Variant ID: 4-90756731-C-G

NM_000345.3(SNCA):c.88G>C;(p.A30P)

This variant was identified in 828 publications

View GRCh38 version.




Publications:


α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

Frontiers In Molecular Biosciences
Brodin, Lennart L; Milovanovic, Dragomir D; Rizzoli, Silvio O SO; Shupliakov, Oleg O
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35664678
Variant Present in the following documents:
  • Main text
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Multi-platform quantitation of alpha-synuclein human brain proteoforms suggests disease-specific biochemical profiles of synucleinopathies.

Acta Neuropathologica Communications
Moors, Tim E TE; Mona, Daniel D; Luehe, Stefan S; Duran-Pacheco, Gonzalo G; Spycher, Liz L; Mundigl, Olaf O; Kaluza, Klaus K; Huber, Sylwia S; Hug, Melanie N MN; Kremer, Thomas T; Ritter, Mirko M; Dziadek, Sebastian S; Dernick, Gregor G; van de Berg, Wilma D J WDJ; Britschgi, Markus M
Publication Date: 2022-06-03

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35659116
Variant Present in the following documents:
  • 40478_2022_Article_1382.pdf
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Comparative Analysis of the Relative Fragmentation Stabilities of Polymorphic Alpha-Synuclein Amyloid Fibrils.

Biomolecules
Sanami, Sarina S; Purton, Tracey J TJ; Smith, David P DP; Tuite, Mick F MF; Xue, Wei-Feng WF
Publication Date: 2022-04-25

Variant appearance in text: SNCA: A30P
PubMed Link: 35625557
Variant Present in the following documents:
  • Main text
  • biomolecules-12-00630.pdf
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Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.

Frontiers In Neurology
Menon, Sindhu S; Armstrong, Sabrina S; Hamzeh, Amir A; Visanji, Naomi P NP; Sardi, Sergio Pablo SP; Tandon, Anurag A
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35614915
Variant Present in the following documents:
  • Main text
  • fneur-13-852003.pdf
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The Role of Extracellular Matrix Components in the Spreading of Pathological Protein Aggregates.

Frontiers In Cellular Neuroscience
Moretto, Edoardo E; Stuart, Skye S; Surana, Sunaina S; Vargas, Jose Norberto S JNS; Schiavo, Giampietro G
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35573838
Variant Present in the following documents:
  • fncel-16-844211.pdf
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Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson's Disease.

Frontiers In Neuroscience
Miller, Sean J SJ; Campbell, Cameron E CE; Jimenez-Corea, Helen A HA; Wu, Guan-Hui GH; Logan, Robert R
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35516803
Variant Present in the following documents:
  • fnins-16-824191.pdf
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Ultrastructural and biochemical classification of pathogenic tau, α-synuclein and TDP-43.

Acta Neuropathologica
Tarutani, Airi A; Adachi, Tadashi T; Akatsu, Hiroyasu H; Hashizume, Yoshio Y; Hasegawa, Kazuko K; Saito, Yuko Y; Robinson, Andrew C AC; Mann, David M A DMA; Yoshida, Mari M; Murayama, Shigeo S; Hasegawa, Masato M
Publication Date: 2022-05-05

Variant appearance in text: SNCA: A30P
PubMed Link: 35513543
Variant Present in the following documents:
  • 401_2022_Article_2426.pdf
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Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson's Disease.

Frontiers In Cellular Neuroscience
Xu, Jianjun J; Minobe, Etsuko E; Kameyama, Masaki M
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35496903
Variant Present in the following documents:
  • fncel-16-867385.pdf
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A NAC domain mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein and recapitulates its pathological diversity.

Science Advances
Kumar, Senthil T ST; Mahul-Mellier, Anne-Laure AL; Hegde, Ramanath Narayana RN; Rivière, Gwladys G; Moons, Rani R; Ibáñez de Opakua, Alain A; Magalhães, Pedro P; Rostami, Iman I; Donzelli, Sonia S; Sobott, Frank F; Zweckstetter, Markus M; Lashuel, Hilal A HA
Publication Date: 2022-04-29

Variant appearance in text: SNCA: A30P
PubMed Link: 35486726
Variant Present in the following documents:
  • sciadv.abn0044.pdf
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Lipid level alteration in human and cellular models of alpha synuclein mutations.

