Variant ID: 4-90749300-C-T

NM_000345.3(SNCA):c.157G>A;(p.A53T)

This variant was identified in 1251 publications

View GRCh38 version.




Publications:


Pathological Role of Natural Killer Cells in Parkinson's Disease: A Systematic Review.

Frontiers In Aging Neuroscience
Zhang, Le L; Zhang, Yingshuang Y; Fan, Dongsheng D
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35663564
Variant Present in the following documents:
  • Main text
View BVdb publication page



From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases.

Neural Regeneration Research
Wakhloo, Debia D; Oberhauser, Jane J; Madira, Angela A; Mahajani, Sameehan S
Publication Date: 2022-12

Variant appearance in text: SNCA: A53T
PubMed Link: 35662189
Variant Present in the following documents:
  • Main text
  • NRR-17-2606.pdf
View BVdb publication page



Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Npj Parkinson'S Disease
Choudhury, Saptamita Paul SP; Bano, Sarika S; Sen, Srijon S; Suchal, Kapil K; Kumar, Saroj S; Nikolajeff, Fredrik F; Dey, Sanjay Kumar SK; Sharma, Vaibhav V
Publication Date: 2022-06-01

Variant appearance in text: SNCA: A53T
PubMed Link: 35650269
Variant Present in the following documents:
  • Main text
  • 41531_2022_Article_324.pdf
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Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases.

Journal Of Personalized Medicine
Gentile, Giulia G; Morello, Giovanna G; La Cognata, Valentina V; Guarnaccia, Maria M; Conforti, Francesca Luisa FL; Cavallaro, Sebastiano S
Publication Date: 2022-05-10

Variant appearance in text: SNCA: A53T
PubMed Link: 35629192
Variant Present in the following documents:
  • jpm-12-00770.pdf
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A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo.

Genes
Lopez, Ana A; Gorb, Alena A; Palha, Nuno N; Fleming, Angeleen A; Rubinsztein, David C DC
Publication Date: 2022-05-12

Variant appearance in text: SNCA: A53T
PubMed Link: 35627253
Variant Present in the following documents:
  • Main text
  • genes-13-00868.pdf
View BVdb publication page



TGF-β as a Key Modulator of Astrocyte Reactivity: Disease Relevance and Therapeutic Implications.

Biomedicines
Luo, Jian J
Publication Date: 2022-05-23

Variant appearance in text: SNCA: A53T
PubMed Link: 35625943
Variant Present in the following documents:
  • Main text
  • biomedicines-10-01206.pdf
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Adeno-Associated Viruses for Modeling Neurological Diseases in Animals: Achievements and Prospects.

Biomedicines
Lunev, Evgenii E; Karan, Anna A; Egorova, Tatiana T; Bardina, Maryana M
Publication Date: 2022-05-15

Variant appearance in text: SNCA: A53T
PubMed Link: 35625877
Variant Present in the following documents:
  • Main text
  • biomedicines-10-01140.pdf
View BVdb publication page



Extracellular Alpha-Synuclein: Mechanisms for Glial Cell Internalization and Activation.

Biomolecules
Chavarría, Cecilia C; Ivagnes, Rodrigo R; Souza, José M JM
Publication Date: 2022-04-30

Variant appearance in text: SNCA: A53T
PubMed Link: 35625583
Variant Present in the following documents:
  • Main text
View BVdb publication page



Comparative Analysis of the Relative Fragmentation Stabilities of Polymorphic Alpha-Synuclein Amyloid Fibrils.

Biomolecules
Sanami, Sarina S; Purton, Tracey J TJ; Smith, David P DP; Tuite, Mick F MF; Xue, Wei-Feng WF
Publication Date: 2022-04-25

Variant appearance in text: SNCA: A53T
PubMed Link: 35625557
Variant Present in the following documents:
  • Main text
  • biomolecules-12-00630.pdf
View BVdb publication page



Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.

Frontiers In Neurology
Menon, Sindhu S; Armstrong, Sabrina S; Hamzeh, Amir A; Visanji, Naomi P NP; Sardi, Sergio Pablo SP; Tandon, Anurag A
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35614915
Variant Present in the following documents:
  • Main text
  • fneur-13-852003.pdf
View BVdb publication page



Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.

Npj Parkinson'S Disease
Patterson, Joseph R JR; Hirst, Warren D WD; Howe, Jacob W JW; Russell, Christopher P CP; Cole-Strauss, Allyson A; Kemp, Christopher J CJ; Duffy, Megan F MF; Lamp, Jared J; Umstead, Andrew A; Kubik, Michael M; Stoll, Anna C AC; Vega, Irving E IE; Steece-Collier, Kathy K; Chen, Yi Y; Campbell, Anne C AC; Nezich, Catherine L CL; Glajch, Kelly E KE; Sortwell, Caryl E CE
Publication Date: 2022-05-24

Variant appearance in text: SNCA: A53T
PubMed Link: 35610264
Variant Present in the following documents:
  • 41531_2022_Article_322.pdf
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Aerobic Exercise Improves Methamphetamine-Induced Olfactory Dysfunction Through α-Synuclein Intervention in Male Mice.

