PIK3CA c.2798A>C ;(p.D933A)

Variant ID: 3-178948026-A-C

NM_006218.2(PIK3CA):c.2798A>C;(p.D933A)

This variant was identified in 35 publications

View GRCh38 version.




Publications:


Maternal and Intrauterine Influences on Feto-Placental Growth Are Accompanied by Sexually Dimorphic Changes in Placental Mitochondrial Respiration, and Metabolic Signalling Pathways.

Cells
Salazar-Petres, Esteban E; Pereira-Carvalho, Daniela D; Lopez-Tello, Jorge J; Sferruzzi-Perri, Amanda N AN
Publication Date: 2023-03-03

Variant appearance in text: PI3K: D933A
PubMed Link: 36899933
Variant Present in the following documents:
  • Main text
  • cells-12-00797.pdf
View BVdb publication page



Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy.

Frontiers In Cell And Developmental Biology
Lopez-Tello, Jorge J; Salazar-Petres, Esteban E; Webb, Liam L; Fowden, Abigail L AL; Sferruzzi-Perri, Amanda N AN
Publication Date: 2022

Variant appearance in text: PI3K: D933A
PubMed Link: 35846351
Variant Present in the following documents:
  • Main text
  • fcell-10-928210.pdf
View BVdb publication page



RGS20 Promotes Tumor Progression through Modulating PI3K/AKT Signaling Activation in Penile Cancer.

Journal Of Oncology
Shi, Dazun D; Tong, Shiyu S; Han, Hui H; Hu, Xiheng X
Publication Date: 2022

Variant appearance in text: PI3K: D933A
PubMed Link: 35498542
Variant Present in the following documents:
  • JO2022-1293622.pdf
View BVdb publication page



Efficacy of Providing the PI3K p110α Inhibitor BYL719 (Alpelisib) to Middle-Aged Mice in Their Diet.

Biomolecules
Hedges, Christopher P CP; Boix, Jordi J; Jaiswal, Jagdish K JK; Shetty, Bhoopika B; Shepherd, Peter R PR; Merry, Troy L TL
Publication Date: 2021-01-25

Variant appearance in text: PI3K: D933A
PubMed Link: 33503847
Variant Present in the following documents:
  • Main text
View BVdb publication page



The role of the PIK3CA gene in the development and aging of the brain.

Scientific Reports
Xie, Shaozhen S; Ni, Jing J; Guo, Hanbing H; Luu, Victor V; Wang, Yanzhi Y; Zhao, Jean J JJ; Roberts, Thomas M TM
Publication Date: 2021-01-11

Variant appearance in text: PIK3CA: D933A
PubMed Link: 33431926
Variant Present in the following documents:
  • Main text
  • 41598_2020_Article_79416.pdf
View BVdb publication page



Class IA PI3Ks regulate subcellular and functional dynamics of IDO1.

Embo Reports
Iacono, Alberta A; Pompa, Andrea A; De Marchis, Francesca F; Panfili, Eleonora E; Greco, Francesco A FA; Coletti, Alice A; Orabona, Ciriana C; Volpi, Claudia C; Belladonna, Maria L ML; Mondanelli, Giada G; Albini, Elisa E; Vacca, Carmine C; Gargaro, Marco M; Fallarino, Francesca F; Bianchi, Roberta R; De Marcos Lousa, Carine C; Mazza, Emilia Mc EM; Bicciato, Silvio S; Proietti, Elisa E; Milano, Francesca F; Martelli, Maria P MP; Iamandii, Ioana M IM; Graupera Garcia-Mila, Mariona M; Llena Sopena, Judith J; Hawkins, Phillip P; Suire, Sabine S; Okkenhaug, Klaus K; Stark, Anne-Katrien AK; Grassi, Fabio F; Bellucci, Michele M; Puccetti, Paolo P; Santambrogio, Laura L; Macchiarulo, Antonio A; Grohmann, Ursula U; Pallotta, Maria T MT
Publication Date: 2020-12-03

Variant appearance in text: PI3K: D933A
PubMed Link: 33159421
Variant Present in the following documents:
  • Main text
View BVdb publication page



Revisiting PI3-kinase signalling in angiogenesis.

Vascular Biology (Bristol, England)
Kobialka, Piotr P; Graupera, Mariona M
Publication Date: 2019

Variant appearance in text: PI3K: D933A
PubMed Link: 32923964
Variant Present in the following documents:
  • Main text
  • VB-19-0025.pdf
View BVdb publication page



For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors.

