Structural and energetic analyses of SARS-CoV-2 N-terminal domain characterise sugar binding pockets and suggest putative impacts of variants on COVID-19 transmission.
Computational And Structural Biotechnology Journal
Lam, Su Datt SD; Waman, Vaishali P VP; Fraternali, Franca F; Orengo, Christine C; Lees, Jonathan J
Variant-specific vaccination induces systems immune responses and potent in vivo protection against SARS-CoV-2.
Cell Reports. Medicine
Peng, Lei L; Renauer, Paul A PA; Ökten, Arya A; Fang, Zhenhao Z; Park, Jonathan J JJ; Zhou, Xiaoyu X; Lin, Qianqian Q; Dong, Matthew B MB; Filler, Renata R; Xiong, Qiancheng Q; Clark, Paul P; Lin, Chenxiang C; Wilen, Craig B CB; Chen, Sidi S
An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.
Cell Reports
Hassan, Ahmed O AO; Shrihari, Swathi S; Gorman, Matthew J MJ; Ying, Baoling B; Yaun, Dansu D; Raju, Saravanan S; Chen, Rita E RE; Dmitriev, Igor P IP; Kashentseva, Elena E; Adams, Lucas J LJ; Mann, Colin C; Davis-Gardner, Meredith E ME; Suthar, Mehul S MS; Shi, Pei-Yong PY; Saphire, Erica Ollmann EO; Fremont, Daved H DH; Curiel, David T DT; Alter, Galit G; Diamond, Michael S MS
An intranasal vaccine durably protects against SARS-CoV-2 variants in mice.
Cell Reports
Hassan, Ahmed O AO; Shrihari, Swathi S; Gorman, Matthew J MJ; Ying, Baoling B; Yuan, Dansu D; Raju, Saravanan S; Chen, Rita E RE; Dmitriev, Igor P IP; Kashentseva, Elena E; Adams, Lucas J LJ; Mann, Colin C; Davis-Gardner, Meredith E ME; Suthar, Mehul S MS; Shi, Pei-Yong PY; Saphire, Erica Ollmann EO; Fremont, Daved H DH; Curiel, David T DT; Alter, Galit G; Diamond, Michael S MS
Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.
Nature Communications
Vergara, Ismael A IA; Mintoff, Christopher P CP; Sandhu, Shahneen S; McIntosh, Lachlan L; Young, Richard J RJ; Wong, Stephen Q SQ; Colebatch, Andrew A; Cameron, Daniel L DL; Kwon, Julia Lai JL; Wolfe, Rory R; Peng, Angela A; Ellul, Jason J; Dou, Xuelin X; Fedele, Clare C; Boyle, Samantha S; Arnau, Gisela Mir GM; Raleigh, Jeanette J; Hatzimihalis, Athena A; Szeto, Pacman P; Mooi, Jennifer J; Widmer, Daniel S DS; Cheng, Phil F PF; Amann, Valerie V; Dummer, Reinhard R; Hayward, Nicholas N; Wilmott, James J; Scolyer, Richard A RA; Cho, Raymond J RJ; Bowtell, David D; Thorne, Heather H; Alsop, Kathryn K; Cordner, Stephen S; Woodford, Noel N; Leditschke, Jodie J; O'Brien, Patricia P; Dawson, Sarah-Jane SJ; McArthur, Grant A GA; Mann, Graham J GJ; Levesque, Mitchell P MP; Papenfuss, Anthony T AT; Shackleton, Mark M
IFN-gamma-induced PD-L1 expression in melanoma depends on p53 expression.
Journal Of Experimental & Clinical Cancer Research : Cr
Thiem, Alexander A; Hesbacher, Sonja S; Kneitz, Hermann H; di Primio, Teresa T; Heppt, Markus V MV; Hermanns, Heike M HM; Goebeler, Matthias M; Meierjohann, Svenja S; Houben, Roland R; Schrama, David D
Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.
Nature Communications
Zhao, Xiang X; Sankaran, Shvetha S; Yap, Jiawei J; Too, Chien Tei CT; Ho, Zi Zong ZZ; Dolton, Garry G; Legut, Mateusz M; Ren, Ee Chee EC; Sewell, Andrew K AK; Bertoletti, Antonio A; MacAry, Paul A PA; Brzostek, Joanna J; Gascoigne, Nicholas R J NRJ