Beta-containing bivalent SARS-CoV-2 protein vaccine elicits durable broad neutralization in macaques and protection in hamsters.
Communications Medicine
Berry, Catherine C; Pavot, Vincent V; Anosova, Natalie G NG; Kishko, Michael M; Li, Lu L; Tibbitts, Tim T; Raillard, Alice A; Gautheron, Sylviane S; Cummings, Sheila S; Bangari, Dinesh S DS; Kar, Swagata S; Atyeo, Caroline C; Deng, Yixiang Y; Alter, Galit G; Gutzeit, Cindy C; Koutsoukos, Marguerite M; Chicz, Roman M RM; Lecouturier, Valerie V
Tetravalent SARS-CoV-2 S1 Subunit Protein Vaccination Elicits Robust Humoral and Cellular Immune Responses in SIV-Infected Rhesus Macaque Controllers.
Biorxiv : The Preprint Server For Biology
Khan, Muhammad S MS; Kim, Eun E; Hingrat, Quentin Le QL; Kleinman, Adam A; Ferrari, Alessandro A; Sammartino, Jose C JC; Percivalle, Elena E; Xu, Cuiling C; Huang, Shaohua S; Kenniston, Thomas W TW; Cassaniti, Irene I; Baldanti, Fausto F; Pandrea, Ivona I; Gambotto, Andrea A; Apetrei, Cristian C
Homologous Ad26.COV2.S vaccination results in reduced boosting of humoral responses in hybrid immunity, but elicits antibodies of similar magnitude regardless of prior infection.
Medrxiv : The Preprint Server For Health Sciences
Moyo-Gwete, Thandeka T; Richardson, Simone I SI; Keeton, Roanne R; Hermanus, Tandile T; Spencer, Holly H; Manamela, Nelia P NP; Ayres, Frances F; Makhado, Zanele Z; Motlou, Thopisang T; Tincho, Marius B MB; Benede, Ntombi N; Ngomti, Amkele A; Baguma, Richard R; Chauke, Masego V MV; Mennen, Mathilda M; Adriaanse, Marguerite M; Skelem, Sango S; Goga, Ameena A; Garrett, Nigel N; Bekker, Linda-Gail LG; Gray, Glenda G; Ntusi, Ntobeko A B NAB; Riou, Catherine C; Burgers, Wendy A WA; Moore, Penny L PL
Persistent SARS-CoV-2-specific immune defects in kidney transplant recipients following third mRNA vaccine doses.
American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons
Werbel, William A WA; Karaba, Andrew H AH; Po-Yu Chiang, Teresa T; Massie, Allan B AB; Brown, Diane M DM; Watson, Natasha N; Chahoud, Maggie M; Thompson, Elizabeth A EA; Johnson, Aileen C AC; Avery, Robin K RK; Cochran, Willa V WV; Warren, Daniel D; Liang, Tao T; Fribourg, Miguel M; Huerta, Christopher C; Samaha, Hady H; Klein, Sabra L SL; Bettinotti, Maria P MP; Clarke, William A WA; Sitaras, Ioannis I; Rouphael, Nadine N; Cox, Andrea L AL; Bailey, Justin R JR; Pekosz, Andrew A; Tobian, Aaron A R AAR; Durand, Christine M CM; Bridges, Nancy D ND; Larsen, Christian P CP; Heeger, Peter S PS; Segev, Dorry L DL; ,
A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Jang, H Josh HJ; Hostetter, Galen G; MacFarlane, Alexander W AW; Madaj, Zachary Z; Ross, Eric A EA; Hinoue, Toshinori T; Kulchycki, Justin R JR; Burgos, Ryan S RS; Tafseer, Mahvish M; Alpaugh, R Katherine RK; Schwebel, Candice L CL; Kokate, Rutika R; Geynisman, Daniel M DM; Zibelman, Matthew R MR; Ghatalia, Pooja P; Nichols, Peter W PW; Chung, Woonbok W; Madzo, Jozef J; Hahn, Noah M NM; Quinn, David I DI; Issa, Jean-Pierre J JJ; Topper, Michael J MJ; Baylin, Stephen B SB; Shen, Hui H; Campbell, Kerry S KS; Jones, Peter A PA; Plimack, Elizabeth R ER
Preclinical safety and efficacy of a therapeutic antibody that targets SARS-CoV-2 at the sotrovimab face but is escaped by Omicron.