Npj Parkinson'S Disease
Avisar, Hila H; Guardia-Laguarta, Cristina C; Surface, Matthew M; Papagiannakis, Nikos N; Maniati, Matina M; Antonellou, Roubina R; Papadimitriou, Dimitra D; Koros, Christos C; Athanassiadou, Aglaia A; Przedborski, Serge S; Lerner, Boaz B; Stefanis, Leonidas L; Area-Gomez, Estela E; Alcalay, Roy N RN
Publication Date: 2022-04-25

Variant appearance in text: SNCA: A30P
PubMed Link: 35468903
Variant Present in the following documents:
  • 41531_2022_Article_313.pdf
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α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword.

Biomolecules
Tan, Li Yang LY; Tang, Kwan Hou KH; Lim, Lynette Yu You LYY; Ong, Jia Xin JX; Park, Hyokeun H; Jung, Sangyong S
Publication Date: 2022-03-27

Variant appearance in text: SNCA: A30P
PubMed Link: 35454096
Variant Present in the following documents:
  • biomolecules-12-00507.pdf
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α-Synuclein Fibrils as Penrose Machines: A Chameleon in the Gear.

Biomolecules
De Giorgi, Francesca F; Uversky, Vladimir N VN; Ichas, François F
Publication Date: 2022-03-24

Variant appearance in text: NACP: A30P
PubMed Link: 35454083
Variant Present in the following documents:
  • biomolecules-12-00494.pdf
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idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R.

Plos One
McFadden, William M WM; Yanowitz, Judith L JL
Publication Date: 2022

Variant appearance in text: NACP: A30P
PubMed Link: 35436286
Variant Present in the following documents:
  • pone.0266929.pdf
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Proteomics Challenges for the Assessment of Synuclein Proteoforms as Clinical Biomarkers in Parkinson's Disease.

Frontiers In Aging Neuroscience
Pons, Marie-Laure ML; Loftus, Neil N; Vialaret, Jerome J; Moreau, Stephane S; Lehmann, Sylvain S; Hirtz, Christophe C
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35431896
Variant Present in the following documents:
  • fnagi-14-818606.pdf
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Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system.

Rsc Advances
Takaramoto, Shunki S; Nakasone, Yusuke Y; Sadakane, Kei K; Maruta, Shinsaku S; Terazima, Masahide M
Publication Date: 2020-12-24

Variant appearance in text: NACP: Ala30Pro
PubMed Link: 35423687
Variant Present in the following documents:
  • RA-011-D0RA09614H.pdf
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The GBA1 D409V mutation exacerbates synuclein pathology to differing extents in two alpha-synuclein models.

Disease Models & Mechanisms
Polinski, Nicole K NK; Martinez, Terina N TN; Ramboz, Sylvie S; Sasner, Michael M; Herberth, Mark M; Switzer, Robert R; Ahmad, Syed O SO; Pelligrino, Lee J LJ; Clark, Sean W SW; Marcus, Jacob N JN; Smith, Sean M SM; Dave, Kuldip D KD; Frasier, Mark A MA
Publication Date: 2022-04-14

Variant appearance in text: SNCA: A30P
PubMed Link: 35419585
Variant Present in the following documents:
  • Main text
View BVdb publication page



Immune Response Modifications in the Genetic Forms of Parkinson's Disease: What Do We Know?

International Journal Of Molecular Sciences
Magistrelli, Luca L; Contaldi, Elena E; Vignaroli, Francesca F; Gallo, Silvia S; Colombatto, Federico F; Cantello, Roberto R; Comi, Cristoforo C
Publication Date: 2022-03-23

Variant appearance in text: SNCA: A30P
PubMed Link: 35408836
Variant Present in the following documents:
  • ijms-23-03476.pdf
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Dysmetabolism and Neurodegeneration: Trick or Treat?

Nutrients
Capucho, Adriana M AM; Chegão, Ana A; Martins, Fátima O FO; Vicente Miranda, Hugo H; Conde, Sílvia V SV
Publication Date: 2022-03-29

Variant appearance in text: SNCA: A30P
PubMed Link: 35406040
Variant Present in the following documents:
  • nutrients-14-01425.pdf
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Initiation and progression of α-synuclein pathology in Parkinson's disease.

Cellular And Molecular Life Sciences : Cmls
Tofaris, George K GK
Publication Date: 2022-03-26

Variant appearance in text: SNCA: A30P
PubMed Link: 35347432
Variant Present in the following documents:
  • 18_2022_Article_4240.pdf
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Chicago sky blue 6B inhibits α-synuclein aggregation and propagation.

