Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: PIK3CA: 1645G>A; Asp549Asn
Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Sivakumar, Smruthy S; Jin, Dexter X DX; Rathod, Ruchita R; Ross, Jeffrey J; Cantley, Lewis C LC; Scaltriti, Maurizio M; Chen, Jessica W JW; Hutchinson, Katherine E KE; Wilson, Timothy R TR; Sokol, Ethan S ES; Vasan, Neil N
Hepcidin Upregulation in Colorectal Cancer Associates with Accumulation of Regulatory Macrophages and Epithelial-Mesenchymal Transition and Correlates with Progression of the Disease.
Cancers
Di Grazia, Antonio A; Di Fusco, Davide D; Franzè, Eleonora E; Colella, Marco M; Strimpakos, Georgios G; Salvatori, Silvia S; Formica, Vincenzo V; Laudisi, Federica F; Maresca, Claudia C; Colantoni, Alfredo A; Ortenzi, Angela A; Stolfi, Carmine C; Monteleone, Ivan I; Monteleone, Giovanni G
Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.
Nature Biotechnology
Sánchez-Rivera, Francisco J FJ; Diaz, Bianca J BJ; Kastenhuber, Edward R ER; Schmidt, Henri H; Katti, Alyna A; Kennedy, Margaret M; Tem, Vincent V; Ho, Yu-Jui YJ; Leibold, Josef J; Paffenholz, Stella V SV; Barriga, Francisco M FM; Chu, Kevan K; Goswami, Sukanya S; Wuest, Alexandra N AN; Simon, Janelle M JM; Tsanov, Kaloyan M KM; Chakravarty, Debyani D; Zhang, Hongxin H; Leslie, Christina S CS; Lowe, Scott W SW; Dow, Lukas E LE
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy.
Cancer Discovery
Song, Kyung W KW; Edgar, Kyle A KA; Hanan, Emily J EJ; Hafner, Marc M; Oeh, Jason J; Merchant, Mark M; Sampath, Deepak D; Nannini, Michelle A MA; Hong, Rebecca R; Phu, Lilian L; Forrest, William F WF; Stawiski, Eric E; Schmidt, Stephen S; Endres, Nicholas N; Guan, Jane J; Wallin, Jeffrey J JJ; Cheong, Jonathan J; Plise, Emile G EG; Lewis Phillips, Gail D GD; Salphati, Laurent L; Heffron, Timothy P TP; Olivero, Alan G AG; Malek, Shiva S; Staben, Steven T ST; Kirkpatrick, Donald S DS; Dey, Anwesha A; Friedman, Lori S LS
Phase and context shape the function of composite oncogenic mutations.
Nature
Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases.
Plos One
Kim, Young-Ho YH; Song, Yura Y; Kim, Jong-Kwang JK; Kim, Tae-Min TM; Sim, Hye Won HW; Kim, Hyung-Lae HL; Jang, Hyonchol H; Kim, Young-Woo YW; Hong, Kyeong-Man KM
Publication Date: 2019
Variant appearance in text: PIK3CA: 1645G>A; D549N
Pro-apoptotic effect of the novel benzylidene derivative MHY695 in human colon cancer cells.
Oncology Letters
Heo, Gwangbeom G; Kang, Dongwan D; Park, Chaeun C; Kim, Su Jin SJ; Choo, Jieun J; Lee, Yunna Y; Yoo, Jin-Wook JW; Jung, Yunjin Y; Lee, Jaewon J; Kim, Nam Deuk ND; Chung, Hae Young HY; Moon, Hyung Ryong HR; Im, Eunok E
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.
Cancer Cell
Woolston, Andrew A; Khan, Khurum K; Spain, Georgia G; Barber, Louise J LJ; Griffiths, Beatrice B; Gonzalez-Exposito, Reyes R; Hornsteiner, Lisa L; Punta, Marco M; Patil, Yatish Y; Newey, Alice A; Mansukhani, Sonia S; Davies, Matthew N MN; Furness, Andrew A; Sclafani, Francesco F; Peckitt, Clare C; Jiménez, Mirta M; Kouvelakis, Kyriakos K; Ranftl, Romana R; Begum, Ruwaida R; Rana, Isma I; Thomas, Janet J; Bryant, Annette A; Quezada, Sergio S; Wotherspoon, Andrew A; Khan, Nasir N; Fotiadis, Nikolaos N; Marafioti, Teresa T; Powles, Thomas T; Lise, Stefano S; Calvo, Fernando F; Guettler, Sebastian S; von Loga, Katharina K; Rao, Sheela S; Watkins, David D; Starling, Naureen N; Chau, Ian I; Sadanandam, Anguraj A; Cunningham, David D; Gerlinger, Marco M
Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.
