Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.
Npj Parkinson'S Disease
Patterson, Joseph R JR; Hirst, Warren D WD; Howe, Jacob W JW; Russell, Christopher P CP; Cole-Strauss, Allyson A; Kemp, Christopher J CJ; Duffy, Megan F MF; Lamp, Jared J; Umstead, Andrew A; Kubik, Michael M; Stoll, Anna C AC; Vega, Irving E IE; Steece-Collier, Kathy K; Chen, Yi Y; Campbell, Anne C AC; Nezich, Catherine L CL; Glajch, Kelly E KE; Sortwell, Caryl E CE
Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.
Acta Neuropathologica
Tarutani, Airi A; Adachi, Tadashi T; Akatsu, Hiroyasu H; Hashizume, Yoshio Y; Hasegawa, Kazuko K; Saito, Yuko Y; Robinson, Andrew C AC; Mann, David M A DMA; Yoshida, Mari M; Murayama, Shigeo S; Hasegawa, Masato M
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Science Advances
Kumar, Senthil T ST; Mahul-Mellier, Anne-Laure AL; Hegde, Ramanath Narayana RN; Rivière, Gwladys G; Moons, Rani R; Ibáñez de Opakua, Alain A; Magalhães, Pedro P; Rostami, Iman I; Donzelli, Sonia S; Sobott, Frank F; Zweckstetter, Markus M; Lashuel, Hilal A HA
APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.
Acta Neuropathologica
Jin, Yunjung Y; Li, Fuyao F; Sonoustoun, Berkiye B; Kondru, Naveen Chandra NC; Martens, Yuka A YA; Qiao, Wenhui W; Heckman, Michael G MG; Ikezu, Tadafumi C TC; Li, Zonghua Z; Burgess, Jeremy D JD; Amerna, Danilyn D; O'Leary, Justin J; DeTure, Michael A MA; Zhao, Jing J; McLean, Pamela J PJ; Dickson, Dennis W DW; Ross, Owen A OA; Bu, Guojun G; Zhao, Na N
Sensitive immunosensing of α-synuclein protein in human plasma samples using gold nanoparticles conjugated with graphene: an innovative immuno-platform towards early stage identification of Parkinson's disease using point of care (POC) analysis.
Rsc Advances
Aminabad, Esmaeil Darvish ED; Mobed, Ahmad A; Hasanzadeh, Mohammad M; Hosseinpour Feizi, Mohammad Ali MA; Safaralizadeh, Reza R; Seidi, Farzad F
The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.
Disease Models & Mechanisms
Polinski, Nicole K NK; Martinez, Terina N TN; Ramboz, Sylvie S; Sasner, Michael M; Herberth, Mark M; Switzer, Robert R; Ahmad, Syed O SO; Pelligrino, Lee J LJ; Clark, Sean W SW; Marcus, Jacob N JN; Smith, Sean M SM; Dave, Kuldip D KD; Frasier, Mark A MA
Defects of Nutrient Signaling and Autophagy in Neurodegeneration.
Frontiers In Cell And Developmental Biology
Ondaro, Jon J; Hernandez-Eguiazu, Haizea H; Garciandia-Arcelus, Maddi M; Loera-Valencia, Raúl R; Rodriguez-Gómez, Laura L; Jiménez-Zúñiga, Andrés A; Goikolea, Julen J; Rodriguez-Rodriguez, Patricia P; Ruiz-Martinez, Javier J; Moreno, Fermín F; Lopez de Munain, Adolfo A; Holt, Ian James IJ; Gil-Bea, Francisco Javier FJ; Gereñu, Gorka G
Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.
Biomolecules
Braczynski, Anne K AK; Sevenich, Marc M; Gering, Ian I; Kupreichyk, Tatsiana T; Agerschou, Emil D ED; Kronimus, Yannick Y; Habib, Pardes P; Stoldt, Matthias M; Willbold, Dieter D; Schulz, Jörg B JB; Bach, Jan-Philipp JP; Falkenburger, Björn H BH; Hoyer, Wolfgang W
HDL Accessory Proteins in Parkinson's Disease-Focusing on Clusterin (Apolipoprotein J) in Regard to Its Involvement in Pathology and Diagnostics-A Review.
Antioxidants (Basel, Switzerland)
Berdowska, Izabela I; Matusiewicz, Małgorzata M; Krzystek-Korpacka, Małgorzata M
Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Azevedo, Carla C; Teku, Gabriel G; Pomeshchik, Yuriy Y; Reyes, Juan F JF; Chumarina, Margarita M; Russ, Kaspar K; Savchenko, Ekaterina E; Hammarberg, Anna A; Lamas, Nuno Jorge NJ; Collin, Anna A; Gouras, Gunnar K GK; Klementieva, Oxana O; Hallbeck, Martin M; Taipa, Ricardo R; Vihinen, Mauno M; Roybon, Laurent L
The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.
Molecules (Basel, Switzerland)
Xu, Catherine K CK; Castellana-Cruz, Marta M; Chen, Serene W SW; Du, Zhen Z; Meisl, Georg G; Levin, Aviad A; Mannini, Benedetta B; Itzhaki, Laura S LS; Knowles, Tuomas P J TPJ; Dobson, Christopher M CM; Cremades, Nunilo N; Kumita, Janet R JR
Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.
Scientific Reports
Torres-Garcia, Laura L; P Domingues, Joana M JM; Brandi, Edoardo E; Haikal, Caroline C; Mudannayake, Janitha M JM; Brás, Inês C IC; Gerhardt, Ellen E; Li, Wen W; Svanbergsson, Alexander A; Outeiro, Tiago F TF; Gouras, Gunnar K GK; Li, Jia-Yi JY
High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease.
Npj Parkinson'S Disease
Antoniou, Nasia N; Prodromidou, Kanella K; Kouroupi, Georgia G; Boumpoureka, Ioanna I; Samiotaki, Martina M; Panayotou, George G; Xilouri, Maria M; Kloukina, Ismini I; Stefanis, Leonidas L; Grailhe, Regis R; Taoufik, Era E; Matsas, Rebecca R
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathologica
de Boni, Laura L; Watson, Aurelia Hays AH; Zaccagnini, Ludovica L; Wallis, Amber A; Zhelcheska, Kristina K; Kim, Nora N; Sanderson, John J; Jiang, Haiyang H; Martin, Elodie E; Cantlon, Adam A; Rovere, Matteo M; Liu, Lei L; Sylvester, Marc M; Lashley, Tammaryn T; Dettmer, Ulf U; Jaunmuktane, Zane Z; Bartels, Tim T
Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ayers, Jacob I JI; Lee, Joanne J; Monteiro, Octovia O; Woerman, Amanda L AL; Lazar, Ann A AA; Condello, Carlo C; Paras, Nick A NA; Prusiner, Stanley B SB
Menšíková, Kateřina K; Matěj, Radoslav R; Colosimo, Carlo C; Rosales, Raymond R; Tučková, Lucie L; Ehrmann, Jiří J; Hraboš, Dominik D; Kolaříková, Kristýna K; Vodička, Radek R; Vrtěl, Radek R; Procházka, Martin M; Nevrlý, Martin M; Kaiserová, Michaela M; Kurčová, Sandra S; Otruba, Pavel P; Kaňovský, Petr P