Biomolecules
Buchanan, Christina M CM; Lee, Kate L KL; Shepherd, Peter R PR
Publication Date: 2019-08-22

Variant appearance in text: PIK3CA: D933A
PubMed Link: 31443495
Variant Present in the following documents:
  • Main text
  • biomolecules-09-00402.pdf
View BVdb publication page



Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.

Elife
López-Tello, Jorge J; Pérez-García, Vicente V; Khaira, Jaspreet J; Kusinski, Laura C LC; Cooper, Wendy N WN; Andreani, Adam A; Grant, Imogen I; Fernández de Liger, Edurne E; Lam, Brian Yh BY; Hemberger, Myriam M; Sandovici, Ionel I; Constancia, Miguel M; Sferruzzi-Perri, Amanda N AN
Publication Date: 2019-06-26

Variant appearance in text: PI3K: D933A
PubMed Link: 31241463
Variant Present in the following documents:
  • Main text
  • elife-45282.pdf
View BVdb publication page



Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer.

International Journal Of Molecular Sciences
Mazloumi Gavgani, Fatemeh F; Smith Arnesen, Victoria V; Jacobsen, Rhîan G RG; Krakstad, Camilla C; Hoivik, Erling A EA; Lewis, Aurélia E AE
Publication Date: 2018-12-07

Variant appearance in text: PI3K: D933A
PubMed Link: 30544563
Variant Present in the following documents:
  • Main text
  • ijms-19-03931.pdf
View BVdb publication page



MAPK and PI3K signaling: At the crossroads of neural crest development.

Developmental Biology
Dinsmore, Colin J CJ; Soriano, Philippe P
Publication Date: 2018-12-01

Variant appearance in text: PI3K: D933A
PubMed Link: 29453943
Variant Present in the following documents:
  • Main text
View BVdb publication page



Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of PI3K activity.

Journal Of Pineal Research
Owino, Sharon S; Sánchez-Bretaño, Aida A; Tchio, Cynthia C; Cecon, Erika E; Karamitri, Angeliki A; Dam, Julie J; Jockers, Ralf R; Piccione, Giuseppe G; Noh, Hye Lim HL; Kim, Taekyoon T; Kim, Jason K JK; Baba, Kenkichi K; Tosini, Gianluca G
Publication Date: 2018-04

Variant appearance in text: PI3K: D933A
PubMed Link: 29247541
Variant Present in the following documents:
  • Main text
View BVdb publication page



Ketoacidosis With Canagliflozin Prescribed for Phosphoinositide 3-Kinase Inhibitor-Induced Hyperglycemia: A Case Report.

Journal Of Investigative Medicine High Impact Case Reports
Bowman, Christopher C; Abramson, Vandana V; Wellons, Melissa M
Publication Date: 2017

Variant appearance in text: PI3K: D933A
PubMed Link: 28856166
Variant Present in the following documents:
  • Main text
  • 10.1177_2324709617725351.pdf
View BVdb publication page



Placental phenotype and the insulin-like growth factors: resource allocation to fetal growth.

The Journal Of Physiology
Sferruzzi-Perri, Amanda N AN; Sandovici, Ionel I; Constancia, Miguel M; Fowden, Abigail L AL
Publication Date: 2017-08-01

Variant appearance in text: PI3K: D933A
PubMed Link: 28337745
Variant Present in the following documents:
  • Main text
View BVdb publication page



Maternal and fetal genomes interplay through phosphoinositol 3-kinase(PI3K)-p110α signaling to modify placental resource allocation.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Sferruzzi-Perri, Amanda N AN; López-Tello, Jorge J; Fowden, Abigail L AL; Constancia, Miguel M
Publication Date: 2016-10-04

Variant appearance in text: PI3K: D933A
PubMed Link: 27621448
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Nature Communications
Hao, Yujun Y; Samuels, Yardena Y; Li, Qingling Q; Krokowski, Dawid D; Guan, Bo-Jhih BJ; Wang, Chao C; Jin, Zhicheng Z; Dong, Bohan B; Cao, Bo B; Feng, Xiujing X; Xiang, Min M; Xu, Claire C; Fink, Stephen S; Meropol, Neal J NJ; Xu, Yan Y; Conlon, Ronald A RA; Markowitz, Sanford S; Kinzler, Kenneth W KW; Velculescu, Victor E VE; Brunengraber, Henri H; Willis, Joseph E JE; LaFramboise, Thomas T; Hatzoglou, Maria M; Zhang, Guo-Fang GF; Vogelstein, Bert B; Wang, Zhenghe Z
Publication Date: 2016-06-20

Variant appearance in text: PIK3CA: D933A
PubMed Link: 27321283
Variant Present in the following documents:
  • Main text
  • ncomms11971-s1.pdf
  • ncomms11971.pdf
View BVdb publication page



Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Soler, Adriana A; Figueiredo, Ana M AM; Castel, Pau P; Martin, Laura L; Monelli, Erika E; Angulo-Urarte, Ana A; Milà-Guasch, Maria M; Viñals, Francesc F; Baselga, Jose J; Casanovas, Oriol O; Graupera, Mariona M
Publication Date: 2016-12-01

Variant appearance in text: PI3K: D933A
PubMed Link: 27225693
Variant Present in the following documents:
  • Main text
View BVdb publication page



Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells.

