Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload.
The Journal Of Clinical Investigation
Preza, Gloria C GC; Ruchala, Piotr P; Pinon, Rogelio R; Ramos, Emilio E; Qiao, Bo B; Peralta, Michael A MA; Sharma, Shantanu S; Waring, Alan A; Ganz, Tomas T; Nemeth, Elizabeta E
The hepcidin-binding site on ferroportin is evolutionarily conserved.
Cell Metabolism
De Domenico, Ivana I; Nemeth, Elizabeta E; Nelson, Jenifer M JM; Phillips, John D JD; Ajioka, Richard S RS; Kay, Michael S MS; Kushner, James P JP; Ganz, Tomas T; Ward, Diane M DM; Kaplan, Jerry J