Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration.
Nature Communications
Law, Ah-Lai AL; Jalal, Shamsinar S; Pallett, Tommy T; Mosis, Fuad F; Guni, Ahmad A; Brayford, Simon S; Yolland, Lawrence L; Marcotti, Stefania S; Levitt, James A JA; Poland, Simon P SP; Rowe-Sampson, Maia M; Jandke, Anett A; Köchl, Robert R; Pula, Giordano G; Ameer-Beg, Simon M SM; Stramer, Brian Marc BM; Krause, Matthias M
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
Elife
Arts, Janine Jg JJ; Mahlandt, Eike K EK; Grönloh, Max Lb ML; Schimmel, Lilian L; Noordstra, Ivar I; Gordon, Emma E; van Steen, Abraham Ci AC; Tol, Simon S; Walzog, Barbara B; van Rijssel, Jos J; Nolte, Martijn A MA; Postma, Marten M; Khuon, Satya S; Heddleston, John M JM; Wait, Eric E; Chew, Teng Leong TL; Winter, Mark M; Montanez, Eloi E; Goedhart, Joachim J; van Buul, Jaap D JD
Rac and Arp2/3-Nucleated Actin Networks Antagonize Rho During Mitotic and Meiotic Cleavages.
Frontiers In Cell And Developmental Biology
Pal, Debadrita D; Ellis, Andrea A; Sepúlveda-Ramírez, Silvia P SP; Salgado, Torey T; Terrazas, Isabella I; Reyes, Gabriela G; De La Rosa, Richard R; Henson, John H JH; Shuster, Charles B CB
Differential regulation of rho GTPases during lung adenocarcinoma migration and invasion reveals a novel role of the tumor suppressor StarD13 in invadopodia regulation.
Cell Communication And Signaling : Ccs
Al Haddad, Maria M; El-Rif, Rayane R; Hanna, Samer S; Jaafar, Leila L; Dennaoui, Rayanne R; Abdellatef, Sandra S; Miskolci, Veronika V; Cox, Dianne D; Hodgson, Louis L; El-Sibai, Mirvat M
An intestinal zinc sensor regulates food intake and developmental growth.
Nature
Redhai, Siamak S; Pilgrim, Clare C; Gaspar, Pedro P; Giesen, Lena van LV; Lopes, Tatiana T; Riabinina, Olena O; Grenier, Théodore T; Milona, Alexandra A; Chanana, Bhavna B; Swadling, Jacob B JB; Wang, Yi-Fang YF; Dahalan, Farah F; Yuan, Michaela M; Wilsch-Brauninger, Michaela M; Lin, Wei-Hsiang WH; Dennison, Nathan N; Capriotti, Paolo P; Lawniczak, Mara K N MKN; Baines, Richard A RA; Warnecke, Tobias T; Windbichler, Nikolai N; Leulier, Francois F; Bellono, Nicholas W NW; Miguel-Aliaga, Irene I
A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance.
Cell
Newby, Gregory A GA; Kiriakov, Szilvia S; Hallacli, Erinc E; Kayatekin, Can C; Tsvetkov, Peter P; Mancuso, Christopher P CP; Bonner, J Maeve JM; Hesse, William R WR; Chakrabortee, Sohini S; Manogaran, Anita L AL; Liebman, Susan W SW; Lindquist, Susan S; Khalil, Ahmad S AS
Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.
Molecular Biology Of The Cell
Rosenberg, Brian J BJ; Gil-Henn, Hava H; Mader, Christopher C CC; Halo, Tiffany T; Yin, Taofei T; Condeelis, John J; Machida, Kazuya K; Wu, Yi I YI; Koleske, Anthony J AJ
A role for activated Cdc42 in glioblastoma multiforme invasion.
