Publications:

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: KIT: M351T

PubMed Link: 35229492

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• PCMR-35-369-s003.xlsx, sheet 12

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Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function.

Cell Reports

Schiapparelli, Paula P; Pirman, Natasha L NL; Mohler, Kyle K; Miranda-Herrera, Pierre A PA; Zarco, Natanael N; Kilic, Onur O; Miller, Chad C; Shah, Sagar R SR; Rogulina, Svetlana S; Hungerford, William W; Abriola, Laura L; Hoyer, Denton D; Turk, Benjamin E BE; Guerrero-Cázares, Hugo H; Isaacs, Farren J FJ; Quiñones-Hinojosa, Alfredo A; Levchenko, Andre A; Rinehart, Jesse J

Publication Date: 2021-07-20

Variant appearance in text: KIT: M351T

PubMed Link: 34289367

Variant Present in the following documents:

• NIHMS1726840-supplement-2.xlsx, sheet 1

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Nanotechnology of Tyrosine Kinase Inhibitors in Cancer Therapy: A Perspective.

International Journal Of Molecular Sciences

Russo, Eleonora E; Spallarossa, Andrea A; Tasso, Bruno B; Villa, Carla C; Brullo, Chiara C

Publication Date: 2021-06-18

Variant appearance in text: SCFR: M351T

PubMed Link: 34207175

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• Main text
• ijms-22-06538.pdf

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Application of a small molecule inhibitor screen approach to identify CXCR4 downstream signaling pathways that promote a mesenchymal and fulvestrant-resistant phenotype in breast cancer cells.

Oncology Letters

Matossian, Margarite D MD; Elliott, Steven S; Rhodes, Lyndsay V LV; Martin, Elizabeth C EC; Hoang, Van T VT; Burks, Hope E HE; Zuercher, William J WJ; Drewry, David H DH; Collins-Burow, Bridgette M BM; Burow, Matthew E ME

Publication Date: 2021-05

Variant appearance in text: KIT: M351T

PubMed Link: 33777204

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• Main text

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Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML).

Cancer Biology & Therapy

Wu, Jiaxin J; Wang, Aoli A; Li, Xixiang X; Chen, Cheng C; Qi, Ziping Z; Hu, Chen C; Wang, Wenliang W; Wu, Hong H; Huang, Tao T; Zhao, Ming M; Wang, Wenchao W; Hu, Zhenquan Z; Liu, Qingwang Q; Wang, Beilei B; Wang, Li L; Li, Lili L; Ge, Jian J; Ren, Tao T; Xia, Ruixiang R; Liu, Jing J; Liu, Qingsong Q

Publication Date: 2019

Variant appearance in text: KIT: M351T

PubMed Link: 30894066

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• Main text

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A kinase profile-adapted drug combination elicits synergistic cooperative effects on leukemic cells carrying BCR-ABL1T315I in Ph+ CML.

Leukemia Research

Gleixner, Karoline V KV; Sadovnik, Irina I; Schneeweiss, Mathias M; Eisenwort, Gregor G; Byrgazov, Konstantin K; Stefanzl, Gabriele G; Berger, Daniela D; Herrmann, Harald H; Hadzijusufovic, Emir E; Lion, Thomas T; Valent, Peter P

Publication Date: 2019-03

Variant appearance in text: KIT: M351T

PubMed Link: 30711891

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• Main text

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Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy.

Journal Of Hematology & Oncology

Rossari, Federico F; Minutolo, Filippo F; Orciuolo, Enrico E

Publication Date: 2018-06-20

Variant appearance in text: CD117: M351T

PubMed Link: 29925402

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• Main text
• 13045_2018_Article_624.pdf

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The combination therapy of imatinib and dasatinib achieves long-term molecular response in two imatinib-resistant and dasatinibintolerant patients with advanced chronic myeloid leukemia.

