Lipoprotein(a) Genotype Influences the Clinical Diagnosis of Familial Hypercholesterolemia.
Journal Of The American Heart Association
Olmastroni, Elena E; Gazzotti, Marta M; Averna, Maurizio M; Arca, Marcello M; Tarugi, Patrizia P; Calandra, Sebastiano S; Bertolini, Stefano S; Catapano, Alberico L AL; Casula, Manuela M; ,
Subclinical atherosclerosis determined by coronary artery calcium deposition in patients with clinical familial hypercholesterolemia.
Atherosclerosis Plus
Borg, Sanna Á SÁ; Sørensen Bork, Christian C; Skjelbo Nielsen, Michael René MR; Jóanesarson, Jan J; Zaremba, Tomas T; Lolas, Ihab Bishara Yousef IBY; Lundbye-Christensen, Søren S; Søgaard, Peter P; Berg Schmidt, Erik E; Joensen, Albert Marni AM
Twelve Variants Polygenic Score for Low-Density Lipoprotein Cholesterol Distribution in a Large Cohort of Patients With Clinically Diagnosed Familial Hypercholesterolemia With or Without Causative Mutations.
Journal Of The American Heart Association
Olmastroni, Elena E; Gazzotti, Marta M; Arca, Marcello M; Averna, Maurizio M; Pirillo, Angela A; Catapano, Alberico Luigi AL; Casula, Manuela M; ,
Case-finding and genetic testing for familial hypercholesterolaemia in primary care.
Heart (British Cardiac Society)
Qureshi, Nadeem N; Akyea, Ralph Kwame RK; Dutton, Brittany B; Humphries, Steve E SE; Abdul Hamid, Hasidah H; Condon, Laura L; Weng, Stephen F SF; Kai, Joe J; ,
A multi-ethnic epigenome-wide association study of leukocyte DNA methylation and blood lipids.
Nature Communications
Jhun, Min-A MA; Mendelson, Michael M; Wilson, Rory R; Gondalia, Rahul R; Joehanes, Roby R; Salfati, Elias E; Zhao, Xiaoping X; Braun, Kim Valeska Emilie KVE; Do, Anh Nguyet AN; Hedman, Åsa K ÅK; Zhang, Tao T; Carnero-Montoro, Elena E; Shen, Jincheng J; Bartz, Traci M TM; Brody, Jennifer A JA; Montasser, May E ME; O'Connell, Jeff R JR; Yao, Chen C; Xia, Rui R; Boerwinkle, Eric E; Grove, Megan M; Guan, Weihua W; Liliane, Pfeiffer P; Singmann, Paula P; Müller-Nurasyid, Martina M; Meitinger, Thomas T; Gieger, Christian C; Peters, Annette A; Zhao, Wei W; Ware, Erin B EB; Smith, Jennifer A JA; Dhana, Klodian K; van Meurs, Joyce J; Uitterlinden, Andre A; Ikram, Mohammad Arfan MA; Ghanbari, Mohsen M; Zhi, Deugi D; Gustafsson, Stefan S; Lind, Lars L; Li, Shengxu S; Sun, Dianjianyi D; Spector, Tim D TD; Chen, Yii-der Ida YI; Damcott, Coleen C; Shuldiner, Alan R AR; Absher, Devin M DM; Horvath, Steve S; Tsao, Philip S PS; Kardia, Sharon S; Psaty, Bruce M BM; Sotoodehnia, Nona N; Bell, Jordana T JT; Ingelsson, Erik E; Chen, Wei W; Dehghan, Abbas A; Arnett, Donna K DK; Waldenberger, Melanie M; Hou, Lifang L; Whitsel, Eric A EA; Baccarelli, Andrea A; Levy, Daniel D; Fornage, Myriam M; Irvin, Marguerite R MR; Assimes, Themistocles L TL
Saadatagah, Seyedmohammad S; Jose, Merin M; Dikilitas, Ozan O; Alhalabi, Lubna L; Miller, Alexandra A AA; Fan, Xiao X; Olson, Janet E JE; Kochan, David C DC; Safarova, Maya M; Kullo, Iftikhar J IJ
Polygenic Markers in Patients Diagnosed of Autosomal Dominant Hypercholesterolemia in Catalonia: Distribution of Weighted LDL-c-Raising SNP Scores and Refinement of Variant Selection.
