PIK3CA c.2102A>C ;(p.H701P)

Variant ID: 3-178938860-A-C

NM_006218.2(PIK3CA):c.2102A>C;(p.H701P)

This variant was identified in 50 publications

View GRCh38 version.




Publications:


Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: PIK3CA: 2102A>C; His701Pro
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics
G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A
Publication Date: 2022

Variant appearance in text: PIK3CA: H701P
PubMed Link: 36561320
Variant Present in the following documents:
  • Table3.xlsx, sheet 1
  • Table2.xlsx, sheet 5
View BVdb publication page



PI3Kinase Inhibition in Hormone Receptor-Positive Breast Cancer.

International Journal Of Molecular Sciences
Dhakal, Ajay A; Acharya, Luna L; O'Regan, Ruth R; Gandhi, Shipra S; Falkson, Carla C
Publication Date: 2021-11-02

Variant appearance in text: PIK3CA: H701P
PubMed Link: 34769309
Variant Present in the following documents:
  • Main text
  • ijms-22-11878.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: PIK3CA: H701P
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Publication Date: 2021-12

Variant appearance in text: PIK3CA: H701P
PubMed Link: 34428346
Variant Present in the following documents:
  • Main text
  • MOL2-15-3317.pdf
View BVdb publication page



Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Publication Date: 2021-12

Variant appearance in text: PIK3CA: H701P
PubMed Link: 34428346
Variant Present in the following documents:
  • Main text
  • MOL2-15-3317.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK.

Bmc Cancer
Tran, Khanh B KB; Kolekar, Sharada S; Jabed, Anower A; Jaynes, Patrick P; Shih, Jen-Hsing JH; Wang, Qian Q; Flanagan, Jack U JU; Rewcastle, Gordon W GW; Baguley, Bruce C BC; Shepherd, Peter R PR
Publication Date: 2021-02-06

Variant appearance in text: PIK3CA: H701P
PubMed Link: 33549048
Variant Present in the following documents:
  • 12885_2021_7826_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913282
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



The relationships between systemic cytokine profiles and inflammatory markers in colorectal cancer and the prognostic significance of these parameters.

British Journal Of Cancer
Park, Ji Won JW; Chang, Hee Jin HJ; Yeo, Hyun Yang HY; Han, Nayoung N; Kim, Byung Chang BC; Kong, Sun-Young SY; Kim, Jeongseon J; Oh, Jae Hwan JH
Publication Date: 2020-08

Variant appearance in text: PIK3CA: H701P
PubMed Link: 32488137
Variant Present in the following documents:
  • 41416_2020_924_MOESM1_ESM.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: PIK3CA: H701P
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.

Nature
Yu, Kwanha K; Lin, Chia-Ching John CJ; Hatcher, Asante A; Lozzi, Brittney B; Kong, Kathleen K; Huang-Hobbs, Emmet E; Cheng, Yi-Ting YT; Beechar, Vivek B VB; Zhu, Wenyi W; Zhang, Yiqun Y; Chen, Fengju F; Mills, Gordon B GB; Mohila, Carrie A CA; Creighton, Chad J CJ; Noebels, Jeffrey L JL; Scott, Kenneth L KL; Deneen, Benjamin B
Publication Date: 2020-02

Variant appearance in text: PIK3CA: H701P
PubMed Link: 31996845
Variant Present in the following documents:
  • Main text
View BVdb publication page



Development and validation of a targeted gene sequencing panel for application to disparate cancers.

Scientific Reports
McCabe, Mark J MJ; Gauthier, Marie-Emilie A MA; Chan, Chia-Ling CL; Thompson, Tanya J TJ; De Sousa, Sunita M C SMC; Puttick, Clare C; Grady, John P JP; Gayevskiy, Velimir V; Tao, Jiang J; Ying, Kevin K; Cipponi, Arcadi A; Deng, Niantao N; Swarbrick, Alex A; Thomas, Melissa L ML; Lord, Reginald V RV; Johns, Amber L AL; Kohonen-Corish, Maija M; O'Toole, Sandra A SA; Clark, Jonathan J; Mueller, Simon A SA; Gupta, Ruta R; McCormack, Ann I AI; Dinger, Marcel E ME; Cowley, Mark J MJ; ,
Publication Date: 2019-11-19

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 31745186
Variant Present in the following documents:
  • 41598_2019_52000_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer.

