Publications:

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ

Acs Medicinal Chemistry Letters

Pinson, Jo-Anne JA; Zheng, Zhaohua Z; Miller, Michelle S MS; Chalmers, David K DK; Jennings, Ian G IG; Thompson, Philip E PE

Publication Date: 2013-02-14

Variant appearance in text: PI3K: Q859D

PubMed Link: 23795239

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Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

The Biochemical Journal

Zheng, Zhaohua Z; Amran, Syazwani I SI; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Kinzler, Kenneth W KW; Vogelstein, Bert B; Shepherd, Peter R PR; Thompson, Philip E PE; Jennings, Ian G IG

Publication Date: 2012-06-15

Variant appearance in text: PI3K: Q859D

PubMed Link: 22502592

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Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

The Biochemical Journal

Frazzetto, Mark M; Suphioglu, Cenk C; Zhu, Jiuxiang J; Schmidt-Kittler, Oleg O; Jennings, Ian G IG; Cranmer, Susan L SL; Jackson, Shaun P SP; Kinzler, Kenneth W KW; Vogelstein, Bert B; Thompson, Philip E PE

Publication Date: 2008-09-15

Variant appearance in text: PI3K: Q859D

PubMed Link: 18489260

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