PIK3CA c.3149G>A ;(p.G1050D)

Variant ID: 3-178952094-G-A

NM_006218.2(PIK3CA):c.3149G>A;(p.G1050D)

This variant was identified in 16 publications

View GRCh38 version.




Publications:


Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: PIK3CA: 3149G>A; G1050D
PubMed Link: 36333792
Variant Present in the following documents:
  • 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.

Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Publication Date: 2022-07-13

Variant appearance in text: PIK3CA: 3149G>A; G1050E
PubMed Link: 35831314
Variant Present in the following documents:
  • 41467_2022_31809_MOESM8_ESM.xlsx, sheet 3
View BVdb publication page



Two Pituitary Neuroendocrine Tumors (PitNETs) with Very High Proliferation and TP53 Mutation - High-Grade PitNET or PitNEC?

Endocrine Pathology
Saeger, Wolfgang W; Mawrin, Christian C; Meinhardt, Matthias M; Wefers, Annika K AK; Jacobsen, Frank F
Publication Date: 2022-06

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 34669159
Variant Present in the following documents:
  • Main text
  • 12022_2021_Article_9693.pdf
View BVdb publication page



Synergism of Checkpoint Inhibitors and Peptide Receptor Radionuclide Therapy in the Treatment of Pituitary Carcinoma.

Journal Of The Endocrine Society
Lin, Andrew L AL; Tabar, Viviane V; Young, Robert J RJ; Cohen, Marc M; Cuaron, John J; Yang, T Jonathan TJ; Rosenblum, Marc M; Rudneva, Vasilisa A VA; Geer, Eliza B EB; Bodei, Lisa L
Publication Date: 2021-10-01

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 34466766
Variant Present in the following documents:
  • Main text
  • bvab133.pdf
View BVdb publication page



Marked Response of a Hypermutated ACTH-Secreting Pituitary Carcinoma to Ipilimumab and Nivolumab.

The Journal Of Clinical Endocrinology And Metabolism
Lin, Andrew L AL; Jonsson, Philip P; Tabar, Viviane V; Yang, T Jonathan TJ; Cuaron, John J; Beal, Katherine K; Cohen, Marc M; Postow, Michael M; Rosenblum, Marc M; Shia, Jinru J; DeAngelis, Lisa M LM; Taylor, Barry S BS; Young, Robert J RJ; Geer, Eliza B EB
Publication Date: 2018-10-01

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 30085142
Variant Present in the following documents:
  • Main text
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Somatic mutations in salivary duct carcinoma and potential therapeutic targets.

Oncotarget
Khoo, Timothy K TK; Yu, Bing B; Smith, Joel A JA; Clarke, Angus J AJ; Luk, Peter P PP; Selinger, Christina I CI; Mahon, Kate L KL; Kraitsek, Spiridoula S; Palme, Carsten C; Boyer, Michael J MJ; Dinger, Marcel E ME; Cowley, Mark J MJ; O'Toole, Sandra A SA; Clark, Jonathan R JR; Gupta, Ruta R
Publication Date: 2017-09-29

Variant appearance in text: PIK3CA: 3149G>A
PubMed Link: 29100278
Variant Present in the following documents:
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: PIK3CA: 3149G>A; G1050D
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: PI3K: 3149G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Epstein-Barr virus-associated gastric cancer reveals intratumoral heterogeneity of PIK3CA mutations.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Böger, C C; Krüger, S S; Behrens, H M HM; Bock, S S; Haag, J J; Kalthoff, H H; Röcken, C C
Publication Date: 2017-05-01

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 28453696
Variant Present in the following documents:
  • mdx047.pdf
View BVdb publication page



Reproducible Analysis of Post-Translational Modifications in Proteomes--Application to Human Mutations.

Plos One
Holehouse, Alex S AS; Naegle, Kristen M KM
Publication Date: 2015

Variant appearance in text: PI3K: G1050D
PubMed Link: 26659599
Variant Present in the following documents:
  • pone.0144692.s002.xlsx, sheet 1
View BVdb publication page



GESPA: classifying nsSNPs to predict disease association.

Bmc Bioinformatics
Khurana, Jay K JK; Reeder, Jay E JE; Shrimpton, Antony E AE; Thakar, Juilee J
Publication Date: 2015-07-25

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 26206375
Variant Present in the following documents:
  • 12859_2015_673_MOESM1_ESM.xls, sheet 2
View BVdb publication page



Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.

Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Publication Date: 2015

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 26010451
Variant Present in the following documents:
  • pone.0127146.s014.xlsx, sheet 3
View BVdb publication page



Correlation between plasma DNA and tumor status in an animal model.

Plos One
Sueoka-Aragane, Naoko N; Sato, Akemi A; Kobayashi, Naomi N; Ide, Masaru M; Yokoo, Masako M; Nagano, Yumi Y; Sueoka, Eisaburo E; Okada, Seiji S; Kimura, Shinya S
Publication Date: 2014

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 25462870
Variant Present in the following documents:
  • pone.0111881.s006.pdf
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: PIK3CA: G1050D
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



The analysis of PIK3CA mutations in gastric carcinoma and metanalysis of literature suggest that exon-selectivity is a signature of cancer type.

Journal Of Experimental & Clinical Cancer Research : Cr
Barbi, Stefano S; Cataldo, Ivana I; De Manzoni, Giovanni G; Bersani, Samantha S; Lamba, Simona S; Mattuzzi, Silvia S; Bardelli, Alberto A; Scarpa, Aldo A
Publication Date: 2010-04-16

Variant appearance in text: PI3K: G1050D
PubMed Link: 20398348
Variant Present in the following documents:
  • Main text
  • 1756-9966-29-32.pdf
View BVdb publication page