Biomedicines
Martín-Campos, Jesús M JM; Ruiz-Nogales, Sheila S; Ibarretxe, Daiana D; Ortega, Emilio E; Sánchez-Pujol, Elisabet E; Royuela-Juncadella, Meritxell M; Vila, Àlex À; Guerrero, Carolina C; Zamora, Alberto A; Soler I Ferrer, Cristina C; Arroyo, Juan Antonio JA; Carreras, Gemma G; Martínez-Figueroa, Susana S; Roig, Rosa R; Plana, Núria N; Blanco-Vaca, Francisco F; Xarxa d'Unitats de Lípids I Arteriosclerosi Xula,
Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels.
Circulation. Genomic And Precision Medicine
Wang, Zhe Z; Chen, Han H; Bartz, Traci M TM; Bielak, Lawrence F LF; Chasman, Daniel I DI; Feitosa, Mary F MF; Franceschini, Nora N; Guo, Xiuqing X; Lim, Elise E; Noordam, Raymond R; Richard, Melissa A MA; Wang, Heming H; Cade, Brian B; Cupples, L Adrienne LA; de Vries, Paul S PS; Giulanini, Franco F; Lee, Jiwon J; Lemaitre, Rozenn N RN; Martin, Lisa W LW; Reiner, Alex P AP; Rich, Stephen S SS; Schreiner, Pamela J PJ; Sidney, Stephen S; Sitlani, Colleen M CM; Smith, Jennifer A JA; Willems van Dijk, Ko K; Yao, Jie J; Zhao, Wei W; Fornage, Myriam M; Kardia, Sharon L R SLR; Kooperberg, Charles C; Liu, Ching-Ti CT; Mook-Kanamori, Dennis O DO; Province, Michael A MA; Psaty, Bruce M BM; Redline, Susan S; Ridker, Paul M PM; Rotter, Jerome I JI; Boerwinkle, Eric E; Morrison, Alanna C AC; ,
Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review.
Medicine
Mofo Mato, Edith Pascale EP; Guewo-Fokeng, Magellan M; Essop, M Faadiel MF; Owira, Peter Mark Oroma PMO
Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci.
Cell Stem Cell
Pashos, Evanthia E EE; Park, YoSon Y; Wang, Xiao X; Raghavan, Avanthi A; Yang, Wenli W; Abbey, Deepti D; Peters, Derek T DT; Arbelaez, Juan J; Hernandez, Mayda M; Kuperwasser, Nicolas N; Li, Wenjun W; Lian, Zhaorui Z; Liu, Ying Y; Lv, Wenjian W; Lytle-Gabbin, Stacey L SL; Marchadier, Dawn H DH; Rogov, Peter P; Shi, Jianting J; Slovik, Katherine J KJ; Stylianou, Ioannis M IM; Wang, Li L; Yan, Ruilan R; Zhang, Xiaolan X; Kathiresan, Sekar S; Duncan, Stephen A SA; Mikkelsen, Tarjei S TS; Morrisey, Edward E EE; Rader, Daniel J DJ; Brown, Christopher D CD; Musunuru, Kiran K
Genetic contribution to lipid levels in early life based on 158 loci validated in adults: the FAMILY study.
Scientific Reports
Christie, Shanice S; Robiou-du-Pont, Sébastien S; Anand, Sonia S SS; Morrison, Katherine M KM; McDonald, Sarah D SD; Paré, Guillaume G; Atkinson, Stephanie A SA; Teo, Koon K KK; Meyre, David D
Analysis with the exome array identifies multiple new independent variants in lipid loci.
