Publications:

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Development of Highly Sensitive Digital Droplet PCR for Detection of cKIT Mutations in Circulating Free DNA That Mediate Resistance to TKI Treatment for Gastrointestinal Stromal Tumor (GIST).

International Journal Of Molecular Sciences

Rassner, Michael M; Waldeck, Silvia S; Follo, Marie M; Jilg, Stefanie S; Philipp, Ulrike U; Jolic, Martina M; Wehrle, Julius J; Jost, Philipp J PJ; Peschel, Christian C; Illert, Anna Lena AL; Duyster, Justus J; Scherer, Florian F; von Bubnoff, Nikolas N

Publication Date: 2023-03-12

Variant appearance in text: KIT: Y823D

PubMed Link: 36982486

Variant Present in the following documents:

• Main text
• ijms-24-05411.pdf

View BVdb publication page

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Activity of Anlotinib in the Second-Line Therapy of Metastatic Gastrointestinal Stromal Tumors: A Prospective, Multicenter, In Vitro Study.

The Oncologist

Zhou, Yongjian Y; Zeng, Chunling C; Sun, Xiaofeng X; Zhang, Jun J; Qu, Hongyan H; Zhang, Xinhua X; Zhou, Ye Y; Liu, Zimin Z; Wu, Xiaojun X; Wu, Xin X; Jiao, Xuelong X; Shen, Lin L; Zhou, Yanbing Y; Wang, Yuexiang Y; Li, Jian J

Publication Date: 2023-02-13

Variant appearance in text: KIT: Y823D

PubMed Link: 36779523

Variant Present in the following documents:

• Main text
• oyac271.pdf

View BVdb publication page

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Clinical utility of Todai OncoPanel in the setting of approved comprehensive cancer genomic profiling tests in Japan.

Cancer Science

Kage, Hidenori H; Shinozaki-Ushiku, Aya A; Ishigaki, Kazunaga K; Sato, Yusuke Y; Tanabe, Masahiko M; Tanaka, Shota S; Tanikawa, Michihiro M; Watanabe, Kousuke K; Kato, Shingo S; Akagi, Kiwamu K; Uchino, Keita K; Mitani, Kinuko K; Takahashi, Shunji S; Miura, Yuji Y; Ikeda, Sadakatsu S; Kojima, Yasushi Y; Watanabe, Kiyotaka K; Mochizuki, Hitoshi H; Yamaguchi, Hironori H; Kawazoe, Yoshimasa Y; Kashiwabara, Kosuke K; Kohsaka, Shinji S; Tatsuno, Kenji K; Ushiku, Tetsuo T; Ohe, Kazuhiko K; Yatomi, Yutaka Y; Seto, Yasuyuki Y; Aburatani, Hiroyuki H; Mano, Hiroyuki H; Miyagawa, Kiyoshi K; Oda, Katsutoshi K

Publication Date: 2023-01-05

Variant appearance in text: KIT: 2467T>G; Y823D

PubMed Link: 36601953

Variant Present in the following documents:

• CAS-114-1710-s001.xlsx, sheet 1

View BVdb publication page

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Escalation of radiotherapy dose in large locally advanced drug-resistant gastrointestinal stromal tumors by multi-shell simultaneous integrated boost intensity-modulated technique: a feasibility study.

Radiation Oncology (London, England)

Cui, Haixia H; Li, Ying Y; Huang, Wei W; Lu, Wenli W; Yi, Xin X

Publication Date: 2022-12-28

Variant appearance in text: KIT: Y823D

PubMed Link: 36578008

Variant Present in the following documents:

• Main text
• 13014_2022_Article_2179.pdf

View BVdb publication page

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Microfluidic-based dynamic BH3 profiling predicts anticancer treatment efficacy.

Npj Precision Oncology

Manzano-Muñoz, Albert A; Yeste, José J; Ortega, María A MA; Martín, Fernando F; López, Anna A; Rosell, Jordi J; Castro, Sandra S; Serrano, César C; Samitier, Josep J; Ramón-Azcón, Javier J; Montero, Joan J

Publication Date: 2022-12-01

Variant appearance in text: KIT: Y823D

PubMed Link: 36456699

Variant Present in the following documents:

• Main text
• 41698_2022_Article_333.pdf

View BVdb publication page

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Plasma Sequencing for Patients with GIST-Limitations and Opportunities in an Academic Setting.

