Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
The Biochemical Journal
Zheng, Zhaohua Z; Amran, Syazwani I SI; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Kinzler, Kenneth W KW; Vogelstein, Bert B; Shepherd, Peter R PR; Thompson, Philip E PE; Jennings, Ian G IG