The small GTPase Rit2 modulates LRRK2 kinase activity, is required for lysosomal function and protects against alpha-synuclein neuropathology.
Npj Parkinson'S Disease
Obergasteiger, Julia J; Castonguay, Anne-Marie AM; Pizzi, Sara S; Magnabosco, Stefano S; Frapporti, Giulia G; Lobbestael, Evy E; Baekelandt, Veerle V; Hicks, Andrew A AA; Pramstaller, Peter P PP; Gravel, Claude C; Corti, Corrado C; Lévesque, Martin M; Volta, Mattia M
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.
Npj Parkinson'S Disease
Ramalingam, Nagendran N; Jin, Shan-Xue SX; Moors, Tim E TE; Fonseca-Ornelas, Luis L; Shimanaka, Kazuma K; Lei, Shi S; Cam, Hugh P HP; Watson, Aurelia Hays AH; Brontesi, Lisa L; Ding, Lai L; Hacibaloglu, Dinc Yasat DY; Jiang, Haiyang H; Choi, Se Joon SJ; Kanter, Ellen E; Liu, Lei L; Bartels, Tim T; Nuber, Silke S; Sulzer, David D; Mosharov, Eugene V EV; Chen, Weisheng V WV; Li, Shaomin S; Selkoe, Dennis J DJ; Dettmer, Ulf U
α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ghanem, Simona S SS; Majbour, Nour K NK; Vaikath, Nishant N NN; Ardah, Mustafa T MT; Erskine, Daniel D; Jensen, Nanna Møller NM; Fayyad, Muneera M; Sudhakaran, Indulekha P IP; Vasili, Eftychia E; Melachroinou, Katerina K; Abdi, Ilham Y IY; Poggiolini, Ilaria I; Santos, Patricia P; Dorn, Anton A; Carloni, Paolo P; Vekrellis, Kostas K; Attems, Johannes J; McKeith, Ian I; Outeiro, Tiago F TF; Jensen, Poul Henning PH; El-Agnaf, Omar M A OMA
SCD Inhibition Protects from α-Synuclein-Induced Neurotoxicity But Is Toxic to Early Neuron Cultures.
Eneuro
Nicholatos, Justin W JW; Groot, Joost J; Dhokai, Shekhar S; Tran, David D; Hrdlicka, Lori L; Carlile, Thomas M TM; Bennion, Melissa M; Dalkilic-Liddle, Isin I; Hirst, Warren D WD; Weihofen, Andreas A
Multiple system atrophy-associated oligodendroglial protein p25α stimulates formation of novel α-synuclein strain with enhanced neurodegenerative potential.
Acta Neuropathologica
Ferreira, Nelson N; Gram, Hjalte H; Sorrentino, Zachary A ZA; Gregersen, Emil E; Schmidt, Sissel Ida SI; Reimer, Lasse L; Betzer, Cristine C; Perez-Gozalbo, Clara C; Beltoja, Marjo M; Nagaraj, Madhu M; Wang, Jie J; Nowak, Jan S JS; Dong, Mingdong M; Willén, Katarina K; Cholak, Ersoy E; Bjerregaard-Andersen, Kaare K; Mendez, Nicolas N; Rabadia, Prakruti P; Shahnawaz, Mohammad M; Soto, Claudio C; Otzen, Daniel E DE; Akbey, Ümit Ü; Meyer, Morten M; Giasson, Benoit I BI; Romero-Ramos, Marina M; Jensen, Poul Henning PH
Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage.
International Journal Of Molecular Sciences
Franco, Rafael R; Rivas-Santisteban, Rafael R; Navarro, Gemma G; Pinna, Annalisa A; Reyes-Resina, Irene I
Alpha-Synuclein Physiology and Pathology: A Perspective on Cellular Structures and Organelles.
Frontiers In Neuroscience
Bernal-Conde, Luis D LD; Ramos-Acevedo, Rodrigo R; Reyes-Hernández, Mario A MA; Balbuena-Olvera, Andrea J AJ; Morales-Moreno, Ishbelt D ID; Argüero-Sánchez, Rubén R; Schüle, Birgitt B; Guerra-Crespo, Magdalena M
Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders.