Journal Of Biomedical Research

Zhu, Yu Y; Pan, Liangqin L; Hong, Ming M; Liu, Weixing W; Qiao, Chun C; Li, Jianyong J; Qian, Sixuan S

Publication Date: 2016-11

Variant appearance in text: CD117: M351T

PubMed Link: 27924071

Variant Present in the following documents:

• jbr-30-06-525.pdf

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Bosutinib for Chronic Myeloid Leukemia.

Rare Cancers And Therapy

Breccia, Massimo M; Binotto, Gianni G

Publication Date: 2015

Variant appearance in text: KIT: M351T

PubMed Link: 27182477

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• Main text
• 40487_2015_Article_10.pdf

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Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution.

Plos One

Tse, Amanda A; Verkhivker, Gennady M GM

Publication Date: 2015

Variant appearance in text: KIT: M351T

PubMed Link: 26075886

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• Main text
• pone.0130203.pdf

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Secondary mutations as mediators of resistance to targeted therapy in leukemia.

Blood

Daver, Naval N; Cortes, Jorge J; Ravandi, Farhad F; Patel, Keyur P KP; Burger, Jan A JA; Konopleva, Marina M; Kantarjian, Hagop H

Publication Date: 2015-05-21

Variant appearance in text: KIT: M351T

PubMed Link: 25795921

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• Main text

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Intratumoral heterogeneity in a minority of ovarian low-grade serous carcinomas.

Bmc Cancer

Tone, Alicia A AA; McConechy, Melissa K MK; Yang, Winnie W; Ding, Jiarui J; Yip, Stephen S; Kong, Esther E; Wong, Kwong-Kwok KK; Gershenson, David M DM; Mackay, Helen H; Shah, Sohrab S; Gilks, Blake B; Tinker, Anna V AV; Clarke, Blaise B; McAlpine, Jessica N JN; Huntsman, David D

Publication Date: 2014-12-18

Variant appearance in text: KIT: M351T

PubMed Link: 25523272

Variant Present in the following documents:

• 12885_2014_5198_MOESM14_ESM.xlsx, sheet 1

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HS-543 induces apoptosis of Imatinib-resistant chronic myelogenous leukemia with T315I mutation.

Oncotarget

Kim, Soo Jung SJ; Jung, Kyung Hee KH; Yan, Hong Hua HH; Son, Mi Kwon MK; Fang, Zhenghuan Z; Ryu, Ye-Lim YL; Lee, Hyunseung H; Lim, Joo Han JH; Suh, Jun-Kyu JK; Kim, JinHee J; Lee, Soyoung S; Hong, Sungwoo S; Hong, Soon-Sun SS

Publication Date: 2015-01-30

Variant appearance in text: KIT: M351T

PubMed Link: 25483100

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• Main text
• oncotarget-06-1507.pdf

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Ponatinib is a pan-BCR-ABL kinase inhibitor: MD simulations and SIE study.

Plos One

Tanneeru, Karunakar K; Guruprasad, Lalitha L

Publication Date: 2013

Variant appearance in text: KIT: M351T

PubMed Link: 24236021

Variant Present in the following documents:

• pone.0078556.pdf

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Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Li, Tianhong T; Kung, Hsing-Jien HJ; Mack, Philip C PC; Gandara, David R DR

Publication Date: 2013-03-10

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PubMed Link: 23401433

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• Main text

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Imatinib resistance: a review of alternative inhibitors in chronic myeloid leukemia.

Revista Brasileira De Hematologia E Hemoterapia

Bitencourt, Roberta R; Zalcberg, Ilana I; Louro, Iúri Drumond ID

Publication Date: 2011

Variant appearance in text: KIT: M351T

PubMed Link: 23049365

Variant Present in the following documents:

• rbhh-33-470.pdf

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The growing arsenal of ATP-competitive and allosteric inhibitors of BCR-ABL.