Human Molecular Genetics
Kanoni, Stavroula S; Masca, Nicholas G D NG; Stirrups, Kathleen E KE; Varga, Tibor V TV; Warren, Helen R HR; Scott, Robert A RA; Southam, Lorraine L; Zhang, Weihua W; Yaghootkar, Hanieh H; Müller-Nurasyid, Martina M; Couto Alves, Alexessander A; Strawbridge, Rona J RJ; Lataniotis, Lazaros L; An Hashim, Nikman N; Besse, Céline C; Boland, Anne A; Braund, Peter S PS; Connell, John M JM; Dominiczak, Anna A; Farmaki, Aliki-Eleni AE; Franks, Stephen S; Grallert, Harald H; Jansson, Jan-Håkan JH; Karaleftheri, Maria M; Keinänen-Kiukaanniemi, Sirkka S; Matchan, Angela A; Pasko, Dorota D; Peters, Annette A; Poulter, Neil N; Rayner, Nigel W NW; Renström, Frida F; Rolandsson, Olov O; Sabater-Lleal, Maria M; Sennblad, Bengt B; Sever, Peter P; Shields, Denis D; Silveira, Angela A; Stanton, Alice V AV; Strauch, Konstantin K; Tomaszewski, Maciej M; Tsafantakis, Emmanouil E; Waldenberger, Melanie M; Blakemore, Alexandra I F AI; Dedoussis, George G; Escher, Stefan A SA; Kooner, Jaspal S JS; McCarthy, Mark I MI; Palmer, Colin N A CN; , ; Hamsten, Anders A; Caulfield, Mark J MJ; Frayling, Timothy M TM; Tobin, Martin D MD; Jarvelin, Marjo-Riitta MR; Zeggini, Eleftheria E; Gieger, Christian C; Chambers, John C JC; Wareham, Nick J NJ; Munroe, Patricia B PB; Franks, Paul W PW; Samani, Nilesh J NJ; Deloukas, Panos P
Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels.
Journal Of Medical Genetics
van Leeuwen, Elisabeth M EM; Sabo, Aniko A; Bis, Joshua C JC; Huffman, Jennifer E JE; Manichaikul, Ani A; Smith, Albert V AV; Feitosa, Mary F MF; Demissie, Serkalem S; Joshi, Peter K PK; Duan, Qing Q; Marten, Jonathan J; van Klinken, Jan B JB; Surakka, Ida I; Nolte, Ilja M IM; Zhang, Weihua W; Mbarek, Hamdi H; Li-Gao, Ruifang R; Trompet, Stella S; Verweij, Niek N; Evangelou, Evangelos E; Lyytikäinen, Leo-Pekka LP; Tayo, Bamidele O BO; Deelen, Joris J; van der Most, Peter J PJ; van der Laan, Sander W SW; Arking, Dan E DE; Morrison, Alanna A; Dehghan, Abbas A; Franco, Oscar H OH; Hofman, Albert A; Rivadeneira, Fernando F; Sijbrands, Eric J EJ; Uitterlinden, Andre G AG; Mychaleckyj, Josyf C JC; Campbell, Archie A; Hocking, Lynne J LJ; Padmanabhan, Sandosh S; Brody, Jennifer A JA; Rice, Kenneth M KM; White, Charles C CC; Harris, Tamara T; Isaacs, Aaron A; Campbell, Harry H; Lange, Leslie A LA; Rudan, Igor I; Kolcic, Ivana I; Navarro, Pau P; Zemunik, Tatijana T; Salomaa, Veikko V; , ; Kooner, Angad S AS; Kooner, Jaspal S JS; Lehne, Benjamin B; Scott, William R WR; Tan, Sian-Tsung ST; de Geus, Eco J EJ; Milaneschi, Yuri Y; Penninx, Brenda W J H BW; Willemsen, Gonneke G; de Mutsert, Renée R; Ford, Ian I; Gansevoort, Ron T RT; Segura-Lepe, Marcelo P MP; Raitakari, Olli T OT; Viikari, Jorma S JS; Nikus, Kjell K; Forrester, Terrence T; McKenzie, Colin A CA; de Craen, Anton J M AJ; de Ruijter, Hester M HM; , ; Pasterkamp, Gerard G; Snieder, Harold H; Oldehinkel, Albertine J AJ; Slagboom, P Eline PE; Cooper, Richard S RS; Kähönen, Mika M; Lehtimäki, Terho T; Elliott, Paul P; van der Harst, Pim P; Jukema, J Wouter JW; Mook-Kanamori, Dennis O DO; Boomsma, Dorret I DI; Chambers, John C JC; Swertz, Morris M; Ripatti, Samuli S; Willems van Dijk, Ko K; Vitart, Veronique V; Polasek, Ozren O; Hayward, Caroline C; Wilson, James G JG; Wilson, James F JF; Gudnason, Vilmundur V; Rich, Stephen S SS; Psaty, Bruce M BM; Borecki, Ingrid B IB; Boerwinkle, Eric E; Rotter, Jerome I JI; Cupples, L Adrienne LA; van Duijn, Cornelia M CM
Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.