Scientific Reports
Schaser, Allison J AJ; Osterberg, Valerie R VR; Dent, Sydney E SE; Stackhouse, Teresa L TL; Wakeham, Colin M CM; Boutros, Sydney W SW; Weston, Leah J LJ; Owen, Nichole N; Weissman, Tamily A TA; Luna, Esteban E; Raber, Jacob J; Luk, Kelvin C KC; McCullough, Amanda K AK; Woltjer, Randall L RL; Unni, Vivek K VK
Evidence for bidirectional and trans-synaptic parasympathetic and sympathetic propagation of alpha-synuclein in rats.
Acta Neuropathologica
Van Den Berge, Nathalie N; Ferreira, Nelson N; Gram, Hjalte H; Mikkelsen, Trine Werenberg TW; Alstrup, Aage Kristian Olsen AKO; Casadei, Nicolas N; Tsung-Pin, Pai P; Riess, Olaf O; Nyengaard, Jens Randel JR; Tamgüney, Gültekin G; Jensen, Poul Henning PH; Borghammer, Per P
α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease.
The Embo Journal
Kang, Seong Su SS; Ahn, Eun Hee EH; Zhang, Zhentao Z; Liu, Xia X; Manfredsson, Fredric P FP; Sandoval, Ivette M IM; Dhakal, Susov S; Iuvone, P Michael PM; Cao, Xuebing X; Ye, Keqiang K
E46K α-synuclein pathological mutation causes cell-autonomous toxicity without altering protein turnover or aggregation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Íñigo-Marco, Ignacio I; Valencia, Miguel M; Larrea, Laura L; Bugallo, Ricardo R; Martínez-Goikoetxea, Mikel M; Zuriguel, Iker I; Arrasate, Montserrat M
α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kang, Seong Su SS; Zhang, Zhentao Z; Liu, Xia X; Manfredsson, Fredric P FP; He, Li L; Iuvone, P Michael PM; Cao, Xuebing X; Sun, Yi E YE; Jin, Lingjing L; Ye, Keqiang K
Nigral overexpression of alpha-synuclein in the absence of parkin enhances alpha-synuclein phosphorylation but does not modulate dopaminergic neurodegeneration.
Molecular Neurodegeneration
Van Rompuy, Anne-Sophie AS; Oliveras-Salvá, Marusela M; Van der Perren, Anke A; Corti, Olga O; Van den Haute, Chris C; Baekelandt, Veerle V
Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.
Plos Genetics
Lázaro, Diana F DF; Rodrigues, Eva F EF; Langohr, Ramona R; Shahpasandzadeh, Hedieh H; Ribeiro, Thales T; Guerreiro, Patrícia P; Gerhardt, Ellen E; Kröhnert, Katharina K; Klucken, Jochen J; Pereira, Marcos D MD; Popova, Blagovesta B; Kruse, Niels N; Mollenhauer, Brit B; Rizzoli, Silvio O SO; Braus, Gerhard H GH; Danzer, Karin M KM; Outeiro, Tiago F TF
DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.
Cell Death & Disease
Zondler, L L; Miller-Fleming, L L; Repici, M M; Gonçalves, S S; Tenreiro, S S; Rosado-Ramos, R R; Betzer, C C; Straatman, K R KR; Jensen, P H PH; Giorgini, F F; Outeiro, T F TF
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.
Human Molecular Genetics
Fares, Mohamed-Bilal MB; Ait-Bouziad, Nadine N; Dikiy, Igor I; Mbefo, Martial K MK; Jovičić, Ana A; Kiely, Aoife A; Holton, Janice L JL; Lee, Seung-Jae SJ; Gitler, Aaron D AD; Eliezer, David D; Lashuel, Hilal A HA
Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein-coupled receptor kinase-dependent manner.
Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
International Journal Of Molecular Sciences
Olivares, David D; Huang, Xudong X; Branden, Lars L; Greig, Nigel H NH; Rogers, Jack T JT
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
The Journal Of Biological Chemistry
Paleologou, Katerina E KE; Schmid, Adrian W AW; Rospigliosi, Carla C CC; Kim, Hai-Young HY; Lamberto, Gonzalo R GR; Fredenburg, Ross A RA; Lansbury, Peter T PT; Fernandez, Claudio O CO; Eliezer, David D; Zweckstetter, Markus M; Lashuel, Hilal A HA