Publications:

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Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.

International Journal Of Molecular Sciences

Masucci, Maria Teresa MT; Motti, Maria Letizia ML; Minopoli, Michele M; Di Carluccio, Gioconda G; Carriero, Maria Vincenza MV

Publication Date: 2023-03-23

Variant appearance in text: KIT: D820E

PubMed Link: 37046997

Variant Present in the following documents:

• Main text
• ijms-24-06026.pdf

View BVdb publication page

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Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting.

Cancers

Falkenhorst, Johanna J; Grunewald, Susanne S; Krzeciesa, Dawid D; Herold, Thomas T; Ketzer, Julia J; Christoff, Miriam M; Hamacher, Rainer R; Kostbade, Karina K; Treckmann, Jürgen J; Köster, Johannes J; Farzaliyev, Farhad F; Fletcher, Benjamin Samulon BS; Dieckmann, Nils N; Kaths, Moritz M; Mühlenberg, Thomas T; Schildhaus, Hans-Ulrich HU; Bauer, Sebastian S

Publication Date: 2022-11-09

Variant appearance in text: KIT: D820E

PubMed Link: 36428589

Variant Present in the following documents:

• Main text
• cancers-14-05496.pdf

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: KIT: D820E

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

View BVdb publication page

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: KIT: D820E

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

View BVdb publication page

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Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Avula, Sreenivas S; Peng, Xudan X; Lang, Xingfen X; Tortorella, Micky M; Josselin, Béatrice B; Bach, Stéphane S; Bourg, Stephane S; Bonnet, Pascal P; Buron, Frédéric F; Ruchaud, Sandrine S; Routier, Sylvain S; Neagoie, Cleopatra C

Publication Date: 2022-12

Variant appearance in text: KIT: D820E

PubMed Link: 35670091

Variant Present in the following documents:

• IENZ_A_2082419_SM0502.pdf

View BVdb publication page

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Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases

Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S

Publication Date: 2022-06-10

Variant appearance in text: KIT: D820E

PubMed Link: 35609344

Variant Present in the following documents:

• id2c00091_si_001.pdf

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Integrative Genomic Profiling Uncovers Therapeutic Targets of Acral Melanoma in Asian Populations.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Shi, Qiong Q; Liu, Lin L; Chen, Jianru J; Zhang, Weigang W; Guo, Weinan W; Wang, Xiao X; Wang, Huina H; Guo, Sen S; Yue, Qiao Q; Ma, Jingjing J; Liu, Yu Y; Zhu, Guannan G; Zhao, Tao T; Zhao, Jianhong J; Liu, Ying Y; Gao, Tianwen T; Li, Chunying C

Publication Date: 2022-06-13

Variant appearance in text: KIT: D820E

PubMed Link: 35294533

Variant Present in the following documents:

• ccr-21-3344_supplementary_data_suppsd1.xlsx, sheet 7

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: KIT: D820E

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: KIT: Asp820Glu

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.

Molecular Oncology

Liu, Juan J; Gao, Jingjing J; Wang, Aoli A; Jiang, Zongru Z; Qi, Shuang S; Qi, Ziping Z; Liu, Feiyang F; Yu, Kailin K; Cao, Jiangyan J; Chen, Cheng C; Hu, Chen C; Wu, Hong H; Wang, Li L; Wang, Wenchao W; Liu, Qingsong Q; Liu, Jing J

Publication Date: 2022-04

Variant appearance in text: KIT: D820E

PubMed Link: 35194937

Variant Present in the following documents:

• Main text
• MOL2-16-1761.pdf

View BVdb publication page

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Future Perspective of Chemotherapy and Pharmacotherapy in Thymic Carcinoma.

