Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists.
Communications Biology
Sokkar, Pandian P; Harms, Mirja M; Stürzel, Christina C; Gilg, Andrea A; Kizilsavas, Gönül G; Raasholm, Martina M; Preising, Nico N; Wagner, Manfred M; Kirchhoff, Frank F; Ständker, Ludger L; Weidinger, Gilbert G; Mayer, Benjamin B; Münch, Jan J; Sanchez-Garcia, Elsa E
Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs.
The Journal Of Biological Chemistry
Rajagopal, Vaishnavi V; Park, Eun-Hee EH; Hinnebusch, Alan G AG; Lorsch, Jon R JR