Frontiers In Molecular Neuroscience
Wang, Zhuo Z; Zheng, Rui R; Wang, Xiaohan X; Huang, Xuekun X; Huang, Jian J; Gu, Cihang C; He, Yitong Y; Wu, Shuo S; Chen, Jingyuan J; Yang, Qintai Q; Qiu, Pingming P
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35586307
Variant Present in the following documents:
  • fnmol-15-884790.pdf
View BVdb publication page



The Role of Extracellular Matrix Components in the Spreading of Pathological Protein Aggregates.

Frontiers In Cellular Neuroscience
Moretto, Edoardo E; Stuart, Skye S; Surana, Sunaina S; Vargas, Jose Norberto S JNS; Schiavo, Giampietro G
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35573838
Variant Present in the following documents:
  • fncel-16-844211.pdf
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Toward Novel [18F]Fluorine-Labeled Radiotracers for the Imaging of α-Synuclein Fibrils.

Frontiers In Aging Neuroscience
Uzuegbunam, Bright C BC; Li, Junhao J; Paslawski, Wojciech W; Weber, Wolfgang W; Svenningsson, Per P; Ågren, Hans H; Yousefi, Behrooz Hooshyar BH
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35572127
Variant Present in the following documents:
  • fnagi-14-830704.pdf
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An Early Disturbance in Serotonergic Neurotransmission Contributes to the Onset of Parkinsonian Phenotypes in Drosophila melanogaster.

Cells
Zárate, Rafaella V RV; Hidalgo, Sergio S; Navarro, Nicole N; Molina-Mateo, Daniela D; Arancibia, Duxan D; Rojo-Cortés, Francisca F; Oliva, Carlos C; Andrés, María Estela ME; Zamorano, Pedro P; Campusano, Jorge M JM
Publication Date: 2022-05-05

Variant appearance in text: SNCA: A53T
PubMed Link: 35563850
Variant Present in the following documents:
  • cells-11-01544.pdf
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Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson's Disease.

Frontiers In Neuroscience
Miller, Sean J SJ; Campbell, Cameron E CE; Jimenez-Corea, Helen A HA; Wu, Guan-Hui GH; Logan, Robert R
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35516803
Variant Present in the following documents:
  • fnins-16-824191.pdf
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Animal Models of Neurodegenerative Disease: Recent Advances in Fly Highlight Innovative Approaches to Drug Discovery.

Frontiers In Molecular Neuroscience
Tello, Judith A JA; Williams, Haley E HE; Eppler, Robert M RM; Steinhilb, Michelle L ML; Khanna, May M
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35514431
Variant Present in the following documents:
  • fnmol-15-883358.pdf
View BVdb publication page



Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Acta Neuropathologica
Tarutani, Airi A; Adachi, Tadashi T; Akatsu, Hiroyasu H; Hashizume, Yoshio Y; Hasegawa, Kazuko K; Saito, Yuko Y; Robinson, Andrew C AC; Mann, David M A DMA; Yoshida, Mari M; Murayama, Shigeo S; Hasegawa, Masato M
Publication Date: 2022-05-05

Variant appearance in text: SNCA: A53T
PubMed Link: 35513543
Variant Present in the following documents:
  • 401_2022_Article_2426.pdf
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Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson's Disease.

Frontiers In Cellular Neuroscience
Xu, Jianjun J; Minobe, Etsuko E; Kameyama, Masaki M
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35496903
Variant Present in the following documents:
  • fncel-16-867385.pdf
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A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.

Science Advances
Kumar, Senthil T ST; Mahul-Mellier, Anne-Laure AL; Hegde, Ramanath Narayana RN; Rivière, Gwladys G; Moons, Rani R; Ibáñez de Opakua, Alain A; Magalhães, Pedro P; Rostami, Iman I; Donzelli, Sonia S; Sobott, Frank F; Zweckstetter, Markus M; Lashuel, Hilal A HA
Publication Date: 2022-04-29

Variant appearance in text: SNCA: A53T
PubMed Link: 35486726
Variant Present in the following documents:
  • sciadv.abn0044.pdf
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Mechanisms of enhanced aggregation and fibril formation of Parkinson's disease-related variants of α-synuclein.

Scientific Reports
Ohgita, Takashi T; Namba, Norihiro N; Kono, Hiroki H; Shimanouchi, Toshinori T; Saito, Hiroyuki H
Publication Date: 2022-04-26

Variant appearance in text: SNCA: A53T
PubMed Link: 35474118
Variant Present in the following documents:
  • 41598_2022_Article_10789.pdf
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APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology.