Cancers

Falkenhorst, Johanna J; Grunewald, Susanne S; Krzeciesa, Dawid D; Herold, Thomas T; Ketzer, Julia J; Christoff, Miriam M; Hamacher, Rainer R; Kostbade, Karina K; Treckmann, Jürgen J; Köster, Johannes J; Farzaliyev, Farhad F; Fletcher, Benjamin Samulon BS; Dieckmann, Nils N; Kaths, Moritz M; Mühlenberg, Thomas T; Schildhaus, Hans-Ulrich HU; Bauer, Sebastian S

Publication Date: 2022-11-09

Variant appearance in text: KIT: Y823D

PubMed Link: 36428589

Variant Present in the following documents:

• Main text
• cancers-14-05496.pdf

View BVdb publication page

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Protein tyrosine kinase inhibitor resistance in malignant tumors: molecular mechanisms and future perspective.

Signal Transduction And Targeted Therapy

Yang, Yang Y; Li, Shuo S; Wang, Yujiao Y; Zhao, Yi Y; Li, Qiu Q

Publication Date: 2022-09-17

Variant appearance in text: KIT: Y823D

PubMed Link: 36115852

Variant Present in the following documents:

• Main text
• 41392_2022_Article_1168.pdf

View BVdb publication page

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: KIT: Y823D

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

View BVdb publication page

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Efficacy and safety of ripretinib in patients with KIT-altered metastatic melanoma.

Esmo Open

Janku, F F; Bauer, S S; Shoumariyeh, K K; Jones, R L RL; Spreafico, A A; Jennings, J J; Psoinos, C C; Meade, J J; Ruiz-Soto, R R; Chi, P P

Publication Date: 2022-08

Variant appearance in text: KIT: Y823D

PubMed Link: 35753087

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Comprehensive Genomic Profiling of 274 Thymic Epithelial Tumors Unveils Oncogenic Pathways and Predictive Biomarkers.

The Oncologist

Girard, Nicolas N; Basse, Clémence C; Schrock, Alexa A; Ramkissoon, Shakti S; Killian, Keith K; Ross, Jeffrey S JS

Publication Date: 2022-11-03

Variant appearance in text: KIT: Y823D

PubMed Link: 35749302

Variant Present in the following documents:

• Main text
• oyac115.pdf

View BVdb publication page

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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications

Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX

Publication Date: 2022-06-15

Variant appearance in text: KIT: Y823D

PubMed Link: 35705558

Variant Present in the following documents:

• 41467_2022_30496_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report.

Frontiers In Oncology

Yue, Xizan X; Liu, Bo B; Han, Tiantian T; Luo, Ningning N; Lu, Guanghua G; Guo, Didi D; Bu, Fanfeng F; Wang, Guangyu G

Publication Date: 2022

Variant appearance in text: KIT: 2467T>G; Y823D

PubMed Link: 35651799

Variant Present in the following documents:

• Main text
• fonc-12-835220.pdf

View BVdb publication page

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Pyronaridine Protects against SARS-CoV-2 Infection in Mouse.

Acs Infectious Diseases

Puhl, Ana C AC; Gomes, Giovanni F GF; Damasceno, Samara S; Godoy, Andre S AS; Noske, Gabriela D GD; Nakamura, Aline M AM; Gawriljuk, Victor O VO; Fernandes, Rafaela S RS; Monakhova, Natalia N; Riabova, Olga O; Lane, Thomas R TR; Makarov, Vadim V; Veras, Flavio P FP; Batah, Sabrina S SS; Fabro, Alexandre T AT; Oliva, Glaucius G; Cunha, Fernando Q FQ; Alves-Filho, José C JC; Cunha, Thiago M TM; Ekins, Sean S

Publication Date: 2022-06-10

Variant appearance in text: KIT: Y823D

PubMed Link: 35609344

Variant Present in the following documents:

• id2c00091_si_001.pdf

View BVdb publication page

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Molecular landscape and therapeutic alterations in Asian soft-tissue sarcoma patients.