Plos Genetics
Guillermet-Guibert, Julie J; Smith, Lee B LB; Halet, Guillaume G; Whitehead, Maria A MA; Pearce, Wayne W; Rebourcet, Diane D; León, Kelly K; Crépieux, Pascale P; Nock, Gemma G; Strömstedt, Maria M; Enerback, Malin M; Chelala, Claude C; Graupera, Mariona M; Carroll, John J; Cosulich, Sabina S; Saunders, Philippa T K PT; Huhtaniemi, Ilpo I; Vanhaesebroeck, Bart B
Publication Date: 2015-07

Variant appearance in text: PI3K: D933A
PubMed Link: 26132308
Variant Present in the following documents:
  • Main text
  • pgen.1005304.pdf
View BVdb publication page



Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis.

Molecular And Cellular Biology
Matheny, Ronald W RW; Riddle-Kottke, Melissa A MA; Leandry, Luis A LA; Lynch, Christine M CM; Abdalla, Mary N MN; Geddis, Alyssa V AV; Piper, David R DR; Zhao, Jean J JJ
Publication Date: 2015-04

Variant appearance in text: PIK3CA: D933A
PubMed Link: 25605332
Variant Present in the following documents:
  • Main text
View BVdb publication page



Leptin receptor signaling in the hypothalamus regulates hepatic autonomic nerve activity via phosphatidylinositol 3-kinase and AMP-activated protein kinase.

The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Tanida, Mamoru M; Yamamoto, Naoki N; Morgan, Donald A DA; Kurata, Yasutaka Y; Shibamoto, Toshishige T; Rahmouni, Kamal K
Publication Date: 2015-01-14

Variant appearance in text: PI3K: D933A
PubMed Link: 25589743
Variant Present in the following documents:
  • Main text
View BVdb publication page



The role of hypothalamic mTORC1 signaling in insulin regulation of food intake, body weight, and sympathetic nerve activity in male mice.

Endocrinology
Muta, Kenjiro K; Morgan, Donald A DA; Rahmouni, Kamal K
Publication Date: 2015-04

Variant appearance in text: PI3K: D933A
PubMed Link: 25574706
Variant Present in the following documents:
  • Main text
View BVdb publication page



PI3K signaling: A key pathway in the control of sympathetic traffic and arterial pressure by leptin.

Molecular Metabolism
Harlan, Shannon M SM; Rahmouni, Kamal K
Publication Date: 2013-03-23

Variant appearance in text: PI3K: D933A
PubMed Link: 24199153
Variant Present in the following documents:
  • Main text
View BVdb publication page



Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

The Journal Of Experimental Medicine
Soler, Adriana A; Serra, Helena H; Pearce, Wayne W; Angulo, Ana A; Guillermet-Guibert, Julie J; Friedman, Lori S LS; Viñals, Francesc F; Gerhardt, Holger H; Casanovas, Oriol O; Graupera, Mariona M; Vanhaesebroeck, Bart B
Publication Date: 2013-09-23

Variant appearance in text: PI3K: D933A
PubMed Link: 24043760
Variant Present in the following documents:
  • Main text
View BVdb publication page



Phosphoinositides: tiny lipids with giant impact on cell regulation.

Physiological Reviews
Balla, Tamas T
Publication Date: 2013-07

Variant appearance in text: PI3K: D933A
PubMed Link: 23899561
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response.

Neoplasia (New York, N.Y.)
Sampath, Deepak D; Oeh, Jason J; Wyatt, Shelby K SK; Cao, Tim C TC; Koeppen, Hartmut H; Eastham-Anderson, Jeffrey J; Robillard, Liliane L; Ho, Calvin C K CC; Ross, Jed J; Zhuang, Guanglei G; Reslan, Hani Bou HB; Vitorino, Philip P; Barck, Kai H KH; Ungersma, Sharon E SE; Vernes, Jean Michel JM; Caunt, Maresa M; Van Bruggen, Nick N; Ye, Weilan W; Vijapurkar, Ulka U; Meng, Yu-Ju Gloria YJ; Ferrara, Napoleone N; Friedman, Lori S LS; Carano, Richard A D RA
Publication Date: 2013-07

Variant appearance in text: PI3K: D933A
PubMed Link: 23814482
Variant Present in the following documents:
  • Main text
View BVdb publication page



Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish.