Molecular Brain
Min, Joo-Ok JO; Strohäker, Timo T; Jeong, Byung-Chul BC; Zweckstetter, Markus M; Lee, Seung-Jae SJ
Publication Date: 2022-03-28

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35346306
Variant Present in the following documents:
  • 13041_2022_Article_913.pdf
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Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition.

Molecules (Basel, Switzerland)
Subedi, Sushma S; Sasidharan, Santanu S; Nag, Niharika N; Saudagar, Prakash P; Tripathi, Timir T
Publication Date: 2022-03-08

Variant appearance in text: SNCA: A30P
PubMed Link: 35335141
Variant Present in the following documents:
  • molecules-27-01776.pdf
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Does the Expression and Epigenetics of Genes Involved in Monogenic Forms of Parkinson's Disease Influence Sporadic Forms?

Genes
Lanore, Aymeric A; Lesage, Suzanne S; Mariani, Louise-Laure LL; Menon, Poornima Jayadev PJ; Ravassard, Philippe P; Cheval, Helene H; Corti, Olga O; Brice, Alexis A; Corvol, Jean-Christophe JC
Publication Date: 2022-03-08

Variant appearance in text: SNCA: A30P
PubMed Link: 35328033
Variant Present in the following documents:
  • genes-13-00479.pdf
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Monogenic Parkinson's Disease: Genotype, Phenotype, Pathophysiology, and Genetic Testing.

Genes
Jia, Fangzhi F; Fellner, Avi A; Kumar, Kishore Raj KR
Publication Date: 2022-03-07

Variant appearance in text: SNCA: A30P
PubMed Link: 35328025
Variant Present in the following documents:
  • genes-13-00471.pdf
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Leukotriene Signaling as a Target in α-Synucleinopathies.

Biomolecules
Strempfl, Katharina K; Unger, Michael S MS; Flunkert, Stefanie S; Trost, Andrea A; Reitsamer, Herbert A HA; Hutter-Paier, Birgit B; Aigner, Ludwig L
Publication Date: 2022-02-23

Variant appearance in text: SNCA: A30P
PubMed Link: 35327537
Variant Present in the following documents:
  • biomolecules-12-00346.pdf
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Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system.

Translational Neurodegeneration
Lopes, Douglas M DM; Llewellyn, Sophie K SK; Harrison, Ian F IF
Publication Date: 2022-03-21

Variant appearance in text: SNCA: A30P
PubMed Link: 35314000
Variant Present in the following documents:
  • 40035_2022_Article_293.pdf
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Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease.

Frontiers In Neurology
Moudio, Serge S; Rodin, Fredrik F; Albargothy, Nazira Jamal NJ; Karlsson, Urban U; Reyes, Juan F JF; Hallbeck, Martin M
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35309552
Variant Present in the following documents:
  • fneur-13-826102.pdf
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Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson's Disease.

Frontiers In Molecular Neuroscience
Sepúlveda, Denisse D; Cisternas-Olmedo, Marisol M; Arcos, Javiera J; Nassif, Melissa M; Vidal, René L RL
Publication Date: 2022

Variant appearance in text: SNCA: A30P
PubMed Link: 35250476
Variant Present in the following documents:
  • fnmol-15-805087.pdf
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Inflammation and immune dysfunction in Parkinson disease.

Nature Reviews. Immunology
Tansey, Malú Gámez MG; Wallings, Rebecca L RL; Houser, Madelyn C MC; Herrick, Mary K MK; Keating, Cody E CE; Joers, Valerie V
Publication Date: 2022-03-04

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35246670
Variant Present in the following documents:
  • 41577_2022_Article_684.pdf
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Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies.

Cellular And Molecular Life Sciences : Cmls
Cascella, Roberta R; Bigi, Alessandra A; Cremades, Nunilo N; Cecchi, Cristina C
Publication Date: 2022-03-04

Variant appearance in text: SNCA: A30P
PubMed Link: 35244787
Variant Present in the following documents:
  • 18_2022_Article_4166.pdf
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Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson's Disease.

Oxidative Medicine And Cellular Longevity
Long, Tao T; Wu, Qian Q; Wei, Jing J; Tang, Yong Y; He, Yan-Ni YN; He, Chang-Long CL; Chen, Xue X; Yu, Lu L; Yu, Chong-Lin CL; Law, Betty Yuen-Kwan BY; Wu, Jian-Ming JM; Qin, Da-Lian DL; Wu, An-Guo AG; Zhou, Xiao-Gang XG
Publication Date: 2022

Variant appearance in text: PARK1: A30P
PubMed Link: 35242276
Variant Present in the following documents:
  • OMCL2022-3723567.pdf
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Animal models in the study of Alzheimer's disease and Parkinson's disease: A historical perspective.