Cancer Research

Hantschel, Oliver O; Grebien, Florian F; Superti-Furga, Giulio G

Publication Date: 2012-10-01

Variant appearance in text: KIT: M351T

PubMed Link: 23002203

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• Main text

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Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics

Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R

Publication Date: 2012

Variant appearance in text: KIT: M351T

PubMed Link: 22346343

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• Main text

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Chronic myeloid leukemia: mechanisms of resistance and treatment.

Hematology/Oncology Clinics Of North America

Jabbour, Elias E; Parikh, Sameer A SA; Kantarjian, Hagop H; Cortes, Jorge J

Publication Date: 2011-10

Variant appearance in text: C-Kit: M351T

PubMed Link: 22054730

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• Main text

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The energy landscape analysis of cancer mutations in protein kinases.

Plos One

Dixit, Anshuman A; Verkhivker, Gennady M GM

Publication Date: 2011

Variant appearance in text: KIT: M351T

PubMed Link: 21998754

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Mechanisms of drug resistance in kinases.

Expert Opinion On Investigational Drugs

Barouch-Bentov, Rina R; Sauer, Karsten K

Publication Date: 2011-02

Variant appearance in text: KIT: M351T

PubMed Link: 21235428

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• Main text

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Refining targeted therapies in chronic myeloid leukemia: development and application of nilotinib, a step beyond imatinib.

Oncotargets And Therapy

Breccia, Massimo M; Alimena, Giuliana G

Publication Date: 2008-10-01

Variant appearance in text: KIT: M351T

PubMed Link: 21127752

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• Main text
• ott-1-049.pdf

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Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model.

Vaccine

Bui, Melanie R MR; Hodson, Victoria V; King, Tom T; Leopold, Derek D; Dai, Shaodong S; Fiolkoski, Valerie V; Oakes, Sarah S; Duke, Richard R; Apelian, David D; Franzusoff, Alex A; DeGregori, James J

Publication Date: 2010-08-23

Variant appearance in text: CD117: M351T

PubMed Link: 20619375

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• Main text

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Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants.

Blood

Weisberg, Ellen E; Choi, Hwan Geun HG; Ray, Arghya A; Barrett, Rosemary R; Zhang, Jianming J; Sim, Taebo T; Zhou, Wenjun W; Seeliger, Markus M; Cameron, Michael M; Azam, Mohammed M; Fletcher, Jonathan A JA; Debiec-Rychter, Maria M; Mayeda, Mark M; Moreno, Daisy D; Kung, Andrew L AL; Janne, Pasi Antero PA; Khosravi-Far, Roya R; Melo, Junia V JV; Manley, Paul W PW; Adamia, Sophia S; Wu, Catherine C; Gray, Nathanael N; Griffin, James D JD

Publication Date: 2010-05-27

Variant appearance in text: KIT: M351T

PubMed Link: 20299508

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Transcriptional repression of c-Myb and GATA-2 is involved in the biologic effects of C/EBPalpha in p210BCR/ABL-expressing cells.

Blood

Soliera, Angela Rachele AR; Lidonnici, Maria Rosa MR; Ferrari-Amorotti, Giovanna G; Prisco, Marco M; Zhang, Ying Y; Martinez, Robert V RV; Donato, Nick J NJ; Calabretta, Bruno B

Publication Date: 2008-09-01

Variant appearance in text: KIT: M351T

PubMed Link: 18550858

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AMN107 (nilotinib): a novel and selective inhibitor of BCR-ABL.

British Journal Of Cancer

Weisberg, E E; Manley, P P; Mestan, J J; Cowan-Jacob, S S; Ray, A A; Griffin, J D JD

Publication Date: 2006-06-19

Variant appearance in text: KIT: M351T

PubMed Link: 16721371

Variant Present in the following documents:

• 94-6603170a.pdf

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Cancer treatment with kinase inhibitors: what have we learnt from imatinib?

British Journal Of Cancer

Ross, D M DM; Hughes, T P TP

Publication Date: 2004-01-12

Variant appearance in text: KIT: M351T

PubMed Link: 14710199

Variant Present in the following documents:

• Main text
• 90-6601507a.pdf

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