Oncotarget
Okura, Hidehiro H; Golbourn, Brian J BJ; Shahzad, Uswa U; Agnihotri, Sameer S; Sabha, Nesrin N; Krieger, Jonathan R JR; Figueiredo, Carlyn A CA; Chalil, Alan A; Landon-Brace, Natalie N; Riemenschneider, Alexandra A; Arai, Hajime H; Smith, Christian A CA; Xu, Songli S; Kaluz, Stefan S; Marcus, Adam I AI; Van Meir, Erwin G EG; Rutka, James T JT
Endocytic membrane turnover at the leading edge is driven by a transient interaction between Cdc42 and GRAF1.
Journal Of Cell Science
Francis, Monika K MK; Holst, Mikkel R MR; Vidal-Quadras, Maite M; Henriksson, Sara S; Santarella-Mellwig, Rachel R; Sandblad, Linda L; Lundmark, Richard R
TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility.
Plos One
Cáceres, Mónica M; Ortiz, Liliana L; Recabarren, Tatiana T; Romero, Anibal A; Colombo, Alicia A; Leiva-Salcedo, Elías E; Varela, Diego D; Rivas, José J; Silva, Ian I; Morales, Diego D; Campusano, Camilo C; Almarza, Oscar O; Simon, Felipe F; Toledo, Hector H; Park, Kang-Sik KS; Trimmer, James S JS; Cerda, Oscar O
Rheb protein binds CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase) protein in a GTP- and effector domain-dependent manner and influences its cellular localization and carbamoyl-phosphate synthetase (CPSase) activity.
Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR).
The Journal Of Biological Chemistry
Mazhab-Jafari, Mohammad T MT; Marshall, Christopher B CB; Ho, Jason J; Ishiyama, Noboru N; Stambolic, Vuk V; Ikura, Mitsuhiko M
Exo70 generates membrane curvature for morphogenesis and cell migration.
Developmental Cell
Zhao, Yuting Y; Liu, Jianglan J; Yang, Changsong C; Capraro, Benjamin R BR; Baumgart, Tobias T; Bradley, Ryan P RP; Ramakrishnan, N N; Xu, Xiaowei X; Radhakrishnan, Ravi R; Svitkina, Tatyana T; Guo, Wei W
Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells.
American Journal Of Physiology. Cell Physiology
Lukyanenko, Valeriy V; Malyukova, Irina I; Hubbard, Ann A; Delannoy, Michael M; Boedeker, Edgar E; Zhu, Chengru C; Cebotaru, Liudmila L; Kovbasnjuk, Olga O
Structure and control of the actin regulatory WAVE complex.
Nature
Chen, Zhucheng Z; Borek, Dominika D; Padrick, Shae B SB; Gomez, Timothy S TS; Metlagel, Zoltan Z; Ismail, Ayman M AM; Umetani, Junko J; Billadeau, Daniel D DD; Otwinowski, Zbyszek Z; Rosen, Michael K MK
GTPase activity plays a key role in the pathobiology of LRRK2.
Plos Genetics
Xiong, Yulan Y; Coombes, Candice E CE; Kilaru, Austin A; Li, Xiaojie X; Gitler, Aaron D AD; Bowers, William J WJ; Dawson, Valina L VL; Dawson, Ted M TM; Moore, Darren J DJ
The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.
Traffic (Copenhagen, Denmark)
Fang, Zhiyou Z; Takizawa, Norio N; Wilson, Korey A KA; Smith, Tara C TC; Delprato, Anna A; Davidson, Michael W MW; Lambright, David G DG; Luna, Elizabeth J EJ
Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor.
The Journal Of Biological Chemistry
Ruusala, Aino A; Pawson, Tony T; Heldin, Carl-Henrik CH; Aspenström, Pontus P
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
The Journal Of Cell Biology
Sakurai-Yageta, Mika M; Recchi, Chiara C; Le Dez, Gaëlle G; Sibarita, Jean-Baptiste JB; Daviet, Laurent L; Camonis, Jacques J; D'Souza-Schorey, Crislyn C; Chavrier, Philippe P