Animal Models And Experimental Medicine
Banerjee, Rajashree R; Rai, Arushi A; Iyer, Shreyas M SM; Narwal, Sonia S; Tare, Meghana M
Publication Date: 2022-02

Variant appearance in text: SNCA: A30P
PubMed Link: 35229999
Variant Present in the following documents:
  • AME2-5-27.pdf
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Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson's Disease.

International Journal Of Molecular Sciences
Boag, Matthew K MK; Roberts, Angus A; Uversky, Vladimir N VN; Ma, Linlin L; Richardson, Des R DR; Pountney, Dean L DL
Publication Date: 2022-02-21

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35216492
Variant Present in the following documents:
  • ijms-23-02378.pdf
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Ischemic stroke causes Parkinson's disease-like pathology and symptoms in transgenic mice overexpressing alpha-synuclein.

Acta Neuropathologica Communications
Lohmann, Stephanie S; Grigoletto, Jessica J; Bernis, Maria Eugenia ME; Pesch, Verena V; Ma, Liang L; Reithofer, Sara S; Tamgüney, Gültekin G
Publication Date: 2022-02-24

Variant appearance in text: SNCA: A30P
PubMed Link: 35209932
Variant Present in the following documents:
  • 40478_2022_Article_1327.pdf
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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity.

Molecules (Basel, Switzerland)
Xu, Catherine K CK; Castellana-Cruz, Marta M; Chen, Serene W SW; Du, Zhen Z; Meisl, Georg G; Levin, Aviad A; Mannini, Benedetta B; Itzhaki, Laura S LS; Knowles, Tuomas P J TPJ; Dobson, Christopher M CM; Cremades, Nunilo N; Kumita, Janet R JR
Publication Date: 2022-02-15

Variant appearance in text: SNCA: A30P
PubMed Link: 35209093
Variant Present in the following documents:
  • molecules-27-01293.pdf
View BVdb publication page



Passive Immunization in Alpha-Synuclein Preclinical Animal Models.

Biomolecules
Folke, Jonas J; Ferreira, Nelson N; Brudek, Tomasz T; Borghammer, Per P; Van Den Berge, Nathalie N
Publication Date: 2022-01-20

Variant appearance in text: SNCA: A30P
PubMed Link: 35204668
Variant Present in the following documents:
  • biomolecules-12-00168.pdf
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Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update.

Biomedicines
Gouda, Noha A NA; Elkamhawy, Ahmed A; Cho, Jungsook J
Publication Date: 2022-02-03

Variant appearance in text: SNCA: A30P
PubMed Link: 35203580
Variant Present in the following documents:
  • biomedicines-10-00371.pdf
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Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation.

Scientific Reports
Torres-Garcia, Laura L; P Domingues, Joana M JM; Brandi, Edoardo E; Haikal, Caroline C; Mudannayake, Janitha M JM; Brás, Inês C IC; Gerhardt, Ellen E; Li, Wen W; Svanbergsson, Alexander A; Outeiro, Tiago F TF; Gouras, Gunnar K GK; Li, Jia-Yi JY
Publication Date: 2022-02-22

Variant appearance in text: SNCA: A30P
PubMed Link: 35194057
Variant Present in the following documents:
  • 41598_2022_Article_6846.pdf
View BVdb publication page



Gene Co-expression Analysis of the Human Substantia Nigra Identifies ZNHIT1 as an SNCA Co-expressed Gene that Protects Against α-Synuclein-Induced Impairments in Neurite Growth and Mitochondrial Dysfunction in SH-SY5Y Cells.

Molecular Neurobiology
McCarthy, Erin E; Barron, Aaron A; Morales-Prieto, Noelia N; Mazzocchi, Martina M; McCarthy, Cathal M CM; Collins, Louise M LM; Sullivan, Aideen M AM; O'Keeffe, Gerard W GW
Publication Date: 2022-02-17

Variant appearance in text: SNCA: A30P
PubMed Link: 35175558
Variant Present in the following documents:
  • 12035_2022_Article_2768.pdf
View BVdb publication page



Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells.