International Journal Of Cancer
Myers, Andrea P AP; Konstantinopoulos, Panagiotis A PA; Barry, William T WT; Luo, Weixiu W; Broaddus, Russell R RR; Makker, Vicky V; Drapkin, Ronny R; Liu, Joyce J; Doyle, Austin A; Horowitz, Neil S NS; Meric-Bernstam, Funda F; Birrer, Michael M; Aghajanian, Carol C; Coleman, Robert L RL; Mills, Gordon B GB; Cantley, Lewis C LC; Matulonis, Ursula A UA; Westin, Shannon N SN
Publication Date: 2020-07-15

Variant appearance in text: PIK3CA: H701P
PubMed Link: 31714586
Variant Present in the following documents:
  • Main text
View BVdb publication page



Validation and Clinical Applications of a Comprehensive Next Generation Sequencing System for Molecular Characterization of Solid Cancer Tissues.

Frontiers In Molecular Biosciences
Dehghani, Mehdi M; Rosenblatt, Kevin P KP; Li, Lei L; Rakhade, Mrudula M; Amato, Robert J RJ
Publication Date: 2019

Variant appearance in text: PIK3CA: His701Pro
PubMed Link: 31681791
Variant Present in the following documents:
  • Data_Sheet_5.pdf
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: PIK3CA: H701P
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



RAS Mutation in Mucinous Carcinoma of the Ovary

Asian Pacific Journal Of Cancer Prevention : Apjcp
Panyavaranant, Pinyada P; Teerapakpinyo, Chinachote C; Pohthipornthawat, Natkrita N; Oranratanaphan, Shina S; Shuangshoti, Shanop S; Triratanachat, Surang S
Publication Date: 2019-04-29

Variant appearance in text: PIK3CA: H701P
PubMed Link: 31030485
Variant Present in the following documents:
  • Main text
  • APJCP-20-1127.pdf
View BVdb publication page



Targeted mutation detection in breast cancer using MammaSeq™.

Breast Cancer Research : Bcr
Smith, Nicholas G NG; Gyanchandani, Rekha R; Shah, Osama S OS; Gurda, Grzegorz T GT; Lucas, Peter C PC; Hartmaier, Ryan J RJ; Brufsky, Adam M AM; Puhalla, Shannon S; Bahreini, Amir A; Kota, Karthik K; Wald, Abigail I AI; Nikiforov, Yuri E YE; Nikiforova, Marina N MN; Oesterreich, Steffi S; Lee, Adrian V AV
Publication Date: 2019-02-08

Variant appearance in text: PIK3CA: H701P
PubMed Link: 30736836
Variant Present in the following documents:
  • 13058_2019_1102_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Validation of the Oncomine™ focus panel for next-generation sequencing of clinical tumour samples.

Virchows Archiv : An International Journal Of Pathology
Williams, Hannah L HL; Walsh, Kathy K; Diamond, Austin A; Oniscu, Anca A; Deans, Zandra C ZC
Publication Date: 2018-10

Variant appearance in text: PIK3CA: 2102A>C
PubMed Link: 30105577
Variant Present in the following documents:
  • 428_2018_2411_MOESM3_ESM.xlsx, sheet 1
  • 428_2018_2411_MOESM1_ESM.xlsx, sheet 3
  • 428_2018_2411_MOESM1_ESM.xlsx, sheet 1
  • 428_2018_Article_2411.pdf
  • 428_2018_2411_MOESM1_ESM.xlsx, sheet 4
  • 428_2018_2411_MOESM2_ESM.xlsx, sheet 1
  • 428_2018_2411_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

Bmc Urology
Kim, Young Saing YS; Kim, Kyung K; Kwon, Ghee-Young GY; Lee, Su Jin SJ; Park, Se Hoon SH
Publication Date: 2018-07-31

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 30064409
Variant Present in the following documents:
  • 12894_2018_380_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Oncogene mutational analysis in Chinese gastrointestinal stromal tumor patients.