Cancer Medicine

Gan, Meifu M; Zhang, Chen C; Qiu, Liqing L; Wang, Yue Y; Bao, Hua H; Yu, Ruoying R; Liu, Rui R; Wu, Xue X; Shao, Yang Y; Hou, Peifeng P; Fei, Zhenglei Z

Publication Date: 2022-11

Variant appearance in text: KIT: 2467T>G; Y823D

PubMed Link: 35586877

Variant Present in the following documents:

• CAM4-11-4070-s004.xlsx, sheet 1

View BVdb publication page

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Molecular Portrait of GISTs Associated With Clinicopathological Features: A Retrospective Study With Molecular Analysis by a Custom 9-Gene Targeted Next-Generation Sequencing Panel.

Frontiers In Genetics

Qian, Haoran H; Yan, Na N; Hu, Xiaotong X; Jiang, Junchang J; Cao, Zhengzheng Z; Shen, Dan D

Publication Date: 2022

Variant appearance in text: KIT: Y823D

PubMed Link: 35547262

Variant Present in the following documents:

• Main text
• fgene-13-864499.pdf
• DataSheet1.xlsx, sheet 1

View BVdb publication page

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Circulating Tumor DNA Mutations in Progressive Gastrointestinal Stromal Tumors Identify Biomarkers of Treatment Resistance and Uncover Potential Therapeutic Strategies.

Frontiers In Oncology

Ko, Tun Kiat TK; Lee, Elizabeth E; Ng, Cedric Chuan-Young CC; Yang, Valerie Shiwen VS; Farid, Mohamad M; Teh, Bin Tean BT; Chan, Jason Yongsheng JY; Somasundaram, Nagavalli N

Publication Date: 2022

Variant appearance in text: KIT: 2467T>G

PubMed Link: 35273917

Variant Present in the following documents:

• Main text
• fonc-12-840843.pdf

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: KIT: Y823D

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: KIT: Tyr823Asp

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Nintedanib overcomes drug resistance from upregulation of FGFR signalling and imatinib-induced KIT mutations in gastrointestinal stromal tumours.

Molecular Oncology

Liu, Juan J; Gao, Jingjing J; Wang, Aoli A; Jiang, Zongru Z; Qi, Shuang S; Qi, Ziping Z; Liu, Feiyang F; Yu, Kailin K; Cao, Jiangyan J; Chen, Cheng C; Hu, Chen C; Wu, Hong H; Wang, Li L; Wang, Wenchao W; Liu, Qingsong Q; Liu, Jing J

Publication Date: 2022-04

Variant appearance in text: KIT: Y823D

PubMed Link: 35194937

Variant Present in the following documents:

• Main text
• MOL2-16-1761.pdf

View BVdb publication page

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Broad spectrum of regorafenib activity on mutant KIT and absence of clonal selection in gastrointestinal stromal tumor (GIST): correlative analysis from the GRID trial.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Jeffers, Michael M; Kappeler, Christian C; Kuss, Iris I; Beckmann, Georg G; Mehnert, Daniel H DH; Fredebohm, Johannes J; Teufel, Michael M

Publication Date: 2022-05

Variant appearance in text: KIT: Y823D

PubMed Link: 35050442

Variant Present in the following documents:

• Main text
• 10120_2021_Article_1274.pdf

View BVdb publication page

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Preclinical model-based evaluation of Imatinib resistance induced by KIT mutations and its overcoming strategies in gastrointestinal stromal tumor (GIST).

American Journal Of Translational Research

Zhao, Qian Q; Zhang, Cheng C; Qi, Changsong C; Yang, Jing J; Chen, Yang Y; Ge, Sai S; Shen, Lin L; Gao, Jing J; Li, Jian J

Publication Date: 2021

Variant appearance in text: KIT: Y823D

PubMed Link: 35035701

Variant Present in the following documents:

• Main text

View BVdb publication page

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The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma.