International Journal Of Molecular Sciences
Seebauer, Lukas L; Schneider, Yanni Y; Drobny, Alice A; Plötz, Sonja S; Koudelka, Tomas T; Tholey, Andreas A; Prots, Iryna I; Winner, Beate B; Zunke, Friederike F; Winkler, Jürgen J; Xiang, Wei W
Publication Date: 2022-02-05

Variant appearance in text: SNCA: A30P
PubMed Link: 35163733
Variant Present in the following documents:
  • ijms-23-01812.pdf
View BVdb publication page



Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.

International Journal Of Molecular Sciences
Suzuki, Mari M; Sango, Kazunori K; Nagai, Yoshitaka Y
Publication Date: 2022-01-28

Variant appearance in text: SNCA: A30P
PubMed Link: 35163450
Variant Present in the following documents:
  • Main text
  • ijms-23-01519.pdf
View BVdb publication page



Fat and Protein Combat Triggers Immunological Weapons of Innate and Adaptive Immune Systems to Launch Neuroinflammation in Parkinson's Disease.

International Journal Of Molecular Sciences
Hatton, Shelby Loraine SL; Pandey, Manoj Kumar MK
Publication Date: 2022-01-19

Variant appearance in text: SNCA: A30P
PubMed Link: 35163013
Variant Present in the following documents:
  • Main text
  • ijms-23-01089.pdf
View BVdb publication page



High content screening and proteomic analysis identify a kinase inhibitor that rescues pathological phenotypes in a patient-derived model of Parkinson's disease.

Npj Parkinson'S Disease
Antoniou, Nasia N; Prodromidou, Kanella K; Kouroupi, Georgia G; Boumpoureka, Ioanna I; Samiotaki, Martina M; Panayotou, George G; Xilouri, Maria M; Kloukina, Ismini I; Stefanis, Leonidas L; Grailhe, Regis R; Taoufik, Era E; Matsas, Rebecca R
Publication Date: 2022-02-11

Variant appearance in text: SNCA: A30P
PubMed Link: 35149677
Variant Present in the following documents:
  • 41531_2022_Article_278.pdf
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Targeting α-Synuclein in Parkinson's Disease by Induced Pluripotent Stem Cell Models.

Frontiers In Neurology
Spathopoulou, Angeliki A; Edenhofer, Frank F; Fellner, Lisa L
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 35145469
Variant Present in the following documents:
  • Main text
View BVdb publication page



Brain region-specific susceptibility of Lewy body pathology in synucleinopathies is governed by α-synuclein conformations.

Acta Neuropathologica
de Boni, Laura L; Watson, Aurelia Hays AH; Zaccagnini, Ludovica L; Wallis, Amber A; Zhelcheska, Kristina K; Kim, Nora N; Sanderson, John J; Jiang, Haiyang H; Martin, Elodie E; Cantlon, Adam A; Rovere, Matteo M; Liu, Lei L; Sylvester, Marc M; Lashley, Tammaryn T; Dettmer, Ulf U; Jaunmuktane, Zane Z; Bartels, Tim T
Publication Date: 2022-02-09

Variant appearance in text: SNCA: A30P
PubMed Link: 35141810
Variant Present in the following documents:
  • 401_2022_Article_2406.pdf
View BVdb publication page



Quantifying regional α -synuclein, amyloid β, and tau accumulation in lewy body dementia.

Annals Of Clinical And Translational Neurology
Miller, Rebecca L RL; Dhavale, Dhruva D DD; O'Shea, Jennifer Y JY; Andruska, Kristin M KM; Liu, Jialu J; Franklin, Erin E EE; Buddhala, Chandana C; Loftin, Susan K SK; Cirrito, John R JR; Perrin, Richard J RJ; Cairns, Nigel J NJ; Campbell, Meghan C MC; Perlmutter, Joel S JS; Kotzbauer, Paul T PT
Publication Date: 2022-01-21

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35060360
Variant Present in the following documents:
  • ACN3-9-106.pdf
View BVdb publication page



Time-Course of Alterations in the Endocannabinoid System after Viral-Mediated Overexpression of α-Synuclein in the Rat Brain.

Molecules (Basel, Switzerland)
Kelly, Rachel R; Bemelmans, Alexis-Pierre AP; Joséphine, Charlène C; Brouillet, Emmanuel E; McKernan, Declan P DP; Dowd, Eilís E
Publication Date: 2022-01-14

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35056822
Variant Present in the following documents:
  • molecules-27-00507.pdf
View BVdb publication page



Lipotoxicity Downstream of α-Synuclein Imbalance: A Relevant Pathomechanism in Synucleinopathies?

