Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine.
Nucleic Acids Research
Spanjaard, Aldo A; Shah, Ronak R; de Groot, Daniël D; Buoninfante, Olimpia Alessandra OA; Morris, Ben B; Lieftink, Cor C; Pritchard, Colin C; Zürcher, Lisa M LM; Ormel, Shirley S; Catsman, Joyce J I JJI; de Korte-Grimmerink, Renske R; Siteur, Bjørn B; Proost, Natalie N; Boadum, Terry T; van de Ven, Marieke M; Song, Ji-Ying JY; Kreft, Maaike M; van den Berk, Paul C M PCM; Beijersbergen, Roderick L RL; Jacobs, Heinz H
TP53 mutations confer resistance to hypomethylating agents and BCL-2 inhibition in myeloid neoplasms.
Blood Advances
Schimmer, Roman R RR; Kovtonyuk, Larisa V LV; Klemm, Nancy N; Fullin, Jonas J; Stolz, Sebastian M SM; Mueller, Jan J; Caiado, Francisco F; Kurppa, Kari J KJ; Ebert, Benjamin L BL; Manz, Markus G MG; Boettcher, Steffen S
Small molecule inhibitor of OGG1 blocks oxidative DNA damage repair at telomeres and potentiates methotrexate anticancer effects.
Scientific Reports
Baquero, Juan Miguel JM; Benítez-Buelga, Carlos C; Rajagopal, Varshni V; Zhenjun, Zhao Z; Torres-Ruiz, Raúl R; Müller, Sarah S; Hanna, Bishoy M F BMF; Loseva, Olga O; Wallner, Olov O; Michel, Maurice M; Rodríguez-Perales, Sandra S; Gad, Helge H; Visnes, Torkild T; Helleday, Thomas T; Benítez, Javier J; Osorio, Ana A
11-Keto-α-Boswellic Acid, a Novel Triterpenoid from Boswellia spp. with Chemotaxonomic Potential and Antitumor Activity against Triple-Negative Breast Cancer Cells.
Molecules (Basel, Switzerland)
Schmiech, Michael M; Ulrich, Judith J; Lang, Sophia Johanna SJ; Büchele, Berthold B; Paetz, Christian C; St-Gelais, Alexis A; Syrovets, Tatiana T; Simmet, Thomas T
Discovery of a selective inhibitor of doublecortin like kinase 1.
Nature Chemical Biology
Ferguson, Fleur M FM; Nabet, Behnam B; Raghavan, Srivatsan S; Liu, Yan Y; Leggett, Alan L AL; Kuljanin, Miljan M; Kalekar, Radha L RL; Yang, Annan A; He, Shuning S; Wang, Jinhua J; Ng, Raymond W S RWS; Sulahian, Rita R; Li, Lianbo L; Poulin, Emily J EJ; Huang, Ling L; Koren, Jost J; Dieguez-Martinez, Nora N; Espinosa, Sergio S; Zeng, Zhiyang Z; Corona, Cesear R CR; Vasta, James D JD; Ohi, Ryoma R; Sim, Taebo T; Kim, Nam Doo ND; Harshbarger, Wayne W; Lizcano, Jose M JM; Robers, Matthew B MB; Muthaswamy, Senthil S; Lin, Charles Y CY; Look, A Thomas AT; Haigis, Kevin M KM; Mancias, Joseph D JD; Wolpin, Brian M BM; Aguirre, Andrew J AJ; Hahn, William C WC; Westover, Kenneth D KD; Gray, Nathanael S NS
Long-term expanding human airway organoids for disease modeling.
The Embo Journal
Sachs, Norman N; Papaspyropoulos, Angelos A; Zomer-van Ommen, Domenique D DD; Heo, Inha I; Böttinger, Lena L; Klay, Dymph D; Weeber, Fleur F; Huelsz-Prince, Guizela G; Iakobachvili, Nino N; Amatngalim, Gimano D GD; de Ligt, Joep J; van Hoeck, Arne A; Proost, Natalie N; Viveen, Marco C MC; Lyubimova, Anna A; Teeven, Luc L; Derakhshan, Sepideh S; Korving, Jeroen J; Begthel, Harry H; Dekkers, Johanna F JF; Kumawat, Kuldeep K; Ramos, Emilio E; van Oosterhout, Matthijs Fm MF; Offerhaus, G Johan GJ; Wiener, Dominique J DJ; Olimpio, Eduardo P EP; Dijkstra, Krijn K KK; Smit, Egbert F EF; van der Linden, Maarten M; Jaksani, Sridevi S; van de Ven, Marieke M; Jonkers, Jos J; Rios, Anne C AC; Voest, Emile E EE; van Moorsel, Coline Hm CH; van der Ent, Cornelis K CK; Cuppen, Edwin E; van Oudenaarden, Alexander A; Coenjaerts, Frank E FE; Meyaard, Linde L; Bont, Louis J LJ; Peters, Peter J PJ; Tans, Sander J SJ; van Zon, Jeroen S JS; Boj, Sylvia F SF; Vries, Robert G RG; Beekman, Jeffrey M JM; Clevers, Hans H
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential.
Nature Medicine
Roberts, Adam B AB; Gu, Xiaodong X; Buffa, Jennifer A JA; Hurd, Alex G AG; Wang, Zeneng Z; Zhu, Weifei W; Gupta, Nilaksh N; Skye, Sarah M SM; Cody, David B DB; Levison, Bruce S BS; Barrington, William T WT; Russell, Matthew W MW; Reed, Jodie M JM; Duzan, Ashraf A; Lang, Jennifer M JM; Fu, Xiaoming X; Li, Lin L; Myers, Alex J AJ; Rachakonda, Suguna S; DiDonato, Joseph A JA; Brown, J Mark JM; Gogonea, Valentin V; Lusis, Aldons J AJ; Garcia-Garcia, Jose Carlos JC; Hazen, Stanley L SL