Publications:

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The molecular landscape of breast mucoepidermoid carcinoma.

Cancer Medicine

Venetis, Konstantinos K; Sajjadi, Elham E; Ivanova, Mariia M; Andaloro, Silvia S; Pessina, Simona S; Zanetti, Chiara C; Ranghiero, Alberto A; Citelli, Gabriele G; Rossi, Chiara C; Lucioni, Marco M; Malapelle, Umberto U; Pagni, Fabio F; Barberis, Massimo M; Guerini-Rocco, Elena E; Viale, Giuseppe G; Fusco, Nicola N

Publication Date: 2023-03-14

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 36916425

Variant Present in the following documents:

• Main text
• CAM4-12-10725.pdf

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ESR1 gene amplification and MAP3K mutations are selected during adjuvant endocrine therapies in relapsing Hormone Receptor-positive, HER2-negative breast cancer (HR+ HER2- BC).

Plos Genetics

Ferrando, Lorenzo L; Vingiani, Andrea A; Garuti, Anna A; Vernieri, Claudio C; Belfiore, Antonino A; Agnelli, Luca L; Dagrada, Gianpaolo G; Ivanoiu, Diana D; Bonizzi, Giuseppina G; Munzone, Elisabetta E; Lippolis, Luana L; Dameri, Martina M; Ravera, Francesco F; Colleoni, Marco M; Viale, Giuseppe G; Magnani, Luca L; Ballestrero, Alberto A; Zoppoli, Gabriele G; Pruneri, Giancarlo G

Publication Date: 2023-01-03

Variant appearance in text: PIK3CA: 3074C>T; T1025I

PubMed Link: 36595552

Variant Present in the following documents:

• pgen.1010563.s004.xlsx, sheet 1

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Uterine lavage identifies cancer mutations and increased TP53 somatic mutation burden in individuals with ovarian cancer.

Cancer Research Communications

Ghezelayagh, Talayeh S TS; Kohrn, Brendan F BF; Fredrickson, Jeanne J; Manhardt, Enna E; Radke, Marc R MR; Katz, Ronit R; Gray, Heidi J HJ; Urban, Renata R RR; Pennington, Kathryn P KP; Liao, John B JB; Doll, Kemi M KM; Simons, Elise J EJ; Burzawa, Jennifer K JK; Goff, Barbara A BA; Speiser, Paul P; Swisher, Elizabeth M EM; Norquist, Barbara M BM; Risques, Rosa Ana RA

Publication Date: 2022-10

Variant appearance in text: PIK3CA: 3074C>T; T1025I

PubMed Link: 36311816

Variant Present in the following documents:

• crc-22-0314-s02.xlsx, sheet 6

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Phase Ib Trial of Copanlisib, A Phosphoinositide-3 Kinase (PI3K) Inhibitor, with Trastuzumab in Advanced Pre-Treated HER2-Positive Breast Cancer "PantHER".

Cancers

Keegan, Niamh M NM; Furney, Simon J SJ; Walshe, Janice M JM; Gullo, Giuseppe G; Kennedy, M John MJ; Smith, Diarmuid D; McCaffrey, John J; Kelly, Catherine M CM; Egan, Keith K; Kerr, Jennifer J; Given, Mark M; O'Donovan, Peter P; Hernando, Andres A; Teiserskiene, Ausra A; Parker, Imelda I; Kay, Elaine E; Farrelly, Angela A; Carr, Aoife A; Calzaferri, Giulio G; McDermott, Ray R; Keane, Maccon M MM; Grogan, Liam L; Breathnach, Oscar O; Morris, Patrick G PG; Toomey, Sinead S; Hennessy, Bryan T BT

Publication Date: 2021-03-11

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 33799597

Variant Present in the following documents:

• Main text
• cancers-13-01225.pdf

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: PIK3CA: 3074C>T; T1025I

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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Dual inhibition of TGFβ and AXL as a novel therapy for human colorectal adenocarcinoma with mesenchymal phenotype.