Oncotargets And Therapy
Chen, Qiong Q; Li, Rong R; Zhang, Zhi-Gao ZG; Deng, Qiao-Ting QT; Li, Kun K; Wang, Hao H; Yang, Xue-Xi XX; Wu, Ying-Song YS
Publication Date: 2018

Variant appearance in text: PIK3CA: H701P
PubMed Link: 29719410
Variant Present in the following documents:
  • Main text
  • ott-11-2279.pdf
View BVdb publication page



Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.

Japanese Journal Of Clinical Oncology
Naito, Yoichi Y; Takahashi, Hideaki H; Shitara, Kohei K; Okamoto, Wataru W; Bando, Hideaki H; Kuwata, Takeshi T; Kuboki, Yasutoshi Y; Matsumoto, Shingo S; Miki, Izumi I; Yamanaka, Takeharu T; Watanabe, Atsushi A; Kojima, Motohiro M
Publication Date: 2018-06-01

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 29659903
Variant Present in the following documents:
  • hyy052supplementaltable1ionver1.xls, sheet 1
View BVdb publication page



Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications
Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM
Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: H701P
PubMed Link: 29636477
Variant Present in the following documents:
  • 41467_2018_3867_MOESM1_ESM.pdf
View BVdb publication page



Proximal Aberrant Crypt Foci Associate with Synchronous Neoplasia and Are Primed for Neoplastic Progression.

Molecular Cancer Research : Mcr
Drew, David A DA; Mo, Allen A; Grady, James J JJ; Stevens, Richard G RG; Levine, Joel B JB; Brenner, Bruce M BM; Anderson, Joseph C JC; Forouhar, Faripour F; O'Brien, Michael J MJ; Devers, Thomas J TJ; Rosenberg, Daniel W DW
Publication Date: 2018-03

Variant appearance in text: PIK3CA: H701P
PubMed Link: 29222172
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract.

Translational Oncology
Lee, Ji Yun JY; Kim, Kyung K; Sung, Hyun Hwan HH; Jeon, Hwang Gyun HG; Jeong, Byong Chang BC; Seo, Seong Il SI; Jeon, Seong Soo SS; Lee, Hyun Moo HM; Choi, Han-Yong HY; Kwon, Ghee-Young GY; Kim, Kyoung-Mee KM; Lee, Jeeyun J; Lim, Ho Yeong HY; Park, Se Hoon SH
Publication Date: 2018-02

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 29161613
Variant Present in the following documents:
  • mmc1.xlsx, sheet 1
View BVdb publication page



Evaluation of PTGS2 Expression, PIK3CA Mutation, Aspirin Use and Colon Cancer Survival in a Population-Based Cohort Study.

Clinical And Translational Gastroenterology
Gray, Ronan T RT; Cantwell, Marie M MM; Coleman, Helen G HG; Loughrey, Maurice B MB; Bankhead, Peter P; McQuaid, Stephen S; O'Neill, Roisin F RF; Arthur, Kenneth K; Bingham, Victoria V; McGready, Claire C; Gavin, Anna T AT; Cardwell, Chris R CR; Johnston, Brian T BT; James, Jacqueline A JA; Hamilton, Peter W PW; Salto-Tellez, Manuel M; Murray, Liam J LJ
Publication Date: 2017-04-27

Variant appearance in text: PIK3CA: H701P
PubMed Link: 28448072
Variant Present in the following documents:
  • Main text
  • ctg201718a.pdf
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

Oncotarget
Xu, Naiqing N; Fang, Wenfeng W; Mu, Libing L; Tang, Yanna Y; Gao, Lei L; Ren, Shengxiang S; Cao, Dengfeng D; Zhou, Lixin L; Zhang, Aiqun A; Liu, Deruo D; Zhou, Caicun C; Wong, Kwok-Kin KK; Yu, Lei L; Zhang, Li L; Chen, Liang L
Publication Date: 2016-01-26

Variant appearance in text: PIK3CA: H701P
PubMed Link: 26646697
Variant Present in the following documents:
  • oncotarget-07-3884-s001.pdf
View BVdb publication page



Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.

Cancer Research
Dogruluk, Turgut T; Tsang, Yiu Huen YH; Espitia, Maribel M; Chen, Fengju F; Chen, Tenghui T; Chong, Zechen Z; Appadurai, Vivek V; Dogruluk, Armel A; Eterovic, Agna Karina AK; Bonnen, Penelope E PE; Creighton, Chad J CJ; Chen, Ken K; Mills, Gordon B GB; Scott, Kenneth L KL
Publication Date: 2015-12-15

Variant appearance in text: PIK3CA: H701P
PubMed Link: 26627007
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer.

