Type and Gene Location of KIT Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon.
Cancers
Incorvaia, Lorena L; Fanale, Daniele D; Vincenzi, Bruno B; De Luca, Ida I; Bartolotta, Tommaso Vincenzo TV; Cannella, Roberto R; Pantuso, Gianni G; Cabibi, Daniela D; Russo, Antonio A; Bazan, Viviana V; Badalamenti, Giuseppe G
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04
Variant appearance in text: KIT: 1673_1693del; K558_N564del
Therapeutic Efficacy Assessment of CK6, a Monoclonal KIT Antibody, in a Panel of Gastrointestinal Stromal Tumor Xenograft Models.
Translational Oncology
Van Looy, Thomas T; Wozniak, Agnieszka A; Floris, Giuseppe G; Li, Haifu H; Wellens, Jasmien J; Vanleeuw, Ulla U; Sciot, Raf R; Debiec-Rychter, Maria M; Schöffski, Patrick P
The HSP90 inhibitor, AT13387, is effective against imatinib-sensitive and -resistant gastrointestinal stromal tumor models.
Molecular Cancer Therapeutics
Smyth, Tomoko T; Van Looy, Thomas T; Curry, Jayne E JE; Rodriguez-Lopez, Ana M AM; Wozniak, Agnieszka A; Zhu, Meijun M; Donsky, Rachel R; Morgan, Jennifer G JG; Mayeda, Mark M; Fletcher, Jonathan A JA; Schöffski, Patrick P; Lyons, John J; Thompson, Neil T NT; Wallis, Nicola G NG