Andrew T AT; Fuchs, Charles S CS; Qian, Zhi Rong ZR; Ogino, Shuji S
Publication Date: 2017-10-20

Variant appearance in text: PIK3CA: 1645G>A
PubMed Link: 29152088
Variant Present in the following documents:
  • oncotarget-08-87379.pdf
View BVdb publication page



Prevalence and detection of low-allele-fraction variants in clinical cancer samples.

Nature Communications
Shin, Hyun-Tae HT; Choi, Yoon-La YL; Yun, Jae Won JW; Kim, Nayoung K D NKD; Kim, Sook-Young SY; Jeon, Hyo Jeong HJ; Nam, Jae-Yong JY; Lee, Chung C; Ryu, Daeun D; Kim, Sang Cheol SC; Park, Kyunghee K; Lee, Eunjin E; Bae, Joon Seol JS; Son, Dae Soon DS; Joung, Je-Gun JG; Lee, Jeeyun J; Kim, Seung Tae ST; Ahn, Myung-Ju MJ; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Lee, Woo Yong WY; Oh, Bo Young BY; Park, Yeon Hee YH; Lee, Jeong Eon JE; Lee, Kwang Hyuk KH; Kim, Hee Cheol HC; Kim, Kyoung-Mee KM; Im, Young-Hyuck YH; Park, Keunchil K; Park, Peter J PJ; Park, Woong-Yang WY
Publication Date: 2017-11-09

Variant appearance in text: PIK3CA: D549N
PubMed Link: 29123093
Variant Present in the following documents:
  • 41467_2017_1470_MOESM11_ESM.xlsx, sheet 1
View BVdb publication page



Predicting ligand-dependent tumors from multi-dimensional signaling features.

Npj Systems Biology And Applications
Hass, Helge H; Masson, Kristina K; Wohlgemuth, Sibylle S; Paragas, Violette V; Allen, John E JE; Sevecka, Mark M; Pace, Emily E; Timmer, Jens J; Stelling, Joerg J; MacBeath, Gavin G; Schoeberl, Birgit B; Raue, Andreas A
Publication Date: 2017

Variant appearance in text: PIK3CA: D549N
PubMed Link: 28944080
Variant Present in the following documents:
  • Main text
  • 41540_2017_Article_30.pdf
View BVdb publication page



Clinical Role of ASCT2 (SLC1A5) in KRAS-Mutated Colorectal Cancer.

International Journal Of Molecular Sciences
Toda, Kosuke K; Nishikawa, Gen G; Iwamoto, Masayoshi M; Itatani, Yoshiro Y; Takahashi, Ryo R; Sakai, Yoshiharu Y; Kawada, Kenji K
Publication Date: 2017-07-27

Variant appearance in text: PIK3CA: D549N
PubMed Link: 28749408
Variant Present in the following documents:
  • Main text
  • ijms-18-01632.pdf
View BVdb publication page



Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.

Molecular Cancer
Berg, Kaja C G KCG; Eide, Peter W PW; Eilertsen, Ina A IA; Johannessen, Bjarne B; Bruun, Jarle J; Danielsen, Stine A SA; Bjørnslett, Merete M; Meza-Zepeda, Leonardo A LA; Eknæs, Mette M; Lind, Guro E GE; Myklebost, Ola O; Skotheim, Rolf I RI; Sveen, Anita A; Lothe, Ragnhild A RA
Publication Date: 2017-07-06

Variant appearance in text: PIK3CA: D549N
PubMed Link: 28683746
Variant Present in the following documents:
  • Main text
  • 12943_2017_691_MOESM1_ESM.xlsx, sheet 5
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 1645G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



ROR1 expression as a biomarker for predicting prognosis in patients with colorectal cancer.

Oncotarget
Zhou, Jian-Kang JK; Zheng, Yu-Zhu YZ; Liu, Xue-Sha XS; Gou, Qiheng Q; Ma, Rui R; Guo, Cheng-Lin CL; Croce, Carlo M CM; Liu, Lunxu L; Peng, Yong Y
Publication Date: 2017-05-16

Variant appearance in text: PIK3CA: D549N
PubMed Link: 28427197
Variant Present in the following documents:
  • Main text
View BVdb publication page



ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer.

Oncotarget
Geißler, Anna-Lena AL; Geißler, Miriam M; Kottmann, Daniel D; Lutz, Lisa L; Fichter, Christiane D CD; Fritsch, Ralph R; Weddeling, Britta B; Makowiec, Frank F; Werner, Martin M; Lassmann, Silke S
Publication Date: 2017-03-07

Variant appearance in text: PIK3CA: Asp549Asn
PubMed Link: 28199979
Variant Present in the following documents:
  • Main text
View BVdb publication page



Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.

Molecular Oncology
Polosukhina, Dina D; Love, Harold D HD; Correa, Hernan H; Su, Zengliu Z; Dahlman, Kimberly B KB; Pao, William W; Moses, Harold L HL; Arteaga, Carlos L CL; Lovvorn, Harold N HN; Zent, Roy R; Clark, Peter E PE
Publication Date: 2017-04

Variant appearance in text: PIK3CA: 1645G>A; D549N
PubMed Link: 28188683
Variant Present in the following documents:
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: PIK3CA: 1645G>A; D549N
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Publication Date: 2015

Variant appearance in text: PIK3CA: D549N
PubMed Link: 26010451
Variant Present in the following documents:
  • pone.0127146.s013.xlsx, sheet 4
  • pone.0127146.s014.xlsx, sheet 1
  • pone.0127146.s014.xlsx, sheet 4
  • pone.0127146.s013.xlsx, sheet 1
  • pone.0127146.s014.xlsx, sheet 2
  • pone.0127146.s013.xlsx, sheet 3
  • pone.0127146.s014.xlsx, sheet 3
  • pone.0127146.s013.xlsx, sheet 2
View BVdb publication page



Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium.

Bmc Cancer
Tops, Bastiaan B J BB; Normanno, Nicola N; Kurth, Henriette H; Amato, Eliana E; Mafficini, Andrea A; Rieber, Nora N; Le Corre, Delphine D; Rachiglio, Anna Maria AM; Reiman, Anne A; Sheils, Orla O; Noppen, Christoph C; Lacroix, Ludovic L; Cree, Ian A IA; Scarpa, Aldo A; Ligtenberg, Marjolijn J L MJ; Laurent-Puig, Pierre P
Publication Date: 2015-01-31

Variant appearance in text: PIK3CA: Asp549Asn
PubMed Link: 25637035
Variant Present in the following documents:
  • 12885_2015_Article_1015.pdf
View BVdb publication page