Publications:

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Tinengotinib (TT-00420), a Novel Spectrum-Selective Small Molecule Kinase Inhibitor, Is Highly Active Against Triple Negative Breast Cancer.

Molecular Cancer Therapeutics

Peng, Peng P; Qiang, Xiaoyan X; Li, Guoyu G; Li, Lin L; Ni, Shumao S; Yu, Qi Q; Sourd, Laura L; Marangoni, Elisabetta E; Hu, Chao C; Wang, Dong D; Wu, Di D; Wu, Frank F

Publication Date: 2022-10-12

Variant appearance in text: PIK3CA: H1048L

PubMed Link: 36223547

Variant Present in the following documents:

• mct-22-0012_supplementary_tables_s1-7_supps1-s7.xlsx, sheet 7

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Large-scale genomic sequencing reveals adaptive opportunity of targeting mutated-PI3Kα in early and advanced HER2-positive breast cancer.

Clinical And Translational Medicine

Guo, Lin-Wei LW; Li, Xiao-Guang XG; Yang, Yun-Song YS; Lu, Xun-Xi XX; Han, Xiang-Chen XC; Lang, Guan-Tian GT; Chen, Li L; Shao, Zhi-Ming ZM; Hu, Xin X

Publication Date: 2021-11

Variant appearance in text: PI3K: H1048L

PubMed Link: 34842356

Variant Present in the following documents:

• Main text
• CTM2-11-e589.pdf

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Mutational Landscape of PI3K-AKT-mTOR Pathway in Breast Cancer: Implications for Targeted Therapeutics.

Journal Of Cancer

Xiao, Weikai W; Zhang, Guochun G; Chen, Bo B; Chen, Xiaoqing X; Wen, Lingzhu L; Lai, Jianguo J; Li, Xuerui X; Li, Min M; Liu, Hao H; Liu, Jing J; Han-Zhang, Han H; Lizaso, Analyn A; Liao, Ning N

Publication Date: 2021

Variant appearance in text: PIK3CA: H1048L

PubMed Link: 34093841

Variant Present in the following documents:

• Main text
• jcav12p4408.pdf

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Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts.

Theranostics

Coussy, Florence F; Lavigne, Marion M; de Koning, Leanne L; Botty, Rania El RE; Nemati, Fariba F; Naguez, Adnan A; Bataillon, Guillaume G; Ouine, Berengère B; Dahmani, Ahmed A; Montaudon, Elodie E; Painsec, Pierre P; Chateau-Joubert, Sophie S; Laetitia, Fuhrmann F; Larcher, Thibaut T; Vacher, Sophie S; Chemlali, Walid W; Briaux, Adrien A; Melaabi, Samia S; Salomon, Anne Vincent AV; Guinebretiere, Jean Marc JM; Bieche, Ivan I; Marangoni, Elisabetta E

Publication Date: 2020

Variant appearance in text: PIK3CA: H1048L

PubMed Link: 32042320

Variant Present in the following documents:

• Main text
• thnov10p1531.pdf
• thnov10p1531s1.pdf

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Characterization of PIK3CA and PIK3R1 somatic mutations in Chinese breast cancer patients.

Nature Communications

Chen, Li L; Yang, Liu L; Yao, Ling L; Kuang, Xia-Ying XY; Zuo, Wen-Jia WJ; Li, Shan S; Qiao, Feng F; Liu, Yi-Rong YR; Cao, Zhi-Gang ZG; Zhou, Shu-Ling SL; Zhou, Xiao-Yan XY; Yang, Wen-Tao WT; Shi, Jin-Xiu JX; Huang, Wei W; Hu, Xin X; Shao, Zhi-Ming ZM

Publication Date: 2018-04-10

Variant appearance in text: PIK3CA: H1048L

PubMed Link: 29636477

Variant Present in the following documents:

• 41467_2018_3867_MOESM1_ESM.pdf

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: PIK3CA: 3143A>T; H1048L

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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Ultra-deep targeted sequencing of advanced oral squamous cell carcinoma identifies a mutation-based prognostic gene signature.

Oncotarget

Chen, Shu-Jen SJ; Liu, Hsuan H; Liao, Chun-Ta CT; Huang, Po-Jung PJ; Huang, Yi Y; Hsu, An A; Tang, Petrus P; Chang, Yu-Sun YS; Chen, Hua-Chien HC; Yen, Tzu-Chen TC

Publication Date: 2015-07-20

Variant appearance in text: PIK3CA: H1048L

PubMed Link: 25980437

Variant Present in the following documents:

• oncotarget-06-18066-s004.xlsx, sheet 1

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