Publications:

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PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer.

Journal For Immunotherapy Of Cancer

Stein, Alexander A; Simnica, Donjete D; Schultheiß, Christoph C; Scholz, Rebekka R; Tintelnot, Joseph J; Gökkurt, Eray E; von Wenserski, Lisa L; Willscher, Edith E; Paschold, Lisa L; Sauer, Markus M; Lorenzen, Sylvie S; Riera-Knorrenschild, Jorge J; Depenbusch, Reinhard R; Ettrich, Thomas J TJ; Dörfel, Steffen S; Al-Batran, Salah-Eddin SE; Karthaus, Meinolf M; Pelzer, Uwe U; Waberer, Lisa L; Hinke, Axel A; Bauer, Marcus M; Massa, Chiara C; Seliger, Barbara B; Wickenhauser, Claudia C; Bokemeyer, Carsten C; Hegewisch-Becker, Susanna S; Binder, Mascha M

Publication Date: 2021-07

Variant appearance in text: PIK3CA: 3141T>C; His1047His

PubMed Link: 34315821

Variant Present in the following documents:

• jitc-2021-002844supp002.xlsx, sheet 1

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Role of NEU3 Overexpression in the Prediction of Efficacy of EGFR-Targeted Therapies in Colon Cancer Cell Lines.

International Journal Of Molecular Sciences

Bovio, Federica F; Epistolio, Samantha S; Mozzi, Alessandra A; Monti, Eugenio E; Fusi, Paola P; Forcella, Matilde M; Frattini, Milo M

Publication Date: 2020-11-20

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 33233823

Variant Present in the following documents:

• Main text
• ijms-21-08805.pdf

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Dissection of major cancer gene variants in subsets of circulating tumor cells in advanced breast cancer.

Scientific Reports

D'Oronzo, Stella S; Lovero, Domenica D; Palmirotta, Raffaele R; Stucci, Luigia Stefania LS; Tucci, Marco M; Felici, Claudia C; Cascardi, Eliano E; Giardina, Carmela C; Cafforio, Paola P; Silvestris, Franco F

Publication Date: 2019-11-21

Variant appearance in text: PIK3CA: 3141T>C; H1047H

PubMed Link: 31754145

Variant Present in the following documents:

• 41598_2019_53660_MOESM1_ESM.pdf

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Helical and kinase domain mutations of PIK3CA, and their association with hormone receptor expression in breast cancer.

Oncology Letters

Vatte, Chittibabu C; Al Amri, Ali Mohammed AM; Cyrus, Cyril C; Chathoth, Shahanas S; Alsayyah, Ahmed A; Ahmad, Arafat A; Akhtar, Mohammed Shakil MS; Alrashidi, Nada Fehaid NF; Jayaseeli, Nithya N; Al Wadani, Hamed H; Al Zahrani, Alhussain A; Al Ali, Amein Kadhem AK

Publication Date: 2019-09

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 31404155

Variant Present in the following documents:

• Main text
• ol-18-03-2427.pdf

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Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine

Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A

Publication Date: 2019-06-28

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 31253177

Variant Present in the following documents:

• 13073_2019_654_MOESM2_ESM.xlsx, sheet 13

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Molecular diagnosis of somatic overgrowth conditions: A single-center experience.

Molecular Genetics & Genomic Medicine

Lalonde, Emilie E; Ebrahimzadeh, Jessica J; Rafferty, Keith K; Richards-Yutz, Jennifer J; Grant, Richard R; Toorens, Erik E; Marie Rosado, Jennifer J; Schindewolf, Erica E; Ganguly, Tapan T; Kalish, Jennifer M JM; Deardorff, Matthew A MA; Ganguly, Arupa A

Publication Date: 2019-03

Variant appearance in text: PIK3CA: His1047His

PubMed Link: 30761771

Variant Present in the following documents:

• Main text
• MGG3-7-na.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 1
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 2

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Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.

Cancer Research

Dogruluk, Turgut T; Tsang, Yiu Huen YH; Espitia, Maribel M; Chen, Fengju F; Chen, Tenghui T; Chong, Zechen Z; Appadurai, Vivek V; Dogruluk, Armel A; Eterovic, Agna Karina AK; Bonnen, Penelope E PE; Creighton, Chad J CJ; Chen, Ken K; Mills, Gordon B GB; Scott, Kenneth L KL

Publication Date: 2015-12-15

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 26627007

Variant Present in the following documents:

• Main text

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Significance of PIK3CA Mutations in Patients with Early Breast Cancer Treated with Adjuvant Chemotherapy: A Hellenic Cooperative Oncology Group (HeCOG) Study.

Plos One

Papaxoinis, George G; Kotoula, Vassiliki V; Alexopoulou, Zoi Z; Kalogeras, Konstantine T KT; Zagouri, Flora F; Timotheadou, Eleni E; Gogas, Helen H; Pentheroudakis, George G; Christodoulou, Christos C; Koutras, Angelos A; Bafaloukos, Dimitrios D; Aravantinos, Gerasimos G; Papakostas, Pavlos P; Charalambous, Elpida E; Papadopoulou, Kyriaki K; Varthalitis, Ioannis I; Efstratiou, Ioannis I; Zaramboukas, Thomas T; Patsea, Helen H; Scopa, Chrisoula D CD; Skondra, Maria M; Kosmidis, Paris P; Pectasides, Dimitrios D; Fountzilas, George G

Publication Date: 2015

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 26452060

Variant Present in the following documents:

• Main text

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In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.

Nature Genetics

Janiszewska, Michalina M; Liu, Lin L; Almendro, Vanessa V; Kuang, Yanan Y; Paweletz, Cloud C; Sakr, Rita A RA; Weigelt, Britta B; Hanker, Ariella B AB; Chandarlapaty, Sarat S; King, Tari A TA; Reis-Filho, Jorge S JS; Arteaga, Carlos L CL; Park, So Yeon SY; Michor, Franziska F; Polyak, Kornelia K

Publication Date: 2015-10

Variant appearance in text: PIK3CA: H1047H

PubMed Link: 26301495

Variant Present in the following documents:

• Main text
• nihms-712806.pdf

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