The mechanism of the reaction catalyzed by uronate isomerase illustrates how an isomerase may have evolved from a hydrolase within the amidohydrolase superfamily.
Biochemistry
Nguyen, Tinh T TT; Fedorov, Alexander A AA; Williams, Lakenya L; Fedorov, Elena V EV; Li, Yingchun Y; Xu, Chengfu C; Almo, Steven C SC; Raushel, Frank M FM