Acta Neuropathologica
Jin, Yunjung Y; Li, Fuyao F; Sonoustoun, Berkiye B; Kondru, Naveen Chandra NC; Martens, Yuka A YA; Qiao, Wenhui W; Heckman, Michael G MG; Ikezu, Tadafumi C TC; Li, Zonghua Z; Burgess, Jeremy D JD; Amerna, Danilyn D; O'Leary, Justin J; DeTure, Michael A MA; Zhao, Jing J; McLean, Pamela J PJ; Dickson, Dennis W DW; Ross, Owen A OA; Bu, Guojun G; Zhao, Na N
Publication Date: 2022-04-26

Variant appearance in text: SNCA: A53T
PubMed Link: 35471463
Variant Present in the following documents:
  • 401_2022_Article_2421.pdf
View BVdb publication page



Lipid level alteration in human and cellular models of alpha synuclein mutations.

Npj Parkinson'S Disease
Avisar, Hila H; Guardia-Laguarta, Cristina C; Surface, Matthew M; Papagiannakis, Nikos N; Maniati, Matina M; Antonellou, Roubina R; Papadimitriou, Dimitra D; Koros, Christos C; Athanassiadou, Aglaia A; Przedborski, Serge S; Lerner, Boaz B; Stefanis, Leonidas L; Area-Gomez, Estela E; Alcalay, Roy N RN
Publication Date: 2022-04-25

Variant appearance in text: SNCA: A53T
PubMed Link: 35468903
Variant Present in the following documents:
  • 41531_2022_Article_313.pdf
View BVdb publication page



Editorial: Genetic and Epigenetic Mechanisms of Parkinson's Disease.

Frontiers In Neuroscience
Li, Song S; Le, Weidong W; Deng, Hao H
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35464312
Variant Present in the following documents:
  • fnins-16-842709.pdf
View BVdb publication page



Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease.

Npj Parkinson'S Disease
Chalazonitis, Alcmène A; Rao, Meenakshi M; Sulzer, David D
Publication Date: 2022-04-22

Variant appearance in text: SNCA: A53T
PubMed Link: 35459867
Variant Present in the following documents:
  • 41531_2022_Article_308.pdf
View BVdb publication page



Biomarker of Neuroinflammation in Parkinson's Disease.

International Journal Of Molecular Sciences
Liu, Tsai-Wei TW; Chen, Chiung-Mei CM; Chang, Kuo-Hsuan KH
Publication Date: 2022-04-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35456966
Variant Present in the following documents:
  • ijms-23-04148.pdf
View BVdb publication page



Circular RNAs: Emblematic Players of Neurogenesis and Neurodegeneration.

International Journal Of Molecular Sciences
D'Anca, Marianna M; Buccellato, Francesca R FR; Fenoglio, Chiara C; Galimberti, Daniela D
Publication Date: 2022-04-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35456950
Variant Present in the following documents:
  • ijms-23-04134.pdf
View BVdb publication page



GBA Variants and Parkinson Disease: Mechanisms and Treatments.

Cells
Smith, Laura L; Schapira, Anthony H V AHV
Publication Date: 2022-04-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35455941
Variant Present in the following documents:
  • cells-11-01261.pdf
View BVdb publication page



α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword.

Biomolecules
Tan, Li Yang LY; Tang, Kwan Hou KH; Lim, Lynette Yu You LYY; Ong, Jia Xin JX; Park, Hyokeun H; Jung, Sangyong S
Publication Date: 2022-03-27

Variant appearance in text: PARK1: A53T
PubMed Link: 35454096
Variant Present in the following documents:
  • biomolecules-12-00507.pdf
View BVdb publication page



α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear.

Biomolecules
De Giorgi, Francesca F; Uversky, Vladimir N VN; Ichas, François F
Publication Date: 2022-03-24

Variant appearance in text: NACP: A53T
PubMed Link: 35454083
Variant Present in the following documents:
  • biomolecules-12-00494.pdf
View BVdb publication page



Redefining the hypotheses driving Parkinson's diseases research.

Npj Parkinson'S Disease
Farrow, Sophie L SL; Cooper, Antony A AA; O'Sullivan, Justin M JM
Publication Date: 2022-04-19

Variant appearance in text: SNCA: A53T
PubMed Link: 35440633
Variant Present in the following documents:
  • 41531_2022_Article_307.pdf
View BVdb publication page



idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R.

Plos One
McFadden, William M WM; Yanowitz, Judith L JL
Publication Date: 2022

Variant appearance in text: NACP: A53T
PubMed Link: 35436286
Variant Present in the following documents:
  • pone.0266929.pdf
View BVdb publication page



Proteomics Challenges for the Assessment of Synuclein Proteoforms as Clinical Biomarkers in Parkinson's Disease.

