APC c.146A>G ;(p.K49R)

Variant ID: 5-112102033-A-G

NM_000038.5(APC):c.146A>G;(p.K49R)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


ABL1-dependent OTULIN phosphorylation promotes genotoxic Wnt/β-catenin activation to enhance drug resistance in breast cancers.

Nature Communications
Wang, Wei W; Li, Mingqi M; Ponnusamy, Suriyan S; Chi, Yayun Y; Xue, Jingyan J; Fahmy, Beshoy B; Fan, Meiyun M; Miranda-Carboni, Gustavo A GA; Narayanan, Ramesh R; Wu, Jiong J; Wu, Zhao-Hui ZH
Publication Date: 2020-08-07

Variant appearance in text: APC: K49R
PubMed Link: 32770022
Variant Present in the following documents:
  • Main text
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Ube2s stabilizes β-Catenin through K11-linked polyubiquitination to promote mesendoderm specification and colorectal cancer development.

Cell Death & Disease
Li, Zhaoyan Z; Wang, Yan Y; Li, Yadan Y; Yin, Wanqi W; Mo, Libin L; Qian, Xianghao X; Zhang, Yiran Y; Wang, Guifen G; Bu, Fan F; Zhang, Zhiling Z; Ren, Xiaofang X; Zhu, Baochang B; Niu, Chang C; Xiao, Wei W; Zhang, Weiwei W
Publication Date: 2018-05-01

Variant appearance in text: APC: K49R
PubMed Link: 29674637
Variant Present in the following documents:
  • Main text
  • 41419_2018_Article_451.pdf
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SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin.

Embo Molecular Medicine
Simic, Petra P; Zainabadi, Kayvan K; Bell, Eric E; Sykes, David B DB; Saez, Borja B; Lotinun, Sutada S; Baron, Roland R; Scadden, David D; Schipani, Ernestina E; Guarente, Leonard L
Publication Date: 2013-03

Variant appearance in text: APC: K49R
PubMed Link: 23364955
Variant Present in the following documents:
  • Main text
View BVdb publication page



PCAF acetylates {beta}-catenin and improves its stability.

Molecular Biology Of The Cell
Ge, Xinjian X; Jin, Qihuang Q; Zhang, Fang F; Yan, Tingting T; Zhai, Qiwei Q
Publication Date: 2009-01

Variant appearance in text: APC: K49R
PubMed Link: 18987336
Variant Present in the following documents:
  • Main text
View BVdb publication page



Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction.

Molecular And Cellular Biology
Lévy, Laurence L; Wei, Yu Y; Labalette, Charlotte C; Wu, Yuanfei Y; Renard, Claire-Angélique CA; Buendia, Marie Annick MA; Neuveut, Christine C
Publication Date: 2004-04

Variant appearance in text: APC: K49R
PubMed Link: 15060161
Variant Present in the following documents:
  • Main text
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A noncanonical sequence phosphorylated by casein kinase 1 in beta-catenin may play a role in casein kinase 1 targeting of important signaling proteins.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Marin, Oriano O; Bustos, Victor H VH; Cesaro, Luca L; Meggio, Flavio F; Pagano, Mario A MA; Antonelli, Marcelo M; Allende, Catherine C CC; Pinna, Lorenzo A LA; Allende, Jorge E JE
Publication Date: 2003-09-02

Variant appearance in text: APC: K49R
PubMed Link: 12925738
Variant Present in the following documents:
  • Main text
View BVdb publication page