Oncotarget
Lee, Ji Yun JY; Park, Kyunghee K; Lim, Sung Hee SH; Kim, Hae Su HS; Yoo, Kwai Han KH; Jung, Ki Sun KS; Song, Haa-Na HN; Hong, Mineui M; Do, In-Gu IG; Ahn, TaeJin T; Lee, Se Kyung SK; Bae, Soo Youn SY; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Jung, Hae Hyun HH; Kim, Ji-Yeon JY; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-12-22

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 26527317
Variant Present in the following documents:
  • oncotarget-06-43731-s002.xlsx, sheet 1
View BVdb publication page



Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF-Mutated Colorectal Cancer.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Kopetz, Scott S; Desai, Jayesh J; Chan, Emily E; Hecht, Joel Randolph JR; O'Dwyer, Peter J PJ; Maru, Dipen D; Morris, Van V; Janku, Filip F; Dasari, Arvind A; Chung, Woonbook W; Issa, Jean-Pierre J JP; Gibbs, Peter P; James, Brian B; Powis, Garth G; Nolop, Keith B KB; Bhattacharya, Suman S; Saltz, Leonard L
Publication Date: 2015-12-01

Variant appearance in text: PIK3CA: H701P
PubMed Link: 26460303
Variant Present in the following documents:
  • supp_33.34.4032_DS_2015.632497.pdf
View BVdb publication page



Patient-derived cell models as preclinical tools for genome-directed targeted therapy.

Oncotarget
Lee, Ji Yun JY; Kim, Sun Young SY; Park, Charny C; Kim, Nayoung K D NK; Jang, Jiryeon J; Park, Kyunghee K; Yi, Jun Ho JH; Hong, Mineui M; Ahn, Taejin T; Rath, Oliver O; Schueler, Julia J; Kim, Seung Tae ST; Do, In-Gu IG; Lee, Sujin S; Park, Se Hoon SH; Ji, Yong Ick YI; Kim, Dukwhan D; Park, Joon Oh JO; Park, Young Suk YS; Kang, Won Ki WK; Kim, Kyoung-Mee KM; Park, Woong-Yang WY; Lim, Ho Yeong HY; Lee, Jeeyun J
Publication Date: 2015-09-22

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 26296973
Variant Present in the following documents:
  • oncotarget-06-25619-s003.xls, sheet 1
View BVdb publication page



Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay.

Oncotarget
Park, Kyunghee K; Choi, Moon Ki MK; Jung, Hae Hyun HH; Do, In-Gu IG; Lee, Kwang Hee KH; Ahn, TaeJin T; Kil, Won Ho WH; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-09-15

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 26009992
Variant Present in the following documents:
  • oncotarget-06-24499-s002.xlsx, sheet 1
View BVdb publication page



Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas.

Bmc Cancer
Tone, Alicia A AA; McConechy, Melissa K MK; Yang, Winnie W; Ding, Jiarui J; Yip, Stephen S; Kong, Esther E; Wong, Kwong-Kwok KK; Gershenson, David M DM; Mackay, Helen H; Shah, Sohrab S; Gilks, Blake B; Tinker, Anna V AV; Clarke, Blaise B; McAlpine, Jessica N JN; Huntsman, David D
Publication Date: 2014-12-18

Variant appearance in text: PIK3CA: H701P
PubMed Link: 25523272
Variant Present in the following documents:
  • 12885_2014_5198_MOESM14_ESM.xlsx, sheet 1
View BVdb publication page



High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer.

Plos One
Kim, Seokhwi S; Lee, Jeeyun J; Hong, Min Eui ME; Do, In-Gu IG; Kang, So Young SY; Ha, Sang Yun SY; Kim, Seung Tae ST; Park, Se Hoon SH; Kang, Won Ki WK; Choi, Min-Gew MG; Lee, Jun Ho JH; Sohn, Tae Sung TS; Bae, Jae Moon JM; Kim, Sung S; Kim, Duk-Hwan DH; Kim, Kyoung-Mee KM
Publication Date: 2014

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 25372287
Variant Present in the following documents:
  • pone.0111693.s003.xls, sheet 1
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: PIK3CA: H701P
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Absence of 19 known hotspot oncogenic mutations in soft tissue clear cell sarcoma: two cases report with review of the literature.