Cancers

Kitadai, Rui R; Okuma, Yusuke Y

Publication Date: 2021-10-19

Variant appearance in text: KIT: D820E

PubMed Link: 34680386

Variant Present in the following documents:

• Main text
• cancers-13-05239.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KIT: D820E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Bauer, Sebastian S; Heinrich, Michael C MC; George, Suzanne S; Zalcberg, John R JR; Serrano, César C; Gelderblom, Hans H; Jones, Robin L RL; Attia, Steven S; D'Amato, Gina G; Chi, Ping P; Reichardt, Peter P; Meade, Julie J; Su, Ying Y; Ruiz-Soto, Rodrigo R; Blay, Jean-Yves JY; von Mehren, Margaret M; Schöffski, Patrick P

Publication Date: 2021-12-01

Variant appearance in text: KIT: D820E

PubMed Link: 34503977

Variant Present in the following documents:

• Main text
• 6333.pdf

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An Overview on Molecular Characterization of Thymic Tumors: Old and New Targets for Clinical Advances.

Pharmaceuticals (Basel, Switzerland)

Tateo, Valentina V; Manuzzi, Lisa L; Parisi, Claudia C; De Giglio, Andrea A; Campana, Davide D; Pantaleo, Maria Abbondanza MA; Lamberti, Giuseppe G

Publication Date: 2021-04-01

Variant appearance in text: KIT: D820E

PubMed Link: 33915954

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: KIT: 2460T>A; D820E

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

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Assessment of Clinical Benefit of Integrative Genomic Profiling in Advanced Solid Tumors.

Jama Oncology

Cobain, Erin F EF; Wu, Yi-Mi YM; Vats, Pankaj P; Chugh, Rashmi R; Worden, Francis F; Smith, David C DC; Schuetze, Scott M SM; Zalupski, Mark M MM; Sahai, Vaibhav V; Alva, Ajjai A; Schott, Anne F AF; Caram, Megan E V MEV; Hayes, Daniel F DF; Stoffel, Elena M EM; Jacobs, Michelle F MF; Kumar-Sinha, Chandan C; Cao, Xuhong X; Wang, Rui R; Lucas, David D; Ning, Yu Y; Rabban, Erica E; Bell, Janice J; Camelo-Piragua, Sandra S; Udager, Aaron M AM; Cieslik, Marcin M; Lonigro, Robert J RJ; Kunju, Lakshmi P LP; Robinson, Dan R DR; Talpaz, Moshe M; Chinnaiyan, Arul M AM

Publication Date: 2021-04-01

Variant appearance in text: KIT: D820E

PubMed Link: 33630025

Variant Present in the following documents:

• jamaoncol-e207987-s004.xlsx, sheet 2

View BVdb publication page

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: KIT: D820E

PubMed Link: 33133066

Variant Present in the following documents:

• Table_2.xlsx, sheet 1
• Table_2.xlsx, sheet 2
• Table_6.xlsx, sheet 4
• Table_6.xlsx, sheet 9
• Table_1.xlsx, sheet 4
• Table_2.xlsx, sheet 7
• Table_1.xlsx, sheet 8

View BVdb publication page

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs1057519711

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KIT: D820E

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: KIT: D820E

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

View BVdb publication page

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Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Frontiers In Oncology

Wang, Shuhang S; Chen, Rongrong R; Tang, Yu Y; Yu, Yue Y; Fang, Yuan Y; Huang, Huiyao H; Wu, Dawei D; Fang, Hong H; Bai, Ying Y; Sun, Chao C; Yu, Anqi A; Fan, Qi Q; Gu, Dejian D; Yi, Xin X; Li, Ning N

Publication Date: 2020

Variant appearance in text: KIT: 2460T>A; D820E

PubMed Link: 32373528

Variant Present in the following documents:

• Table_6.xlsx, sheet 1

View BVdb publication page

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Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells.

Cancers

Hamid, Abdulaziz B AB; Petreaca, Ruben C RC

Publication Date: 2020-04-09

Variant appearance in text: KIT: D820E

PubMed Link: 32283832

Variant Present in the following documents:

• cancers-12-00927-s001.pdf

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KIT: D820E

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib.

