Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.
Journal Of The American Society For Mass Spectrometry
Jeacock, Kiani K; Chappard, Alexandre A; Gallagher, Kelly J KJ; Mackay, C Logan CL; Kilgour, David P A DPA; Horrocks, Mathew H MH; Kunath, Tilo T; Clarke, David J DJ
Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein.
In Silico Study of the Interactions of Anle138b Isomer, an Inhibitor of Amyloid Aggregation, with Partner Proteins.
International Journal Of Molecular Sciences
Kondratyev, Maxim S MS; Rudnev, Vladimir R VR; Nikolsky, Kirill S KS; Petrovsky, Denis V DV; Kulikova, Liudmila I LI; Malsagova, Kristina A KA; Stepanov, Alexander A AA; Kopylov, Arthur T AT; Kaysheva, Anna L AL
Structures of α-synuclein filaments from human brains with Lewy pathology.
Nature
Yang, Yang Y; Shi, Yang Y; Schweighauser, Manuel M; Zhang, Xianjun X; Kotecha, Abhay A; Murzin, Alexey G AG; Garringer, Holly J HJ; Cullinane, Patrick W PW; Saito, Yuko Y; Foroud, Tatiana T; Warner, Thomas T TT; Hasegawa, Kazuko K; Vidal, Ruben R; Murayama, Shigeo S; Revesz, Tamas T; Ghetti, Bernardino B; Hasegawa, Masato M; Lashley, Tammaryn T; Scheres, Sjors H W SHW; Goedert, Michel M
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Nature Neuroscience
Choi, Minee L ML; Chappard, Alexandre A; Singh, Bhanu P BP; Maclachlan, Catherine C; Rodrigues, Margarida M; Fedotova, Evgeniya I EI; Berezhnov, Alexey V AV; De, Suman S; Peddie, Christopher J CJ; Athauda, Dilan D; Virdi, Gurvir S GS; Zhang, Weijia W; Evans, James R JR; Wernick, Anna I AI; Zanjani, Zeinab Shadman ZS; Angelova, Plamena R PR; Esteras, Noemi N; Vinokurov, Andrey Y AY; Morris, Katie K; Jeacock, Kiani K; Tosatto, Laura L; Little, Daniel D; Gissen, Paul P; Clarke, David J DJ; Kunath, Tilo T; Collinson, Lucy L; Klenerman, David D; Abramov, Andrey Y AY; Horrocks, Mathew H MH; Gandhi, Sonia S
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Biochemistry
Bell, Rosie R; Thrush, Rebecca J RJ; Castellana-Cruz, Marta M; Oeller, Marc M; Staats, Roxine R; Nene, Aishwarya A; Flagmeier, Patrick P; Xu, Catherine K CK; Satapathy, Sandeep S; Galvagnion, Celine C; Wilson, Mark R MR; Dobson, Christopher M CM; Kumita, Janet R JR; Vendruscolo, Michele M
Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies.
Acta Neuropathologica Communications
Koss, David J DJ; Erskine, Daniel D; Porter, Andrew A; Palmoski, Pawel P; Menon, Hariharan H; Todd, Olivia G J OGJ; Leite, Marta M; Attems, Johannes J; Outeiro, Tiago F TF
A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.
Science Advances
Kumar, Senthil T ST; Mahul-Mellier, Anne-Laure AL; Hegde, Ramanath Narayana RN; Rivière, Gwladys G; Moons, Rani R; Ibáñez de Opakua, Alain A; Magalhães, Pedro P; Rostami, Iman I; Donzelli, Sonia S; Sobott, Frank F; Zweckstetter, Markus M; Lashuel, Hilal A HA
Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation.
Human Molecular Genetics
Geertsma, Haley M HM; Suk, Terry R TR; Ricke, Konrad M KM; Horsthuis, Kyra K; Parmasad, Jean-Louis A JA; Fisk, Zoe A ZA; Callaghan, Steve M SM; Rousseaux, Maxime W C MWC
Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.
Acta Neuropathologica
de Boni, Laura L; Watson, Aurelia Hays AH; Zaccagnini, Ludovica L; Wallis, Amber A; Zhelcheska, Kristina K; Kim, Nora N; Sanderson, John J; Jiang, Haiyang H; Martin, Elodie E; Cantlon, Adam A; Rovere, Matteo M; Liu, Lei L; Sylvester, Marc M; Lashley, Tammaryn T; Dettmer, Ulf U; Jaunmuktane, Zane Z; Bartels, Tim T
Novel engineered nanobodies specific for N-terminal region of alpha-synuclein recognize Lewy-body pathology and inhibit in-vitro seeded aggregation and toxicity.
The Febs Journal
Hmila, Issam I; Vaikath, Nishant N NN; Majbour, Nour K NK; Erskine, Daniel D; Sudhakaran, Indulekha P IP; Gupta, Vijay V; Ghanem, Simona S SS; Islam, Zeyaul Z; Emara, Mohamed M MM; Abdesselem, Houari B HB; Kolatkar, Prasanna R PR; Achappa, Devaya K DK; Vinardell, Tatiana T; El-Agnaf, Omar M A OMA