Bmc Cancer

Karachaliou, Georgia Sofia GS; Alkallas, Rached R; Carroll, Sarah B SB; Caressi, Chongshan C; Zakria, Danny D; Patel, Nirali M NM; Trembath, Dimitri G DG; Ezzell, Jennifer A JA; Pegna, Guillaume J GJ; Googe, Paul B PB; Galeotti, Jonathan P JP; Ayvali, Fatih F; Collichio, Frances A FA; Lee, Carrie B CB; Ollila, David W DW; Gulley, Margaret L ML; Johnson, Douglas B DB; Kim, Kevin B KB; Watson, Ian R IR; Moschos, Stergios J SJ

Publication Date: 2022-01-05

Variant appearance in text: KIT: Y823D

PubMed Link: 34986841

Variant Present in the following documents:

• 12885_2021_8908_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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The clinical significance of adenomatous polyposis coli (APC) and catenin Beta 1 (CTNNB1) genetic aberrations in patients with melanoma.

Bmc Cancer

Karachaliou, Georgia Sofia GS; Alkallas, Rached R; Carroll, Sarah B SB; Caressi, Chongshan C; Zakria, Danny D; Patel, Nirali M NM; Trembath, Dimitri G DG; Ezzell, Jennifer A JA; Pegna, Guillaume J GJ; Googe, Paul B PB; Galeotti, Jonathan P JP; Ayvali, Fatih F; Collichio, Frances A FA; Lee, Carrie B CB; Ollila, David W DW; Gulley, Margaret L ML; Johnson, Douglas B DB; Kim, Kevin B KB; Watson, Ian R IR; Moschos, Stergios J SJ

Publication Date: 2022-01-05

Variant appearance in text: KIT: Y823D

PubMed Link: 34986841

Variant Present in the following documents:

• 12885_2021_8908_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KIT: Y823D

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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The value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients: a case series.

Oncotarget

Drenner, Kevin K; Basu, Gargi D GD; Goodman, Laurie J LJ; Ozols, Audrey A AA; LoBello, Janine R JR; Royce, Thomas T; Gordon, Michael S MS; Borazanci, Erkut H EH; Steinbach, Margaux A MA; Trent, Jeffrey J; Sharma, Sunil S

Publication Date: 2021-08-31

Variant appearance in text: KIT: Y823D

PubMed Link: 34504655

Variant Present in the following documents:

• Main text
• oncotarget-12-1836.pdf

View BVdb publication page

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Clinical Activity of Ripretinib in Patients with Advanced Gastrointestinal Stromal Tumor Harboring Heterogeneous KIT/PDGFRA Mutations in the Phase III INVICTUS Study.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Bauer, Sebastian S; Heinrich, Michael C MC; George, Suzanne S; Zalcberg, John R JR; Serrano, César C; Gelderblom, Hans H; Jones, Robin L RL; Attia, Steven S; D'Amato, Gina G; Chi, Ping P; Reichardt, Peter P; Meade, Julie J; Su, Ying Y; Ruiz-Soto, Rodrigo R; Blay, Jean-Yves JY; von Mehren, Margaret M; Schöffski, Patrick P

Publication Date: 2021-12-01

Variant appearance in text: KIT: Y823D

PubMed Link: 34503977

Variant Present in the following documents:

• Main text
• 6333.pdf

View BVdb publication page

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Recent Progress and Challenges in the Diagnosis and Treatment of Gastrointestinal Stromal Tumors.

Cancers

Nishida, Toshirou T; Yoshinaga, Shigetaka S; Takahashi, Tsuyoshi T; Naito, Yoichi Y

Publication Date: 2021-06-24

Variant appearance in text: KIT: Y823D

PubMed Link: 34202544

Variant Present in the following documents:

• Main text
• cancers-13-03158.pdf

View BVdb publication page

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Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer

Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA

Publication Date: 2021-05

Variant appearance in text: KIT: 2467T>G; Y823D

PubMed Link: 33704917

Variant Present in the following documents:

• TCA-12-1271-s003.xls, sheet 1

View BVdb publication page

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The Immunogenic Potential of Recurrent Cancer Drug Resistance Mutations: An In Silico Study.

