Genetically determining individualized clinical reference ranges for the biomarker tryptase can limit unnecessary procedures and unmask myeloid neoplasms.
Blood Advances
Chovanec, Jack J; Tunc, Ilker I; Hughes, Jason J; Halstead, Joseph J; Mateja, Allyson A; Liu, Yihui Y; O'Connell, Michael M; Kim, Jiwon J; Park, Young Hwan YH; Wang, Qinlu Q; Le, Quang Trong QT; Pirooznia, Mehdi M; Trivedi, Neil N; Bai, Yun Y; Yin, Yuzhi Y; Hsu, Amy P AP; McElwee, Joshua J JJ; Lassiter, Sheryce S; Nelson, Celeste C; Bandoh, Judy J; DiMaggio, Thomas T; Selb, Julij J; Rijavec, Matija M; Carter, Melody C MC; Komarow, Hirsh H; Sabato, Vito V; Steinberg, Joshua A JA; Hafer, Kurt M KM; Feuille, Elizabeth E; Hourigan, Christopher S CS; Lack, Justin J; Khoury, Paneez P; Maric, Irina I; Zanotti, Roberta R; Bonadonna, Patrizia P; Schwartz, Lawrence B LB; Milner, Joshua D JD; Glover, Sarah S; Ebo, Didier G DG; Korosec, Peter P; Caughey, George G; Brittain, Erica E; Busby, Ben B; Metcalfe, Dean D DD; Lyons, Jonathan J JJ
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
The longitudinal dynamics and natural history of clonal haematopoiesis.
Nature
Fabre, Margarete A MA; de Almeida, José Guilherme JG; Fiorillo, Edoardo E; Mitchell, Emily E; Damaskou, Aristi A; Rak, Justyna J; Orrù, Valeria V; Marongiu, Michele M; Chapman, Michael Spencer MS; Vijayabaskar, M S MS; Baxter, Joanna J; Hardy, Claire C; Abascal, Federico F; Williams, Nicholas N; Nangalia, Jyoti J; Martincorena, Iñigo I; Campbell, Peter J PJ; McKinney, Eoin F EF; Cucca, Francesco F; Gerstung, Moritz M; Vassiliou, George S GS
Association of clonal hematopoiesis with chronic obstructive pulmonary disease.
Blood
Miller, Peter G PG; Qiao, Dandi D; Rojas-Quintero, Joselyn J; Honigberg, Michael C MC; Sperling, Adam S AS; Gibson, Christopher J CJ; Bick, Alexander G AG; Niroula, Abhishek A; McConkey, Marie E ME; Sandoval, Brittany B; Miller, Brian C BC; Shi, Weiwei W; Viswanathan, Kaushik K; Leventhal, Matthew M; Werner, Lillian L; Moll, Matthew M; Cade, Brian E BE; Barr, R Graham RG; Correa, Adolfo A; Cupples, L Adrienne LA; Gharib, Sina A SA; Jain, Deepti D; Gogarten, Stephanie M SM; Lange, Leslie A LA; London, Stephanie J SJ; Manichaikul, Ani A; O'Connor, George T GT; Oelsner, Elizabeth C EC; Redline, Susan S; Rich, Stephen S SS; Rotter, Jerome I JI; Ramachandran, Vasan V; Yu, Bing B; Sholl, Lynette L; Neuberg, Donna D; Jaiswal, Siddhartha S; Levy, Bruce D BD; Owen, Caroline A CA; Natarajan, Pradeep P; Silverman, Edwin K EK; van Galen, Peter P; Tesfaigzi, Yohannes Y; Cho, Michael H MH; Ebert, Benjamin L BL; ,
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Nature
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