Publications:

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Cellular Models of Alpha-Synuclein Aggregation: What Have We Learned and Implications for Future Study.

Biomedicines

Albert, Katrina K; Kälvälä, Sara S; Hakosalo, Vili V; Syvänen, Valtteri V; Krupa, Patryk P; Niskanen, Jonna J; Peltonen, Sanni S; Sonninen, Tuuli-Maria TM; Lehtonen, Šárka Š

Publication Date: 2022-10-20

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PubMed Link: 36289910

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• biomedicines-10-02649.pdf

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Association of Glial Activation and α-Synuclein Pathology in Parkinson's Disease.

Neuroscience Bulletin

Wang, Rui R; Ren, Haigang H; Kaznacheyeva, Elena E; Lu, Xiaojun X; Wang, Guanghui G

Publication Date: 2022-10-14

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PubMed Link: 36229715

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• 12264_2022_Article_957.pdf

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Propagation of Parkinson's disease by extracellular vesicle production and secretion.

Biochemical Society Transactions

Shippey, Laura E LE; Campbell, Susan G SG; Hill, Andrew F AF; Smith, David P DP

Publication Date: 2022-10-31

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PubMed Link: 36111783

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• BST-50-1303.pdf

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Oligomeropathies, inflammation and prion protein binding.

Frontiers In Neuroscience

Forloni, Gianluigi G; La Vitola, Pietro P; Balducci, Claudia C

Publication Date: 2022

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PubMed Link: 36081661

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Single Molecule Fingerprinting Reveals Different Amplification Properties of α-Synuclein Oligomers and Preformed Fibrils in Seeding Assay.

Acs Chemical Neuroscience

Lau, Derrick D; Magnan, Chloé C; Hill, Kathryn K; Cooper, Antony A; Gambin, Yann Y; Sierecki, Emma E

Publication Date: 2022-04-06

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PubMed Link: 35286811

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Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.

Cells

Heger, Leonie M LM; Wise, Rachel M RM; Hees, J Tabitha JT; Harbauer, Angelika B AB; Burbulla, Lena F LF

Publication Date: 2021-12-07

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PubMed Link: 34943944

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• cells-10-03436.pdf

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The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses.

International Journal Of Molecular Sciences

Jan, Asad A; Gonçalves, Nádia Pereira NP; Vaegter, Christian Bjerggaard CB; Jensen, Poul Henning PH; Ferreira, Nelson N

Publication Date: 2021-08-03

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PubMed Link: 34361100

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• ijms-22-08338.pdf

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α-synuclein pathogenesis in hiPSC models of Parkinson's disease.

Neuronal Signaling

Baena-Montes, Jara M JM; Avazzadeh, Sahar S; Quinlan, Leo R LR

Publication Date: 2021-06

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PubMed Link: 34239711

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• ns-05-ns20210021.pdf

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Comprehensive Perspectives on Experimental Models for Parkinson's Disease.

Aging And Disease

Ke, Minjing M; Chong, Cheong-Meng CM; Zhu, Qi Q; Zhang, Ke K; Cai, Cui-Zan CZ; Lu, Jia-Hong JH; Qin, Dajiang D; Su, Huanxing H

Publication Date: 2021-02

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PubMed Link: 33532138

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Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders.

Molecular Psychiatry

de Rus Jacquet, Aurélie A; Denis, Hélèna L HL; Cicchetti, Francesca F; Alpaugh, Melanie M

Publication Date: 2021-07

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PubMed Link: 33495544

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Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration.

Frontiers In Cell And Developmental Biology

Regensburger, Martin M; Stemick, Judith J; Masliah, Eliezer E; Kohl, Zacharias Z; Winner, Beate B

Publication Date: 2020

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PubMed Link: 33262984

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• fcell-08-561963.pdf

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The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders.

International Journal Of Molecular Sciences

Morato Torres, C Alejandra CA; Wassouf, Zinah Z; Zafar, Faria F; Sastre, Danuta D; Outeiro, Tiago Fleming TF; Schüle, Birgitt B

Publication Date: 2020-08-10

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PubMed Link: 32785033

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Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease.

Aging Cell

Mao, Kanmin K; Chen, Jialong J; Yu, Honglin H; Li, Huihui H; Ren, Yixian Y; Wu, Xian X; Wen, Yue Y; Zou, Fei F; Li, Wenjun W

Publication Date: 2020-06

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PubMed Link: 32475059

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• ACEL-19-e13163.pdf

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Modeling Parkinson's Disease With the Alpha-Synuclein Protein.

Frontiers In Pharmacology

Gómez-Benito, Mónica M; Granado, Noelia N; García-Sanz, Patricia P; Michel, Anne A; Dumoulin, Mireille M; Moratalla, Rosario R

Publication Date: 2020

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PubMed Link: 32390826

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• fphar-11-00356.pdf

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Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery.

Expert Opinion On Drug Discovery

Marotta, Nick N; Kim, Soojin S; Krainc, Dimitri D

Publication Date: 2020-04

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PubMed Link: 31899983

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Alpha-synuclein structure and Parkinson's disease - lessons and emerging principles.