International Journal Of Clinical And Experimental Pathology
Liu, Chunxia C; Ren, Yan Y; Li, Xiaoying X; Cao, Yuwen Y; Chen, Yunzhao Y; Cui, Xiaobin X; Li, Li L; Li, Feng F
Publication Date: 2014

Variant appearance in text: PIK3CA: H701P
PubMed Link: 25197404
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

The Journal Of Molecular Diagnostics : Jmd
MacConaill, Laura E LE; Garcia, Elizabeth E; Shivdasani, Priyanka P; Ducar, Matthew M; Adusumilli, Ravali R; Breneiser, Marc M; Byrne, Mark M; Chung, Lawrence L; Conneely, Jodie J; Crosby, Lauren L; Garraway, Levi A LA; Gong, Xin X; Hahn, William C WC; Hatton, Charlie C; Kantoff, Philip W PW; Kluk, Michael M; Kuo, Frank F; Jia, Yonghui Y; Joshi, Ruchi R; Longtine, Janina J; Manning, Allison A; Palescandolo, Emanuele E; Sharaf, Nematullah N; Sholl, Lynette L; van Hummelen, Paul P; Wade, Jacqueline J; Wollinson, Bruce M BM; Zepf, Dimity D; Rollins, Barrett J BJ; Lindeman, Neal I NI
Publication Date: 2014-11

Variant appearance in text: PIK3CA: H701P
PubMed Link: 25157968
Variant Present in the following documents:
  • Main text
View BVdb publication page



AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

Plos One
Rashmi, Ramachandran R; DeSelm, Carl C; Helms, Cynthia C; Bowcock, Anne A; Rogers, Buck E BE; Rader, Janet L JL; Rader, Janet J; Grigsby, Perry W PW; Schwarz, Julie K JK
Publication Date: 2014

Variant appearance in text: PIK3CA: H701P
PubMed Link: 24705275
Variant Present in the following documents:
  • Main text
  • pone.0092948.pdf
View BVdb publication page



Oncogene mutational profile in nasopharyngeal carcinoma.

Oncotargets And Therapy
Zhang, Zi-Chen ZC; Fu, Sha S; Wang, Fang F; Wang, Hai-Yun HY; Zeng, Yi-Xin YX; Shao, Jian-Yong JY
Publication Date: 2014

Variant appearance in text: PIK3CA: H701P
PubMed Link: 24672248
Variant Present in the following documents:
  • Main text
  • ott-7-457.pdf
View BVdb publication page



CanDrA: cancer-specific driver missense mutation annotation with optimized features.

Plos One
Mao, Yong Y; Chen, Han H; Liang, Han H; Meric-Bernstam, Funda F; Mills, Gordon B GB; Chen, Ken K
Publication Date: 2013

Variant appearance in text: PIK3CA: H701P
PubMed Link: 24205039
Variant Present in the following documents:
  • pone.0077945.s001.xls, sheet 11
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: PIK3CA: H701P
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page



Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Li, Tianhong T; Kung, Hsing-Jien HJ; Mack, Philip C PC; Gandara, David R DR
Publication Date: 2013-03-10

Variant appearance in text: PIK3CA: H701P
PubMed Link: 23401433
Variant Present in the following documents:
  • Main text
View BVdb publication page



