Publications:

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Monitoring α-synuclein ubiquitination dynamics reveals key endosomal effectors mediating its trafficking and degradation.

Science Advances

Zenko, Dmitry D; Marsh, Jade J; Castle, Andrew R AR; Lewin, Rahel R; Fischer, Roman R; Tofaris, George K GK

Publication Date: 2023-06-16

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PubMed Link: 37315142

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• sciadv.add8910.pdf

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Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study.

Biomedicines

Albert, Katrina K; Kälvälä, Sara S; Hakosalo, Vili V; Syvänen, Valtteri V; Krupa, Patryk P; Niskanen, Jonna J; Peltonen, Sanni S; Sonninen, Tuuli-Maria TM; Lehtonen, Šárka Š

Publication Date: 2022-10-20

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PubMed Link: 36289910

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• biomedicines-10-02649.pdf

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Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.

Npj Parkinson'S Disease

Fonseca-Ornelas, Luis L; Stricker, Jonathan M S JMS; Soriano-Cruz, Stephanie S; Weykopf, Beatrice B; Dettmer, Ulf U; Muratore, Christina R CR; Scherzer, Clemens R CR; Selkoe, Dennis J DJ

Publication Date: 2022-09-16

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PubMed Link: 36114228

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• Main text
• 41531_2022_Article_380.pdf

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Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules

Tripathi, Arati A; Fanning, Saranna S; Dettmer, Ulf U

Publication Date: 2021-12-28

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PubMed Link: 35053188

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• biomolecules-12-00040.pdf

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Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules

Tripathi, Arati A; Fanning, Saranna S; Dettmer, Ulf U

Publication Date: 2021-12-28

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PubMed Link: 35053188

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• Main text
• biomolecules-12-00040.pdf

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Alpha-Synuclein and Lipids: The Elephant in the Room?

Cells

Sarchione, Alessia A; Marchand, Antoine A; Taymans, Jean-Marc JM; Chartier-Harlin, Marie-Christine MC

Publication Date: 2021-09-17

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PubMed Link: 34572099

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• cells-10-02452.pdf

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Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease.

Cell Reports

Fonseca-Ornelas, Luis L; Viennet, Thibault T; Rovere, Matteo M; Jiang, Haiyang H; Liu, Lei L; Nuber, Silke S; Ericsson, Maria M; Arthanari, Haribabu H; Selkoe, Dennis J DJ

Publication Date: 2021-07-06

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PubMed Link: 34233191

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• nihms-1747464.pdf

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A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.

Annals Of Neurology

Nuber, Silke S; Nam, Alice Y AY; Rajsombath, Molly M MM; Cirka, Haley H; Hronowski, Xiaoping X; Wang, Junmin J; Hodgetts, Kevin K; Kalinichenko, Liubov S LS; Müller, Christian P CP; Lambrecht, Vera V; Winkler, Jürgen J; Weihofen, Andreas A; Imberdis, Thibaut T; Dettmer, Ulf U; Fanning, Saranna S; Selkoe, Dennis J DJ

Publication Date: 2021-01

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PubMed Link: 32996158

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• ANA-89-74.pdf

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Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor.

International Journal Of Molecular Sciences

Terry-Kantor, Elizabeth E; Tripathi, Arati A; Imberdis, Thibaut T; LaVoie, Zachary M ZM; Ho, Gary P H GPH; Selkoe, Dennis D; Fanning, Saranna S; Ramalingam, Nagendran N; Dettmer, Ulf U

Publication Date: 2020-07-22

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PubMed Link: 32707907

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• ijms-21-05193.pdf

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Parkinson's disease: proteinopathy or lipidopathy?

Npj Parkinson'S Disease

Fanning, Saranna S; Selkoe, Dennis D; Dettmer, Ulf U

Publication Date: 2020

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PubMed Link: 31909184

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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Imberdis, Thibaut T; Negri, Joseph J; Ramalingam, Nagendran N; Terry-Kantor, Elizabeth E; Ho, Gary P H GPH; Fanning, Saranna S; Stirtz, Georgia G; Kim, Tae-Eun TE; Levy, Oren A OA; Young-Pearse, Tracy L TL; Selkoe, Dennis D; Dettmer, Ulf U

Publication Date: 2019-10-08

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PubMed Link: 31548371

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• pnas.201903216.pdf

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Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Neuron

Nuber, Silke S; Rajsombath, Molly M; Minakaki, Georgia G; Winkler, Jürgen J; Müller, Christian P CP; Ericsson, Maria M; Caldarone, Barbara B; Dettmer, Ulf U; Selkoe, Dennis J DJ

Publication Date: 2018-10-10

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PubMed Link: 30308173

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Cryo-EM structure of alpha-synuclein fibrils.

Elife

Guerrero-Ferreira, Ricardo R; Taylor, Nicholas Mi NM; Mona, Daniel D; Ringler, Philippe P; Lauer, Matthias E ME; Riek, Roland R; Britschgi, Markus M; Stahlberg, Henning H

Publication Date: 2018-07-03

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PubMed Link: 29969391

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• elife-36402.pdf

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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Human Molecular Genetics

Dettmer, Ulf U; Ramalingam, Nagendran N; von Saucken, Victoria E VE; Kim, Tae-Eun TE; Newman, Andrew J AJ; Terry-Kantor, Elizabeth E; Nuber, Silke S; Ericsson, Maria M; Fanning, Saranna S; Bartels, Tim T; Lindquist, Susan S; Levy, Oren A OA; Selkoe, Dennis D

Publication Date: 2017-09-15

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PubMed Link: 28911198

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