Cell & Bioscience

Zhu, Guangrong G; Shi, Jun J; Zhang, Shaoting S; Guo, Yue Y; Huang, Ling L; Zhao, Hui H; Jiang, Yideng Y; Sun, Jianmin J

Publication Date: 2020

Variant appearance in text: KIT: D820E

PubMed Link: 32082541

Variant Present in the following documents:

• Main text
• 13578_2020_Article_377.pdf

View BVdb publication page

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Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: KIT: D820E

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

View BVdb publication page

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Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature

Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E

Publication Date: 2019-11

Variant appearance in text: KIT: Asp820Glu

PubMed Link: 31645765

Variant Present in the following documents:

• 41586_2019_1689_MOESM14_ESM.xlsx, sheet 1
• 41586_2019_1689_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

The Journal Of Clinical Investigation

Willoughby, Catherine E CE; Jiang, Yanyan Y; Thomas, Huw D HD; Willmore, Elaine E; Kyle, Suzanne S; Wittner, Anita A; Phillips, Nicole N; Zhao, Yan Y; Tudhope, Susan J SJ; Prendergast, Lisa L; Junge, Gesa G; Lourenco, Luiza Madia LM; Finlay, M Raymond V MRV; Turner, Paul P; Munck, Joanne M JM; Griffin, Roger J RJ; Rennison, Tommy T; Pickles, James J; Cano, Celine C; Newell, David R DR; Reeves, Helen L HL; Ryan, Anderson J AJ; Wedge, Stephen R SR

Publication Date: 2020-01-02

Variant appearance in text: KIT: D820E

PubMed Link: 31581151

Variant Present in the following documents:

• jci-130-127483-s144.pdf

View BVdb publication page

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Lack of Response to Imatinib in Melanoma Carrying Rare KIT Mutation p.T632I.

Case Reports In Oncology

Orlova, Kristina V KV; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Venina, Aigul R AR; Iyevleva, Aglaya G AG; Demidov, Lev V LV; Imyanitov, Evgeny N EN

Publication Date: 2019

Variant appearance in text: KIT: D820E

PubMed Link: 31043947

Variant Present in the following documents:

• cro-0012-0109-s01.pdf

View BVdb publication page

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Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs).

Clinical Sarcoma Research

Heinrich, Michael C MC; Patterson, Janice J; Beadling, Carol C; Wang, Yuexiang Y; Debiec-Rychter, Maria M; Dewaele, Barbara B; Corless, Christopher L CL; Duensing, Anette A; Raut, Chandrajit P CP; Rubin, Brian B; Ordog, Tamas T; van de Rijn, Matt M; Call, Jerry J; Mühlenberg, Thomas T; Fletcher, Jonathan A JA; Bauer, Sebastian S

Publication Date: 2019

Variant appearance in text: KIT: D820E

PubMed Link: 30867899

Variant Present in the following documents:

• Main text
• 13569_2019_Article_112.pdf
• 13569_2019_112_MOESM5_ESM.xlsx, sheet 1

View BVdb publication page

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Computational analysis reveals histotype-dependent molecular profile and actionable mutation effects across cancers.

Genome Medicine

Heim, Daniel D; Montavon, Grégoire G; Hufnagl, Peter P; Müller, Klaus-Robert KR; Klauschen, Frederick F

Publication Date: 2018-11-15

Variant appearance in text: KIT: D820E

PubMed Link: 30442178

Variant Present in the following documents:

• 13073_2018_591_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Recent Studies on Ponatinib in Cancers Other Than Chronic Myeloid Leukemia.

Cancers

Musumeci, Francesca F; Greco, Chiara C; Grossi, Giancarlo G; Molinari, Alessio A; Schenone, Silvia S

Publication Date: 2018-11-09

Variant appearance in text: KIT: D820E

PubMed Link: 30423915

Variant Present in the following documents:

• Main text
• cancers-10-00430.pdf

View BVdb publication page

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: KIT: D820E

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 3

View BVdb publication page

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Establishment and characterization of patient-derived xenograft models of gastrointestinal stromal tumor resistant to standard tyrosine kinase inhibitors.

