Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties.
Biochemistry
Jayaraman, Murali M; Mishra, Rakesh R; Kodali, Ravindra R; Thakur, Ashwani K AK; Koharudin, Leonardus M I LM; Gronenborn, Angela M AM; Wetzel, Ronald R
Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates.
Journal Of Molecular Biology
Mishra, Rakesh R; Jayaraman, Murali M; Roland, Bartholomew P BP; Landrum, Elizabeth E; Fullam, Timothy T; Kodali, Ravindra R; Thakur, Ashwani K AK; Arduini, Irene I; Wetzel, Ronald R
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism.
Nature Structural & Molecular Biology
Thakur, Ashwani K AK; Jayaraman, Murali M; Mishra, Rakesh R; Thakur, Monika M; Chellgren, Veronique M VM; Byeon, In-Ja L IJ; Anjum, Dalaver H DH; Kodali, Ravindra R; Creamer, Trevor P TP; Conway, James F JF; Gronenborn, Angela M AM; Wetzel, Ronald R