Frontiers In Aging Neuroscience
Pons, Marie-Laure ML; Loftus, Neil N; Vialaret, Jerome J; Moreau, Stephane S; Lehmann, Sylvain S; Hirtz, Christophe C
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35431896
Variant Present in the following documents:
  • fnagi-14-818606.pdf
View BVdb publication page



Sensitive immunosensing of α-synuclein protein in human plasma samples using gold nanoparticles conjugated with graphene: an innovative immuno-platform towards early stage identification of Parkinson's disease using point of care (POC) analysis.

Rsc Advances
Aminabad, Esmaeil Darvish ED; Mobed, Ahmad A; Hasanzadeh, Mohammad M; Hosseinpour Feizi, Mohammad Ali MA; Safaralizadeh, Reza R; Seidi, Farzad F
Publication Date: 2022-01-28

Variant appearance in text: SNCA: A53T
PubMed Link: 35425437
Variant Present in the following documents:
  • RA-012-D1RA06437A.pdf
View BVdb publication page



The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.

Disease Models & Mechanisms
Polinski, Nicole K NK; Martinez, Terina N TN; Ramboz, Sylvie S; Sasner, Michael M; Herberth, Mark M; Switzer, Robert R; Ahmad, Syed O SO; Pelligrino, Lee J LJ; Clark, Sean W SW; Marcus, Jacob N JN; Smith, Sean M SM; Dave, Kuldip D KD; Frasier, Mark A MA
Publication Date: 2022-04-14

Variant appearance in text: SNCA: A53T
PubMed Link: 35419585
Variant Present in the following documents:
  • Main text
View BVdb publication page



Defects of Nutrient Signaling and Autophagy in Neurodegeneration.

Frontiers In Cell And Developmental Biology
Ondaro, Jon J; Hernandez-Eguiazu, Haizea H; Garciandia-Arcelus, Maddi M; Loera-Valencia, Raúl R; Rodriguez-Gómez, Laura L; Jiménez-Zúñiga, Andrés A; Goikolea, Julen J; Rodriguez-Rodriguez, Patricia P; Ruiz-Martinez, Javier J; Moreno, Fermín F; Lopez de Munain, Adolfo A; Holt, Ian James IJ; Gil-Bea, Francisco Javier FJ; Gereñu, Gorka G
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35419363
Variant Present in the following documents:
  • fcell-10-836196.pdf
View BVdb publication page



Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson's Disease.

International Journal Of Molecular Sciences
Rakowski, Michał M; Porębski, Szymon S; Grzelak, Agnieszka A
Publication Date: 2022-03-26

Variant appearance in text: SNCA: A53T
PubMed Link: 35408992
Variant Present in the following documents:
  • ijms-23-03625.pdf
View BVdb publication page



Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?

International Journal Of Molecular Sciences
Magistrelli, Luca L; Contaldi, Elena E; Vignaroli, Francesca F; Gallo, Silvia S; Colombatto, Federico F; Cantello, Roberto R; Comi, Cristoforo C
Publication Date: 2022-03-23

Variant appearance in text: SNCA: A53T
PubMed Link: 35408836
Variant Present in the following documents:
  • ijms-23-03476.pdf
View BVdb publication page



Glucocerebrosidase Mutations Cause Mitochondrial and Lysosomal Dysfunction in Parkinson's Disease: Pathogenesis and Therapeutic Implications.

Frontiers In Aging Neuroscience
Zheng, Wei W; Fan, Dongsheng D
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35401150
Variant Present in the following documents:
  • fnagi-14-851135.pdf
View BVdb publication page



Genetic heterogeneity on sleep disorders in Parkinson's disease: a systematic review and meta-analysis.

Translational Neurodegeneration
Huang, Jingxuan J; Cheng, Yangfan Y; Li, Chunyu C; Shang, Huifang H
Publication Date: 2022-04-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35395825
Variant Present in the following documents:
  • 40035_2022_Article_294.pdf
View BVdb publication page



Emerging Potential of Exosomal Non-coding RNA in Parkinson's Disease: A Review.

Frontiers In Aging Neuroscience
Zhang, Peng P; Rasheed, Madiha M; Liang, Junhan J; Wang, Chaolei C; Feng, Lin L; Chen, Zixuan Z
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35360206
Variant Present in the following documents:
  • fnagi-14-819836.pdf
View BVdb publication page



Initiation and progression of α-synuclein pathology in Parkinson's disease.

Cellular And Molecular Life Sciences : Cmls
Tofaris, George K GK
Publication Date: 2022-03-26

Variant appearance in text: SNCA: A53T
PubMed Link: 35347432
Variant Present in the following documents:
  • 18_2022_Article_4240.pdf
View BVdb publication page



Chicago sky blue 6B inhibits α-synuclein aggregation and propagation.

