A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins.
Journal Of Medicinal Chemistry
Povedano, Juan Manuel JM; Rallabandi, Rameshu R; Bai, Xin X; Ye, Xuecheng X; Liou, Joel J; Chen, Hong H; Kim, Jiwoong J; Xie, Yang Y; Posner, Bruce B; Rice, Luke L; De Brabander, Jef K JK; McFadden, David G DG
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.
Nature Chemical Biology
Masureel, Matthieu M; Zou, Yaozhong Y; Picard, Louis-Philippe LP; van der Westhuizen, Emma E; Mahoney, Jacob P JP; Rodrigues, João P G L M JPGLM; Mildorf, Thomas J TJ; Dror, Ron O RO; Shaw, David E DE; Bouvier, Michel M; Pardon, Els E; Steyaert, Jan J; Sunahara, Roger K RK; Weis, William I WI; Zhang, Cheng C; Kobilka, Brian K BK
p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex.
Rna (New York, N.Y.)
Tiedje, Christopher C; Lubas, Michal M; Tehrani, Mohammad M; Menon, Manoj B MB; Ronkina, Natalia N; Rousseau, Simon S; Cohen, Philip P; Kotlyarov, Alexey A; Gaestel, Matthias M