Nature Communications
Tang, Clara S CS; Zhang, He H; Cheung, Chloe Y Y CY; Xu, Ming M; Ho, Jenny C Y JC; Zhou, Wei W; Cherny, Stacey S SS; Zhang, Yan Y; Holmen, Oddgeir O; Au, Ka-Wing KW; Yu, Haiyi H; Xu, Lin L; Jia, Jia J; Porsch, Robert M RM; Sun, Lijie L; Xu, Weixian W; Zheng, Huiping H; Wong, Lai-Yung LY; Mu, Yiming Y; Dou, Jingtao J; Fong, Carol H Y CH; Wang, Shuyu S; Hong, Xueyu X; Dong, Liguang L; Liao, Yanhua Y; Wang, Jiansong J; Lam, Levina S M LS; Su, Xi X; Yan, Hua H; Yang, Min-Lee ML; Chen, Jin J; Siu, Chung-Wah CW; Xie, Gaoqiang G; Woo, Yu-Cho YC; Wu, Yangfeng Y; Tan, Kathryn C B KC; Hveem, Kristian K; Cheung, Bernard M Y BM; Zöllner, Sebastian S; Xu, Aimin A; Eugene Chen, Y Y; Jiang, Chao Qiang CQ; Zhang, Youyi Y; Lam, Tai-Hing TH; Ganesh, Santhi K SK; Huo, Yong Y; Sham, Pak C PC; Lam, Karen S L KS; Willer, Cristen J CJ; Tse, Hung-Fat HF; Gao, Wei W
Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.
Plos One
Kulminski, Alexander M AM; Culminskaya, Irina I; Arbeev, Konstantin G KG; Arbeeva, Liubov L; Ukraintseva, Svetlana V SV; Stallard, Eric E; Wu, Deqing D; Yashin, Anatoliy I AI
A multivariate genome-wide association analysis of 10 LDL subfractions, and their response to statin treatment, in 1868 Caucasians.
Plos One
Shim, Heejung H; Chasman, Daniel I DI; Smith, Joshua D JD; Mora, Samia S; Ridker, Paul M PM; Nickerson, Deborah A DA; Krauss, Ronald M RM; Stephens, Matthew M
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.
Nature Communications
Benyamin, Beben B; Esko, Tonu T; Ried, Janina S JS; Radhakrishnan, Aparna A; Vermeulen, Sita H SH; Traglia, Michela M; Gögele, Martin M; Anderson, Denise D; Broer, Linda L; Podmore, Clara C; Luan, Jian'an J; Kutalik, Zoltan Z; Sanna, Serena S; van der Meer, Peter P; Tanaka, Toshiko T; Wang, Fudi F; Westra, Harm-Jan HJ; Franke, Lude L; Mihailov, Evelin E; Milani, Lili L; Hälldin, Jonas J; Häldin, Jonas J; Winkelmann, Juliane J; Meitinger, Thomas T; Thiery, Joachim J; Peters, Annette A; Waldenberger, Melanie M; Rendon, Augusto A; Jolley, Jennifer J; Sambrook, Jennifer J; Kiemeney, Lambertus A LA; Sweep, Fred C FC; Sala, Cinzia F CF; Schwienbacher, Christine C; Pichler, Irene I; Hui, Jennie J; Demirkan, Ayse A; Isaacs, Aaron A; Amin, Najaf N; Steri, Maristella M; Waeber, Gérard G; Verweij, Niek N; Powell, Joseph E JE; Nyholt, Dale R DR; Heath, Andrew C AC; Madden, Pamela A F PA; Visscher, Peter M PM; Wright, Margaret J MJ; Montgomery, Grant W GW; Martin, Nicholas G NG; Hernandez, Dena D; Bandinelli, Stefania S; van der Harst, Pim P; Uda, Manuela M; Vollenweider, Peter P; Scott, Robert A RA; Langenberg, Claudia C; Wareham, Nicholas J NJ; , ; van Duijn, Cornelia C; Beilby, John J; Pramstaller, Peter P PP; Hicks, Andrew A AA; Ouwehand, Willem H WH; Oexle, Konrad K; Gieger, Christian C; Metspalu, Andres A; Camaschella, Clara C; Toniolo, Daniela D; Swinkels, Dorine W DW; Whitfield, John B JB
A systematic evaluation of short tandem repeats in lipid candidate genes: riding on the SNP-wave.