Molecular Brain
Min, Joo-Ok JO; Strohäker, Timo T; Jeong, Byung-Chul BC; Zweckstetter, Markus M; Lee, Seung-Jae SJ
Publication Date: 2022-03-28

Variant appearance in text: SNCA: A53T
PubMed Link: 35346306
Variant Present in the following documents:
  • 13041_2022_Article_913.pdf
View BVdb publication page



Prognostic significance of SNCA and its methylation in bladder cancer.

Bmc Cancer
Wu, Zhengcun Z; Xia, Chengxing C; Zhang, Chao C; Yang, Delin D; Ma, Kaili K
Publication Date: 2022-03-26

Variant appearance in text: SNCA: A53T
PubMed Link: 35346107
Variant Present in the following documents:
  • 12885_2022_Article_9411.pdf
View BVdb publication page



Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition.

Molecules (Basel, Switzerland)
Subedi, Sushma S; Sasidharan, Santanu S; Nag, Niharika N; Saudagar, Prakash P; Tripathi, Timir T
Publication Date: 2022-03-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35335141
Variant Present in the following documents:
  • molecules-27-01776.pdf
View BVdb publication page



Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson's Disease Influence Sporadic Forms?

Genes
Lanore, Aymeric A; Lesage, Suzanne S; Mariani, Louise-Laure LL; Menon, Poornima Jayadev PJ; Ravassard, Philippe P; Cheval, Helene H; Corti, Olga O; Brice, Alexis A; Corvol, Jean-Christophe JC
Publication Date: 2022-03-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35328033
Variant Present in the following documents:
  • genes-13-00479.pdf
View BVdb publication page



Monogenic Parkinson's Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing.

Genes
Jia, Fangzhi F; Fellner, Avi A; Kumar, Kishore Raj KR
Publication Date: 2022-03-07

Variant appearance in text: SNCA: A53T
PubMed Link: 35328025
Variant Present in the following documents:
  • genes-13-00471.pdf
View BVdb publication page



Alpha-Synuclein-Specific Naturally Occurring Antibodies Inhibit Aggregation In Vitro and In Vivo.

Biomolecules
Braczynski, Anne K AK; Sevenich, Marc M; Gering, Ian I; Kupreichyk, Tatsiana T; Agerschou, Emil D ED; Kronimus, Yannick Y; Habib, Pardes P; Stoldt, Matthias M; Willbold, Dieter D; Schulz, Jörg B JB; Bach, Jan-Philipp JP; Falkenburger, Björn H BH; Hoyer, Wolfgang W
Publication Date: 2022-03-18

Variant appearance in text: SNCA: A53T
PubMed Link: 35327661
Variant Present in the following documents:
  • biomolecules-12-00469.pdf
View BVdb publication page



Leukotriene Signaling as a Target in α-Synucleinopathies.

Biomolecules
Strempfl, Katharina K; Unger, Michael S MS; Flunkert, Stefanie S; Trost, Andrea A; Reitsamer, Herbert A HA; Hutter-Paier, Birgit B; Aigner, Ludwig L
Publication Date: 2022-02-23

Variant appearance in text: SNCA: A53T
PubMed Link: 35327537
Variant Present in the following documents:
  • biomolecules-12-00346.pdf
View BVdb publication page



HDL Accessory Proteins in Parkinson's Disease-Focusing on Clusterin (Apolipoprotein J) in Regard to Its Involvement in Pathology and Diagnostics-A Review.

Antioxidants (Basel, Switzerland)
Berdowska, Izabela I; Matusiewicz, Małgorzata M; Krzystek-Korpacka, Małgorzata M
Publication Date: 2022-03-09

Variant appearance in text: SNCA: A53T
PubMed Link: 35326174
Variant Present in the following documents:
  • antioxidants-11-00524.pdf
View BVdb publication page



Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy.

Plos One
Jovanovic, Predrag P; Wang, Yidan Y; Vit, Jean-Philippe JP; Novinbakht, Edward E; Morones, Nancy N; Hogg, Elliot E; Tagliati, Michele M; Riera, Celine E CE
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35316276
Variant Present in the following documents:
  • pone.0263074.pdf
View BVdb publication page



Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.

Translational Neurodegeneration
Lopes, Douglas M DM; Llewellyn, Sophie K SK; Harrison, Ian F IF
Publication Date: 2022-03-21

Variant appearance in text: SNCA: A53T
PubMed Link: 35314000
Variant Present in the following documents:
  • 40035_2022_Article_293.pdf
View BVdb publication page



Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease.