Oncotarget

Na, Young-Soon YS; Ryu, Min-Hee MH; Yoo, Changhoon C; Lee, Ju-Kyung JK; Park, Jung Min JM; Lee, Chae-Won CW; Lee, Sun Young SY; Shin, Young-Kyoung YK; Ku, Ja-Lok JL; Ahn, Sung-Min SM; Kang, Yoon-Koo YK

Publication Date: 2017-09-29

Variant appearance in text: KIT: D820E

PubMed Link: 29100343

Variant Present in the following documents:

• Main text
• oncotarget-08-76712.pdf

View BVdb publication page

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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications

Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ

Publication Date: 2017-08-04

Variant appearance in text: KIT: 2460T>A; D820E

PubMed Link: 28775315

Variant Present in the following documents:

• 41467_2017_289_MOESM7_ESM.xlsx, sheet 1

View BVdb publication page

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A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607).

Cancer

Kalinsky, Kevin K; Lee, Sandra S; Rubin, Krista M KM; Lawrence, Donald P DP; Iafrarte, Anthony J AJ; Borger, Darell R DR; Margolin, Kim A KA; Leitao, Mario M MM; Tarhini, Ahmad A AA; Koon, Henry B HB; Pecora, Andrew L AL; Jaslowski, Anthony J AJ; Cohen, Gary I GI; Kuzel, Timothy M TM; Lao, Christopher D CD; Kirkwood, John M JM

Publication Date: 2017-07-15

Variant appearance in text: KIT: D820E

PubMed Link: 28334439

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: KIT: 2460T>A; D820E

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

View BVdb publication page

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Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives.

Oncotargets And Therapy

Mulet-Margalef, Nuria N; Garcia-Del-Muro, Xavier X

Publication Date: 2016

Variant appearance in text: KIT: D820E

PubMed Link: 28008275

Variant Present in the following documents:

• Main text
• ott-9-7573.pdf

View BVdb publication page

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FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors.

Journal Of Translational Medicine

Shi, Eileen E; Chmielecki, Juliann J; Tang, Chih-Min CM; Wang, Kai K; Heinrich, Michael C MC; Kang, Guhyun G; Corless, Christopher L CL; Hong, David D; Fero, Katherine E KE; Murphy, James D JD; Fanta, Paul T PT; Ali, Siraj M SM; De Siena, Martina M; Burgoyne, Adam M AM; Movva, Sujana S; Madlensky, Lisa L; Heestand, Gregory M GM; Trent, Jonathan C JC; Kurzrock, Razelle R; Morosini, Deborah D; Ross, Jeffrey S JS; Harismendy, Olivier O; Sicklick, Jason K JK

Publication Date: 2016-12-14

Variant appearance in text: KIT: D820E

PubMed Link: 27974047

Variant Present in the following documents:

• 12967_2016_1075_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Receptor tyrosine kinase (c-Kit) inhibitors: a potential therapeutic target in cancer cells.

Drug Design, Development And Therapy

Abbaspour Babaei, Maryam M; Kamalidehghan, Behnam B; Saleem, Mohammad M; Huri, Hasniza Zaman HZ; Ahmadipour, Fatemeh F

Publication Date: 2016

Variant appearance in text: KIT: D820E

PubMed Link: 27536065

Variant Present in the following documents:

• Main text
• dddt-10-2443.pdf

View BVdb publication page

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Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

Plos One

de Leng, Wendy W J WW; Gadellaa-van Hooijdonk, Christa G CG; Barendregt-Smouter, Françoise A S FA; Koudijs, Marco J MJ; Nijman, Ies I; Hinrichs, John W J JW; Cuppen, Edwin E; van Lieshout, Stef S; Loberg, Robert D RD; de Jonge, Maja M; Voest, Emile E EE; de Weger, Roel A RA; Steeghs, Neeltje N; Langenberg, Marlies H G MH; Sleijfer, Stefan S; Willems, Stefan M SM; Lolkema, Martijn P MP

Publication Date: 2016

Variant appearance in text: KIT: D820E

PubMed Link: 26919633

Variant Present in the following documents:

• pone.0149405.s010.xlsx, sheet 1

View BVdb publication page

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Phase II clinical and exploratory biomarker study of dacomitinib in recurrent and/or metastatic esophageal squamous cell carcinoma.