The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature
Barretina, Jordi J; Caponigro, Giordano G; Stransky, Nicolas N; Venkatesan, Kavitha K; Margolin, Adam A AA; Kim, Sungjoon S; Wilson, Christopher J CJ; Lehár, Joseph J; Kryukov, Gregory V GV; Sonkin, Dmitriy D; Reddy, Anupama A; Liu, Manway M; Murray, Lauren L; Berger, Michael F MF; Monahan, John E JE; Morais, Paula P; Meltzer, Jodi J; Korejwa, Adam A; Jané-Valbuena, Judit J; Mapa, Felipa A FA; Thibault, Joseph J; Bric-Furlong, Eva E; Raman, Pichai P; Shipway, Aaron A; Engels, Ingo H IH; Cheng, Jill J; Yu, Guoying K GK; Yu, Jianjun J; Aspesi, Peter P; de Silva, Melanie M; Jagtap, Kalpana K; Jones, Michael D MD; Wang, Li L; Hatton, Charles C; Palescandolo, Emanuele E; Gupta, Supriya S; Mahan, Scott S; Sougnez, Carrie C; Onofrio, Robert C RC; Liefeld, Ted T; MacConaill, Laura L; Winckler, Wendy W; Reich, Michael M; Li, Nanxin N; Mesirov, Jill P JP; Gabriel, Stacey B SB; Getz, Gad G; Ardlie, Kristin K; Chan, Vivien V; Myer, Vic E VE; Weber, Barbara L BL; Porter, Jeff J; Warmuth, Markus M; Finan, Peter P; Harris, Jennifer L JL; Meyerson, Matthew M; Golub, Todd R TR; Morrissey, Michael P MP; Sellers, William R WR; Schlegel, Robert R; Garraway, Levi A LA
Publication Date: 2012-03-28

Variant appearance in text: PIK3CA: 2102A>C; H701P
PubMed Link: 22460905
Variant Present in the following documents:
  • NIHMS361223-supplement-4.xlsx, sheet 3
View BVdb publication page



Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics
Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R
Publication Date: 2012

Variant appearance in text: PIK3CA: H701P
PubMed Link: 22346343
Variant Present in the following documents:
  • Main text
View BVdb publication page



High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes.

Cancer
Choy, Edwin E; Hornicek, Francis F; MacConaill, Laura L; Harmon, David D; Tariq, Zeeshan Z; Garraway, Levi L; Duan, Zhenfeng Z
Publication Date: 2012-06-01

Variant appearance in text: PIK3CA: H701P
PubMed Link: 22006429
Variant Present in the following documents:
  • Main text
View BVdb publication page



Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology
Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF
Publication Date: 2012-02

Variant appearance in text: PIK3CA: H701P
PubMed Link: 21748247
Variant Present in the following documents:
  • 10434_2011_1892_MOESM2_ESM.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: H701P
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



A rapid, sensitive, reproducible and cost-effective method for mutation profiling of colon cancer and metastatic lymph nodes.

Bmc Cancer
Fumagalli, Debora D; Gavin, Patrick G PG; Taniyama, Yusuke Y; Kim, Seung-Il SI; Choi, Hyun-Joo HJ; Paik, Soonmyung S; Pogue-Geile, Katherine L KL
Publication Date: 2010-03-16

Variant appearance in text: PIK3CA: H701P
PubMed Link: 20233444
Variant Present in the following documents:
  • Main text
  • 1471-2407-10-101.pdf
View BVdb publication page



Profiling critical cancer gene mutations in clinical tumor samples.

Plos One
MacConaill, Laura E LE; Campbell, Catarina D CD; Kehoe, Sarah M SM; Bass, Adam J AJ; Hatton, Charles C; Niu, Lili L; Davis, Matt M; Yao, Keluo K; Hanna, Megan M; Mondal, Chandrani C; Luongo, Lauren L; Emery, Caroline M CM; Baker, Alissa C AC; Philips, Juliet J; Goff, Deborah J DJ; Fiorentino, Michelangelo M; Rubin, Mark A MA; Polyak, Kornelia K; Chan, Jennifer J; Wang, Yuexiang Y; Fletcher, Jonathan A JA; Santagata, Sandro S; Corso, Gianni G; Roviello, Franco F; Shivdasani, Ramesh R; Kieran, Mark W MW; Ligon, Keith L KL; Stiles, Charles D CD; Hahn, William C WC; Meyerson, Matthew L ML; Garraway, Levi A LA
Publication Date: 2009-11-18

Variant appearance in text: PIK3CA: H701P
PubMed Link: 19924296
Variant Present in the following documents:
  • Main text
  • pone.0007887.s002.xls, sheet 1
View BVdb publication page



Rare cancer-specific mutations in PIK3CA show gain of function.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Gymnopoulos, Marco M; Elsliger, Marc-André MA; Vogt, Peter K PK
Publication Date: 2007-03-27

Variant appearance in text: PI3K: H701P
PubMed Link: 17376864
Variant Present in the following documents:
  • Main text
View BVdb publication page