Frontiers In Neurology
Moudio, Serge S; Rodin, Fredrik F; Albargothy, Nazira Jamal NJ; Karlsson, Urban U; Reyes, Juan F JF; Hallbeck, Martin M
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35309552
Variant Present in the following documents:
  • fneur-13-826102.pdf
View BVdb publication page



Parkinson's disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Azevedo, Carla C; Teku, Gabriel G; Pomeshchik, Yuriy Y; Reyes, Juan F JF; Chumarina, Margarita M; Russ, Kaspar K; Savchenko, Ekaterina E; Hammarberg, Anna A; Lamas, Nuno Jorge NJ; Collin, Anna A; Gouras, Gunnar K GK; Klementieva, Oxana O; Hallbeck, Martin M; Taipa, Ricardo R; Vihinen, Mauno M; Roybon, Laurent L
Publication Date: 2022-03-22

Variant appearance in text: SNCA: A53T
PubMed Link: 35294277
Variant Present in the following documents:
  • pnas.2111405119.sapp.pdf
  • pnas.202111405.pdf
View BVdb publication page



Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease.

Molecular Therapy. Nucleic Acids
Stein, Colleen S CS; McLendon, Jared M JM; Witmer, Nathan H NH; Boudreau, Ryan L RL
Publication Date: 2022-06-14

Variant appearance in text: SNCA: A53T
PubMed Link: 35280925
Variant Present in the following documents:
  • mmc3.pdf
  • main.pdf
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Beneficial Effects of Spirulina Consumption on Brain Health.

Nutrients
Trotta, Teresa T; Porro, Chiara C; Cianciulli, Antonia A; Panaro, Maria Antonietta MA
Publication Date: 2022-02-05

Variant appearance in text: SNCA: A53T
PubMed Link: 35277035
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  • nutrients-14-00676.pdf
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Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease.

Frontiers In Molecular Neuroscience
Sepúlveda, Denisse D; Cisternas-Olmedo, Marisol M; Arcos, Javiera J; Nassif, Melissa M; Vidal, René L RL
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35250476
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  • fnmol-15-805087.pdf
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Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.

Cellular And Molecular Life Sciences : Cmls
Cascella, Roberta R; Bigi, Alessandra A; Cremades, Nunilo N; Cecchi, Cristina C
Publication Date: 2022-03-04

Variant appearance in text: SNCA: A53T
PubMed Link: 35244787
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  • 18_2022_Article_4166.pdf
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Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson's Disease.

Oxidative Medicine And Cellular Longevity
Long, Tao T; Wu, Qian Q; Wei, Jing J; Tang, Yong Y; He, Yan-Ni YN; He, Chang-Long CL; Chen, Xue X; Yu, Lu L; Yu, Chong-Lin CL; Law, Betty Yuen-Kwan BY; Wu, Jian-Ming JM; Qin, Da-Lian DL; Wu, An-Guo AG; Zhou, Xiao-Gang XG
Publication Date: 2022

Variant appearance in text: PARK1: A53T
PubMed Link: 35242276
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  • OMCL2022-3723567.pdf
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Dietary Plant Polyphenols as the Potential Drugs in Neurodegenerative Diseases: Current Evidence, Advances, and Opportunities.

Oxidative Medicine And Cellular Longevity
Yan, Lu L; Guo, Min-Song MS; Zhang, Yue Y; Yu, Lu L; Wu, Jian-Ming JM; Tang, Yong Y; Ai, Wei W; Zhu, Feng-Dan FD; Law, Betty Yuen-Kwan BY; Chen, Qi Q; Yu, Chong-Lin CL; Wong, Vincent Kam-Wai VK; Li, Hua H; Li, Mao M; Zhou, Xiao-Gang XG; Qin, Da-Lian DL; Wu, An-Guo AG
Publication Date: 2022

Variant appearance in text: SNCA: A53T
PubMed Link: 35237381
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  • OMCL2022-5288698.pdf
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Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective.

Animal Models And Experimental Medicine
Banerjee, Rajashree R; Rai, Arushi A; Iyer, Shreyas M SM; Narwal, Sonia S; Tare, Meghana M
Publication Date: 2022-02

Variant appearance in text: SNCA: A53T
PubMed Link: 35229999
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  • AME2-5-27.pdf
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Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease.

International Journal Of Molecular Sciences
Boag, Matthew K MK; Roberts, Angus A; Uversky, Vladimir N VN; Ma, Linlin L; Richardson, Des R DR; Pountney, Dean L DL
Publication Date: 2022-02-21

Variant appearance in text: PARK1: A53T
PubMed Link: 35216492
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  • ijms-23-02378.pdf
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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy.

Translational Psychiatry
Miquel-Rio, Lluis L; Alarcón-Arís, Diana D; Torres-López, María M; Cóppola-Segovia, Valentín V; Pavia-Collado, Rubén R; Paz, Verónica V; Ruiz-Bronchal, Esther E; Campa, Leticia L; Casal, Carme C; Montefeltro, Andrés A; Vila, Miquel M; Artigas, Francesc F; Revilla, Raquel R; Bortolozzi, Analia A
Publication Date: 2022-02-24

Variant appearance in text: SNCA: A53T
PubMed Link: 35210396
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  • 41398_2022_Article_1842.pdf
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Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.