Oncotarget

Kim, Hyo Song HS; Kim, Sung-Moo SM; Kim, Hyunki H; Pyo, Kyoung-Ho KH; Sun, Jong-Mu JM; Ahn, Myung-Ju MJ; Park, Keunchil K; Keam, Bhumsuk B; Kwon, Nak-Jung NJ; Yun, Hwan Jung HJ; Kim, Hoon-Gu HG; Chung, Ik-Joo IJ; Lee, Jong Seok JS; Lee, Kyung Hee KH; Kim, Dae Joon DJ; Lee, Chang-Geol CG; Hur, Jin J; Chung, Hyunsoo H; Park, Jun Chul JC; Shin, Sung Kwan SK; Lee, Sang Kil SK; Kim, Hye Ryun HR; Moon, Yong Wha YW; Lee, Yong Chan YC; Kim, Joo Hang JH; Paik, Soonmyung S; Cho, Byoung Chul BC

Publication Date: 2015-12-29

Variant appearance in text: KIT: D820E

PubMed Link: 26462025

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Massively parallel sequencing fails to detect minor resistant subclones in tissue samples prior to tyrosine kinase inhibitor therapy.

Bmc Cancer

Heydt, Carina C; Kumm, Niklas N; Fassunke, Jana J; Künstlinger, Helen H; Ihle, Michaela Angelika MA; Scheel, Andreas A; Schildhaus, Hans-Ulrich HU; Haller, Florian F; Büttner, Reinhard R; Odenthal, Margarete M; Wardelmann, Eva E; Merkelbach-Bruse, Sabine S

Publication Date: 2015-04-15

Variant appearance in text: KIT: D820E

PubMed Link: 25886408

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Response to nab-paclitaxel and nedaplatin in a heavily-metastatic thymic carcinoma: A case report.

Oncology Letters

Zhan, Ping P; Xie, Haiyan H; Yu, Li-Ke LK

Publication Date: 2015-04

Variant appearance in text: KIT: D820E

PubMed Link: 25789028

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• Main text
• ol-09-04-1715.pdf

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Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Garner, Andrew P AP; Gozgit, Joseph M JM; Anjum, Rana R; Vodala, Sadanand S; Schrock, Alexa A; Zhou, Tianjun T; Serrano, Cesar C; Eilers, Grant G; Zhu, Meijun M; Ketzer, Julia J; Wardwell, Scott S; Ning, Yaoyu Y; Song, Youngchul Y; Kohlmann, Anna A; Wang, Frank F; Clackson, Tim T; Heinrich, Michael C MC; Fletcher, Jonathan A JA; Bauer, Sebastian S; Rivera, Victor M VM

Publication Date: 2014-11-15

Variant appearance in text: KIT: D820E

PubMed Link: 25239608

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Antitumor activity of sorafenib and imatinib in a patient with thymic carcinoma harboring c-KIT exon 13 missense mutation K642E.

Oncotargets And Therapy

Catania, Chiara C; Conforti, Fabio F; Spitaleri, Gianluca G; Barberis, Massimo M; Preda, Lorenzo L; Noberasco, Cristina C; Lazzari, Chiara C; Toffalorio, Francesca F; de Marinis, Filippo F; Manzotti, Michela M; De Pas, Tommaso Martino TM

Publication Date: 2014

Variant appearance in text: KIT: D820E

PubMed Link: 24855380

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• Main text
• ott-7-697.pdf

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High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.

Pigment Cell & Melanoma Research

Masaki, Taro T; Wang, Yun Y; DiGiovanna, John J JJ; Khan, Sikandar G SG; Raffeld, Mark M; Beltaifa, Senda S; Hornyak, Thomas J TJ; Darling, Thomas N TN; Lee, Chyi-Chia R CC; Kraemer, Kenneth H KH

Publication Date: 2014-05

Variant appearance in text: KIT: D820E

PubMed Link: 24483290

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