Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.
Cell Reports
Schiapparelli, Paula P; Pirman, Natasha L NL; Mohler, Kyle K; Miranda-Herrera, Pierre A PA; Zarco, Natanael N; Kilic, Onur O; Miller, Chad C; Shah, Sagar R SR; Rogulina, Svetlana S; Hungerford, William W; Abriola, Laura L; Hoyer, Denton D; Turk, Benjamin E BE; Guerrero-Cázares, Hugo H; Isaacs, Farren J FJ; Quiñones-Hinojosa, Alfredo A; Levchenko, Andre A; Rinehart, Jesse J
Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.
Oncology Letters
Matossian, Margarite D MD; Elliott, Steven S; Rhodes, Lyndsay V LV; Martin, Elizabeth C EC; Hoang, Van T VT; Burks, Hope E HE; Zuercher, William J WJ; Drewry, David H DH; Collins-Burow, Bridgette M BM; Burow, Matthew E ME
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
The Journal Of Biological Chemistry
Liu, Qingsong Q; Kirubakaran, Sivapriya S; Hur, Wooyoung W; Niepel, Mario M; Westover, Kenneth K; Thoreen, Carson C CC; Wang, Jinhua J; Ni, Jing J; Patricelli, Matthew P MP; Vogel, Kurt K; Riddle, Steve S; Waller, David L DL; Traynor, Ryan R; Sanda, Takaomi T; Zhao, Zheng Z; Kang, Seong A SA; Zhao, Jean J; Look, A Thomas AT; Sorger, Peter K PK; Sabatini, David M DM; Gray, Nathanael S NS
Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.
Blood
Weisberg, Ellen E; Choi, Hwan Geun HG; Ray, Arghya A; Barrett, Rosemary R; Zhang, Jianming J; Sim, Taebo T; Zhou, Wenjun W; Seeliger, Markus M; Cameron, Michael M; Azam, Mohammed M; Fletcher, Jonathan A JA; Debiec-Rychter, Maria M; Mayeda, Mark M; Moreno, Daisy D; Kung, Andrew L AL; Janne, Pasi Antero PA; Khosravi-Far, Roya R; Melo, Junia V JV; Manley, Paul W PW; Adamia, Sophia S; Wu, Catherine C; Gray, Nathanael N; Griffin, James D JD