Publications:

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Characterization of driver mutations in Chinese non-small cell lung cancer patients using a novel targeted sequencing panel.

Journal Of Thoracic Disease

Zhao, Jing J; Wu, Yang Y; Chen, Min-Jiang MJ; Xu, Yan Y; Zhong, Wei W; Wang, Meng-Zhao MZ

Publication Date: 2022-12

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 36647494

Variant Present in the following documents:

• Main text
• jtd-14-12-4669.pdf

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

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Bacillus Calmette-Guérin Treatment Changes the Tumor Microenvironment of Non-Muscle-Invasive Bladder Cancer.

Frontiers In Oncology

Su, Fei F; Liu, Ming M; Zhang, Wei W; Tang, Min M; Zhang, Jinsong J; Li, Hexin H; Zou, Lihui L; Zhang, Rui R; Liu, Yudong Y; Li, Lin L; Ma, Jie J; Zhang, Yaqun Y; Chen, Meng M; Xiao, Fei F

Publication Date: 2022

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 35311085

Variant Present in the following documents:

• Main text
• fonc-12-842182.pdf
• Table_1.xlsx, sheet 4

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Large-scale genomic sequencing reveals adaptive opportunity of targeting mutated-PI3Kα in early and advanced HER2-positive breast cancer.

Clinical And Translational Medicine

Guo, Lin-Wei LW; Li, Xiao-Guang XG; Yang, Yun-Song YS; Lu, Xun-Xi XX; Han, Xiang-Chen XC; Lang, Guan-Tian GT; Chen, Li L; Shao, Zhi-Ming ZM; Hu, Xin X

Publication Date: 2021-11

Variant appearance in text: PI3K: M1040I

PubMed Link: 34842356

Variant Present in the following documents:

• Main text
• CTM2-11-e589.pdf

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Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.

The Journal Of Clinical Investigation

Jin, Nan N; Keam, Bhumsuk B; Cho, Janice J; Lee, Michelle J MJ; Kim, Hye Ryun HR; Torosyan, Hayarpi H; Jura, Natalia N; Ng, Patrick Ks PK; Mills, Gordon B GB; Li, Hua H; Zeng, Yan Y; Barbash, Zohar Z; Tarcic, Gabi G; Kang, Hyunseok H; Bauman, Julie E JE; Kim, Mi-Ok MO; VanLandingham, Nathan K NK; Swaney, Danielle L DL; Krogan, Nevan J NJ; Johnson, Daniel E DE; Grandis, Jennifer R JR

Publication Date: 2021-11-15

Variant appearance in text: PI3K: M1040I

PubMed Link: 34779417

Variant Present in the following documents:

• Main text

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Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications

Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L

Publication Date: 2021-04-19

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 33875650

Variant Present in the following documents:

• 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1

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Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity.

Cancer Biology & Medicine

Chen, Xuanming X; Shen, Cheng C; Wei, Zhe Z; Zhang, Rui R; Wang, Yongsheng Y; Jiang, Lili L; Chen, Ke K; Qiu, Shuang S; Zhang, Yuanli Y; Zhang, Ting T; Chen, Bin B; Xu, Yanjun Y; Feng, Qiyi Q; Huang, Jinxing J; Zhong, Zhihui Z; Li, Hongxia H; Che, Guowei G; Xiao, Kai K

Publication Date: 2021-02-15

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 33628593

Variant Present in the following documents:

• Main text
• cbm-18-184.pdf

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mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis.

Cell Reports

Triki, Mouna M; Rinaldi, Gianmarco G; Planque, Melanie M; Broekaert, Dorien D; Winkelkotte, Alina M AM; Maier, Carina R CR; Janaki Raman, Sudha S; Vandekeere, Anke A; Van Elsen, Joke J; Orth, Martin F MF; Grünewald, Thomas G P TGP; Schulze, Almut A; Fendt, Sarah-Maria SM

Publication Date: 2020-06-23

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 32579932

Variant Present in the following documents:

• mmc5.xlsx, sheet 3

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

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DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Ebiomedicine

Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P

Publication Date: 2019-01

Variant appearance in text: PIK3CA: Met1040Ile

PubMed Link: 30578081

Variant Present in the following documents:

• mmc1.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 3

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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications

Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM

Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 29636477

Variant Present in the following documents:

• 41467_2018_3867_MOESM1_ESM.pdf

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Comprehensive immunoproteogenomic analyses of malignant pleural mesothelioma.

Jci Insight

Lee, Hyun-Sung HS; Jang, Hee-Jin HJ; Choi, Jong Min JM; Zhang, Jun J; de Rosen, Veronica Lenge VL; Wheeler, Thomas M TM; Lee, Ju-Seog JS; Tu, Thuydung T; Jindra, Peter T PT; Kerman, Ronald H RH; Jung, Sung Yun SY; Kheradmand, Farrah F; Sugarbaker, David J DJ; Burt, Bryan M BM

Publication Date: 2018-04-05

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 29618661

Variant Present in the following documents:

• jciinsight-3-98575-s002.xlsx, sheet 1

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Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases.

Journal Of Clinical Pathology

Malapelle, Umberto U; Pisapia, Pasquale P; Sgariglia, Roberta R; Vigliar, Elena E; Biglietto, Maria M; Carlomagno, Chiara C; Giuffrè, Giuseppe G; Bellevicine, Claudio C; Troncone, Giancarlo G

Publication Date: 2016-09

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 26797410

Variant Present in the following documents:

• jclinpath-2015-203403-s4.pdf
• jclinpath-2015-203403-s2.pdf

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Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study.

Plos One

Papaxoinis, George G; Kotoula, Vassiliki V; Alexopoulou, Zoi Z; Kalogeras, Konstantine T KT; Zagouri, Flora F; Timotheadou, Eleni E; Gogas, Helen H; Pentheroudakis, George G; Christodoulou, Christos C; Koutras, Angelos A; Bafaloukos, Dimitrios D; Aravantinos, Gerasimos G; Papakostas, Pavlos P; Charalambous, Elpida E; Papadopoulou, Kyriaki K; Varthalitis, Ioannis I; Efstratiou, Ioannis I; Zaramboukas, Thomas T; Patsea, Helen H; Scopa, Chrisoula D CD; Skondra, Maria M; Kosmidis, Paris P; Pectasides, Dimitrios D; Fountzilas, George G

Publication Date: 2015

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 26452060

Variant Present in the following documents:

• Main text
• pone.0140293.pdf

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Novel secondary somatic mutations in Ewing's sarcoma and desmoplastic small round cell tumors.

Plos One

Jiang, Yunyun Y; Subbiah, Vivek V; Janku, Filip F; Ludwig, Joseph A JA; Naing, Aung A; Benjamin, Robert S RS; Brown, Robert E RE; Anderson, Pete P; Kurzrock, Razelle R

Publication Date: 2014

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 25119929

Variant Present in the following documents:

• Main text
• pone.0093676.pdf

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Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma.

British Journal Of Cancer

Mezzapelle, R R; Miglio, U U; Rena, O O; Paganotti, A A; Allegrini, S S; Antona, J J; Molinari, F F; Frattini, M M; Monga, G G; Alabiso, O O; Boldorini, R R

Publication Date: 2013-04-30

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 23558893

Variant Present in the following documents:

• bjc2013130a.pdf

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: M1040I

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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