Iscience
Kreye, Jakob J; Reincke, S Momsen SM; Edelburg, Stefan S; Jeworowski, Lara M LM; Kornau, Hans-Christian HC; Trimpert, Jakob J; Hombach, Peter P; Halbe, Sophia S; Nölle, Volker V; Meyer, Martin M; Kattenbach, Stefanie S; Sánchez-Sendin, Elisa E; Schmidt, Marie L ML; Schwarz, Tatjana T; Rose, Ruben R; Krumbholz, Andi A; Merz, Sophie S; Adler, Julia M JM; Eschke, Kathrin K; Abdelgawad, Azza A; Schmitz, Dietmar D; Sander, Leif E LE; Janssen, Uwe U; Corman, Victor M VM; Prüss, Harald H
Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant.
Cell Reports. Medicine
Richardson, Simone I SI; Kgagudi, Prudence P; Manamela, Nelia P NP; Kaldine, Haajira H; Venter, Elizabeth M EM; Pillay, Thanusha T; Lambson, Bronwen E BE; van der Mescht, Mieke A MA; Hermanus, Tandile T; Balla, Sashkia R SR; de Beer, Zelda Z; de Villiers, Talita R TR; Bodenstein, Annie A; van den Berg, Gretha G; du Pisanie, Marizane M; Burgers, Wendy A WA; Ntusi, Ntobeko A B NAB; Abdullah, Fareed F; Ueckermann, Veronica V; Rossouw, Theresa M TM; Boswell, Michael T MT; Moore, Penny L PL
Risk factors for severe disease and impact of severity on pregnant women with COVID-19: a case-control study based on data from a nationwide survey of maternity services in Japan.
The second COVID-19 mRNA vaccine dose enhances the capacity of Spike RBD-specific memory B cells to bind Omicron BA.2.
Allergy
Hartley, Gemma E GE; Edwards, Emily S J ESJ; Varese, Nirupama N; Boo, Irene I; Aui, Pei M PM; Bornheimer, Scott J SJ; Hogarth, P Mark PM; Drummer, Heidi E HE; O'Hehir, Robyn E RE; van Zelm, Menno C MC
High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection.
Nature Communications
Jacobsen, Eva-Maria EM; Fabricius, Dorit D; Class, Magdalena M; Topfstedt, Fernando F; Lorenzetti, Raquel R; Janowska, Iga I; Schmidt, Franziska F; Staniek, Julian J; Zernickel, Maria M; Stamminger, Thomas T; Dietz, Andrea N AN; Zellmer, Angela A; Hecht, Manuel M; Rauch, Peter P; Blum, Carmen C; Ludwig, Carolin C; Jahrsdörfer, Bernd B; Schrezenmeier, Hubert H; Heeg, Maximilian M; Mayer, Benjamin B; Seidel, Alina A; Groß, Rüdiger R; Münch, Jan J; Kirchhoff, Frank F; Bode, Sebastian F N SFN; Strauss, Gudrun G; Renk, Hanna H; Elling, Roland R; Stich, Maximillian M; Voll, Reinhard E RE; Tönshof, Burkhard B; Franz, Axel R AR; Henneke, Philipp P; Debatin, Klaus-Michael KM; Rizzi, Marta M; Janda, Ales A
Asymptomatic or symptomatic SARS-CoV-2 infection plus vaccination confers increased adaptive immunity to variants of concern.
