Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.
Journal Of The American Society For Mass Spectrometry
Jeacock, Kiani K; Chappard, Alexandre A; Gallagher, Kelly J KJ; Mackay, C Logan CL; Kilgour, David P A DPA; Horrocks, Mathew H MH; Kunath, Tilo T; Clarke, David J DJ
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
Npj Parkinson'S Disease
Ramalingam, Nagendran N; Jin, Shan-Xue SX; Moors, Tim E TE; Fonseca-Ornelas, Luis L; Shimanaka, Kazuma K; Lei, Shi S; Cam, Hugh P HP; Watson, Aurelia Hays AH; Brontesi, Lisa L; Ding, Lai L; Hacibaloglu, Dinc Yasat DY; Jiang, Haiyang H; Choi, Se Joon SJ; Kanter, Ellen E; Liu, Lei L; Bartels, Tim T; Nuber, Silke S; Sulzer, David D; Mosharov, Eugene V EV; Chen, Weisheng V WV; Li, Shaomin S; Selkoe, Dennis J DJ; Dettmer, Ulf U
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties.
The Journal Of Biological Chemistry
Dent, Sydney E SE; King, Dennisha P DP; Osterberg, Valerie R VR; Adams, Eleanor K EK; Mackiewicz, Marilyn R MR; Weissman, Tamily A TA; Unni, Vivek K VK
Phosphorylation of the aggregate-forming protein alpha-synuclein on serine-129 inhibits its DNA-bending properties.
The Journal Of Biological Chemistry
Dent, Sydney E SE; King, Dennisha P DP; Osterberg, Valerie R VR; Adams, Eleanor K EK; Mackiewicz, Marilyn R MR; Weissman, Tamily A TA; Unni, Vivek K VK
Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson's Disease.
Frontiers In Neuroscience
Gilmozzi, Valentina V; Gentile, Giovanna G; Castelo Rueda, Maria Paulina MP; Hicks, Andrew A AA; Pramstaller, Peter P PP; Zanon, Alessandra A; Lévesque, Martin M; Pichler, Irene I
Carboxy-terminal truncation and phosphorylation of α-synuclein elongates survival in a prion-like seeding mouse model of synucleinopathy.
Neuroscience Letters
Sorrentino, Zachary A ZA; Hass, Ethan E; Vijayaraghavan, Niran N; Gorion, Kimberly-Marie KM; Riffe, Cara J CJ; Dhillon, Jess-Karan S JS; Giasson, Benoit I BI
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles.
Frontiers In Neuroscience
Bernal-Conde, Luis D LD; Ramos-Acevedo, Rodrigo R; Reyes-Hernández, Mario A MA; Balbuena-Olvera, Andrea J AJ; Morales-Moreno, Ishbelt D ID; Argüero-Sánchez, Rubén R; Schüle, Birgitt B; Guerra-Crespo, Magdalena M
Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Grassi, Diego D; Howard, Shannon S; Zhou, Minghai M; Diaz-Perez, Natalia N; Urban, Nicolai T NT; Guerrero-Given, Debbie D; Kamasawa, Naomi N; Volpicelli-Daley, Laura A LA; LoGrasso, Philip P; Lasmézas, Corinne Ida CI
α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
Science Translational Medicine
Di Maio, Roberto R; Barrett, Paul J PJ; Hoffman, Eric K EK; Barrett, Caitlyn W CW; Zharikov, Alevtina A; Borah, Anupom A; Hu, Xiaoping X; McCoy, Jennifer J; Chu, Charleen T CT; Burton, Edward A EA; Hastings, Teresa G TG; Greenamyre, J Timothy JT
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Plos Genetics
Lázaro, Diana F DF; Rodrigues, Eva F EF; Langohr, Ramona R; Shahpasandzadeh, Hedieh H; Ribeiro, Thales T; Guerreiro, Patrícia P; Gerhardt, Ellen E; Kröhnert, Katharina K; Klucken, Jochen J; Pereira, Marcos D MD; Popova, Blagovesta B; Kruse, Niels N; Mollenhauer, Brit B; Rizzoli, Silvio O SO; Braus, Gerhard H GH; Danzer, Karin M KM; Outeiro, Tiago F TF
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
The Journal Of Biological Chemistry
Paleologou, Katerina E KE; Schmid, Adrian W AW; Rospigliosi, Carla C CC; Kim, Hai-Young HY; Lamberto, Gonzalo R GR; Fredenburg, Ross A RA; Lansbury, Peter T PT; Fernandez, Claudio O CO; Eliezer, David D; Zweckstetter, Markus M; Lashuel, Hilal A HA