Frontiers In Immunology

Punta, Marco M; Jennings, Victoria A VA; Melcher, Alan A AA; Lise, Stefano S

Publication Date: 2020

Variant appearance in text: KIT: Y823D

PubMed Link: 33133066

Variant Present in the following documents:

• Table_1.xlsx, sheet 8
• Table_6.xlsx, sheet 10
• Table_1.xlsx, sheet 5
• Table_2.xlsx, sheet 1
• Table_6.xlsx, sheet 5
• Table_2.xlsx, sheet 7
• Table_2.xlsx, sheet 2

View BVdb publication page

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Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports

Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O

Publication Date: 2020-10-13

Variant appearance in text: rs1057519761

PubMed Link: 33051506

Variant Present in the following documents:

• 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KIT: Y823D

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

View BVdb publication page

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Research Autopsy Demonstrates Polyclonal Acquired Resistance in a Patient With Metastatic GI Stromal Tumor.

Jco Precision Oncology

Paruchuri, Anoosha A; Chen, Hui-Zi HZ; Bonneville, Russell R; Reeser, Julie W JW; Wing, Michele R MR; Krook, Melanie A MA; Samorodnitsky, Eric E; Miya, Jharna J; Dao, Thuy T; Smith, Amy A; Freud, Aharon G AG; Allenby, Patricia P; Roychowdhury, Sameek S

Publication Date: 2020

Variant appearance in text: KIT: Y823D

PubMed Link: 32923900

Variant Present in the following documents:

• Main text

View BVdb publication page

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Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: KIT: Y823D

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Plocabulin, a novel tubulin inhibitor, has potent antitumor activity in patient-derived xenograft models of gastrointestinal stromal tumors.

Translational Oncology

Wang, Yannick Y; Wozniak, Agnieszka A; Wellens, Jasmien J; Gebreyohannes, Yemarshet K YK; Guillén, Maria Jose MJ; Avilés, Pablo M PM; Debiec-Rychter, Maria M; Sciot, Raf R; Schöffski, Patrick P

Publication Date: 2020-11

Variant appearance in text: KIT: Y823D

PubMed Link: 32711367

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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A prospective multicenter phase II study on the efficacy and safety of dasatinib in the treatment of metastatic gastrointestinal stromal tumors failed by imatinib and sunitinib and analysis of NGS in peripheral blood.

Cancer Medicine

Zhou, Ye Y; Zhang, Xinhua X; Wu, Xiaojun X; Zhou, Yongjian Y; Zhang, Bo B; Liu, Xiufeng X; Wu, Xin X; Li, Yan Y; Shen, Lin L; Li, Jian J

Publication Date: 2020-09

Variant appearance in text: KIT: Y823D

PubMed Link: 32677196

Variant Present in the following documents:

• Main text
• CAM4-9-6225.pdf

View BVdb publication page

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Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics

Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z

Publication Date: 2021-05-20

Variant appearance in text: KIT: Y823D

PubMed Link: 32510566

Variant Present in the following documents:

• Main text

View BVdb publication page

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Phase and context shape the function of composite oncogenic mutations.

Nature

Gorelick, Alexander N AN; Sánchez-Rivera, Francisco J FJ; Cai, Yanyan Y; Bielski, Craig M CM; Biederstedt, Evan E; Jonsson, Philip P; Richards, Allison L AL; Vasan, Neil N; Penson, Alexander V AV; Friedman, Noah D ND; Ho, Yu-Jui YJ; Baslan, Timour T; Bandlamudi, Chaitanya C; Scaltriti, Maurizio M; Schultz, Nikolaus N; Lowe, Scott W SW; Reznik, Ed E; Taylor, Barry S BS

Publication Date: 2020-06

Variant appearance in text: KIT: Y823D

PubMed Link: 32461694

Variant Present in the following documents:

• NIHMS1582596-supplement-1582596_Supp_Tab1-5.xlsx, sheet 2

View BVdb publication page

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Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies.

Frontiers In Oncology

Wang, Shuhang S; Chen, Rongrong R; Tang, Yu Y; Yu, Yue Y; Fang, Yuan Y; Huang, Huiyao H; Wu, Dawei D; Fang, Hong H; Bai, Ying Y; Sun, Chao C; Yu, Anqi A; Fan, Qi Q; Gu, Dejian D; Yi, Xin X; Li, Ning N

Publication Date: 2020

Variant appearance in text: KIT: 2467T>G; Y823D

PubMed Link: 32373528

Variant Present in the following documents:

• Table_6.xlsx, sheet 1

View BVdb publication page

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Mutational spectrum and classification of novel mutations in patients with metastatic gastrointestinal stromal tumours.