Iscience
Sun, Peifang P; Ramos, Irene I; Coelho, Camila H CH; Grifoni, Alba A; Balinsky, Corey A CA; Vangeti, Sindhu S; Tarke, Alison A; Bloom, Nathaniel I NI; Jani, Vihasi V; Jakubski, Silvia J SJ; Boulifard, David A DA; Cooper, Elizabeth E; Goforth, Carl W CW; Marayag, Jan J; Marrone, Amethyst A; Nunez, Edgar E; White, Lindsey L; Porter, Chad K CK; Sugiharto, Victor A VA; Schilling, Megan M; Mahajan, Avinash S AS; Beckett, Charmagne C; Sette, Alessandro A; Sealfon, Stuart C SC; Crotty, Shane S; Letizia, Andrew G AG
Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2.
Frontiers In Immunology
Wines, Bruce D BD; Kurtovic, Liriye L; Trist, Halina M HM; Esparon, Sandra S; Lopez, Ester E; Chappin, Klasina K; Chan, Li-Jin LJ; Mordant, Francesca L FL; Lee, Wen Shi WS; Gherardin, Nicholas A NA; Patel, Sheila K SK; Hartley, Gemma E GE; Pymm, Phillip P; Cooney, James P JP; Beeson, James G JG; Godfrey, Dale I DI; Burrell, Louise M LM; van Zelm, Menno C MC; Wheatley, Adam K AK; Chung, Amy W AW; Tham, Wai-Hong WH; Subbarao, Kanta K; Kent, Stephen J SJ; Hogarth, P Mark PM
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies.
Communications Biology
Li, Ruofan R; Mor, Michael M; Ma, Bingting B; Clark, Alex E AE; Alter, Joel J; Werbner, Michal M; Lee, Jamie Casey JC; Leibel, Sandra L SL; Carlin, Aaron F AF; Dessau, Moshe M; Gal-Tanamy, Meital M; Croker, Ben A BA; Xiang, Ye Y; Freund, Natalia T NT
Systemic Neutralizing Antibodies and Local Immune Responses Are Critical for the Control of SARS-CoV-2.
Viruses
Chandrasekar, Shaswath S SS; Phanse, Yashdeep Y; Riel, Mariah M; Hildebrand, Rachel E RE; Hanafy, Mostafa M; Osorio, Jorge E JE; Abdelgayed, Sherein S SS; Talaat, Adel M AM
Antibody and Memory B-Cell Immunity in a Heterogeneously SARS-CoV-2-Infected and -Vaccinated Population.
Mbio
Bednarski, Eva E; Del Rio Estrada, Perla M PM; DaSilva, Justin J; Boukadida, Celia C; Zhang, Fengwen F; Luna-Villalobos, Yara A YA; Rodríguez-Rangel, Ximena X; Pitén-Isidro, Elvira E; Luna-García, Edgar E; Díaz Rivera, Dafne D; López-Sánchez, Dulce M DM; Tapia-Trejo, Daniela D; Soto-Nava, Maribel M; Astorga-Castañeda, Myriam M; Martínez-Moreno, José O JO; Urbina-Granados, Guadalupe S GS; Jiménez-Jacinto, José A JA; Serna Alvarado, Francisco J FJ; Enriquez-López, Yerania E YE; López-Arellano, Oliva O; Reyes-Teran, Gustavo G; Bieniasz, Paul D PD; Avila-Rios, Santiago S; Hatziioannou, Theodora T
A Multivalent Vaccine Based on Ferritin Nanocage Elicits Potent Protective Immune Responses against SARS-CoV-2 Mutations.
International Journal Of Molecular Sciences
Kim, Seong A SA; Kim, Seohyun S; Kim, Gi Beom GB; Goo, Jiyoung J; Kim, Nayeon N; Lee, Yeram Y; Nam, Gi-Hoon GH; Lim, Seungho S; Kim, Taeerk T; Chang, Ki Hwan KH; Lee, Tae Gyu TG; Kim, In-San IS; Lee, Eun Jung EJ