Molecular Neurodegeneration

Meade, Richard M RM; Fairlie, David P DP; Mason, Jody M JM

Publication Date: 2019-07-22

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PubMed Link: 31331359

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• 13024_2019_Article_329.pdf

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New Perspectives on Roles of Alpha-Synuclein in Parkinson's Disease.

Frontiers In Aging Neuroscience

Zhang, Guoxin G; Xia, Yun Y; Wan, Fang F; Ma, Kai K; Guo, Xingfang X; Kou, Liang L; Yin, Sijia S; Han, Chao C; Liu, Ling L; Huang, Jinsha J; Xiong, Nian N; Wang, Tao T

Publication Date: 2018

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PubMed Link: 30524265

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• fnagi-10-00370.pdf

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α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Prots, Iryna I; Grosch, Janina J; Brazdis, Razvan-Marius RM; Simmnacher, Katrin K; Veber, Vanesa V; Havlicek, Steven S; Hannappel, Christian C; Krach, Florian F; Krumbiegel, Mandy M; Schütz, Oliver O; Reis, André A; Wrasidlo, Wolfgang W; Galasko, Douglas R DR; Groemer, Teja W TW; Masliah, Eliezer E; Schlötzer-Schrehardt, Ursula U; Xiang, Wei W; Winkler, Jürgen J; Winner, Beate B

Publication Date: 2018-07-24

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PubMed Link: 29991596

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• pnas.201713129.pdf

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Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Human Molecular Genetics

Dettmer, Ulf U; Ramalingam, Nagendran N; von Saucken, Victoria E VE; Kim, Tae-Eun TE; Newman, Andrew J AJ; Terry-Kantor, Elizabeth E; Nuber, Silke S; Ericsson, Maria M; Fanning, Saranna S; Bartels, Tim T; Lindquist, Susan S; Levy, Oren A OA; Selkoe, Dennis D

Publication Date: 2017-09-15

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PubMed Link: 28911198

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Alpha-synuclein oligomers: a new hope.

Acta Neuropathologica

Bengoa-Vergniory, Nora N; Roberts, Rosalind F RF; Wade-Martins, Richard R; Alegre-Abarrategui, Javier J

Publication Date: 2017-12

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PubMed Link: 28803412

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• 401_2017_Article_1755.pdf

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A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.

Brain : A Journal Of Neurology

Wrasidlo, Wolfgang W; Tsigelny, Igor F IF; Price, Diana L DL; Dutta, Garima G; Rockenstein, Edward E; Schwarz, Thomas C TC; Ledolter, Karin K; Bonhaus, Douglas D; Paulino, Amy A; Eleuteri, Simona S; Skjevik, Åge A ÅA; Kouznetsova, Valentina L VL; Spencer, Brian B; Desplats, Paula P; Gonzalez-Ruelas, Tania T; Trejo-Morales, Margarita M; Overk, Cassia R CR; Winter, Stefan S; Zhu, Chunni C; Chesselet, Marie-Francoise MF; Meier, Dieter D; Moessler, Herbert H; Konrat, Robert R; Masliah, Eliezer E

Publication Date: 2016-12

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PubMed Link: 27679481

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Alpha-Synuclein Oligomers-Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders.

Frontiers In Neuroscience

Ingelsson, Martin M

Publication Date: 2016

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PubMed Link: 27656123

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• fnins-10-00408.pdf

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The associations between Parkinson's disease and cancer: the plot thickens.

Translational Neurodegeneration

Feng, Danielle D DD; Cai, Waijiao W; Chen, Xiqun X

Publication Date: 2015

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PubMed Link: 26504519

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• 40035_2015_Article_43.pdf

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Effects of impaired membrane interactions on α-synuclein aggregation and neurotoxicity.

Neurobiology Of Disease

Ysselstein, Daniel D; Joshi, Mehul M; Mishra, Vartika V; Griggs, Amy M AM; Asiago, Josephat M JM; McCabe, George P GP; Stanciu, Lia A LA; Post, Carol Beth CB; Rochet, Jean-Christophe JC

Publication Date: 2015-07

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PubMed Link: 25931201

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Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Plos Genetics

Lázaro, Diana F DF; Rodrigues, Eva F EF; Langohr, Ramona R; Shahpasandzadeh, Hedieh H; Ribeiro, Thales T; Guerreiro, Patrícia P; Gerhardt, Ellen E; Kröhnert, Katharina K; Klucken, Jochen J; Pereira, Marcos D MD; Popova, Blagovesta B; Kruse, Niels N; Mollenhauer, Brit B; Rizzoli, Silvio O SO; Braus, Gerhard H GH; Danzer, Karin M KM; Outeiro, Tiago F TF

Publication Date: 2014-11

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PubMed Link: 25393002

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• pgen.1004741.pdf

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The many faces of α-synuclein: from structure and toxicity to therapeutic target.

Nature Reviews. Neuroscience

Lashuel, Hilal A HA; Overk, Cassia R CR; Oueslati, Abid A; Masliah, Eliezer E

Publication Date: 2013-01

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PubMed Link: 23254192

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α-Synuclein oligomers and clinical implications for Parkinson disease.

Annals Of Neurology

Kalia, Lorraine V LV; Kalia, Suneil K SK; McLean, Pamela J PJ; Lozano, Andres M AM; Lang, Anthony E AE

Publication Date: 2013-02

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PubMed Link: 23225525

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