Biomolecules
Tripathi, Arati A; Fanning, Saranna S; Dettmer, Ulf U
Publication Date: 2021-12-28

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 35053188
Variant Present in the following documents:
  • biomolecules-12-00040.pdf
View BVdb publication page



Cognitive Impairment in Genetic Parkinson's Disease.

Parkinson'S Disease
Planas-Ballvé, A A; Vilas, D D
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 35003622
Variant Present in the following documents:
  • Main text
  • PD2021-8610285.pdf
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Sleep and circadian rhythms in Parkinson's disease and preclinical models.

Molecular Neurodegeneration
Hunt, Jeremy J; Coulson, Elizabeth J EJ; Rajnarayanan, Rajendram R; Oster, Henrik H; Videnovic, Aleksandar A; Rawashdeh, Oliver O
Publication Date: 2022-01-09

Variant appearance in text: SNCA: A30P
PubMed Link: 35000606
Variant Present in the following documents:
  • Main text
  • 13024_2021_Article_504.pdf
View BVdb publication page



Mitochondrial Function and Parkinson's Disease: From the Perspective of the Electron Transport Chain.

Frontiers In Molecular Neuroscience
Li, Jeng-Lin JL; Lin, Tai-Yi TY; Chen, Po-Lin PL; Guo, Ting-Ni TN; Huang, Shu-Yi SY; Chen, Chun-Hong CH; Lin, Chin-Hsien CH; Chan, Chih-Chiang CC
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 34955747
Variant Present in the following documents:
  • fnmol-14-797833.pdf
View BVdb publication page



Autophagy-Lysosomal Pathway as Potential Therapeutic Target in Parkinson's Disease.

Cells
Bonam, Srinivasa Reddy SR; Tranchant, Christine C; Muller, Sylviane S
Publication Date: 2021-12-15

Variant appearance in text: SNCA: A30P
PubMed Link: 34944054
Variant Present in the following documents:
  • Main text
  • cells-10-03547.pdf
View BVdb publication page



Mitochondrial Phenotypes in Parkinson's Diseases-A Focus on Human iPSC-Derived Dopaminergic Neurons.

Cells
Heger, Leonie M LM; Wise, Rachel M RM; Hees, J Tabitha JT; Harbauer, Angelika B AB; Burbulla, Lena F LF
Publication Date: 2021-12-07

Variant appearance in text: SNCA: A30P
PubMed Link: 34943944
Variant Present in the following documents:
  • cells-10-03436.pdf
View BVdb publication page



Neuropathology and molecular diagnosis of Synucleinopathies.

Molecular Neurodegeneration
Koga, Shunsuke S; Sekiya, Hiroaki H; Kondru, Naveen N; Ross, Owen A OA; Dickson, Dennis W DW
Publication Date: 2021-12-18

Variant appearance in text: SNCA: A30P
PubMed Link: 34922583
Variant Present in the following documents:
  • Main text
  • 13024_2021_Article_501.pdf
View BVdb publication page



Alpha-synuclein as a biomarker in Parkinson's disease: focus on neural derived extracelluar vesicles.

Neural Regeneration Research
Agliardi, Cristina C; Guerini, Franca R FR; Meloni, Mario M; Clerici, Mario M
Publication Date: 2022-07

Variant appearance in text: SNCA: A30P
PubMed Link: 34916434
Variant Present in the following documents:
  • Main text
  • NRR-17-1503.pdf
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Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders.

Current Research In Pharmacology And Drug Discovery
Khatri, Dharmendra Kumar DK; Kadbhane, Amey A; Patel, Monica M; Nene, Shweta S; Atmakuri, Srividya S; Srivastava, Saurabh S; Singh, Shashi Bala SB
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 34909657
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  • Main text
  • main.pdf
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Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson's Disease.

Frontiers In Pharmacology
Wang, Yumin Y; Gao, Luyan L; Chen, Jichao J; Li, Qiang Q; Huo, Liang L; Wang, Yanchao Y; Wang, Hongquan H; Du, Jichen J
Publication Date: 2021

Variant appearance in text: PARK4: A30P
PubMed Link: 34887759
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  • Main text
  • fphar-12-757161.pdf
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Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight.

Molecules (Basel, Switzerland)
Upcott, Matthew M; Chaprov, Kirill D KD; Buchman, Vladimir L VL
Publication Date: 2021-12-03

Variant appearance in text: SNCA: A30P
PubMed Link: 34885933
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  • Main text
  • molecules-26-07351.pdf
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Basal lamina changes in neurodegenerative disorders.

