Publications:

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Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Avula, Sreenivas S; Peng, Xudan X; Lang, Xingfen X; Tortorella, Micky M; Josselin, Béatrice B; Bach, Stéphane S; Bourg, Stephane S; Bonnet, Pascal P; Buron, Frédéric F; Ruchaud, Sandrine S; Routier, Sylvain S; Neagoie, Cleopatra C

Publication Date: 2022-12

Variant appearance in text: KIT: T670E

PubMed Link: 35670091

Variant Present in the following documents:

• IENZ_A_2082419_SM0502.pdf

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Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases

Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S

Publication Date: 2022-06-10

Variant appearance in text: KIT: T670E

PubMed Link: 35609344

Variant Present in the following documents:

• id2c00091_si_001.pdf

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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.

Molecular Oncology

Liu, Juan J; Gao, Jingjing J; Wang, Aoli A; Jiang, Zongru Z; Qi, Shuang S; Qi, Ziping Z; Liu, Feiyang F; Yu, Kailin K; Cao, Jiangyan J; Chen, Cheng C; Hu, Chen C; Wu, Hong H; Wang, Li L; Wang, Wenchao W; Liu, Qingsong Q; Liu, Jing J

Publication Date: 2022-04

Variant appearance in text: KIT: T670E

PubMed Link: 35194937

Variant Present in the following documents:

• Main text
• MOL2-16-1761.pdf

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: KIT: T670E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: KIT: T670E

PubMed Link: 33133066

Variant Present in the following documents:

• Table_2.xlsx, sheet 1
• Table_2.xlsx, sheet 2
• Table_6.xlsx, sheet 4
• Table_6.xlsx, sheet 9
• Table_1.xlsx, sheet 4
• Table_2.xlsx, sheet 7
• Table_1.xlsx, sheet 8

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Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics

Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z

Publication Date: 2021-05-20

Variant appearance in text: KIT: T670E

PubMed Link: 32510566

Variant Present in the following documents:

• Main text

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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

Cancers

Hamid, Abdulaziz B AB; Petreaca, Ruben C RC

Publication Date: 2020-04-09

Variant appearance in text: KIT: T670E

PubMed Link: 32283832

Variant Present in the following documents:

• cancers-12-00927-s001.pdf

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Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: KIT: T670E

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

The Journal Of Clinical Investigation

Willoughby, Catherine E CE; Jiang, Yanyan Y; Thomas, Huw D HD; Willmore, Elaine E; Kyle, Suzanne S; Wittner, Anita A; Phillips, Nicole N; Zhao, Yan Y; Tudhope, Susan J SJ; Prendergast, Lisa L; Junge, Gesa G; Lourenco, Luiza Madia LM; Finlay, M Raymond V MRV; Turner, Paul P; Munck, Joanne M JM; Griffin, Roger J RJ; Rennison, Tommy T; Pickles, James J; Cano, Celine C; Newell, David R DR; Reeves, Helen L HL; Ryan, Anderson J AJ; Wedge, Stephen R SR

Publication Date: 2020-01-02

Variant appearance in text: KIT: T670E

PubMed Link: 31581151

Variant Present in the following documents:

• jci-130-127483-s144.pdf

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Combining Mutational Signatures, Clonal Fitness, and Drug Affinity to Define Drug-Specific Resistance Mutations in Cancer.

Cell Chemical Biology

Kaserer, Teresa T; Blagg, Julian J

Publication Date: 2018-11-15

Variant appearance in text: KIT: T670E

PubMed Link: 30146241

Variant Present in the following documents:

• Main text
• mmc9.pdf
• main.pdf

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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: KIT: T670E

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

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FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.

Journal Of Translational Medicine

Shi, Eileen E; Chmielecki, Juliann J; Tang, Chih-Min CM; Wang, Kai K; Heinrich, Michael C MC; Kang, Guhyun G; Corless, Christopher L CL; Hong, David D; Fero, Katherine E KE; Murphy, James D JD; Fanta, Paul T PT; Ali, Siraj M SM; De Siena, Martina M; Burgoyne, Adam M AM; Movva, Sujana S; Madlensky, Lisa L; Heestand, Gregory M GM; Trent, Jonathan C JC; Kurzrock, Razelle R; Morosini, Deborah D; Ross, Jeffrey S JS; Harismendy, Olivier O; Sicklick, Jason K JK

Publication Date: 2016-12-14

Variant appearance in text: KIT: T670E

PubMed Link: 27974047

Variant Present in the following documents:

• 12967_2016_1075_MOESM2_ESM.xlsx, sheet 1

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Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy.

Bmc Cancer

Heydt, Carina C; Kumm, Niklas N; Fassunke, Jana J; Künstlinger, Helen H; Ihle, Michaela Angelika MA; Scheel, Andreas A; Schildhaus, Hans-Ulrich HU; Haller, Florian F; Büttner, Reinhard R; Odenthal, Margarete M; Wardelmann, Eva E; Merkelbach-Bruse, Sabine S

Publication Date: 2015-04-15

Variant appearance in text: KIT: T670E

PubMed Link: 25886408

Variant Present in the following documents:

• Main text
• 12885_2015_Article_1311.pdf

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Structure-functional prediction and analysis of cancer mutation effects in protein kinases.

Computational And Mathematical Methods In Medicine

Dixit, Anshuman A; Verkhivker, Gennady M GM

Publication Date: 2014

Variant appearance in text: KIT: T670E

PubMed Link: 24817905

Variant Present in the following documents:

• CMMM2014-653487.pdf

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: KIT: T670E

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 1

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Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology

Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF

Publication Date: 2012-02

Variant appearance in text: KIT: T670E

PubMed Link: 21748247

Variant Present in the following documents:

• 10434_2011_1892_MOESM2_ESM.pdf

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Sequence and structure signatures of cancer mutation hotspots in protein kinases.

Plos One

Dixit, Anshuman A; Yi, Lin L; Gowthaman, Ragul R; Torkamani, Ali A; Schork, Nicholas J NJ; Verkhivker, Gennady M GM

Publication Date: 2009-10-16

Variant appearance in text: KIT: T670E

PubMed Link: 19834613

Variant Present in the following documents:

• Main text
• pone.0007485.pdf

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