Medical Oncology (Northwood, London, England)

Ciardiello, Davide D; Blauensteiner, Bernadette B; Matrone, Nunzia N; Belli, Valentina V; Mohr, Thomas T; Vitiello, Pietro Paolo PP; Martini, Giulia G; Poliero, Luca L; Cardone, Claudia C; Napolitano, Stefania S; De Falco, Vincenzo V; Giunta, Emilio Francesco EF; Ciaramella, Vincenza V; Corte, Carminia Della CD; Barra, Giusi G; Selvaggi, Francesco F; Franco, Renato R; Marino, Federica Zito FZ; Cuomo, Antonio A; Morgillo, Floriana F; Troiani, Teresa T; Sibilia, Maria M; Ciardiello, Fortunato F; Martinelli, Erika E

Publication Date: 2021-02-11

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 33570712

Variant Present in the following documents:

• Main text
• 12032_2021_Article_1464.pdf

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Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer.

Cancer Medicine

Sivapiragasam, Abirami A; Ashok Kumar, Prashanth P; Sokol, Ethan S ES; Albacker, Lee A LA; Killian, Jonathan K JK; Ramkissoon, Shakti H SH; Huang, Richard S P RSP; Severson, Eric A EA; Brown, Charlotte A CA; Danziger, Natalie N; McGregor, Kimberly K; Ross, Jeffrey S JS

Publication Date: 2021-01

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 33314633

Variant Present in the following documents:

• CAM4-10-53-s002.xlsx, sheet 1

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Clinicopathological characteristics and genetic analysis of pulmonary carcinoid tumors: A single-center retrospective cohort study and literature review.

Oncology Letters

Li, Xiongfei X; Hou, Yuelong Y; Shi, Tao T; He, Yue Y; Ren, Dian D; Song, Zuoqing Z; Wei, Sen S; Chen, Gang G; Chen, Jun J; Xu, Song S

Publication Date: 2020-03

Variant appearance in text: PI3K: 3074C>T

PubMed Link: 32194744

Variant Present in the following documents:

• Main text
• ol-19-03-2446.pdf

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Comparison of TCGA and GENIE genomic datasets for the detection of clinically actionable alterations in breast cancer.

Scientific Reports

Kaur, Pushpinder P; Porras, Tania B TB; Ring, Alexander A; Carpten, John D JD; Lang, Julie E JE

Publication Date: 2019-02-06

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 30728399

Variant Present in the following documents:

• 41598_2018_37574_MOESM1_ESM.pdf

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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target.

Nature Communications

Dufva, Olli O; Kankainen, Matti M; Kelkka, Tiina T; Sekiguchi, Nodoka N; Awad, Shady Adnan SA; Eldfors, Samuli S; Yadav, Bhagwan B; Kuusanmäki, Heikki H; Malani, Disha D; Andersson, Emma I EI; Pietarinen, Paavo P; Saikko, Leena L; Kovanen, Panu E PE; Ojala, Teija T; Lee, Dean A DA; Loughran, Thomas P TP; Nakazawa, Hideyuki H; Suzumiya, Junji J; Suzuki, Ritsuro R; Ko, Young Hyeh YH; Kim, Won Seog WS; Chuang, Shih-Sung SS; Aittokallio, Tero T; Chan, Wing C WC; Ohshima, Koichi K; Ishida, Fumihiro F; Mustjoki, Satu S

Publication Date: 2018-04-19

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 29674644

Variant Present in the following documents:

• 41467_2018_3987_MOESM9_ESM.xlsx, sheet 8

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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications

Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM

Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 29636477

Variant Present in the following documents:

• 41467_2018_3867_MOESM1_ESM.pdf

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: PI3K: T1025I

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: PIK3CA: 3074C>T; T1025I

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail.

British Journal Of Cancer

Ong, M M; Carreira, S S; Goodall, J J; Mateo, J J; Figueiredo, I I; Rodrigues, D N DN; Perkins, G G; Seed, G G; Yap, T A TA; Attard, G G; de Bono, J S JS

Publication Date: 2014-08-26

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 24983367

Variant Present in the following documents:

• Main text
• bjc2014350a.pdf

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Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours.

Oncology Reports

Capodanno, Alessandra A; Boldrini, Laura L; Alì, Greta G; Pelliccioni, Serena S; Mussi, Alfredo A; Fontanini, Gabriella G

Publication Date: 2012-11

Variant appearance in text: PIK3CA: 3074C>T

PubMed Link: 22949056

Variant Present in the following documents:

• or-28-05-1559.pdf

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Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology

Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF

Publication Date: 2012-02

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 21748247

Variant Present in the following documents:

• 10434_2011_1892_MOESM2_ESM.pdf

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: T1025I

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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