Molecular Neurodegeneration
Nguyen, Benjamin B; Bix, Gregory G; Yao, Yao Y
Publication Date: 2021-12-07

Variant appearance in text: SNCA: A30P
PubMed Link: 34876200
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Alpha-Synuclein and Cognitive Decline in Parkinson Disease.

Life (Basel, Switzerland)
Fan, Tian-Sin TS; Liu, Sam Chi-Hao SC; Wu, Ruey-Meei RM
Publication Date: 2021-11-16

Variant appearance in text: SNCA: A30P
PubMed Link: 34833115
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  • Main text
  • life-11-01239.pdf
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Examining the Toxicity of α-Synuclein in Neurodegenerative Disorders.

Life (Basel, Switzerland)
Shan, Frank Y FY; Fung, Kar-Ming KM; Zieneldien, Tarek T; Kim, Janice J; Cao, Chuanhai C; Huang, Jason H JH
Publication Date: 2021-10-22

Variant appearance in text: SNCA: A30P
PubMed Link: 34833002
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  • Main text
  • life-11-01126.pdf
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Autophagy in α-Synucleinopathies-An Overstrained System.

Cells
Fellner, Lisa L; Gabassi, Elisa E; Haybaeck, Johannes J; Edenhofer, Frank F
Publication Date: 2021-11-12

Variant appearance in text: SNCA: A30P
PubMed Link: 34831366
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  • Main text
  • cells-10-03143.pdf
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Protein Misfolding and Aggregation: The Relatedness between Parkinson's Disease and Hepatic Endoplasmic Reticulum Storage Disorders.

International Journal Of Molecular Sciences
Padilla-Godínez, Francisco J FJ; Ramos-Acevedo, Rodrigo R; Martínez-Becerril, Hilda Angélica HA; Bernal-Conde, Luis D LD; Garrido-Figueroa, Jerónimo F JF; Hiriart, Marcia M; Hernández-López, Adriana A; Argüero-Sánchez, Rubén R; Callea, Francesco F; Guerra-Crespo, Magdalena M
Publication Date: 2021-11-18

Variant appearance in text: SNCA: A30P
PubMed Link: 34830348
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  • Main text
  • ijms-22-12467.pdf
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The Emerging Roles of Autophagy in Human Diseases.

Biomedicines
Lei, Yuchen Y; Klionsky, Daniel J DJ
Publication Date: 2021-11-09

Variant appearance in text: SNCA: A30P
PubMed Link: 34829881
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  • Main text
  • biomedicines-09-01651.pdf
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Mitochondria-Endoplasmic Reticulum Crosstalk in Parkinson's Disease: The Role of Brain Renin Angiotensin System Components.

Biomolecules
Sunanda, Tuladhar T; Ray, Bipul B; Mahalakshmi, Arehally M AM; Bhat, Abid A; Rashan, Luay L; Rungratanawanich, Wiramon W; Song, Byoung-Joon BJ; Essa, Musthafa Mohamed MM; Sakharkar, Meena Kishore MK; Chidambaram, Saravana Babu SB
Publication Date: 2021-11-10

Variant appearance in text: SNCA: A30P
PubMed Link: 34827667
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α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox.

Cell & Bioscience
Simon, Christopher C; Soga, Tomoko T; Okano, Hirotaka James HJ; Parhar, Ishwar I
Publication Date: 2021-11-19

Variant appearance in text: NACP: A30P
PubMed Link: 34798911
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  • Main text
  • 13578_2021_Article_709.pdf
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Ca2+ administration prevents α-synuclein proteotoxicity by stimulating calcineurin-dependent lysosomal proteolysis.

Plos Genetics
Habernig, Lukas L; Broeskamp, Filomena F; Aufschnaiter, Andreas A; Diessl, Jutta J; Peselj, Carlotta C; Urbauer, Elisabeth E; Eisenberg, Tobias T; de Ory, Ana A; Büttner, Sabrina S
Publication Date: 2021-11

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 34780474
Variant Present in the following documents:
  • pgen.1009911.pdf
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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans.