Acta Neuropathologica Communications
Lohmann, Stephanie S; Grigoletto, Jessica J; Bernis, Maria Eugenia ME; Pesch, Verena V; Ma, Liang L; Reithofer, Sara S; Tamgüney, Gültekin G
Publication Date: 2022-02-24

Variant appearance in text: SNCA: A53T
PubMed Link: 35209932
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  • 40478_2022_Article_1327.pdf
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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

Molecules (Basel, Switzerland)
Xu, Catherine K CK; Castellana-Cruz, Marta M; Chen, Serene W SW; Du, Zhen Z; Meisl, Georg G; Levin, Aviad A; Mannini, Benedetta B; Itzhaki, Laura S LS; Knowles, Tuomas P J TPJ; Dobson, Christopher M CM; Cremades, Nunilo N; Kumita, Janet R JR
Publication Date: 2022-02-15

Variant appearance in text: SNCA: A53T
PubMed Link: 35209093
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  • molecules-27-01293.pdf
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The Potential of Metabolomics in Biomedical Applications.

Metabolites
Gonzalez-Covarrubias, Vanessa V; Martínez-Martínez, Eduardo E; Del Bosque-Plata, Laura L
Publication Date: 2022-02-19

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PubMed Link: 35208267
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  • metabolites-12-00194.pdf
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Passive Immunization in Alpha-Synuclein Preclinical Animal Models.

Biomolecules
Folke, Jonas J; Ferreira, Nelson N; Brudek, Tomasz T; Borghammer, Per P; Van Den Berge, Nathalie N
Publication Date: 2022-01-20

Variant appearance in text: SNCA: A53T
PubMed Link: 35204668
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  • biomolecules-12-00168.pdf
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Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update.

Biomedicines
Gouda, Noha A NA; Elkamhawy, Ahmed A; Cho, Jungsook J
Publication Date: 2022-02-03

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PubMed Link: 35203580
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  • biomedicines-10-00371.pdf
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Interaction of Mitochondrial Calcium and ROS in Neurodegeneration.

Cells
Baev, Artyom Y AY; Vinokurov, Andrey Y AY; Novikova, Irina N IN; Dremin, Viktor V VV; Potapova, Elena V EV; Abramov, Andrey Y AY
Publication Date: 2022-02-17

Variant appearance in text: SNCA: A53t
PubMed Link: 35203354
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  • cells-11-00706.pdf
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Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.

Scientific Reports
Torres-Garcia, Laura L; P Domingues, Joana M JM; Brandi, Edoardo E; Haikal, Caroline C; Mudannayake, Janitha M JM; Brás, Inês C IC; Gerhardt, Ellen E; Li, Wen W; Svanbergsson, Alexander A; Outeiro, Tiago F TF; Gouras, Gunnar K GK; Li, Jia-Yi JY
Publication Date: 2022-02-22

Variant appearance in text: NACP: A53T
PubMed Link: 35194057
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  • 41598_2022_Article_6846.pdf
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α-Synuclein-containing erythrocytic extracellular vesicles: essential contributors to hyperactivation of monocytes in Parkinson's disease.

Journal Of Neuroinflammation
Liu, Zongran Z; Chan, Robin Barry RB; Cai, Zhijian Z; Liu, Xiaodan X; Wu, Yufeng Y; Yu, Zhenwei Z; Feng, Tao T; Yang, Ying Y; Zhang, Jing J
Publication Date: 2022-02-22

Variant appearance in text: SNCA: A53T
PubMed Link: 35193594
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  • 12974_2022_Article_2413.pdf
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Retinal Degeneration: A Window to Understand the Origin and Progression of Parkinson's Disease?

Frontiers In Neuroscience
Zhang, Yanyan Y; Zhang, Xiaoguang X; Yue, Yunhua Y; Tian, Tian T
Publication Date: 2021

Variant appearance in text: SNCA: A53T
PubMed Link: 35185448
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  • fnins-15-799526.pdf
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Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.

International Journal Of Molecular Sciences
Suzuki, Mari M; Sango, Kazunori K; Nagai, Yoshitaka Y
Publication Date: 2022-01-28

Variant appearance in text: SNCA: A53T
PubMed Link: 35163450
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  • Main text
  • ijms-23-01519.pdf
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Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease.

International Journal Of Molecular Sciences
Hatton, Shelby Loraine SL; Pandey, Manoj Kumar MK
Publication Date: 2022-01-19

Variant appearance in text: SNCA: A53T
PubMed Link: 35163013
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  • Main text
  • ijms-23-01089.pdf
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Dictyostelium discoideum: A Model System for Neurological Disorders.

Cells
Storey, Claire Louise CL; Williams, Robin Simon Brooke RSB; Fisher, Paul Robert PR; Annesley, Sarah Jane SJ
Publication Date: 2022-01-28

Variant appearance in text: SNCA: A53T
PubMed Link: 35159273
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  • Main text
  • cells-11-00463.pdf
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High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease.

