DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity.
Journal For Immunotherapy Of Cancer
Muik, Alexander A; Adams 3rd, Homer C HC; Gieseke, Friederike F; Altintas, Isil I; Schoedel, Kristina B KB; Blum, Jordan M JM; Sänger, Bianca B; Burm, Saskia M SM; Stanganello, Eliana E; Verzijl, Dennis D; Spires, Vanessa M VM; Vascotto, Fulvia F; Toker, Aras A; Quinkhardt, Juliane J; Fereshteh, Mark M; Diken, Mustafa M; Satijn, David P E DPE; Kreiter, Sebastian S; Ahmadi, Tahamtan T; Breij, Esther C W ECW; Türeci, Özlem Ö; Sasser, Kate K; Sahin, Ugur U; Jure-Kunkel, Maria M
Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
Cancer Discovery
Muik, Alexander A; Garralda, Elena E; Altintas, Isil I; Gieseke, Friederike F; Geva, Ravit R; Ben-Ami, Eytan E; Maurice-Dror, Corinne C; Calvo, Emiliano E; LoRusso, Patricia M PM; Alonso, Guzman G; Rodriguez-Ruiz, Maria E ME; Schoedel, Kristina B KB; Blum, Jordan M JM; Sänger, Bianca B; Salcedo, Theodora W TW; Burm, Saskia M SM; Stanganello, Eliana E; Verzijl, Dennis D; Vascotto, Fulvia F; Sette, Angelica A; Quinkhardt, Juliane J; Plantinga, Theo S TS; Toker, Aras A; van den Brink, Edward N EN; Fereshteh, Mark M; Diken, Mustafa M; Satijn, David D; Kreiter, Sebastian S; Breij, Esther C W ECW; Bajaj, Gaurav G; Lagkadinou, Eleni E; Sasser, Kate K; Türeci, Özlem Ö; Forssmann, Ulf U; Ahmadi, Tahamtan T; Şahin, Uğur U; Jure-Kunkel, Maria M; Melero, Ignacio I
CD19/BAFF-R dual-targeted CAR T cells for the treatment of mixed antigen-negative variants of acute lymphoblastic leukemia.
Leukemia
Wang, Xiuli X; Dong, Zhenyuan Z; Awuah, Dennis D; Chang, Wen-Chung WC; Cheng, Wesley A WA; Vyas, Vibhuti V; Cha, Soung-Chul SC; Anderson, Aaron J AJ; Zhang, Tiantian T; Wang, Zhe Z; Szymura, Szymon J SJ; Kuang, Benjamin Z BZ; Clark, Mary C MC; Aldoss, Ibrahim I; Forman, Stephen J SJ; Kwak, Larry W LW; Qin, Hong H
KIR3DL3 Is an Inhibitory Receptor for HHLA2 that Mediates an Alternative Immunoinhibitory Pathway to PD1.
Cancer Immunology Research
Bhatt, Rupal S RS; Berjis, Abdulla A; Konge, Julie C JC; Mahoney, Kathleen M KM; Klee, Alyssa N AN; Freeman, Samuel S SS; Chen, Chun-Hau CH; Jegede, Opeyemi A OA; Catalano, Paul J PJ; Pignon, Jean-Christophe JC; Sticco-Ivins, Maura M; Zhu, Baogong B; Hua, Ping P; Soden, Jo J; Zhu, Jie J; McDermott, David F DF; Arulanandam, Antonio R AR; Signoretti, Sabina S; Freeman, Gordon J GJ
The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a.
Journal For Immunotherapy Of Cancer
Peluso, Marisa O MO; Adam, Ammar A; Armet, Caroline M CM; Zhang, Li L; O'Connor, Rachel W RW; Lee, Benjamin H BH; Lake, Andrew C AC; Normant, Emmanuel E; Chappel, Scott C SC; Hill, Jonathan A JA; Palombella, Vito J VJ; Holland, Pamela M PM; Paterson, Alison M AM
CMVpp65 Vaccine Enhances the Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV-Specific T Cells.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Wang, Xiuli X; Wong, ChingLam W CW; Urak, Ryan R; Mardiros, Armen A; Budde, Lihua E LE; Chang, Wen-Chung WC; Thomas, Sandra H SH; Brown, Christine E CE; La Rosa, Corinna C; Diamond, Don J DJ; Jensen, Michael C MC; Nakamura, Ryotaro R; Zaia, John A JA; Forman, Stephen J SJ
Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells.
Proceedings Of The National Academy Of Sciences Of The United States Of America
von Allmen, Caroline E CE; Schmitz, Nicole N; Bauer, Monika M; Hinton, Heather J HJ; Kurrer, Michael O MO; Buser, Regula B RB; Gwerder, Myriam M; Muntwiler, Simone S; Sparwasser, Tim T; Beerli, Roger R RR; Bachmann, Martin F MF