Molecular Neurodegeneration
Chen, Kevin S KS; Menezes, Krystal K; Rodgers, Jarlath B JB; O'Hara, Darren M DM; Tran, Nhat N; Fujisawa, Kazuko K; Ishikura, Seiya S; Khodaei, Shahin S; Chau, Hien H; Cranston, Anna A; Kapadia, Minesh M; Pawar, Grishma G; Ping, Susan S; Krizus, Aldis A; Lacoste, Alix A; Spangler, Scott S; Visanji, Naomi P NP; Marras, Connie C; Majbour, Nour K NK; El-Agnaf, Omar M A OMA; Lozano, Andres M AM; Culotti, Joseph J; Suo, Satoshi S; Ryu, William S WS; Kalia, Suneil K SK; Kalia, Lorraine V LV
Publication Date: 2021-11-12

Variant appearance in text: SNCA: A30P
PubMed Link: 34772429
Variant Present in the following documents:
  • Main text
  • 13024_2021_Article_497.pdf
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Focus on the Small GTPase Rab1: A Key Player in the Pathogenesis of Parkinson's Disease.

International Journal Of Molecular Sciences
Martínez-Menárguez, José Ángel JÁ; Martínez-Alonso, Emma E; Cara-Esteban, Mireia M; Tomás, Mónica M
Publication Date: 2021-11-08

Variant appearance in text: SNCA: A30P
PubMed Link: 34769517
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Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro.

International Journal Of Molecular Sciences
Inden, Masatoshi M; Takagi, Ayaka A; Kitai, Hazuki H; Ito, Taisei T; Kurita, Hisaka H; Honda, Ryo R; Kamatari, Yuji O YO; Nozaki, Sora S; Wen, Xiaopeng X; Hijioka, Masanori M; Kitamura, Yoshihisa Y; Hozumi, Isao I
Publication Date: 2021-10-25

Variant appearance in text: SNCA: A30P
PubMed Link: 34768913
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  • Main text
  • ijms-22-11484.pdf
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Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells.

International Journal Of Molecular Sciences
Lorentzon, Emma E; Horvath, Istvan I; Kumar, Ranjeet R; Rodrigues, Joana Isabel JI; Tamás, Markus J MJ; Wittung-Stafshede, Pernilla P
Publication Date: 2021-10-24

Variant appearance in text: SNCA: A30P
PubMed Link: 34768886
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  • Main text
  • ijms-22-11455.pdf
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Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function.

Scientific Reports
Barbuti, Peter A PA; Ohnmacht, Jochen J; Santos, Bruno F R BFR; Antony, Paul M PM; Massart, François F; Cruciani, Gérald G; Dording, Claire M CM; Pavelka, Lukas L; Casadei, Nicolas N; Kwon, Yong-Jun YJ; Krüger, Rejko R
Publication Date: 2021-11-09

Variant appearance in text: SNCA: 88G>C; A30P
PubMed Link: 34754035
Variant Present in the following documents:
  • Main text
  • 41598_2021_1505_MOESM1_ESM.pdf
  • 41598_2021_Article_1505.pdf
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Transgenic Mice Expressing Human α-Synuclein 1-103 Fragment as a Novel Model of Parkinson's Disease.

Frontiers In Aging Neuroscience
Tian, Ye Y; He, Mingyang M; Pan, Lina L; Yuan, Xin X; Xiong, Min M; Meng, Lanxia L; Yao, Zhaohui Z; Yu, Zhui Z; Ye, Keqiang K; Zhang, Zhentao Z
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 34744697
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  • Main text
  • fnagi-13-760781.pdf
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A Quantitative Perspective of Alpha-Synuclein Dynamics - Why Numbers Matter.

Frontiers In Synaptic Neuroscience
Specht, Christian G CG
Publication Date: 2021

Variant appearance in text: SNCA: Ala30Pro
PubMed Link: 34744680
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  • fnsyn-13-753462.pdf
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Alpha-Synuclein Aggregation in Parkinson's Disease.

Frontiers In Medicine
Srinivasan, E E; Chandrasekhar, G G; Chandrasekar, P P; Anbarasu, K K; Vickram, A S AS; Karunakaran, Rohini R; Rajasekaran, R R; Srikumar, P S PS
Publication Date: 2021

Variant appearance in text: SNCA: A30P
PubMed Link: 34733860
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Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease.

Acta Pharmaceutica Sinica. B
Zhang, Kai K; Zhu, Shiou S; Li, Jiamei J; Jiang, Tingting T; Feng, Lu L; Pei, Junping J; Wang, Guan G; Ouyang, Liang L; Liu, Bo B
Publication Date: 2021-10

Variant appearance in text: SNCA: A30P
PubMed Link: 34729301
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  • Main text
  • main.pdf
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