Npj Parkinson'S Disease
Antoniou, Nasia N; Prodromidou, Kanella K; Kouroupi, Georgia G; Boumpoureka, Ioanna I; Samiotaki, Martina M; Panayotou, George G; Xilouri, Maria M; Kloukina, Ismini I; Stefanis, Leonidas L; Grailhe, Regis R; Taoufik, Era E; Matsas, Rebecca R
Publication Date: 2022-02-11

Variant appearance in text: SNCA: A53T
PubMed Link: 35149677
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  • 41531_2022_Article_278.pdf
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Targeting α-Synuclein in Parkinson's Disease by Induced Pluripotent Stem Cell Models.

Frontiers In Neurology
Spathopoulou, Angeliki A; Edenhofer, Frank F; Fellner, Lisa L
Publication Date: 2021

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PubMed Link: 35145469
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  • Main text
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Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity.

Neural Regeneration Research
Segura-Aguilar, Juan J; Mannervik, Bengt B; Inzunza, José J; Varshney, Mukesh M; Nalvarte, Ivan I; Muñoz, Patricia P
Publication Date: 2022-09

Variant appearance in text: SNCA: A53T
PubMed Link: 35142659
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  • NRR-17-1861.pdf
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Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Acta Neuropathologica
de Boni, Laura L; Watson, Aurelia Hays AH; Zaccagnini, Ludovica L; Wallis, Amber A; Zhelcheska, Kristina K; Kim, Nora N; Sanderson, John J; Jiang, Haiyang H; Martin, Elodie E; Cantlon, Adam A; Rovere, Matteo M; Liu, Lei L; Sylvester, Marc M; Lashley, Tammaryn T; Dettmer, Ulf U; Jaunmuktane, Zane Z; Bartels, Tim T
Publication Date: 2022-02-09

Variant appearance in text: SNCA: A53T
PubMed Link: 35141810
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  • 401_2022_Article_2406.pdf
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Senescence and impaired DNA damage responses in alpha-synucleinopathy models.

Experimental & Molecular Medicine
Yoon, Ye-Seul YS; You, Jueng Soo JS; Kim, Tae-Kyung TK; Ahn, Woo Jung WJ; Kim, Myoung Jun MJ; Son, Keun Hong KH; Ricarte, Diadem D; Ortiz, Darlene D; Lee, Seung-Jae SJ; Lee, He-Jin HJ
Publication Date: 2022-02-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35136202
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  • 12276_2022_Article_727.pdf
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Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Ayers, Jacob I JI; Lee, Joanne J; Monteiro, Octovia O; Woerman, Amanda L AL; Lazar, Ann A AA; Condello, Carlo C; Paras, Nick A NA; Prusiner, Stanley B SB
Publication Date: 2022-02-08

Variant appearance in text: SNCA: A53T
PubMed Link: 35115402
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  • Main text
  • pnas.202113489.pdf
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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration.

Translational Neurodegeneration
Verma, Manish M; Lizama, Britney N BN; Chu, Charleen T CT
Publication Date: 2022-01-25

Variant appearance in text: SNCA: A53T
PubMed Link: 35078537
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  • Main text
  • 40035_2021_Article_278.pdf
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Phosphorylation of endogenous α-synuclein induced by extracellular seeds initiates at the pre-synaptic region and spreads to the cell body.

Scientific Reports
Awa, Shiori S; Suzuki, Genjiro G; Masuda-Suzukake, Masami M; Nonaka, Takashi T; Saito, Minoru M; Hasegawa, Masato M
Publication Date: 2022-01-21

Variant appearance in text: SNCA: A53T
PubMed Link: 35064139
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  • 41598_2022_Article_4780.pdf
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Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain.

Molecules (Basel, Switzerland)
Kelly, Rachel R; Bemelmans, Alexis-Pierre AP; Joséphine, Charlène C; Brouillet, Emmanuel E; McKernan, Declan P DP; Dowd, Eilís E
Publication Date: 2022-01-14

Variant appearance in text: SNCA: A53T
PubMed Link: 35056822
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  • Main text
  • molecules-27-00507.pdf
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Lewy body disease or diseases with Lewy bodies?

Npj Parkinson'S Disease
Menšíková, Kateřina K; Matěj, Radoslav R; Colosimo, Carlo C; Rosales, Raymond R; Tučková, Lucie L; Ehrmann, Jiří J; Hraboš, Dominik D; Kolaříková, Kristýna K; Vodička, Radek R; Vrtěl, Radek R; Procházka, Martin M; Nevrlý, Martin M; Kaiserová, Michaela M; Kurčová, Sandra S; Otruba, Pavel P; Kaňovský, Petr P
Publication Date: 2022-01-10

Variant appearance in text: SNCA: A53T
PubMed Link: 35013341
Variant Present in the following documents:
  • 41531_2021_Article_273.pdf
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