Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.
The Biochemical Journal
Zheng, Zhaohua Z; Amran, Syazwani I SI; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Kinzler, Kenneth W KW; Vogelstein, Bert B; Shepherd, Peter R PR; Thompson, Philip E PE; Jennings, Ian G IG
Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.
The Biochemical Journal
Frazzetto, Mark M; Suphioglu, Cenk C; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Jennings, Ian G IG; Cranmer, Susan L SL; Jackson, Shaun P SP; Kinzler, Kenneth W KW; Vogelstein, Bert B; Thompson, Philip E PE