A pesticide and iPSC dopaminergic neuron screen identifies and classifies Parkinson-relevant pesticides.
Nature Communications
Paul, Kimberly C KC; Krolewski, Richard C RC; Lucumi Moreno, Edinson E; Blank, Jack J; Holton, Kristina M KM; Ahfeldt, Tim T; Furlong, Melissa M; Yu, Yu Y; Cockburn, Myles M; Thompson, Laura K LK; Kreymerman, Alexander A; Ricci-Blair, Elisabeth M EM; Li, Yu Jun YJ; Patel, Heer B HB; Lee, Richard T RT; Bronstein, Jeff J; Rubin, Lee L LL; Khurana, Vikram V; Ritz, Beate B
Determining the Location of the α-Synuclein Dimer Interface Using Native Top-Down Fragmentation and Isotope Depletion-Mass Spectrometry.
Journal Of The American Society For Mass Spectrometry
Jeacock, Kiani K; Chappard, Alexandre A; Gallagher, Kelly J KJ; Mackay, C Logan CL; Kilgour, David P A DPA; Horrocks, Mathew H MH; Kunath, Tilo T; Clarke, David J DJ
Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein.
In Silico Study of the Interactions of Anle138b Isomer, an Inhibitor of Amyloid Aggregation, with Partner Proteins.
International Journal Of Molecular Sciences
Kondratyev, Maxim S MS; Rudnev, Vladimir R VR; Nikolsky, Kirill S KS; Petrovsky, Denis V DV; Kulikova, Liudmila I LI; Malsagova, Kristina A KA; Stepanov, Alexander A AA; Kopylov, Arthur T AT; Kaysheva, Anna L AL
Croft, Cara L CL; Paterno, Giavanna G; Vause, Ava R AR; Rowe, Lyla A LA; Ryu, Daniel H DH; Goodwin, Marshall S MS; Moran, Corey A CA; Cruz, Pedro E PE; Giasson, Benoit I BI; Golde, Todd E TE
Pathological structural conversion of α-synuclein at the mitochondria induces neuronal toxicity.
Nature Neuroscience
Choi, Minee L ML; Chappard, Alexandre A; Singh, Bhanu P BP; Maclachlan, Catherine C; Rodrigues, Margarida M; Fedotova, Evgeniya I EI; Berezhnov, Alexey V AV; De, Suman S; Peddie, Christopher J CJ; Athauda, Dilan D; Virdi, Gurvir S GS; Zhang, Weijia W; Evans, James R JR; Wernick, Anna I AI; Zanjani, Zeinab Shadman ZS; Angelova, Plamena R PR; Esteras, Noemi N; Vinokurov, Andrey Y AY; Morris, Katie K; Jeacock, Kiani K; Tosatto, Laura L; Little, Daniel D; Gissen, Paul P; Clarke, David J DJ; Kunath, Tilo T; Collinson, Lucy L; Klenerman, David D; Abramov, Andrey Y AY; Horrocks, Mathew H MH; Gandhi, Sonia S
N-Terminal Acetylation of α-Synuclein Slows down Its Aggregation Process and Alters the Morphology of the Resulting Aggregates.
Biochemistry
Bell, Rosie R; Thrush, Rebecca J RJ; Castellana-Cruz, Marta M; Oeller, Marc M; Staats, Roxine R; Nene, Aishwarya A; Flagmeier, Patrick P; Xu, Catherine K CK; Satapathy, Sandeep S; Galvagnion, Celine C; Wilson, Mark R MR; Dobson, Christopher M CM; Kumita, Janet R JR; Vendruscolo, Michele M