Molecular basis for differential activation of p101 and p84 complexes of PI3Kγ by Ras and GPCRs.
Cell Reports
Rathinaswamy, Manoj K MK; Jenkins, Meredith L ML; Duewell, Benjamin R BR; Zhang, Xuxiao X; Harris, Noah J NJ; Evans, John T JT; Stariha, Jordan T B JTB; Dalwadi, Udit U; Fleming, Kaelin D KD; Ranga-Prasad, Harish H; Yip, Calvin K CK; Williams, Roger L RL; Hansen, Scott D SD; Burke, John E JE
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS.
Embo Molecular Medicine
Nieuwenhuis, Bart B; Barber, Amanda C AC; Evans, Rachel S RS; Pearson, Craig S CS; Fuchs, Joachim J; MacQueen, Amy R AR; van Erp, Susan S; Haenzi, Barbara B; Hulshof, Lianne A LA; Osborne, Andrew A; Conceicao, Raquel R; Khatib, Tasneem Z TZ; Deshpande, Sarita S SS; Cave, Joshua J; Ffrench-Constant, Charles C; Smith, Patrice D PD; Okkenhaug, Klaus K; Eickholt, Britta J BJ; Martin, Keith R KR; Fawcett, James W JW; Eva, Richard R
Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells.
Elife
Hung, Yin P YP; Teragawa, Carolyn C; Kosaisawe, Nont N; Gillies, Taryn E TE; Pargett, Michael M; Minguet, Marta M; Distor, Kevin K; Rocha-Gregg, Briana L BL; Coloff, Jonathan L JL; Keibler, Mark A MA; Stephanopoulos, Gregory G; Yellen, Gary G; Brugge, Joan S JS; Albeck, John G JG
Affimer proteins are versatile and renewable affinity reagents.
Elife
Tiede, Christian C; Bedford, Robert R; Heseltine, Sophie J SJ; Smith, Gina G; Wijetunga, Imeshi I; Ross, Rebecca R; AlQallaf, Danah D; Roberts, Ashley Pe AP; Balls, Alexander A; Curd, Alistair A; Hughes, Ruth E RE; Martin, Heather H; Needham, Sarah R SR; Zanetti-Domingues, Laura C LC; Sadigh, Yashar Y; Peacock, Thomas P TP; Tang, Anna A AA; Gibson, Naomi N; Kyle, Hannah H; Platt, Geoffrey W GW; Ingram, Nicola N; Taylor, Thomas T; Coletta, Louise P LP; Manfield, Iain I; Knowles, Margaret M; Bell, Sandra S; Esteves, Filomena F; Maqbool, Azhar A; Prasad, Raj K RK; Drinkhill, Mark M; Bon, Robin S RS; Patel, Vikesh V; Goodchild, Sarah A SA; Martin-Fernandez, Marisa M; Owens, Ray J RJ; Nettleship, Joanne E JE; Webb, Michael E ME; Harrison, Michael M; Lippiat, Jonathan D JD; Ponnambalam, Sreenivasan S; Peckham, Michelle M; Smith, Alastair A; Ferrigno, Paul Ko PK; Johnson, Matt M; McPherson, Michael J MJ; Tomlinson, Darren Charles DC
Deconvolution of Buparlisib's mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention.
Nature Communications
Bohnacker, Thomas T; Prota, Andrea E AE; Beaufils, Florent F; Burke, John E JE; Melone, Anna A; Inglis, Alison J AJ; Rageot, Denise D; Sele, Alexander M AM; Cmiljanovic, Vladimir V; Cmiljanovic, Natasa N; Bargsten, Katja K; Aher, Amol A; Akhmanova, Anna A; Díaz, J Fernando JF; Fabbro, Doriano D; Zvelebil, Marketa M; Williams, Roger L RL; Steinmetz, Michel O MO; Wymann, Matthias P MP