Cell Death & Disease
De Bessa, Tiphany Coralie TC; Pagano, Alessandra A; Moretti, Ana Iochabel Soares AIS; Oliveira, Percillia Victoria Santos PVS; Mendonça, Samir Andrade SA; Kovacic, Herve H; Laurindo, Francisco Rafael Martins FRM
Role of epigenetic factors in the selection of the alternative splicing isoforms of human KRAS in colorectal cancer cell lines.
Oncotarget
Riffo-Campos, Ángela L ÁL; Gimeno-Valiente, Francisco F; Rodríguez, Fernanda M FM; Cervantes, Andrés A; López-Rodas, Gerardo G; Franco, Luis L; Castillo, Josefa J
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.
Bmc Cancer
Klauck, Peter J PJ; Bagby, Stacey M SM; Capasso, Anna A; Bradshaw-Pierce, Erica L EL; Selby, Heather M HM; Spreafico, Anna A; Tentler, John J JJ; Tan, Aik Choon AC; Kim, Jihye J; Arcaroli, John J JJ; Purkey, Alicia A; Messersmith, Wells A WA; Kuida, Keisuke K; Eckhardt, S Gail SG; Pitts, Todd M TM
Aspirin exerts high anti-cancer activity in PIK3CA-mutant colon cancer cells.
Oncotarget
Gu, Mancang M; Nishihara, Reiko R; Chen, Yang Y; Li, Wanwan W; Shi, Yan Y; Masugi, Yohei Y; Hamada, Tsuyoshi T; Kosumi, Keisuke K; Liu, Li L; da Silva, Annacarolina A; Nowak, Jonathan A JA; Twombly, Tyler T; Du, Chunxia C; Koh, Hideo H; Li, Wenbin W; Meyerhardt, Jeffrey A JA; Wolpin, Brian M BM; Giannakis, Marios M; Aguirre, Andrew J AJ; Bass, Adam J AJ; Drew, David A DA; Chan, Andrew T AT; Fuchs, Charles S CS; Qian, Zhi Rong ZR; Ogino, Shuji S
Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.
Molecular Cancer
Berg, Kaja C G KCG; Eide, Peter W PW; Eilertsen, Ina A IA; Johannessen, Bjarne B; Bruun, Jarle J; Danielsen, Stine A SA; Bjørnslett, Merete M; Meza-Zepeda, Leonardo A LA; Eknæs, Mette M; Lind, Guro E GE; Myklebost, Ola O; Skotheim, Rolf I RI; Sveen, Anita A; Lothe, Ragnhild A RA
ATM mutations and E-cadherin expression define sensitivity to EGFR-targeted therapy in colorectal cancer.
Oncotarget
Geißler, Anna-Lena AL; Geißler, Miriam M; Kottmann, Daniel D; Lutz, Lisa L; Fichter, Christiane D CD; Fritsch, Ralph R; Weddeling, Britta B; Makowiec, Frank F; Werner, Martin M; Lassmann, Silke S
Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.
Molecular Oncology
Polosukhina, Dina D; Love, Harold D HD; Correa, Hernan H; Su, Zengliu Z; Dahlman, Kimberly B KB; Pao, William W; Moses, Harold L HL; Arteaga, Carlos L CL; Lovvorn, Harold N HN; Zent, Roy R; Clark, Peter E PE
Publication Date: 2017-04
Variant appearance in text: PIK3CA: 1645G>A; D549N
A Landscape of Pharmacogenomic Interactions in Cancer.
Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28
Variant appearance in text: PIK3CA: 1645G>A; D549N
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium.
Bmc Cancer
Tops, Bastiaan B J BB; Normanno, Nicola N; Kurth, Henriette H; Amato, Eliana E; Mafficini, Andrea A; Rieber, Nora N; Le Corre, Delphine D; Rachiglio, Anna Maria AM; Reiman, Anne A; Sheils, Orla O; Noppen, Christoph C; Lacroix, Ludovic L; Cree, Ian A IA; Scarpa, Aldo A; Ligtenberg, Marjolijn J L MJ; Laurent-Puig, Pierre P