Publications:

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Structural mechanisms of CFTR function and dysfunction.

The Journal Of General Physiology

Hwang, Tzyh-Chang TC; Yeh, Jiunn-Tyng JT; Zhang, Jingyao J; Yu, Ying-Chun YC; Yeh, Han-I HI; Destefano, Samantha S

Publication Date: 2018-04-02

Variant appearance in text: CFTR: K190C

PubMed Link: 29581173

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• JGP_201711946.pdf

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Transmembrane helical interactions in the CFTR channel pore.

Plos Computational Biology

Das, Jhuma J; Aleksandrov, Andrei A AA; Cui, Liying L; He, Lihua L; Riordan, John R JR; Dokholyan, Nikolay V NV

Publication Date: 2017-06

Variant appearance in text: CFTR: K190C

PubMed Link: 28640808

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• Main text
• pcbi.1005594.pdf

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Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2015-06-19

Variant appearance in text: CFTR: K190C

PubMed Link: 25944907

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Converting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutations.

The Journal Of Biological Chemistry

Okeyo, George G; Wang, Wei W; Wei, Shipeng S; Kirk, Kevin L KL

Publication Date: 2013-06-14

Variant appearance in text: CFTR: K190C

PubMed Link: 23620589

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Thermally unstable gating of the most common cystic fibrosis mutant channel (ΔF508): "rescue" by suppressor mutations in nucleotide binding domain 1 and by constitutive mutations in the cytosolic loops.

The Journal Of Biological Chemistry

Wang, Wei W; Okeyo, George O GO; Tao, Binli B; Hong, Jeong S JS; Kirk, Kevin L KL

Publication Date: 2011-12-09

Variant appearance in text: CFTR: K190C

PubMed Link: 21965669

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The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2011-01-21

Variant appearance in text: CFTR: K190C

PubMed Link: 21059651

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ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Wang, Wei W; Wu, Jianping J; Bernard, Karen K; Li, Ge G; Wang, Guangyu G; Bevensee, Mark O MO; Kirk, Kevin L KL

Publication Date: 2010-02-23

Variant appearance in text: CFTR: K190C

PubMed Link: 20133716

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