Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.
Elife
Karandur, Deepti D; Bhattacharyya, Moitrayee M; Xia, Zijie Z; Lee, Young Kwang YK; Muratcioglu, Serena S; McAffee, Darren D; McSpadden, Ethan D ED; Qiu, Baiyu B; Groves, Jay T JT; Williams, Evan R ER; Kuriyan, John J
Activation-triggered subunit exchange between CaMKII holoenzymes facilitates the spread of kinase activity.
Elife
Stratton, Margaret M; Lee, Il-Hyung IH; Bhattacharyya, Moitrayee M; Christensen, Sune M SM; Chao, Luke H LH; Schulman, Howard H; Groves, Jay T JT; Kuriyan, John J