Plos One
Lamina, Claudia C; Haun, Margot M; Coassin, Stefan S; Kloss-Brandstätter, Anita A; Gieger, Christian C; Peters, Annette A; Grallert, Harald H; Strauch, Konstantin K; Meitinger, Thomas T; Kedenko, Lyudmyla L; Paulweber, Bernhard B; Kronenberg, Florian F
Whole exome sequencing of familial hypercholesterolaemia patients negative for LDLR/APOB/PCSK9 mutations.
Journal Of Medical Genetics
Futema, Marta M; Plagnol, Vincent V; Li, KaWah K; Whittall, Ros A RA; Neil, H Andrew W HA; Seed, Mary M; , ; Bertolini, Stefano S; Calandra, Sebastiano S; Descamps, Olivier S OS; Graham, Colin A CA; Hegele, Robert A RA; Karpe, Fredrik F; Durst, Ronen R; Leitersdorf, Eran E; Lench, Nicholas N; Nair, Devaki R DR; Soran, Handrean H; Van Bockxmeer, Frank M FM; , ; Humphries, Steve E SE
LipidSeq: a next-generation clinical resequencing panel for monogenic dyslipidemias.
Journal Of Lipid Research
Johansen, Christopher T CT; Dubé, Joseph B JB; Loyzer, Melissa N MN; MacDonald, Austin A; Carter, David E DE; McIntyre, Adam D AD; Cao, Henian H; Wang, Jian J; Robinson, John F JF; Hegele, Robert A RA
Characterization of statin dose response in electronic medical records.
Clinical Pharmacology And Therapeutics
Wei, W-Q WQ; Feng, Q Q; Jiang, L L; Waitara, M S MS; Iwuchukwu, O F OF; Roden, D M DM; Jiang, M M; Xu, H H; Krauss, R M RM; Rotter, J I JI; Nickerson, D A DA; Davis, R L RL; Berg, R L RL; Peissig, P L PL; McCarty, C A CA; Wilke, R A RA; Denny, J C JC
PREDICTING TEMPORAL LOBE VOLUME ON MRI FROM GENOTYPES USING L(1)-L(2) REGULARIZED REGRESSION.
Proceedings. Ieee International Symposium On Biomedical Imaging
Kohannim, Omid O; Hibar, Derrek P DP; Jahanshad, Neda N; Stein, Jason L JL; Hua, Xue X; Toga, Arthur W AW; Jack, Clifford R CR; Weiner, Michael W MW; Thompson, Paul M PM; ,
Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.
Plos One
Lucas, Gavin G; Lluís-Ganella, Carla C; Subirana, Isaac I; Musameh, Muntaser D MD; Gonzalez, Juan Ramon JR; Nelson, Christopher P CP; Sentí, Mariano M; , ; , ; Schwartz, Stephen M SM; Siscovick, David D; O'Donnell, Christopher J CJ; Melander, Olle O; Salomaa, Veikko V; Purcell, Shaun S; Altshuler, David D; Samani, Nilesh J NJ; Kathiresan, Sekar S; Elosua, Roberto R
Biological, clinical and population relevance of 95 loci for blood lipids.
Nature
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