International Journal Of Oncology

Bombac, Alenka A; Zakotnik, Branko B; Bucic, Marina M; Setrajcic Dragos, Vita V; Gazic, Barbara B; Stegel, Vida V; Klancar, Gasper G; Novakovic, Srdjan S

Publication Date: 2020-06

Variant appearance in text: KIT: 2467T>G; Tyr823Asp

PubMed Link: 32236636

Variant Present in the following documents:

• Supplementary_Data.pdf

View BVdb publication page

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Pretreatment Tumor DNA Sequencing of KIT and PDGFRA in Endosonography-Guided Biopsies Optimizes the Preoperative Management of Gastrointestinal Stromal Tumors.

Molecular Diagnosis & Therapy

Hedenström, Per P; Andersson, Carola C; Sjövall, Henrik H; Enlund, Fredrik F; Nilsson, Ola O; Nilsson, Bengt B; Sadik, Riadh R

Publication Date: 2020-04

Variant appearance in text: KIT: Y823D

PubMed Link: 32124386

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KIT: Y823D

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib.

Cell & Bioscience

Zhu, Guangrong G; Shi, Jun J; Zhang, Shaoting S; Guo, Yue Y; Huang, Ling L; Zhao, Hui H; Jiang, Yideng Y; Sun, Jianmin J

Publication Date: 2020

Variant appearance in text: KIT: Y823D

PubMed Link: 32082541

Variant Present in the following documents:

• Main text

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Clinical value of next generation sequencing of plasma cell-free DNA in gastrointestinal stromal tumors.

Bmc Cancer

Serrano, César C; Vivancos, Ana A; López-Pousa, Antonio A; Matito, Judit J; Mancuso, Francesco M FM; Valverde, Claudia C; Quiroga, Sergi S; Landolfi, Stefania S; Castro, Sandra S; Dopazo, Cristina C; Sebio, Ana A; Virgili, Anna C AC; Menso, María M MM; Martín-Broto, Javier J; Sansó, Miriam M; García-Valverde, Alfonso A; Rosell, Jordi J; Fletcher, Jonathan A JA; George, Suzanne S; Carles, Joan J; Arribas, Joaquín J

Publication Date: 2020-02-05

Variant appearance in text: KIT: Y823D

PubMed Link: 32024476

Variant Present in the following documents:

• Main text
• 12885_2020_Article_6597.pdf

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Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases.

Scientific Reports

Šimčíková, Daniela D; Heneberg, Petr P

Publication Date: 2019-12-09

Variant appearance in text: KIT: Y823D

PubMed Link: 31819097

Variant Present in the following documents:

• 41598_2019_54976_MOESM2_ESM.xlsx, sheet 8

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Pan-cancer whole-genome analyses of metastatic solid tumours.

Nature

Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E

Publication Date: 2019-11

Variant appearance in text: KIT: Tyr823Asp

PubMed Link: 31645765

Variant Present in the following documents:

• 41586_2019_1689_MOESM10_ESM.xlsx, sheet 1
• 41586_2019_1689_MOESM14_ESM.xlsx, sheet 1

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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.

The Journal Of Clinical Investigation

Willoughby, Catherine E CE; Jiang, Yanyan Y; Thomas, Huw D HD; Willmore, Elaine E; Kyle, Suzanne S; Wittner, Anita A; Phillips, Nicole N; Zhao, Yan Y; Tudhope, Susan J SJ; Prendergast, Lisa L; Junge, Gesa G; Lourenco, Luiza Madia LM; Finlay, M Raymond V MRV; Turner, Paul P; Munck, Joanne M JM; Griffin, Roger J RJ; Rennison, Tommy T; Pickles, James J; Cano, Celine C; Newell, David R DR; Reeves, Helen L HL; Ryan, Anderson J AJ; Wedge, Stephen R SR

Publication Date: 2020-01-02

Variant appearance in text: KIT: Y823D

PubMed Link: 31581151

Variant Present in the following documents:

• jci-130-127483-s144.pdf

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: KIT: Y823D

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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