Disease Models & Mechanisms
Choorapoikayil, Suma S; Weijts, Bart B; Kers, Rianne R; de Bruin, Alain A; den Hertog, Jeroen J
Publication Date: 2013-09

Variant appearance in text: PI3K: D933A
PubMed Link: 23720233
Variant Present in the following documents:
  • Main text
View BVdb publication page



Hypothalamic mTORC1 signaling controls sympathetic nerve activity and arterial pressure and mediates leptin effects.

Cell Metabolism
Harlan, Shannon M SM; Guo, Deng-Fu DF; Morgan, Donald A DA; Fernandes-Santos, Caroline C; Rahmouni, Kamal K
Publication Date: 2013-04-02

Variant appearance in text: PI3K: D933A
PubMed Link: 23541372
Variant Present in the following documents:
  • Main text
View BVdb publication page



Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.

Embo Molecular Medicine
Foukas, Lazaros C LC; Bilanges, Benoit B; Bettedi, Lucia L; Pearce, Wayne W; Ali, Khaled K; Sancho, Sara S; Withers, Dominic J DJ; Vanhaesebroeck, Bart B
Publication Date: 2013-04

Variant appearance in text: PI3K: D933A
PubMed Link: 23483710
Variant Present in the following documents:
  • Main text
  • emmm0005-0563-sd2.pdf
  • emmm0005-0563-sd1.pdf
  • emmm0005-0563.pdf
View BVdb publication page



Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.

The Biochemical Journal
Berenjeno, Inma M IM; Guillermet-Guibert, Julie J; Pearce, Wayne W; Gray, Alexander A; Fleming, Stewart S; Vanhaesebroeck, Bart B
Publication Date: 2012-02-15

Variant appearance in text: PI3K: D933A
PubMed Link: 22150431
Variant Present in the following documents:
  • Main text
  • bj4420151.pdf
View BVdb publication page



Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase.

Cell Cycle (Georgetown, Tex.)
Sun, Minghao M; Hart, Jonathan R JR; Hillmann, Petra P; Gymnopoulos, Marco M; Vogt, Peter K PK
Publication Date: 2011-11-01

Variant appearance in text: PI3K: D933A
PubMed Link: 22045127
Variant Present in the following documents:
  • Main text
View BVdb publication page



The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

Science Signaling
Ramadani, Faruk F; Bolland, Daniel J DJ; Garcon, Fabien F; Emery, Juliet L JL; Vanhaesebroeck, Bart B; Corcoran, Anne E AE; Okkenhaug, Klaus K
Publication Date: 2010-08-10

Variant appearance in text: PI3K: D933A
PubMed Link: 20699475
Variant Present in the following documents:
  • Main text
View BVdb publication page



Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.

Cell Metabolism
Sopasakis, Victoria Rotter VR; Liu, Pixu P; Suzuki, Ryo R; Kondo, Tatsuya T; Winnay, Jonathon J; Tran, Thien T TT; Asano, Tomoichiro T; Smyth, Graham G; Sajan, Mini P MP; Farese, Robert V RV; Kahn, C Ronald CR; Zhao, Jean J JJ
Publication Date: 2010-03-03

Variant appearance in text: PI3K: D933A
PubMed Link: 20197055
Variant Present in the following documents:
  • Main text
View BVdb publication page



Targeting the phosphoinositide 3-kinase pathway in cancer.

Nature Reviews. Drug Discovery
Liu, Pixu P; Cheng, Hailing H; Roberts, Thomas M TM; Zhao, Jean J JJ
Publication Date: 2009-08

Variant appearance in text: PI3K: D933A
PubMed Link: 19644473
Variant Present in the following documents:
  • Main text
View BVdb publication page



Should individual PI3 kinase isoforms be targeted in cancer?

Current Opinion In Cell Biology
Jia, Shidong S; Roberts, Thomas M TM; Zhao, Jean J JJ
Publication Date: 2009-04

Variant appearance in text: PIK3CA: D933A
PubMed Link: 19200708
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Kang, Sohye S; Denley, Adam A; Vanhaesebroeck, Bart B; Vogt, Peter K PK
Publication Date: 2006-01-31

Variant appearance in text: PI3K: D933A
PubMed Link: 16432180
Variant Present in the following documents:
  • Main text
View BVdb publication page